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Search Results: 1 - 10 of 1092 matches for " Ryo Takayanagi "
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Activation and detection of HTLV-I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat model
Takashi Ohashi, Mika Nagai, Hiroyuki Okada, Ryo Takayanagi, Hisatoshi Shida
Retrovirology , 2008, DOI: 10.1186/1742-4690-5-90
Abstract: We have established expression vectors which encode SCTs of rat MHC-I (RT1.Al) with Tax180-188 peptide. Human cell lines transfected with the established expression vectors were able to induce IFN-γ and TNF-α production by a Tax180-188-specific CTL line, 4O1/C8. We have further fused the C-terminus of SCTs to EGFP and established cells expressing SCT-EGFP fusion protein on the surface. By co-cultivating the cells with 4O1/C8, we have confirmed that the epitope-specific CTLs acquired SCT-EGFP fusion proteins and that these EGFP-possessed CTLs were detectable by flow cytometric analysis.We have generated a SCT of rat MHC-I linked to Tax epitope peptide, which can be applicable for the induction of Tax-specific CTLs in rat model systems of HTLV-I infection. We have also established a detection system of Tax-specific CTLs by using cells expressing SCTs fused with EGFP. These systems will be useful tools in understanding the role of HTLV-I specific CTLs in HTLV-I pathogenesis.Human T-cell leukemia virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL) [1,2], a chronic progressive neurological disorder termed HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) [3,4], and various other human diseases [5-8]. ATL is a malignant lymphoproliferative disease affecting a subgroup of middle-aged HTLV-I carriers characterized by the presence of mature T cell phenotype [9]. HTLV-I genome contains a unique 3' region, designated as pX, which encodes the viral transactivator protein, Tax [10]. Because of its broad transactivation capabilities [11], it is speculated that Tax plays a central role in HTLV-I associated immortalization and transformation of T cells, which may lead to the development of ATL.Tax is also known as a major target protein recognized by cytotoxic T lymphocytes (CTL) of HTLV-I carriers [12]. It has been reported that the levels of HTLV-I-specific CTL are quite diverse among HTLV-I carriers and that ATL patients have impaired l
Notes on Giant Gravitons on PP-waves
Hiromitsu Takayanagi,Tadashi Takayanagi
Physics , 2002, DOI: 10.1088/1126-6708/2002/12/018
Abstract: We investigate the giant gravitons in the maximally supersymmetric IIB pp-wave from several viewpoints: (i) the dynamics of D3-branes, (ii) the world-sheet description and (iii) the correlation functions in the dual N=4 Yang-Mills theory. In particular, we derive the BPS equation of a D3-brane with magnetic flux, which is equivalent to multiple D-strings, and discuss the behavior of solutions in the presence of RR-flux. We find solutions which represent the excitations of the giant gravitons in that system.
Open Strings in Exactly Solvable Model of Curved Spacetime and PP-Wave Limit
Hiromitsu Takayanagi,Tadashi Takayanagi
Physics , 2002, DOI: 10.1088/1126-6708/2002/05/012
Abstract: In this paper we study the superstring version of the exactly solvable string model constructed by Russo and Tseytlin. This model represents superstring theory in a curved spacetime and can be seen as a generalization of the Melvin background. We investigate D-branes in this model as probes of the background geometry by constructing the boundary states. We find that spacetime singularities in the model become smooth at high energy from the viewpoint of open string. We show that there always exist bulk (movable) D-branes by the effect of electric flux. The model also includes Nappi-Witten model as the Penrose limit and supersymmetry is enhanced in the limit. We examine this phenomenon in the open string spectrum. We also find the similar enhancement of supersymmetry can be occurred in several coset models.
Friendship Motivation, Aggression, and Self-Esteem in Japanese Undergraduate Students  [PDF]
Ryo Okada
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.31002
Abstract: The purpose of this study was to examine the relationship among self-determined friendship motivation (motivation for friendship formation), aggression, and self-esteem in a sample of 262 Japanese university students. The hypothetical model posited that self-determined friendship motivation predicted lower levels of aggression, which, in turn, predicted lower levels of self-esteem. The results showed that self-determined friendship motivation predicted lower levels of anger, hostility, and physical aggression and that hostility and anger predicted lower levels of self-esteem. Verbal aggression was found to be positively associated with self-determined friendship motivation and self-esteem. The different relationships between self-determined friendship motivation and each facet of aggression are discussed.
