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Search Results: 1 - 10 of 471636 matches for " S. N. Wadhwa "
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Alkaline protease from senesced leaves of invasive weed
S Gaur, N Wadhwa
African Journal of Biotechnology , 2008,
Abstract: Protease from senesced leaves of the weed Lantana camara was purified in a 2-step procedure involving ammonium sulfate precipitation and Sephadex G-250 gel permeation chromatography. The Sephadex-G-250 fraction of senesced leaves of Lantana camara showed 28.31 fold with a yield of 6.19%. The enzyme was shown to have a low molecular weight of 43 kda by SDS-PAGE. It was strongly activated by metal ions such as Cu2+, Zn2+, Mg2+, Co2+ and Mn2+. It remained active at 60°C, pH 10.5 even after 1 h of incubation when casein was used as substrate. The compatibility of the enzyme was studied with commercial and local detergents, 60% activity of the enzyme was retained even after 1 h of incubation at pH 10.0. The easy availability of the senesced leaves of this common weed makes it a cheaper enzyme source and potential additive in detergents.
Vaccines and Antibodies for Therapeutic Use in Cancers  [PDF]
G. P. Talwar, Jagdish C. Gupta, M. Diwan, J. Frick, S. K. Sharma, S. N. Wadhwa, R. M. Gupta, S. K. Gupta, Shilpi Purswani, Hemant K. Vyas
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.76040
Abstract: This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. Monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. MoAb730 and MoAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as MOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “Magic Bullet”. All MOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved Mycobacterium indicus pranii (MiP) as adjuvant. MiP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, MiP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O Myelomas in mice.
Quantitative Stereology: The Use of Camera Lucida for Counting Neurons by Physical Disector Method in Chick Brainstem Auditory Nuclei
Wadhwa S
Journal of Postgraduate Medicine , 2003,
An Unusual Case of Acute Pancreatitis in a Child
BG Joshi,N Wadhwa
Journal of Nepal Paediatric Society , 2012, DOI: 10.3126/jnps.v32i1.5484
Abstract: Ascaris lumbricoides is a common intestinal parasite in tropical regions.Pancreatitis due to worm infestation is an uncommon but important cause in this region. While there are reports of pancreatic duct invasion by round worms in adults, such cases are rarely reported in pediatric population. We report one such case in a sixteen year old child.?
Developing human optic nerve in prenatal period changes in the numbers of retinal axons.
Wadhwa S,Bijlani V
Indian Journal of Ophthalmology , 1987,
Abstract: A quantitative estimation of the number of axons in the optic nerves of human foetuses ranging from approximately 8 to 26 weeks has been made. This study shows that from 8 weeks there is a steady increase in the number of axons with subsequent decrease by 26 weeks, during the period of lamination in the dorsal lateral geniculate nucleus (dLGN).
Foreign Direct Investment into Developing Asian Countries: The Role of Market Seeking, Resource Seeking and Efficiency Seeking Factors
Kavita Wadhwa,Sudhakara Reddy S
International Journal of Business and Management , 2011, DOI: 10.5539/ijbm.v6n11p219
Abstract: According to eclectic theory of Dunning, FDI could be of four types: market seeking, resource seeking, efficiency seeking and strategic asset seeking. Market seeking factors of FDI such as market size, market growth, structure of domestic market, etc. aim at penetrating the local markets of host countries. While resource seeking investments are made in order to have access to cheap raw material, pool of labor, infrastructure, etc. New sources of competitiveness, economies of scope and specialization and low cost of production are some of the efficiency seeking factors of FDI. An attempt is made to study the impact of market seeking, efficiency seeking and resource seeking factors of host countries on FDI inflows of host countries by taking sample 10 Asian countries in the time period 1991 to 2008. Panel regression results show that all categories of FDI motivating factors have a significant impact on FDI inflows.
Varying light regimes in naturally growing Jatropha curcus: pigment, proline and photosynthetic performance
Wadhwa R.,N. Kumari,V. Sharma
Journal of Stress Physiology & Biochemistry , 2010,
Abstract: Light stress is a major abiotic stress which adversely affects productivity of the plants. Tolerance to abiotic stresses is very complex, due to the intricate of interactions between stress factors and various molecular, biochemical and physiological phenomena affecting plant growth and development. In many cases, high yield potential can contribute to yield in moderate stress environment. We studied chlorophyll (Chl) a fluorescence parameters and analyzed D1 core protein in one year old plants of Jatropha curcus under different light regimes (10–1200 μmol m–2 s–1) in sun and shade plants. Chl a fluorescence provides insights into the responses of the photosynthetic system to increasing irradiance. Total Chl content was 1.43 and 0.61 mg/g-1 FM for shade and sun exposed plants respectively. The effective quantum yield (ΔF/Fm') of the sun plants was lower as compared to shade plants but the amount of the D1 core protein was higher in plants grown under high light intensity. A decrease in ΔF/Fm' indicates down regulation of photosynthesis or photoinhibition. D1 protein is the membrane protein complex of the PSII reaction centre. The degradation of D1 protein may regulate the functioning of the PSII repair cycle under photoinhibitory conditions. It has been shown that low-light grown or shade plants are more susceptible to photoinhibition than high light or sun plants. This higher susceptibility is accompanied by slow degradation of damaged D1 protein. High light intensity or exposure to photooxidation leads to the irreversible damage in photosynthetic performance and consequently has an overall inhibitory effect on crop productivity.
Nikam Balkrishna,Amladi Sangeeta,Wadhwa S
Indian Journal of Dermatology, Venereology and Leprology , 2006,
How reliable are serological tests in diagnosis of cysticercosis?
Wadhwa V,Kharbanda P,Rai S
Indian Journal of Medical Microbiology , 2006,
Cutaneous vasculitis with peripheral neuropathy
Joshi R,Phadke V,Wadhwa S
Indian Journal of Dermatology, Venereology and Leprology , 1995,
Abstract: a 40-year-old male patient presented with cutaneous vasculitis affecting both lower legs without any evidence of systemic involvement and a bilateral sensory neuropathy affecting both lateral popliteal nerves. Treatment with oral prednisolone resulted in healing of the cutaneous lesions but the sensory loss persisted.
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