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Search Results: 1 - 10 of 5639 matches for " Ryan Arnold "
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Efficient Implementations of the Generalized Lasso Dual Path Algorithm
Taylor Arnold,Ryan Tibshirani
Computer Science , 2014,
Abstract: We consider efficient implementations of the generalized lasso dual path algorithm of Tibshirani and Taylor (2011). We first describe a generic approach that covers any penalty matrix D and any (full column rank) matrix X of predictor variables. We then describe fast implementations for the special cases of trend filtering problems, fused lasso problems, and sparse fused lasso problems, both with X=I and a general matrix X. These specialized implementations offer a considerable improvement over the generic implementation, both in terms of numerical stability and efficiency of the solution path computation. These algorithms are all available for use in the genlasso R package, which can be found in the CRAN repository.
The impact of increasing body mass on peak and mean plantar pressure in asymptomatic adult subjects during walking
John B. Arnold,Ryan Causby,Sara Jones
Diabetic Foot & Ankle , 2010, DOI: 10.3402/dfa.v1i0.5518
Abstract: Introduction: The implication of high peak plantar pressure on foot pathology in individuals both with and without diabetes has been recognized. The aim of this study was to investigate and clarify the relationship between increasing body mass and peak and mean plantar pressure in an asymptomatic adult population during walking. Methods: Thirty adults without any relevant medical history, structural foot deformities or foot posture assessed as highly pronated or supinated, and within a normal body mass index range were included in the study. An experimental, same subjects, repeated measures design was used. Peak and mean plantar pressure were evaluated with the F-Scan in-shoe plantar pressure measurement system under four different loading conditions (0, 5, 10, and 15 kg) simulated with a weighted vest. Pressure data were gathered from three stances utilizing the mid-gait protocol. Results: There were statistically significant increases in peak pressure between the 10 and 15 kg load conditions compared to the control (0 kg) within the heel and second to fifth metatarsal regions. The first metatarsal and hallux regions only displayed statistically significant increases in peak pressure between 15 kg and the control (0 kg). The midfoot and lesser digits regions did not display any statistically significant differences in peak pressure between any load conditions compared to the control (0 kg). The second to fifth metatarsal region displayed statistically significant increases in mean pressure in the 5, 10 and 15 kg groups compared to the control (0 kg). A statistically significant increase in peak pressure between the 15 kg and control (0 kg) group was evident in all other regions. Conclusion: The relationship between increasing body mass and peak and mean plantar pressure was dependent upon the plantar region. This study provides more detail outlining the response of peak and mean pressure to different loading conditions than previously reported in the literature. Further research including measurement of temporal parameters is warranted.
Audio-Visual Speech Cue Combination
Derek H. Arnold,Morgan Tear,Ryan Schindel,Warrick Roseboom
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010217
Abstract: Different sources of sensory information can interact, often shaping what we think we have seen or heard. This can enhance the precision of perceptual decisions relative to those made on the basis of a single source of information. From a computational perspective, there are multiple reasons why this might happen, and each predicts a different degree of enhanced precision. Relatively slight improvements can arise when perceptual decisions are made on the basis of multiple independent sensory estimates, as opposed to just one. These improvements can arise as a consequence of probability summation. Greater improvements can occur if two initially independent estimates are summated to form a single integrated code, especially if the summation is weighted in accordance with the variance associated with each independent estimate. This form of combination is often described as a Bayesian maximum likelihood estimate. Still greater improvements are possible if the two sources of information are encoded via a common physiological process.
Magnetic-Field Effects on Donor Impurity States in a Quantum Well  [PDF]
Arnold Abramov
World Journal of Condensed Matter Physics (WJCMP) , 2012, DOI: 10.4236/wjcmp.2012.24031
Abstract: Green’s function technique is used to obtain the solution of Shredinger equation for impurity states in a quantum well (QW) under the magnetic field. Binding energy of impurity states is defined as poles of the wave function. We studied effects of the magnetic field magnitude and impurity position on the binding energy. The calculations were performed for both ground and excited states. The dependences of binding energies versus impurity position and magnetic field are presented for GaAs/Al0.3Ga0.7As QW.
Creativity, Wicked Problems and the Contemporary PhD  [PDF]
Josie Arnold
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.48019
Abstract: In this paper, I survey the challenges the creative and contemporary PhD make to the academy. I look at the scholarship entailed in creative production and in identifying and working with wicked problems as having similar attributes contributing to the need to create new PhD models. Traditionally, the PhD has been a preparation for a career in the academy, with scholars undertaking it so as to show their capacity to identify a research gap in their area, to develop a research question from that and to build a major and new contribution to knowledge in a written submission of some 100,000 words. This traditional model is based upon the certainties of scholarship within enlightenment ideals of science. These have delivered us great strides in many areas of medicine and science and have also come, because of their productivity, to dominate the arts, particularly the social sciences and psychology. Whilst its value should not be debased, this enlightenment model has been challenged from such different areas of scholarship as creative production and wicked problems. The core ideas in this paper are how we might utilise creativity and emerging ideas of wicked problems to debate the importance of understanding the contemporary PhD.
