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Search Results: 1 - 10 of 324928 matches for " S Kotwal "
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Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature
Deshpande Archana,Kotwal M,Bobhate S
Indian Journal of Cancer , 2004,
Abstract: Glassy cell carcinoma is a poorly differentiated variant of adenosquamous carcinoma of the cervix associated with an aggressive course and a poor prognosis. We present three cases of glassy cell carcinoma of the cervix. Patients presented with a cervical growth which was biopsied. Histology the tumours showed nests of cells with a granular or clear cytoplasm, displaying marked pleomorphism and mitoses. Stroma showed an eosinophilic infiltrate. Two tumours showed a pure glassy cell pattern and one showed glandular differentiation with intracellular and extracellular mucin. Patients were treated with a combination of surgery, radiotherapy and chemotherapy but showed a poor response. Two patients died of the disease of pelvic or distant metastases within two years of diagnosis and one was lost to follow up. Although glassy cell carcinoma runs an aggressive clinical course, an early diagnosis may help in a more effective management and offer a better prognosis.
Inflammatory Myofibroblastic Tumor of the Urinary Bladder—A Case Report with Review of Literature  [PDF]
Mahesh Deshmukh, Radhika Pagey, Komal S. Galani, Prasanna Joshi, Amol Bitey, Mrunmayi Kotwal
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.44023
Abstract: Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with unknown malignant potential that has been described in most organ systems. We herein present a case of a young female who presented with macroscopic hematuria. An IMT of the urinary bladder which was not suspected after clinical, radiological and surgical work-up was diagnosed microscopically and confirmed by immunohistochemistry. A close clinical follow-up is recommended because of the unknown biological behavior of this tumor. A brief review of literature is also presented here.
Role of fine needle aspiration cytology in preoperative diagnosis of ameloblastoma
Bisht S,Kotwal S,Gupta P,Dawar R
Indian Journal of Cancer , 2009,
Giant cystosarcoma phyllodes tumor of prostate: Case report of a rare entity
Bhat Dharitri,Poflee S,Kotwal M,Pangarkar M
Indian Journal of Cancer , 2004,
Abstract: Although glandular and stromal proliferations of prostate are very common in adult men, neoplastic proliferations of prostatic stroma are distinctly uncommon. These tumors are now grouped as Prostatic Stromal Proliferations of Uncertain Malignant Potential (PSPUMP). Phyllodes tumor of the prostate is a rare neoplasm in this group with cellular, sarcomatoid stroma and benign hyperplastic glands. It is a locally expansile tumor with clinical course varying from benign to aggressive. We report a case of a 45-year-old man presented with retention of urine and abdominal lump. On laparotomy it was a huge tumor of 4 kg and was histologicaly characterized by cellular pleomorphic stroma and hyperplastic epithelium. Immunohistochemistry demonstrated prostate specific antigen in the glands. It was diagnosed as cystosarcoma phyllodes tumor of prostate. This is extremely uncommon tumor similar in histology to that of breast and it′s clinical course varies with the grade. The patient was without recurrence one year after surgery.
Sachin Kotwal,R.L. Parate,S.S. Mane,V.V. Deshmukh
International Journal of Science, Environment and Technology , 2012,
Sachin Kotwal,R.L. Parate,S.S. Mane,V.V. Deshmukh
International Journal of Science, Environment and Technology , 2012,
Enhanced fluorescent properties of an OmpT site deleted mutant of Green Fluorescent Protein
Shardul S Salunkhe, Veena A Raiker, Sachin Rewanwar, Prakash Kotwal, Avijeet Kumar, Sriram Padmanabhan
Microbial Cell Factories , 2010, DOI: 10.1186/1475-2859-9-26
Abstract: We describe the construction of two GFP variants with modified putative OmpT proteolytic sites by site directed mutagenesis (SDM). Such modified genes upon arabinose induction exhibited varied degrees of GFP fluorescence. While the mutation of K79G/R80A (SDM I) resulted in dramatic loss of fluorescence activity, the modification of K214A/R215A (SDM II) resulted in four fold enhanced fluorescence of GFP.This is the first report on effect of OmpT protease site modification on GFP fluorescence. The wild type and the GFP variants showed similar growth profile in bioreactor studies with similar amounts of recombinant GFP expressed in the soluble fraction of the cell. Our observations on higher levels of fluorescence of SDM II GFP mutant over native GFPuv in an OmpT+ host like DH5α, JM109 and LE392 at 37°C reiterates the role played by host OmpT in determining differences in fluorescent property of the expressed GFP. Both the WT GFP and the SDM II GFP plasmids in E. coli BL21 cells showed similar expression levels and similar GFP fluorescent activity at 37°C. This result substantiates our hypothesis that OmpT protease could be a possible factor responsible for reducing the expression of GFP at 37°C for WT GFP clone in K12 hosts like DH5α, JM109, LE 392 since the levels of GFP expression of SDM II clone in such cells at 37°C is higher than that seen with WT GFP clone at the same temperature.The Green Fluorescent Protein (GFP) isolated from coelenterates, such as the Pacific jellyfish, Aequoria victoria, has been popularly used as a reporter gene in the determination of gene expression, cell lineage tracer and for protein localization [1,2]. When linked to other proteins as N- and C-terminal fusions, GFP maintains its fluorescent properties in the absence of any substrate or cofactor, hence functions as a convenient fluorescent tag. Several organisms that have been tested successfully for expression of GFP include bacteria, yeast, slime mold, plants, drosophila, zebrafish,
International Journal of Engineering and Technology , 2012,
Abstract: In this paper, a real-time location tracing application has been discussed to cater the needs of the people who distinctly and constantly want to stay connected with their peers as well as it can be used in disaster management situations. It is developed on the BlackBerry platform provided by RIM(Research In Motion) which is a highly secure platform and is used to mitigate security risks. The application is integrated with Blackberry Messenger which has alarge number of social networking users which is a value added feature of this application. The function of this project is to trace a number of people even in an environment buzzing with hoards of people. This application will also provide the user with features such as data-sharing, forming and managing groups, communities and other location based services.
Isolated Tuberculosis of Thyroid Gland
N.A.Khan,A.R.Patigaroo,S.W,Murtaza,Sunil Kotwal.
JK Science : Journal of Medical Education & Research , 2002,
Abstract: Involvement of thyroid gland with tuberculosis is extremely rare. The authors report a case ofmberculous thyroiditis.
Health care workers and universal precautions: Perceptions and determinants of non-compliance
Kotwal Anupam,Taneja D
Indian Journal of Community Medicine , 2010,
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