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Search Results: 1 - 10 of 473262 matches for " Sérgio Monteiro de; "
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Central Nervous System Paracoccidioidomycosis: an overview
Almeida, Sérgio Monteiro de;
Brazilian Journal of Infectious Diseases , 2005, DOI: 10.1590/S1413-86702005000200002
Abstract: paracoccidioidomycosis (pcm) is an infectious disease, endemic to subtropical areas of central and south america, caused by the dimorphic fungus paracoccidioides brasiliensis. it is a chronic disease, mostly affecting adult males, with a mean patient age of 44 years. central nervous system involvement (cns pcm) has been found in 13% of the patients with systemic disease. we reviewed the clinical presentation, diagnosis techniques and treatments for cns pcm.
Evaluation of the blood-brain barrier in the chronic graft versus host disease
Arquivos de Neuro-Psiquiatria , 1998,
Genotypical diversity of HIV clades and central nervous system impairment
Rotta, Indianara;Almeida, Sérgio Monteiro de;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000700023
Abstract: the central nervous system (cns) and the immune system are considered major target organs for hiv infection. the neurological manifestations directly related to hiv are acute viral meningitis, chronic meningitis, hiv associated dementia, vacuolar myelopathy and involvement of the peripheral nervous system. changes in diagnosis and clinical management have changed the aspect of hiv infection so that it is no longer a fatal disease, and has become a chronic disease requiring sustained medical management. after haart the incidence of most opportunistic infections, including those affecting the cns, has dropped markedly. some studies suggest that neurological involvement of infected patient occur with different frequency, depending on hiv subtype involved in the infection. subtype c may have reduced neuroinvasive capacity, possibly due to its different primary conformation of hiv transactivating regulatory protein (tat), involved in monocyte chemotaxis. this review focus on physiopathologic aspects of hiv infection in cns and its correlation with hiv clades.
Membrana neovascular sub-retineana justapapilar em paciente com papiledema e hipertens?o intracraniana idiopática
Monteiro, Mário Luiz Ribeiro;Jales, Martha de Queiroz Monteiro;Pimentel, Sérgio Luis Gianotti;
Revista Brasileira de Oftalmologia , 2009, DOI: 10.1590/S0034-72802009000100008
Abstract: we report a 41-years-old woman with idiopathic intracranial hyperthension (psedotumor cerebri syndrome) that presented with visual loss in one eye due to subretinal neovascular membrane involving the macular area. despite the introduction of adequate medical treatment followed by optic nerve sheath fenestration that lead to optic disc edema regression there was no improvement in the subretinal neovascular membrane even after performing three sequential intravitreal injection of bevacizumab. we stress the importance of recognizing this uncommon complication of papilledema and review the literature regarding such an occurrence. we also discuss the possible causes for developing subretinal membrane in papilledema, its most common outcome and the treatment modalities available for managing subretinal neovascular membrane in patients with pseudotumor cerebri syndrome.
Pathophysiology of acute meningitis caused by Streptococcus pneumoniae and adjunctive therapy approaches
Barichello, Tatiana;Generoso, Jaqueline S.;Collodel, Allan;Moreira, Ana Paula;Almeida, Sérgio Monteiro de;
Arquivos de Neuro-Psiquiatria , 2012, DOI: 10.1590/S0004-282X2012000500011
Abstract: pneumococcal meningitis is a life-threatening disease characterized by an acute purulent infection affecting piamater, arachnoid and the subarachnoid space. the intense inflammatory host's response is potentially fatal and contributes to the neurological sequelae. streptococcus pneumoniae colonizes the nasopharynx, followed by bacteremia, microbial invasion and blood-brain barrier traversal. s. pneumoniae is recognized by antigen-presenting cells through the binding of toll-like receptors inducing the activation of factor nuclear kappa b or mitogen-activated protein kinase pathways and subsequent up-regulation of lymphocyte populations and expression of numerous proteins involved in inflammation and immune response. many brain cells can produce cytokines, chemokines and others pro-inflammatory molecules in response to bacteria stimuli, as consequence, polymorphonuclear are attracted, activated and released in large amounts of superoxide anion and nitric oxide, leading to the peroxynitrite formation, generating oxidative stress. this cascade leads to lipid peroxidation, mitochondrial damage, blood-brain barrier breakdown contributing to cell injury during pneumococcal meningitis.
