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Search Results: 1 - 10 of 203177 matches for " Russell P Landry "
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Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain
Christian Ndong, Russell P Landry, Joyce A DeLeo, E. Alfonso Romero-Sandoval
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-34
Abstract: We cloned rat spinal cord MKP-1 and optimize MKP-1 cDNA in vitro using transfections to BV-2 cells. We observed that in vitro overexpression of MKP-1 blocked lipopolysaccharide-induced phosphorylation of p38 (and other MAPKs) as well as release of pro-algesic effectors (i.e., cytokines, chemokines, nitric oxide). Using this cDNA MKP-1 and a non-viral, in vivo nanoparticle transfection approach, we found that spinal cord overexpression of MKP-1 prevented development of peripheral nerve-injury-induced tactile hypersensitivity and reduced pro-inflammatory cytokines and chemokines and the phosphorylated form of p38.Our results indicate that MKP-1, the natural regulator of p-p38, mediates resolution of the spinal cord pro-inflammatory milieu induced by peripheral nerve injury, resulting in prevention of chronic mechanical hypersensitivity. We propose that MKP-1 is a potential therapeutic target for pain treatment or prevention.
Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation
Edgar Romero-Sandoval, Ryan Horvath, Russell P Landry, Joyce A DeLeo
Molecular Pain , 2009, DOI: 10.1186/1744-8069-5-25
Abstract: JWH015 (a CBR2 agonist) increased MKP-1 and MKP-3 expression, which in turn reduced p-ERK1/2 in LPS-stimulated primary microglia. These effects resulted in a significant reduction of tumor necrosis factor-α (TNF) expression and microglial migration. We confirmed the causative link of these findings by using MKP inhibitors. We found that the selective inhibition of MKP-1 by Ro-31-8220 and PSI2106, did not affect p-ERK expression in LPS+JWH015-treated microglia. However, the inhibition of both MKP-1 and MKP-3 by triptolide induced an increase in p-ERK expression and in microglial migration using LPS+JWH015-treated microglia.Our results uncover a cellular microglial pathway triggered by CBR2 activation. These data suggest that the reduction of pro-inflammatory factors and microglial migration via MKP-3 induction is part of the mechanism of action of CBR2 agonists. These findings may have clinical implications for further drug development.Microglia are the innate immune cells of the central nervous system (CNS) and as such act as the first glial responders after CNS or peripheral nerve injury [1-3]. The main responses of microglia to peripheral or CNS insults are increased expression of surface or cytosolic markers, pro-inflammatory factor production (e.g. cytokines, chemokines, nitric oxide, prostaglandins), morphological changes, enhanced phagocytic activity, migration and proliferation. In rodent models of pain including peripheral nerve injury [4], paw incision [5], paw inflammation [6] or spinal cord injury [7], microglia become reactive and produce a pro-inflammatory spinal milieu, which may contribute to neuronal sensitization and behavioral hypersensitivity.Cannabinoids exert most of their effects by binding to G protein-coupled cannabinoid receptors (CBR) type 1 and 2. CBR2 are expressed in glia in normal human and rat brain [8,9] and their glial expression increases especially during inflammation [10,11]. Using a rat paw incision or a peripheral nerve injury m
Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain
Matthew S. Alkaitis,Carlos Solorzano,Russell P. Landry,Daniele Piomelli,Joyce A. DeLeo,E. Alfonso Romero-Sandoval
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010891
Abstract: An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors type 1 (CB1) and type 2 (CB2). We have previously shown that intrathecal administration of a CB2 receptor agonist reverses both surgical incision-induced behavioral hypersensitivity and associated over-expression of spinal glial markers. We therefore hypothesized that endocannabinoid signaling promotes the resolution of acute postoperative pain by modulating pro-inflammatory signaling in spinal cord glial cells.
Protostellar Disk Evolution Over Million-Year Timescales with a Prescription for Magnetized Turbulence
Russell Landry,Sarah E. Dodson-Robinson,Neal J. Turner,Greg Abram
Physics , 2013, DOI: 10.1088/0004-637X/771/2/80
Abstract: Magnetorotational instability (MRI) is the most promising mechanism behind accretion in low-mass protostellar disks. Here we present the first analysis of the global structure and evolution of non-ideal MRI-driven T-Tauri disks on million-year timescales. We accomplish this in a 1+1D simulation by calculating magnetic diffusivities and utilizing turbulence activity criteria to determine thermal structure and accretion rate without resorting to a 3-D magnetohydrodynamical (MHD) simulation. Our major findings are as follows. First, even for modest surface densities of just a few times the minimum-mass solar nebula, the dead zone encompasses the giant planet-forming region, preserving any compositional gradients. Second, the surface density of the active layer is nearly constant in time at roughly 10 g/cm2, which we use to derive a simple prescription for viscous heating in MRI-active disks for those who wish to avoid detailed MHD computations. Furthermore, unlike a standard disk with constant-alpha viscosity, the disk midplane does not cool off over time, though the surface cools as the star evolves along the Hayashi track. The ice line is firmly in the terrestrial planet-forming region throughout disk evolution and can move either inward or outward with time, depending on whether pileups form near the star. Finally, steady-state mass transport is a poor description of flow through an MRI-active disk. We caution that MRI activity is sensitive to many parameters, including stellar X-ray flux, grain size, gas/small grain mass ratio and magnetic field strength, and we have not performed an exhaustive parameter study here.
