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Search Results: 1 - 10 of 398920 matches for " Rosimere J.;Le?o "
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Tireotoxicose por triiodotironina e sua variante: relato de três casos
Machado Marise,Teixeira Rosimere J.,Leo Lenora Maria C.S.M.,Tabet Ana Lúcia O.
Arquivos Brasileiros de Endocrinologia & Metabologia , 2003,
Abstract: Tireotoxicose ocorre na presen a de níveis séricos elevados de triiodotironina (T3) e tiroxina (T4) totais ou livres (L) e baixos de tirotropina (TSH). Em áreas endêmicas, pode-se encontrar um aumento da concentra o de T3 com T4 total e T4L normal ou baixo. Tal condi o é conhecida como "tireotoxicose por T3" (TpT3). Uma variante, conhecida como "tireotoxicose por T3 livre" (TpT3L) tem sido descrita, apresentando-se com valores séricos subnormais de TSH e T3 total, T4L normais, mas altos níveis de T3L. A tireotoxicose aumenta a reabsor o óssea e, portanto, a incidência de fraturas; altera o sistema cardiovascular por modifica es hemodinamicas e dos receptores no músculo cardíaco, mostrando a importancia do seu diagnóstico e tratamento precoces, a fim de reduzir a morbidade dos riscos de osteoporose e arritmias. O diagnóstico precoce e o tratamento do hipertireoidismo podem previnir estas complica es. Descrevemos três pacientes com critérios para o diagnóstico de TpT3 - um deles com TpT3L. Todos moravam em área n o-endêmica e eram portadores de bócio difuso. Como o rastreamento para doen as tireoidianas consta apenas das dosagens de TSH e T4L, sugerimos que, em caso de TSH suprimido, seja avaliado o nível de T3 total. Caso este seja normal, dosar o T3L a fim de se diagnosticar a TpT3L. Acreditamos que o estudo desses casos possa esclarecer melhor tais considera es.
Tireotoxicose por triiodotironina e sua variante: relato de três casos
Machado, Marise;Teixeira, Rosimere J.;Leo, Lenora Maria C.S.M.;Tabet, Ana Lúcia O.;Bosignoli, Rogério;Henriques, Jodélia L.M.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2003, DOI: 10.1590/S0004-27302003000100016
Abstract: thyrotoxicosis is confirmed by high serum total or free triiodothyronine (t3/ft3) and thyroxine (t4/ft4) and low serum thyrotropin (tsh) concentrations. in endemic areas, a predominant increase of t3 with normal or low t4 and ft4 can be found, referred to as "t3-thyrotoxicosis". one variant, known as "free t3-toxicosis" has recently been described presenting subnormal serum tsh, normal ft4 and total t3 concentrations, but high serum ft3. thyrotoxicosis increases bone turnover, especially resorption, with bone loss and increases fracture rates; involves the cardiovascular system both in systemic hemodynamics and t3-mediated effects on cardiac myocite-specific gene expression. detecting t3- thyrotoxicosis is important because of the high morbidity, increased risk of osteoporosis and arrythmias. thus, the early diagnosis and treatment of the hyperthyroidism can prevent complications. we studied three patients with criteria for t3-toxicosis - one of them with ft3 toxicosis. they live in areas with adequate iodine intake and all three present with diffuse goiter. because the screening for thyroid diseases only measures ft4 and tsh, we suggest that patients with subnormal tsh levels and normal ft4 should be worked up with measurement of total t3. if normal, a ft3 can be obtained to identify ft3 toxicosis. the study of such cases must continue to provide valuable insights into the thyrotoxicosis.
Computational Analysis of Theacrine, a Purported Nootropic and Energy-Enhancing Nutritional Supplement  [PDF]
Bradley O. Ashburn, Diana J. Le, Corin K. Nishimura
Computational Chemistry (CC) , 2019, DOI: 10.4236/cc.2019.71002
Abstract:
Herein is the first reported conceptual density functional theory (DFT) investigation of the purine alkaloid theacrine and the comparison of quantum chemical properties to the closely related stimulant caffeine. DFT global chemical reactivity descriptors (chemical hardness/softness, chemical potential/ electronegativity, and electrophilicity) and local reactivity descriptors (Fukui functions and dual descriptor) were calculated for both compounds using Spartan ‘16 software. All calculations were carried out at the B3LYP/6-31G* level of theory. Reactivity analysis of the Fukui dual descriptor calculations reveals sites of nucleophilic and electrophilic attack. The results provide a solid chemical foundation for understanding how theacrine interacts with cellular systems.
Globulina ligadora dos horm nios sexuais e proteína ligadora 1 do IGF-1: marcadores para resistência à insulina na pubarca precoce?
