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Search Results: 1 - 10 of 438386 matches for " S?NIA BEATRIZ F.;LEBOREIRO-FERNANDEZ "
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Terson's syndrome: report of a case with favorable outcome
Arquivos de Neuro-Psiquiatria , 1998, DOI: 10.1590/S0004-282X1998000100024
Abstract: terson's syndrome is characterized by the presence of a subarachnoid hemorrhage accompanied by retinal and vitreous hemorrhage leading to a not very favorable prognosis. we describe a case with a good outcome, probably because of a early diagnosis and medical intervention. we emphasize the routine optician's check up as very important in the evaluation of a prognosis in the cases of a suspect intracranial hemorrhage .
Terson's syndrome: report of a case with favorable outcome
Arquivos de Neuro-Psiquiatria , 1998,
Abstract: Terson's syndrome is characterized by the presence of a subarachnoid hemorrhage accompanied by retinal and vitreous hemorrhage leading to a not very favorable prognosis. We describe a case with a good outcome, probably because of a early diagnosis and medical intervention. We emphasize the routine optician's check up as very important in the evaluation of a prognosis in the cases of a suspect intracranial hemorrhage .
Infarto estriatocapsular na infancia: relato de quatro casos
Leboreiro-Fernandez, A.;Leboreiro, I.E.F.;Moura-Ribeiro, M.V.L.;
Arquivos de Neuro-Psiquiatria , 1994, DOI: 10.1590/S0004-282X1994000300018
Abstract: the authors present the study of four children that manifested asymmetric hemiparesis with sudden onset, without consciousness loss. the diagnosis of striatocapsular infarction was confirmed by computed tomography (ct) and magnetic resonance imaging (mri). the clinical and neurological examination, and laboratorial results are discussed. familial history of migraine was found in two of the patients. migraine was diagnosed in two, mild head trauma, viral miocarditis and mitral valve prolapse in one. left hemiparesis, with brachiofacial features in three, and brachial in one. ct showed lenticular nucleus and internal capsule lesions in all of them, head of caudate nucleus in three, and white substance in two. mri was done in two and confirmed ct findings. electroencephalogram, at the acute phase in three, showed abnormalities in all patients.
Cytokines in cerebrospinal fluid of children with West syndrome
Sousa, MA Dias de;Bonatti, RCF;Rodrigues Jr, V;Azevedo, DS;Santos, MHA;Pereira, ROL;Leboreiro-Fernandez, A;
Journal of Epilepsy and Clinical Neurophysiology , 2012, DOI: 10.1590/S1676-26492012000200010
Abstract: in this study we aimed to determine the levels of tumor necrosis factor beta (tnf-b), interleukin (il) 1-beta (il-1b), il-5, il-10, and interferon gamma (ifn-g ) in csf from children during the onset of west syndrome (ws). we observed elevated levels of il-1b and ifn-g correlated to clinical, eeg, therapeutic response, and follow-up suggesting the involvement of immune response in ws. these results suggest that inflammatory and immunologic mediators may play a role in the pathophysiologic mechanisms of infantile spasms. our findings may explain the perfusion and cognitive disfunctions and actions of adrenocorticotropic hormone (acth), corticosteroids, and intravenous immunoglobulin (ivig) observed in ws. in conclusion, ws results from association of neurophysiological mechanisms and structural abnormalities with participation of cytokines mainly in symptomatic group.
Mumps meningoencephalitis: an epidemiological approach
Leboreiro-Fernandez, Alfredo;Moura-Ribeiro, Maria Valeriana L;Leboreiro, Ivone Elisabete Ferreira;Sawan, Fahim Miguel;Ventura, Alessandra Ribeiro;Barbosa, Kellen Cristina Kamimura;
Arquivos de Neuro-Psiquiatria , 1997, DOI: 10.1590/S0004-282X1997000100003
Abstract: the aim of this study was to analyse distribution of meningoencefalitis caused by mumps viras in children related to sex, age and seasonal influences. thirty seven children were evaluated, ages ranging from 2 to 14 years. they were seen at emergency unit of faculdade de medicina do triangulo mineiro and at hospital da crian?a, in uberaba-mg, brazil, from march 1st 1991 to february 1st 1993 and they were hospitalized for about 5 days. through a protocol findings were studied during hospitalization and clinical course stressing epidemiology, symptomatology, cerebrospinal fluid studies, electroencephalogram and cortical function analysis. only epidemiological data were considered in the present study. data analysis revealed male predominance, at a range from 5 to 9 years and great number of occurrences at the last quarter of the year.