Pigmented villonodular synovitis of the thoracic spine: case report and review of the literature
Arnold, Paul M.;Dunlay, Ryan P.;Haynes, Neal G.;Tawfik, Ossama;Hodges, Jacob;
Coluna/Columna , 2009, DOI: 10.1590/S1808-18512009000100019
Abstract: pigmented villonodular synovitis (pvns), a lesion of the synovial tissues, is rarely found in the spine. we present a 73-year-old male with increasing lower extremity weakness and paresthesias. mri scans revealed disc herniation and spinal cord compression at the t11-t12 and t12- l1 levels. intraoperative exploration revealed an epidural mass originating in the t12 lamina, compressing the spinal cord at t11-t12. pathologic examination was consistent with pigmented villonodular synovitis.
On the optimal stacking of noisy observations
?. Ryan
Mathematics , 2010,
Abstract: Observations where additive noise is present can for many models be grouped into a compound observation matrix, adhering to the same type of model. There are many ways the observations can be stacked, for instance vertically, horizontally, or quadratically. An estimator for the spectrum of the underlying model can be formulated for each stacking scenario in the case of Gaussian noise. We compare these spectrum estimators for the different stacking scenarios, and show that all kinds of stacking actually decreases the variance when compared to just taking an average of the observations. We show that, regardless of the number of observations, the variance of the estimator is smallest when the compound observation matrix is made as square as possible. When the number of observations grow, however, it is shown that the difference between the estimators is marginal: Two stacking scenarios where the number of columns and rows grow to infinity are shown to have the same variance asymptotically, even if the asymptotic matrix aspect ratios differ. Only the cases of vertical and horizontal stackings display different behaviour, giving a higher variance asymptotically. Models where not all kinds of stackings are possible are also discussed.
Managing Ethical Risks and Crises: Beyond Legal Compliance  [PDF]
Diane Huberman Arnold, Keith Arnold, Vanessa J. Arnold
Beijing Law Review (BLR) , 2010, DOI: 10.4236/blr.2010.11001
Abstract: Recent interest in culture stems from its power to explain corporate and organizational failures. Such failures are both internal and external: accounting fraud, management misconduct, harassment and bullying in the workplace, racism, sexism, environmental issues, and health and safety concerns. Current theory holds that these failures are to be explained partly by the particular, poor organizational culture and unhealthy climate, poor leadership, and by the misdeeds of a few bad apples. When economic conditions are negative, organizations look to legislation, regulations, and codes, to reform their culture, and manage the risks of organizational failure. Both the compliance strategy, demanding obedience to laws, regulations and codes, and the integrity or values strategy, focusing on ethics training, education, tone at the top, and the hiring of employees with integrity and values, are the mainstay of recent legislation and regulations in North America and the European Union. We criticize the reliance on legislation, regulations and codes, the focus of a compliance solution which we find inadequate, ineffective, and unenforceable. We suggest reliance on a front-end, proactive and preventive program of best, precautionary practices, will better meet the challenge, in prosperity or poverty, of setting corporate culture on the right track.
Trial Designs Likely to Meet Valid Long-Term Alzheimer's Disease Progression Effects: Learning from the Past, Preparing for the Future
Aaron S. Kemp,George T. Grossberg,Steven J. Romano,Douglas L. Arnold,J. Michael Ryan,Roger Bullock,David L. Streiner
International Journal of Alzheimer's Disease , 2009, DOI: 10.4061/2009/949271
Abstract: The International Society for CNS Clinical Trials and Methodology (ISCTM) held its 4th Annual Autumn Conference in Toronto, Ontario, October 6-7, 2008. The purpose of the present report is to provide an overview of one of the sessions at the conference which focused on the designs and methodologies to be applied in clinical trials of new treatments for Alzheimer's disease (AD) with purported “disease-modifying” effects. The session began with a discussion of how neuroimaging has been applied in multiple sclerosis clinical trials (another condition for which disease modification claims have been achieved). The next two lectures provided a pharmaceutical industry perspective on some of the specific challenges and possible solutions for designing trials to measure disease progression and/or modification. The final lecture provided an academic viewpoint and the closing discussion included additional academic and regulatory perspectives on trial designs, methodologies, and statistical issues relevant to the disease modification concept.
The Efficacy of Hyaluronic Acid in the Restoration of Soft Tissue Volume of the Lips and Lower 1/3 of the Face: The Evolution of the Injection Technique  [PDF]
Arnold William Klein
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.14022
Abstract: Study objective: To establish the safety and efficacy of small-gel particle hyaluronic acid (SGP-HA; Restylane®, Medicis Aesthetics Inc., Scottsdale, AZ) for lip augmentation. Study design: This was a Phase 3, prospective, open-label, evaluator-blinded, single-center pilot study of SGP-HA use in lip augmentation. The primary efficacy objectives were to investigate the efficacy of SGP-HA in lip augmentation and to assess subject satisfaction with the procedure 12 weeks after treatment. Secondary efficacy objectives were to validate 3D imaging to measure lip augmentation, identify subject satisfaction at all points in time, and identify the duration of lip augmentation and palpability of SGP-HA in the lips. The primary safety objective was to assess the incidence, duration, and severity of all adverse experiences. Results: All 20 subjects and the treating investigator indicated improvement in the appearance of subjects’ lips at weeks 2, 6, and 12. SGP-HA administered for augmentation was well tolerated. Four (20%) subjects treated with SGP-HA experienced 7 treatment-emergent adverse events (TEAEs). Conclusions: Results of this study show promising efficacy and an absence of safety issues with the use of SGP-HA in lip augmentation.
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