Hórrido yermo de inflamada arena . Cienfuegos and Romantic Cosmic Pain Hórrido yermo de inflamada arena . Cienfuegos y el dolor cósmico romántico
Russell P. SEBOLD
Cuadernos Dieciochistas , 2011,
Abstract: It was painful to be a journalist and poet with noble aspirations for reform during the reign of Charles IV. in the years immediately preceding, nine well known Spanish poets had already expressed in romantic form their deep anxiety and insecurity regarding the universe in which they dwelt. One of them, Meléndez Valdés, inventor of the Spanish name for romantic cosmic grief, fastidio universal, was Cienfuegos’s poetic mentor and friend. the present article explains how Cienfuegos joined the European and Spanish philosophical and literary traditions that led to the poetic expression of the afflicted romantic mentality, and how he at the same time became an outstanding innovator in this tradition. Era doloroso ser periodista y poeta de nobles aspiraciones reformativas durante el reinado de Carlos IV. Ya en a os inmediatamente anteriores, nueve conocidos poetas espa oles habían expresado en forma romántica su honda angustia e inseguridad ante el universo en que moraban. Uno de éstos, Meléndez Valdés, inventor del nombre espa ol del dolor cósmico romántico, fastidio universal, fue el mentor poético y amigo de Cienfuegos. En el presente artículo se explica cómo Cienfuegos reunió las tradiciones filosóficas y literarias europeas y espa olas que llevaron a la expresión poética de la afligida mentalidad romántica, y cómo llegó al mismo tiempo a ser un destacado innovador en esta tradición.
New Fits for the Non-Perturbative Parameters in the CSS Resummation Formalism
F. Landry,R. Brock,G. Ladinsky,C. -P. Yuan
Physics , 1999, DOI: 10.1103/PhysRevD.63.013004
Abstract: We update the non-perturbative function of the Collins-Soper- Sterman resummation formalism in hadron collisions. Two functional forms in impact parameter space are considered, one with a pure Gaussian form with two parameters and the other with an additional linear term. The results for the two parameter fit are found to be g1=0.24+0.08-0.07 GeV^2, g2=0.34+0.07-0.08 GeV^2. The results for the three parameter fit are g1=0.15+004-0.03 GeV^2, g2=0.48+0.07-0.05 GeV^2, and g3=-0.58+0.26-0.20 GeV^-1. We discuss the potential for the full Tevatron Run I Z boson data for further testing of the universality of the non-perturbative function.
Tyrosine hydroxylase and Lewy body molecules immunoreactivity in the SNC neurons of an AS/AGU mutantrat  [PDF]
A. G. Al-Kushi, D. Russell, A. P. Payne
World Journal of Neuroscience (WJNS) , 2012, DOI: 10.4236/wjns.2012.23023
Abstract: The AS/AGU rat has a recessive single point mutation in the gene coding for the gamma isoform of protein kinase C (PKC-γ) resulting in a failure to release dopamine in the striatum and impaired movement including a staggering gait, difficulty in initiating movement and a slight whole body tremor. This study examined the levels tyrosine hydroxylase, ubiquitin and parkin in individual SNC cell bodies, there was no evidence of a reduction in tyrosine hydroxylase levels although levels of ubiquitin and parkin were elevated in the cytoplasm. The findings support the hypothesis that the initial bar to dopamine availability in the striatum is reduced release, with substantia nigra cell death being a later phenomenon.
Collision Vehicle Detection System Based on GPS/INS Integration  [PDF]
Neda Navidi, Rene Jr. Landry
Journal of Computer and Communications (JCC) , 2017, DOI: 10.4236/jcc.2017.52006
Abstract: Continuous vehicle tracking as well as detecting accidents, are significant services that are needed by many industries including insurance and vehicle rental companies. The main goal of this paper is to provide methods to detect the position of car accident. The models consider GPS/INS-based navigation algorithm, calibration of navigational sensors, a de-nosing method as long as vehicle accident, expressed by a set of raw measurements which are obtained from various environmental sensors. In addition, the location-based accident detection model is tested in different scenarios. The results illustrate that under harsh environments with no GPS signal, location of accident can be detected. Also results confirm that calibration of sensors has an important role in position correction algorithm. Finally, the results present that the proposed accident detection algorithm can recognize accidents and related its positions.
Les gar ons et les filles du neuvième art 1970 - 1989
Landry Passa
Genre & Histoire , 2009,
Abstract: La bande dessinée est un phénomène culturel de masse d’une ampleur qui fut largement sous estimée. Aujourd’hui il est de bon ton de se réclamer d’une culture “bédéphile” mais cela n’a pas toujours été le cas. Des avancées notables permettent de reconna tre la bande dessinée comme un pan non négligeable du paysage culturel du XXe siècle et les petits “miquets” sont révélateurs du contexte socioculturel dans lequel ils ont été produits. Le cinéma puise avec plus ou moins de bonheur dans ce vivi...
Media, Technologies and Human Rights: Competing Concepts. Canadian and International Cases
Normand LANDRY
Essachess : Journal for Communication Studies , 2012,
Abstract: This article discusses the conceptual issues and contemporary legal debates with regard to human rights and communication. It provides a historical analysis of the controversies that have accompanied the emergence of discourses calling for the adoption a universal right to communicate.
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