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Search Results: 1 - 10 of 10202 matches for " Rui Curi "
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Fisiologia da nutri o humana: aspectos básicos, aplicados e funcionais
Rui Curi
Revista Brasileira de Ciências Farmacêuticas , 2007, DOI: 10.1590/s1516-93322007000300019
Abstract:
Histology
Rui Curi
Brazilian Journal of Pharmaceutical Sciences , 2011, DOI: 10.1590/s1984-82502011000100031
Abstract:
Conseqüências do exercício para o metabolismo da glutamina e fun??o imune
Garcia Júnior, Jair Rodrigues;Pithon-Curi, Tania Cristina;Curi, Rui;
Revista Brasileira de Medicina do Esporte , 2000, DOI: 10.1590/S1517-86922000000300006
Abstract: the purpose of training for the athletes is to improve physical capacity in order to achieve the best performance in competitions. for this reason, they constantly look for updated training methods. one important aspect in a training program is the rest period between exercise sessions, which is important to promote physiological adaptations such as morphological alterations and fuel store overcompensation. the release of glutamine by skeletal muscles is increased during exercise activities. as a consequence, the content of glutamine in the muscle decreases after a strenuous exercise session. this amino acid, however, plays an important role in leukocyte functioning (lymphocytes, macrophages, and neutrophils). therefore, after heavy and intense exercising, plasma glutamine levels decrease, impairing immune function and leading the subject to become more susceptible to respiratory infections. in this review, the implications of exercise on skeletal muscles and leukocytes metabolism are discussed.
Ciclo de Krebs como fator limitante na utiliza o de ácidos graxos durante o exercício aeróbico
Curi Rui,Lagranha Cláudia J.,G. Jr Jair Rodrigues,Pithon-Curi Tania Cristina
Arquivos Brasileiros de Endocrinologia & Metabologia , 2003,
Abstract: Os ácidos graxos (AG) representam uma fonte importante de energia durante exercícios de intensidade leve ou moderada, e principalmente naqueles de dura o prolongada. A utiliza o dos AG pelos músculos esqueléticos depende de passos importantes como a mobiliza o, transporte via corrente sangüínea, passagem pelas membranas plasmática e mitoc ndrial, beta-oxida o e, finalmente, a oxida o no ciclo de Krebs e atividade da cadeia respiratória. O exercício agudo e o treinamento induzem adapta es que possibilitam maior aproveitamento dos AG como fonte de energia, ao mesmo tempo em que o glicogênio muscular é preservado. Contudo, as tentativas de manipula o da dieta e suplementa o com agentes ativos para aumentar a mobiliza o e utiliza o dos AG durante o exercício n o apresentam resultados conclusivos. Nesse trabalho, a hipótese de que o ciclo de Krebs é o fator limitante da utiliza o de ácidos graxos pelo tecido muscular no exercício prolongado é apresentada.
Control of the Intracellular Redox State by Glucose Participates in the Insulin Secretion Mechanism
Eduardo Rebelato, Fernando Abdulkader, Rui Curi, Angelo Rafael Carpinelli
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024507
Abstract: Background Production of reactive oxygen species (ROS) due to chronic exposure to glucose has been associated with impaired beta cell function and diabetes. However, physiologically, beta cells are well equipped to deal with episodic glucose loads, to which they respond with a fine tuned glucose-stimulated insulin secretion (GSIS). In the present study, a systematic investigation in rat pancreatic islets about the changes in the redox environment induced by acute exposure to glucose was carried out. Methodology/Principal Findings Short term incubations were performed in isolated rat pancreatic islets. Glucose dose- and time-dependently reduced the intracellular ROS content in pancreatic islets as assayed by fluorescence in a confocal microscope. This decrease was due to activation of pentose-phosphate pathway (PPP). Inhibition of PPP blunted the redox control as well as GSIS in a dose-dependent manner. The addition of low doses of ROS scavengers at high glucose concentration acutely improved beta cell function. The ROS scavenger N-acetyl-L-cysteine increased the intracellular calcium response to glucose that was associated with a small decrease in ROS content. Additionally, the presence of the hydrogen peroxide-specific scavenger catalase, in its membrane-permeable form, nearly doubled glucose metabolism. Interestingly, though an increase in GSIS was also observed, this did not match the effect on glucose metabolism. Conclusions The control of ROS content via PPP activation by glucose importantly contributes to the mechanisms that couple the glucose stimulus to insulin secretion. Moreover, we identified intracellular hydrogen peroxide as an inhibitor of glucose metabolism intrinsic to rat pancreatic islets. These findings suggest that the intracellular adjustment of the redox environment by glucose plays an important role in the mechanism of GSIS.