Pareto Distribution of Wealth Based on Overlapping Generation Model  [PDF]
Ryo Nagata
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.811155
Abstract: In this paper, we shed light on the Pareto distribution of wealth on the basis of an overlapping generation model. We deduce in the model that the basic reason for a particular shape of Pareto distribution is attributed to the distribution of utility function among consumers. More specifically, we show that a formula relating the distribution of utility function to the distribution of wealth is analytically obtainable on the basis of the Cobb-Douglas utility function. By simulation, we recognize that the formula actually gives us a well approximation of a Pareto distribution.
Overview of osteoimmunology: What's happened? And what's going on?
Hiroshi Takayanagi
Arthritis Research & Therapy , 2012, DOI: 10.1186/ar3567
Abstract:
Why Japanese Aid is Ineffective in Reducing Poverty
Akio Takayanagi
Kasarinlan : Philippine Journal of Third World Studies , 1990,
Abstract: Japan is expected to become the largest donor of ODA (Official Development Assistance) in the world, due to the rapid increase of its ODA budget in recent years, high yen rate, and decrease in the ODA of the United States, erstwhile the biggest aid donor. The quality, however, of Japan's ODA has come under fire: the proportion of grants to loans is low; its beneficiaries are said to be Japanese corporations; and instead of helping the poor in the Third World, it has contributed to socio-cultural problems and environmental destruction. This paper discusses the allocation of ODA, Japan's policy on aid, the implementation of ODA, and recent trends.
Augmentation Mammaplasty Using Implants: A Review
Susumu Takayanagi
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.5.448
Abstract: One of the techniques for augmentation mammaplasty is the procedure using implants. Eventhough this technique has been used for many years, there are still several controversial issuesto be discussed and overcome for patient safety. In this review article, capsular contracture,leak or rupture of the implants, possible systemic disease, relation with breast cancer, andrecent problems with Poly Implant Prothese implants are described and discussed.
Prevention of Adiposity by the Oral Administration of β-Cryptoxanthin
Katsuhiko Takayanagi
Frontiers in Neurology , 2011, DOI: 10.3389/fneur.2011.00067
Abstract: β-Cryptoxanthin (β-CRX) is a carotenoid found in human blood. It is specifically rich in Satsuma mandarin (Citrus unshiu Marc.) but very little in other fruits or vegetables. Several reports indicate the health promoting benefits of β-CRX. As we had reported visceral fat reduction on mildly obese male by the oral administration of β-CRX, a detailed mechanism has not been identified. To identify the mechanism, obese model mouse, TSOD was used in the present study. Oral administration of β-CRX repressed body weight, abdominal adipose tissue weight, and serum lipid concentrations on TSOD mice. The outstanding observation is the significant repression of adipocyte hypertrophy. DNA microarray analysis strongly indicates that the oral administration of β-CRX represses the inflammatory cytokine secretion and improves the lipid metabolism and the energy consumption. It also suggests these effects are partly mediated by PPAR-α, not only lipid metabolism and adipocyte differentiation control but possibly internal circadian clock modulation.
Entanglement Entropy from a Holographic Viewpoint
Tadashi Takayanagi
Physics , 2012, DOI: 10.1088/0264-9381/29/15/153001
Abstract: The entanglement entropy has been historically studied by many authors in order to obtain quantum mechanical interpretations of the gravitational entropy. The discovery of AdS/CFT correspondence leads to the idea of holographic entanglement entropy, which is a clear solution to this important problem in gravity. In this article, we would like to give a quick survey of recent progresses on the holographic entanglement entropy. We focus on its gravitational aspects, so that it is comprehensible to those who are familiar with general relativity and basics of quantum field theory.
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