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Search Results: 1 - 10 of 3612 matches for " Ruth Arnon "
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Therapeutic MUC1-Based Cancer Vaccine Expressed in Flagella-Efficacy in an Aggressive Model of Breast Cancer  [PDF]
Nathalie Machluf, Ruth Arnon
World Journal of Vaccines (WJV) , 2012, DOI: 10.4236/wjv.2012.23015
Abstract: MUC1, a tumor-associated antigen overexpressed in many carcinomas, represents a candidate of choice for cancer immunotherapy. Flagella-based MUC1 vaccines were tested in therapeutic setting in two aggressive breast cancer models, comprising the implantation of the 4T1-MUC1 cell line in either Balb/c, or Human MUC1 transgenic mice in which spontaneous metastases occurs. Recombinant flagella carrying only 7 amino acid of MUC1 elicited therapeutic activity, affecting both the growth of established growing tumors and the number of metastases. Higher therapeutic activity was achieved with an additional recombinant flagella designed with the SYFPEITHI algorithm. The vaccines triggered a Th1 response against MUC1 with no evident autoimmune response towards healthy MUC1-expressing tissues. Recombinant flagella carrying a 25-residue fragment of MUC1, induced the most effective response, as evidenced by a significant reduction of both the size and growth rate of the tumor as well as by the lower number of metastases, and expanding life span of vaccinated mice.
Interven??o musicoterápica no ambiente da unidade de terapia intensiva neonatal
Arnon, Shmuel;
Jornal de Pediatria , 2011, DOI: 10.1590/S0021-75572011000300001
Abstract: estudos que usam a música em díades pai/m?e-filho têm a vantagem de melhorar os objetivos de desenvolvimento na utin e atuam no sentido de reduzir o estresse, estimular o desenvolvimento durante um período crítico de crescimento, promover o vínculo com os pais e facilitar a comunica??o e o desenvolvimento neurológico e social. s?o necessários mais estudos sobre o uso da música em lactentes prematuros. desenhos metodológicos meticulosos e relatos de estudos sobre o uso da música na utin ir?o promover a prática baseada em evidência na área.
The Challenges of Fighting in Densely Populated Areas: The Israeli Case
Arnon Soffer
Military and Strategic Affairs , 2012,
Abstract: Since the middle of the twentieth century there has been a process of dramatic change in the history of warfare. The change in the landscape, i.e., natural landscapes turning into urban areas, requires a change in the nature of war, both on the part of the defense and on the part of the attacker. Longstanding rules among military experts to avoid entering cities unless absolutely necessary are no longer relevant given the changing reality. Today, areas that in the past were open have become urban, thereby not leaving the attacker any choice but to conduct urban warfare. Moreover, decisions are no longer taken on the open battlefield, rather in the offices of the decision makers, relatively few in number, who are generally tucked away in city centers (often near TV studios and other communications centers shielded by massive numbers of hostages).
A Logical Framework for Set Theories
Arnon Avron
Electronic Proceedings in Theoretical Computer Science , 2012, DOI: 10.4204/eptcs.81.1
Abstract: Axiomatic set theory is almost universally accepted as the basic theory which provides the foundations of mathematics, and in which the whole of present day mathematics can be developed. As such, it is the most natural framework for Mathematical Knowledge Management. However, in order to be used for this task it is necessary to overcome serious gaps that exist between the "official" formulations of set theory (as given e.g. by formal set theory ZF) and actual mathematical practice. In this work we present a new unified framework for formalizations of axiomatic set theories of different strength, from rudimentary set theory to full ZF. It allows the use of set terms, but provides a static check of their validity.
Arnon Dar
Physics , 1995,
Abstract: Astrophysics and cosmology can be used to test the standard model of particle physics under conditions and over distance and time scales not accessible to laboratory experiments. Most of the astrophysical observations are in good agreement with the standard model. In particular, primordial nucleosynthesis, supernova explosions, stellar evolution and cosmic background radiations have been used to derive strong limits on physics beyond the standard model. However, the solution of some important astrophysical and cosmological problems may require new physics beyond the standard model. These include the origin of the initial conditions, large scale structure formation, the baryon asymmetry in the observed Universe, the dark matter problem, the solar neutrino problem and some cosmic ray puzzles. Here I review some important developments relevant to some of these problems, which took place most recently.