Teixeira Rosimere J.,Ginzbarg Denise,Freitas Josele R.,Fucks Gabriela
Arquivos Brasileiros de Endocrinologia & Metabologia , 2003,
Abstract: A hiperinsulinemia parece contribuir para o hiperandrogenismo por reduzir os níveis séricos tanto da SHBG quanto da IGFBP-1. Avaliamos os níveis de SHBG e IGFBP-1 e sua correla o com androgênios e insulina em 44 meninas selecionadas com pubarca precoce (PP) e 18 controles (C) pré-puberais (7,3±1,3 x 6,8±1,6 anos). Foram avaliados: o índice de massa corporal (IMC), a idade óssea (IO) e os níveis séricos de SHBG, IGFBP-1, insulina (I), glicose (G), testosterona (T), androstenediona (A), SDHEA e cortisol (F). Calculamos a rela o glicose: insulina (G/I) no jejum como índice de resistência à insulina (RI). A IO foi maior na PP, mas o IMC foi semelhante aos C. Os níveis de SDHEA, T e A foram maiores, enquanto a SHBG e a IGFBP-1 foram menores na PP do que nos C. Na regress o simples, a SHBG mostrou correla o com IMC, F, SDHEA, T, I, G/I e IGFBP-1, enquanto a IGFBP-1 se correlacionou com IMC, I e a G/I. No modelo de regress o múltipla, tanto a SHBG quanto a IGFBP-1 correlacionaram-se apenas com o IMC e a taxa G/I (r2=0,45; p<0,01 e r2=0,44; p<0,01, respectivamente). Nossos dados demonstram que o peso corporal e a insulina têm um papel sinérgico na regula o dos níveis da SHBG e da IGFBP-1, sugerindo que ambos podem ser marcadores sutis da RI na PP.
Simulación de grietas cortas originadas por fatiga de bajo ciclaje en aceros 2Cr 1Mo
BORNIA,O; VOGT,J.B; LEóN,J. B;
Revista de la Facultad de Ingeniería Universidad Central de Venezuela , 2006,
Abstract: the 2.25cr 1mo steels have been studied in low cycle fatigue (lcf) to high temperatures in a previous paper. low cycle fatigue is characterized by a multiple cracking stage where conventional fracture mechanics do not reproduce kinetic short crack growth, thus providing a challenge in the area of simulation. a modification made to the kinetic equation proposed by lankford10 and a lcf adaptation on tomkins9 equation, allows us to reproduce the phenomenon to high temperatures in this type of steel before the macroscopic crack induces the failure of the material. in this work, the low cycle fatigue is simulated based on damage knowledge and the statistical record of crack populations using the computational language java (tm) 2sdk, v 1.4.2-001 as a platform. the simulator reproduces the multiple typical cracking in this type of steel under pseudo-random conditions, generating an approximation of 90 % to the experimental results.
Remote Access to Expensive SDRAM Test Equipment: Qimonda Opens the Shop-floor to Test Course Students
Ana C. Leo,J. M. Martins Ferreira 2
International Journal of Online Engineering (iJOE) , 2007,
Abstract: Remote labs are increasingly used in a variety of blended-learning scenarios, with the objective of complementing the work done in real labs. In such cases, the workbenches present in the real labs comprise a set of instruments that may be used over the internet. The lab work to be done by the students may be carried out from any location within or outside the campus, enabling them to carry out their assignments from home or from any other place, at a time of their choice. However, remote experimentation is not necessarily related to students accessing academic labs. Small and medium-size companies may be interested in specialised equipment available in university research labs (e.g. an electron microscope). Alternatively, student skills in various areas may be improved if they are able to work with equipment available in factories or other industry installations. This paper describes a collaboration initiative between the Qimonda SDRAM factory at Vila do Conde, in the vicinity of Porto, and the Faculty of Engineering of the University of Porto (FEUP), whereby an expensive test station used by Qimonda SDRAM factories is remotely accessible to test course students in higher-education institutions.