Aspects of immune and inflammatory response in mumps meningoencephalitis: cytokines quantification
Arquivos de Neuro-Psiquiatria , 1999,
Detection of Contamination and Analysis of Vertical Transmission of BmNPV in Eggs and Moths of Bombyx mori  [PDF]
Cláudia Regina das Neves Saez, Roxelle Ethienne Ferreira Munhoz, Naiara Climas Pereira, Thaís Souto Bignotto, Ver?nica Aureliana Fassina, Graziele Milani Pessini, Laura Beatriz Garay, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalh?o, Maria Aparecida Fernandez
Open Journal of Genetics (OJGen) , 2014, DOI: 10.4236/ojgen.2014.45034

This study reports the molecular detection of Bombyx mori nucleopolyhedrovirus (BmNPV) in silkworm strains of the Universidade Estadual de Maringá Brazilian Germplasm Bank (UBGB). DNA extraction was carried out by using six Bombyx mori female moths of each strain, followed by PCR amplification. A pair of primers was designed based on a specific sequence of the baculovirus genome related to the BmNPV ORF 14. Another pair of primers was used to amplify the silkworm Actin A3 gene segment, which was used as positive control. Twenty gene pools were analyzed, and fifteen revealed a fragment of 443 base pairs (bp), which indicated the presence of the BmNPV. The frequency of contaminated moths was as following: 100% for silkworm strains M18-2, M12-2 and J1; 83% for C25, C75 and C24 strains; 66% for KR01; 50% for M11-A; 33% for AS3, B106, M8 and M11 and 16% for C211, E8 and Hindu strains. These are promising results for the identification of contaminated B. mori moths by BmNPV, which may prevent virus proliferation in subsequent generations. We also analyzed DNA samples extracted from B. mori eggs, but the results were not conclusive regarding the detection of the fragments of the expected size (443 bp). The difficulty in detecting BmNPV contamination in B. mori eggs may be due to the low concentration of virus in samples.

Lúpus neonatal e Lúpus Eritematoso Cutaneo Subagudo na infancia
Freire, Marlene;Teodoro, Reginaldo Botelho;Silva, José Humberto da;Fernandez, Alfredo Leboreiro;Oliveira, Lília Beatriz;Bianco, José Ant?nio de Paula;
Revista Brasileira de Reumatologia , 2004, DOI: 10.1590/S0482-50042004000300012
Abstract: although lupus erythematosus (le) rarely occurs in childhood when it does the most frequent form is the systemic one (sle). lupus erythematosus restricted to the skin is particularly rare and can be classified into three variants: chronic discoid le (cdle), subacute cutaneous le (scle), and neonatal lupus erythematosus (nle). based on literature data and in the rarity of the disease, we present two cases of cutaneous lupus in infants. one case of scle started in a four-month child presenting systematization manifested by neurological disorder by the age of 5 years old; and one of ln. this case refers to a white, male, 5 year-old patient, with multiple round lesions with papulosquamous, alopecia, arthralgias and walking disorder. the neurological exam presented retarded motor development and signs of pyramidal syndrome. in the second case we report neonatal lupus erythematosus in a one-month child, whose mother had scle, presenting annular erythematous skin lesions noticed at birth. other clinical features included anemia, thrombocytopenia and patent ductus arteriosus. the diagnosis of nle was based on laboratory, histology, and family antecedents clinical data. we considering that the rarity of infant cutaneous lupus, when facing suspicious cases, we should pay close attention in order to established early diagnosis and careful follow-up to detect possible complications and systematization of the disease.
Clinical and epidemiological profile of patients with multiple sclerosis in Uberaba, Minas Gerais, Brazil
Ribeiro, Snia Beatriz Félix;Maia, Danilo Fonseca;Ribeiro, Jo?o Batista;Cardoso, Fabrízio Ant?nio Gomide;Silva, Cátia;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000200008
Abstract: multiple sclerosis (ms) is an immune-mediated disease that affects the central nervous system. clinical presentation and prevalence vary widely around the world. objective: to describe the clinical and epidemiological aspects of patients with ms in uberaba (mg). method: we conducted a transversal descriptive study, with data analysis of 35 patients with ms. results: prevalence of ms was 12.5 cases/100,000 inhabitants, with a predominance in females (71.4%) and caucasoid (85.7%). the current average age was (43.8 ys). the most common initial symptom was sensory (40%), followed by optical neuritis (25.7%). expanded disability status scale average score was 2.4. the relapsing-remitting form was predominant (88.6%), most (74.3%) were on immunomodulatory treatment and (40%) had college education. conclusion: prevalence of ms in uberaba (mg) is considered average in accordance to kurtzke and page and clinical features are consistent with most brazilian studies.
DNA Methylation Dynamics in Blood after Hematopoietic Cell Transplant
Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Rubén Salvanés, Manuel Muro, Pablo Martínez-Camblor, Enrique Colado, Miguel Alcoceba Sánchez, Marcos González Díaz, Agustin F. Fernandez, Mario F. Fraga, Carlos Lopez-Larrea
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056931
Abstract: Epigenetic deregulation is considered a common hallmark of cancer. Nevertheless, recent publications have demonstrated its association with a large array of human diseases. Here, we explore the DNA methylation dynamics in blood samples during hematopoietic cell transplant and how they are affected by pathophysiological events during transplant evolution. We analyzed global DNA methylation in a cohort of 47 patients with allogenic transplant up to 12 months post-transplant. Recipients stably maintained the donor’s global methylation levels after transplant. Nonetheless, global methylation is affected by chimerism status. Methylation analysis of promoters revealed that methylation in more than 200 genes is altered 1 month post-transplant when compared with non-pathological methylation levels in the donor. This number decreased by 6 months post-transplant. Finally, we analyzed methylation in IFN-γ, FASL, IL-10, and PRF1 and found association with the severity of the acute graft-versus-host disease. Our results provide strong evidence that methylation changes in blood are linked to underlying physiological events and demonstrate that DNA methylation analysis is a viable strategy for the study of transplantation and for development of biomarkers.
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