Standard Solar Neutrinos
Arnon Dar
Physics , 1996, DOI: 10.1016/0920-5632(96)00268-X
Abstract: The predictions of an improved standard solar model are compared with the observations of the four solar neutrino experiments. The improved model includes premain sequence evolution, element diffusion, partial ionization effects, and all the possible nuclear reactions between the main elements. It uses updated values for the initial solar element abundances, the solar age, the solar luminosity, the nuclear reaction rates and the radiative opacities. Neither nuclear equilibrium, nor complete ionization are assumed. The calculated $^8$B solar neutrino flux is consistent, within the theoretical and experimental uncertainties, with the solar neutrino flux measured by Kamiokande. The results from the $^{37}$Cl and $^{71}$Ga radiochemical experiments seem to suggest that the terrestrial $^7$Be solar neutrino flux is much smaller than that predicted. However, the present terrestrial ``defecit'' of $^7$Be solar neutrinos may be due to the use of inaccurate theoretical neutrino absorption cross sections near threshold for extracting solar neutrino fluxes from production rates. Conclusive evidence for a real deficit of $^7$Be solar neutrinos will require experiments such as BOREXINO or HELLAZ. A real defecit of $^7$Be solar neutrinos can be due to either astrophysical reasons or neutrino properties beyond the standard electroweak model. Only future neutrino experiments, such as SNO, Superkamiokande, BOREXINO and HELLAZ, will be able to provide conclusive evidence that the solar neutrino problem is a consequence of neutrino properties beyond the standard electroweak model. Earlier indications may be provided by long baseline neutrino oscillation experiments.
Can Fireball or Firecone Models Explain Gamma Ray Bursts?
Arnon Dar
Physics , 1997, DOI: 10.1086/311401
Abstract: The observed afterglows of gamma ray bursts, in particular that of GRB 970228 six months later, seem to rule out relativistic fireballs and relativistic firecones driven by merger or accretion induced collapse of compact stellar objects in galaxies as the origin of GRBs. GRBs can be produced by superluminal jets from such events.
Are extragalactic gamma ray bursts the source of the highest energy cosmic rays?
Arnon Dar
Physics , 1999,
Abstract: Recent observations with the large air shower arrays of ultra high energy cosmic rays (UHECR) and recent measurements/estimates of the redshifts of gamma ray bursts (GRBs) seem to rule out extragalactic GRBs as the source of the cosmic rays that are observed near Earth, including those with the highest energies.
Dark Matter and Big Bang Nucleosynthesis
Arnon Dar
Physics , 1995, DOI: 10.1086/176078
Abstract: The recently observed Deuterium abundance in a low- metallicity high-redshift hydrogen cloud, which is about ten times larger than that observed in the near interstellar medium, is that expected from the Standard Big Bang Nucleosynthesis theory and the observed abundances of $^4$He and $^7$Li extrapolated to their primordial values. The inferred cosmic baryon to photon ratio, $\eta=(1.60\pm 0.1)\times 10^{-10},$ yields a mean cosmic baryon density, in critical mass units, of $\Omega_b\approx (0.6\pm 0.1)\times 10^{-2}h^{-2},$ with $h$ being the Hubble constant in units of $100 km~s^{-1} Mpc^{-1}$. This baryon density is consistent with the mean cosmic density of matter visible optically and in X-rays. It implies that most of the baryons in the Universe are visible and are not dark. Combined with the observed ratio of baryons to light in X-ray emitting clusters, it yields the value $\Omega \approx 0.15$ for the mean mass density of the Universe, which is consistent with that obtained from the mass to light ratio in clusters. This mass density is about ten times larger than the mean baryon mass density. It indicates that most of the matter in the Universe consists of nonbaryonic dark matter.
Standard Physics Solution To The Solar Neutrino Problem?
Arnon Dar
Physics , 1996,
Abstract: The $^8$B solar neutrino flux predicted by the standard solar model (SSM) is consistent within the theoretical and experimental uncertainties with that observed at Kamiokande. The Gallium and Chlorine solar neutrino experiments, however, seem to imply that the $^7$Be solar neutrino flux is strongly suppressed compared with that predicted by the SSM. If the $^7$Be solar neutrino flux is suppressed, still it can be due to astrophysical effects not included in the simplistic SSM. Such effects include short term fluctuations or periodic variation of the temperature in the solar core, rotational mixing of $^3$He in the solar core, and dense plasma effects which may strongly enhance p-capture by $^7$Be relative to e-capture. The new generation of solar observations which already look non stop deep into the sun, like Superkamiokande through neutrinos, and SOHO and GONG through acoustic waves, may point at the correct solution. Only Superkamiokande and/or future solar neutrino experiments, such as SNO, BOREXINO and HELLAZ, will be able to find out whether the solar neutrino problem is caused by neutrino properties beyond the minimal standard electroweak model or whether it is just a problem of the too simplistic standard solar model.
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