The CANADA-FRANCE REDSHIFT SURVEY XIII: The luminosity density and star-formation history of the Universe to z ~ 1
S. J. Lilly,O. Le Fevre,F. Hammer,David Crampton
Physics , 1996, DOI: 10.1086/309975
Abstract: The comoving luminosity density of the Universe is estimated from the CFRS faint galaxy sample in three wavebands (2800A, 4400A and 1 micron) over the redshift range 0 < z < 1. In all three wavebands, the comoving luminosity density increases markedly with redshift. For a (q_0 = 0.5, Omega = 1.0) cosmological model, the comoving luminosity density increases as $(1+z)^{2.1 \pm 0.5}$ at 1 micron, as $(1+z)^{2.7 \pm 0.5}$ at 4400A and as $(1+z)^{3.9 \pm 0.75}$ at 2800A, these exponents being reduced by 0.43 and 1.12 for (0.05,0.1) and (-0.85,0.1) cosmological models respectively. The variation of the luminosity density with epoch can be reasonably well modelled by an actively evolving stellar population with a Salpeter initial mass function (IMF) extending to 125 M_sun, a star-formation rate declining with a power 2.5, and a turn-on of star-formation at early epochs. A Scalo (1986) IMF extending to the same mass limit produces too many long-lived low mass stars. This rapid evolution of the star-formation rate and comoving luminosity density of the Universe is in good agreement with the conclusions of Pei and Fall (1995) from their analysis of the evolving metallicity of the Universe. One consequence of this evolution is that the physical luminosity density at short wavelengths has probably declined by two orders of magnitude since z ~ 1.
Clustering around the radio-galaxy MRC0316-257 at z=3.14
O. Le Fevre,J. M. Deltorn,D. Crampton,M. Dickinson
Physics , 1996, DOI: 10.1086/310319
Abstract: We report here the spectroscopic identification of galaxies in the neighborhood of the radio-galaxy MRC0316-257, at a redshift $z\sim3.14$. Candidate cluster galaxies were selected from deep V and I images combined with narrow band imaging at the wavelength of redshifted Ly$\alpha$. Follow-up multi-slit spectroscopy has allowed confirmation of the redshift of the radio-galaxy, $z=3.1420\pm0.0020$, and identification of two associated galaxies at redshifts $z=3.1378\pm0.0028$ and $z=3.1351\pm0.0028$ respectively. The first galaxy is 0.3 $h_{50}^{-1}$ Mpc from the radio-galaxy, is resolved with an intrinsic size $11.6\pm h_{50}^{-1}$ kpc, and shows $Ly\alpha$ in emission with rest $W_{Ly\alpha}=55\pm14$\AA. In addition, its extremely blue $V-I$ color might possibly indicate a proto-galaxy forming a first generation of stars in a low dust medium. The second galaxy is 1.3 $h_{50}^{-1}$ Mpc away from the radio-galaxy, is marginally resolved and, in addition to Ly$\alpha$ in emission, shows CIV in emission with a broad component indicating the contribution from an AGN. The comoving density of galaxies with $V<23.8$ and a $Ly\alpha$ flux $>10^{-16}$ ergcm$^{-2}$sec$^{-1}$ in the vicinity of MRC0316-257 is $\sim2.5\times10^{-3}h^3_{50}Mpc^{-3}$, significantly higher than the expected background density of field galaxies with similar properties, and might indicate a rich cluster or proto-cluster environment.
The gravitational lens CFRS14.1311 = HST 14176+5226
David Crampton,O. Le Fevre,F. Hammer,S. J. Lilly
Physics , 1996,
Abstract: Ratnatunga et al. (1995) have recently proposed that an object, HST 14176+5226, in the "Groth-Westphal" HST survey strip is an "Einstein cross" gravitational lens. By chance, this object has been previously observed in the Canada-France Redshift Survey. The candidate lens, catalogued as CFRS14.1311, is an elliptical galaxy at z = 0.81. In addition, the spectrum shows a strong, spatially-extended, emission feature at 5342A that almost certainly originates from two of the four "lensed" images. We tentatively identify this emission line as Ly alpha at z =3.4. A less prominent emission feature at 6822A may be C IV 1549. Our data thus support the identification of this system as a new quadruple-image lens.
THE CANADA-FRANCE REDSHIFT SURVEY IV: Spectroscopic Selection Effects and 0300+00 Field Spectroscopic Data
F. Hammer,David Crampton,O. Le Fevre,S. J. Lilly
Physics , 1995, DOI: 10.1086/176558
Abstract: Possible surface brightness selection effects in the redshift catalogs of the Canada-France Redshift Survey are investigated through comparisons of subsamples of the data. Our analyses demonstrate that the securing of redshifts is independent of possible biases arising from surface brightness effects and/or differing galaxy morphologies and orientations. The unusual geometry of the mask designs for our spectroscopic observations also do not produce any significant bias. There is however a bias at the highest and lowest redshifts, especially for absorption-line galaxies at z > 1 and z < 0.2, due to the adopted spectral range (4250A to 8500A). Apart from the latter, we conclude that our sample of identified galaxies is an unbiased subsample of the original photometric catalogue and is essentially limited by I-band flux density ($17.5 \leq I_{AB} \leq 22.5$). Finally, spectroscopic data for 273 objects in the 0300+00 CFRS field are presented.
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