Repression of Ppargcla Gene in Liver of Hyperglycemic Rats Induced with High Fat Diet Combined with Streptozotocin
Hernández,Alfonso; Curi,Rui; Salazar,Luis A;
International Journal of Morphology , 2012, DOI: 10.4067/S0717-95022012000200047
Abstract: type 2 diabetes mellitus implies deregulation of multiple metabolic processes, being the maintenance of glycemia one of the most important. many genes are involved in the deregulation of this particular process. therefore, the aim of this study was to evaluate gene expression of genes related to type 2 diabetes mellitus, in the liver and pancreas of rats with hyperglycemia induced by high fat diet along with a low single dose of streptozotocin. ahsg and ppargc1a genes were studied in liver, whereas kcnj11 and slc2a2 genes were analyzed in pancreas. for this purpose, 210-240 g female rats were fed a high fat diet or a control diet for three weeks. at day 14, animals fed with high fat diet were injected with a single low dose of streptozotocin (35 mg/kg) and the control group rats were injected only with the vehicle. plasmatic glucose, triglycerides and total cholesterol levels were measured at the beginning, day 14 and end of treatment. body weight was also measured. once the treatment was complete, rats were appropriately euthanized and then, pancreas and liver were surgically removed and frozen in liquid nitrogen. total rna was isolated using trizol reagent, treated with dnase i and reversely transcribed to cdna. gene expression analysis was performed using sybr green - real time pcr and comparative cq method, using three reference genes. rats fed with high fat diet and treated with streptozotocin showed higher values of plasmatic glucose (17.09 ± 0.43 vs. 5.91 ± 0.29 mmol/l, p < 0.01) and a minor expression of ppargc1a versus the control group (2-fold less expressed, p < 0.05) in liver. we conclude that repression of ppargc1a gene may be an important process in the establishment of chronic hyperglycemia, probably through deregulation of hepatic gluconeogenesis. however, further studies need to be performed in order to clarify the role of ppargc1a deregulation in liver glucose homeostasis.
Mecanismos envolvidos na cicatriza??o: uma revis?o
Balbino, Carlos Aberto;Pereira, Leonardo Madeira;Curi, Rui;
Revista Brasileira de Ciências Farmacêuticas , 2005, DOI: 10.1590/S1516-93322005000100004
Abstract: the mechanisms involved in tissue repair are revised. the wound healing process occurs basically in three phases: inflammation, formation of granulating tissue and extracellular tissue deposition, and tissue remodeling. the cellular and tissue events of each phase are described and discussed. the chemical mediators and their interplay with the wound healing events and cells involved are also discussed. however, especial attention was given to the role played by the growth factors in the tissue repair process.