Desigualdade e heterogeneidade no desenvolvimento da Amaz?nia no século XXI
Lira, Sérgio Roberto Bacury de;Silva, Márcio Luiz Monteiro da;Pinto, Rosenira Siqueira;
Nova Economia , 2009, DOI: 10.1590/S0103-63512009000100007
Abstract: the deforestation of the amazon forest is one of the most important environmental problems faced by the brazilian government. the economic literature points to numerous factors responsible for deforestation, and many of these are, directly or indirectly, derived from federal spending. this article analyzes, through a panel data econometric model, how federal spending can influence, or mitigate, amazonian deforestation. the state of pará is used as a case study, as it presents the highest degree of deforestation among all amazonian states.
Ageing of the DGEBA/TETA epoxy system with off-stoichiometric compositions
d'Almeida, José Roberto Moraes;Menezes, Gustavo Wagner de;Monteiro, Sérgio Neves;
Materials Research , 2003, DOI: 10.1590/S1516-14392003000300017
Abstract: an investigation was carried out on the room temperature ageing of off-stoichiometric dgeba/teta epoxy formulations. the results obtained show that the epoxy rich mixtures have their inherent brittleness increased by the ageing treatment due to recrystalization of the unreacted epoxy monomers, although homopolymerization could also play a minor role. the initial reaction steps dominated by the amine addition reactions control the macromolecular structure and the mechanical performance of the stoichiometric and near stoichiometric formulation with excess of epoxy monomer. plasticization due to absorbed -oh results on a significant increase of the deformability of these formulations. the amine rich mixtures have the more stable structures, although plasticization due to moisture absorption from the surrounding environment also produces an increase on the deformability of all, but one, of the formulations investigated.
Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration
Almeida, Sérgio Monteiro de;Cunha, Dione Sosnitzki da;Yamada, Edna;Doi, Elvira Missako;Ono, Margaret;
Arquivos de Neuro-Psiquiatria , 2008, DOI: 10.1590/S0004-282X2008000500022
Abstract: several markers have been studied for their ability to make the cns infiltration diagnosis earlier and more precise; previous studies showed that csf ferritin concentrations were higher in patients with malignant invasion of cns. the objective was to determine the importance of csf ferritin as a biomarker for the diagnosis of cns neoplasic infiltration. this study is based on 93 csf samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). csf ferritin values were determined by micro particle enzyme immunoassay. csf ferritin level (mean±sd) in the group with neoplasic cells in the csf was 42.8±49.7 ng /ml, higher than in the other groups (p<0.0001). we conclude that csf ferritin with the cut off 20 ng/ml could be an adjuvant biomarker to the diagnosis of cns malignant infiltration.
Crude antigen from Taenia crassiceps cysticercus used as heterologous antigen in ELISA and in EITB for neurocysticercosis diagnosis of patients from Paraná-Brazil
Minozzo, Jo?o Carlos;Moura, Juliana de;Almeida, Sérgio Monteiro;Thomaz-Soccol, Vanete;
Brazilian Archives of Biology and Technology , 2008, DOI: 10.1590/S1516-89132008000600007
Abstract: neurocysticercosis (ncc), the cerebral presence of taenia solium metacestode (cysticercus cellulosae), is responsible for neurological disorders worldwide. in order to validate an immunodiagnosis for public-health patients in the state of parana-brazil, crude antigen of taenia crassicepsmetacestode (cysticercus longicollis) was used as an alternative heterologous antigen to be used in elisa and in electroimmunotransfer blotting (eitb) for active and inactive ncc diagnosis. indirect elisa was able to discriminate between active and inactive samples and presented high specificity and sensitivity. any immunodominant band was able to distinguish the ncc stages, although the eitb showed 100% specificity. the immunological results proved to be an important auxiliary toll for ncc diagnosis, mainly for public-health systems in developing countries, where either the neuroimage techniques are not accessible or the resources are scarce.
Tatumella ptyseos causing severe human infection: report of the first two Brazilian cases
Costa, Paulo Sérgio Gon?alves da;Mendes, Juliana Monteiro de Castro;Ribeiro, Geyza Machado;
Brazilian Journal of Infectious Diseases , 2008, DOI: 10.1590/S1413-86702008000500017
Abstract: tatumella ptyseos is the type species of the tatumella genus (enterobacteriaceae). this fermentative gram-negative rod has only rarely been reported as a cause of human infections; there is very little information about it in the medical literature. we report here the first two brazilian cases of t. ptyseos infections, both evolving to severe sepsis.
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