Repression of Ppargcla Gene in Liver of Hyperglycemic Rats Induced with High Fat Diet Combined with Streptozotocin Represión del Gen Ppargcla en Hígado de Ratas con Hiperglicemia Inducida por Dieta Alta en Grasas Combinada con Estreptozotocina
Alfonso Hernández,Rui Curi,Luis A Salazar
International Journal of Morphology , 2012,
Abstract: Type 2 diabetes mellitus implies deregulation of multiple metabolic processes, being the maintenance of glycemia one of the most important. Many genes are involved in the deregulation of this particular process. Therefore, the aim of this study was to evaluate gene expression of genes related to type 2 diabetes mellitus, in the liver and pancreas of rats with hyperglycemia induced by high fat diet along with a low single dose of streptozotocin. Ahsg and Ppargc1a genes were studied in liver, whereas Kcnj11 and Slc2a2 genes were analyzed in pancreas. For this purpose, 210-240 g female rats were fed a high fat diet or a control diet for three weeks. At day 14, animals fed with high fat diet were injected with a single low dose of streptozotocin (35 mg/kg) and the control group rats were injected only with the vehicle. Plasmatic glucose, triglycerides and total cholesterol levels were measured at the beginning, day 14 and end of treatment. Body weight was also measured. Once the treatment was complete, rats were appropriately euthanized and then, pancreas and liver were surgically removed and frozen in liquid nitrogen. Total RNA was isolated using TRIzol reagent, treated with DNase I and reversely transcribed to cDNA. Gene expression analysis was performed using SYBR Green - Real time PCR and comparative Cq method, using three reference genes. Rats fed with high fat diet and treated with streptozotocin showed higher values of plasmatic glucose (17.09 ± 0.43 vs. 5.91 ± 0.29 mmol/L, p < 0.01) and a minor expression of Ppargc1a versus the control group (2-fold less expressed, p < 0.05) in liver. We conclude that repression of Ppargc1a gene may be an important process in the establishment of chronic hyperglycemia, probably through deregulation of hepatic gluconeogenesis. However, further studies need to be performed in order to clarify the role of Ppargc1a deregulation in liver glucose homeostasis. La diabetes mellitus tipo 2 implica desregulación de varios procesos metabólicos, siendo la mantención de la glicemia uno de los más importantes. Varios genes están involucrados en este proceso. Así, el objetivo del presente estudio fue evaluar la expresión génica de genes relacionados a diabetes mellitus tipo 2 en hígado y páncreas de ratas con hiperglicemia inducida con una dieta alta en grasas junto con una baja dosis de estreptozotocina. Ratas hembra de 210 - 240 g fueron alimentadas con una dieta alta en grasas o con una dieta control por tres semanas. Al día 14, los animales alimentados con dieta alta en grasas fueron inyectados con una dosis baja de estreptozot
Revealing the translation control by transcriptome analysis
Augusto Ducati Luchessi,Rui Curi,Claudio Miguel Costa-Neto
Einstein (S?o Paulo) , 2006,
Abstract: Taking the eukaryotic translation initiation factor 5A (eIF5A) asmodel, some aspects of different points of gene expression controland transcriptome studies are discussed. A parallel with proteomicstudies is presented, as well as the optimization of thetranscriptome analysis using polysome profile assay. The polysomeprofile assay application reveals the translational control of mRNAsnot identified by traditional differential analysis of transcriptomes,which is widely employed to study diseases, such as tumors.
Mecanismos adaptativos do sistema imunológico em resposta ao treinamento físico
Leandro, Carol Góis;Castro, Raul Manh?es de;Nascimento, Elizabeth;Pithon-Curi, Tania Cristina;Curi, Rui;
Revista Brasileira de Medicina do Esporte , 2007, DOI: 10.1590/S1517-86922007000500012
Abstract: moderate physical training enhances the defense mechanisms, while intense physical training induces to immune suppression. the underlying mechanisms are associated with the link between nervous, endocrine, and immune systems. it suggests autonomic patterns and modulation of immune response. immune cells, when exposed to regular bouts of stress, develop a mechanism of tolerance. in many tissues, it has been demonstrated that the response to aggressive conditions is attenuated by moderate physical training. thus, training can induce tolerance to aggressive/stressful situations. in this review, studies suggesting the adaptation mechanisms of the immune system in response to physical training will be reported.
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