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Search Results: 1 - 10 of 2021 matches for " Rosana FZ;Lambertucci "
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Schistosomal myeloradiculopathy due to Schistosoma mansoni: report on 23 cases
Nobre, Vandack;Silva, Luciana CS;Ribas, Jo?o G;Rayes, Abdunnabi;Serufo, JC;Lana-Peixoto, MA;Marinho, Rosana FZ;Lambertucci, JR;
Memórias do Instituto Oswaldo Cruz , 2001, DOI: 10.1590/S0074-02762001000900020
Abstract: schistosoma mansoni infection is likely to be responsible for a significant proportion of cases of myelopathy occurring in areas where schistosomiasis is endemic. the aim of this study is to describe the clinical, laboratory and therapeutic data of 23 patients with schistosomal myeloradiculopathy. the medical records of 23 patients with schistosomal myelopathy admitted to two general hospitals of belo horizonte (mg), in brazil, from 1995 to 1999, were reviewed retrospectively. seventeen patients were male (74%). the mean age for the whole group was 27 years. lower limb weakness and associated lumbar and/or lower limb pain were reported by 20 patients (87%), and 16 (70%) were unable to walk. all individuals presented urinary retention and 19 (83%) complained of intestinal dysfunction. the treatment was based on the association of antischistosomal drugs and corticosteroids. five patients (22%) presented a full response to treatment, 13 (57%) partial response without functional limitations and 4 (17%) partial improvement with limitations or no response. three out of the 4 patients who stopped steroids before 45 days of treatment developed recurrence of the symptoms and signs of myelopathy. our cases demonstrate the severe presentation of the disease and the data disclosed here suggest that treatment with steroids should be kept for months after clinical improvement.
Attempt at the determination of aluminum nitrate LD50 and the study of its neurotoxicological effect in Wistar rat
FZ Azzaoui
Biology and Medicine , 2012,
Abstract: Values of oral lethal dose of aluminum (Al) nitrate are extremely different and rare in the literature. The study is an attempt to determine the oral LD50 of aluminum nitrate in the Wistar rats and to measure the effect of the high doses of this aluminum compound on rats’ different organs, on acetylcholinesterase (AChE) activity, and on acetylcholine (ACh) levels in the hippocampus. Four groups of male Wistar rats are used (n = 28). The treated groups receive three doses of aluminum nitrate (Al1 = 2,500 mg/kg, Al2 = 3,500 mg/kg, and Al3 = 4,500 mg/kg) once by gavage, while control rats receive tap water. All rats are examined twice daily for mortality and impairment during the 2-week experiment. The bodyweight (BW) is measured at the beginning and at the end of the experiment. Dissection is realized for each dyed rat and the dosage of AChE activity and ACh levels isrealized at the end of the experiment by colorimetric method. The obtained results show that the higher dose (Al3) kills 30% of the rats under study and causes spleens’ dark discoloration in the dyed rats. Both Al2 and Al3decrease significantly the spleen weight (p < 0.01) and AChE activity (p < 0.01), but increase significantly the ACh levels (p < 0.01 and p < 0.001, respectively), in hippocampus of rats. Even if the lethal dose of aluminum nitrate is not reached, the effect of the high acute doses on viscera and cholinergic system is demonstrated.
FZ Zainal
Malaysian Family Physician , 2007,
Malaysian Family Physician , 2008,
The Effects of Isosorbide Dinitrate on in Vitro Proliferation of WEHI-164 Cells and Peripheral Blood Mononuclear Cells
Hajighasemi F,Resvan Madani FZ
Tehran University Medical Journal , 2012,
Abstract: Background: Isosorbide dinitrate has been broadly used in the treatment of various ischemic heart diseases. Isosorbide is a nitric oxide donor which increases blood flow to tumors through vasodilatation and consequently accelerates the access of chemo-drugs to them. Furthermore, this drug has inhibitory effects on angiogenesis, tumor growth and metastasis in vivo. Moreover, its ant-inflammatory effects have also been reported. In the present study we evaluated the effects of isosorbide on the proliferative activity of fibrosarcoma WEHI-164 cell line and peripheral blood mononuclear cells (PBMCs). Methods: WEHI-164 fibrosarcoma cells and human PBMCs were cultured in complete Roswell Park Memorial Institute (RPMI) 1640 medium with 10% fetal bovine serum and 2×104 cells/mL for WEHI-164 and 2×105 cells/mL for PBMCs. The cells were then incubated at the exponential growth phase with different concentrations of isosorbide (4×10-6-1.6×10-3 M) for 24, 48 and 72 hours. Subsequently, isosorbide effects on proliferation of the cells were evaluated by trypan blue dye exclusion (TB) test and MTT assay. Statistical comparisons between groups were made by analysis of variance. Results: The proliferative activity of WEHI-164 fibrosarcoma cells and human PBMCs treated with different concentrations of isosorbide, did not show any significant difference with untreated control cells. Conclusion: The results of this study showed that isosorbide neither had any significant effects on the proliferative activity of fibrosarcoma WEHI-164 cells nor on human PBMCs. Our findings suggest that anti-tumoral effects of isosorbide reported by other investigators may be mediated through non-cytotoxic mechanisms.
Biología y conservación del Cóndor Andino (Vultur gryphus) en Argentina
Lambertucci,Sergio A.;
El hornero , 2007,
Abstract: the andean condor (vultur gryphus) is currently distributed along western south america. although it is considered a near threatened species, included in cites i, little is known about many aspects of its biology. here, i present a review of the biology and conservation status of the andean condor, focusing on the available information for argentina. i also suggest research needs to promote its conservation. the andean condor populations have been critically reduced in the northern portion of its distributional range. southern populations are healthier but some signs of retraction still remain. this species has one of the lowest reproductive rates and highest survival rates among birds. behavioural characteristics (large aggregations to feed and roost) make the andean condor very vulnerable to environmental disturbances that may cause a massive loss of individuals, considering that it has a slow demographic response. some of the current threats to condors include the false belief that it is a hunter species, poisoning and lead consumption, electrocution, furtive hunting, competition for food, and traps, among others. it is necessary to estimate population numbers and trends as well as survival rates, to weigh up the mortality factors, to detect important areas for the species, and to determine the distribution and availability of food in each country. the biology of the andean condor together with the lack of knowledge and the human caused threats create a dangerous combination for its survival.
Acute schistosomiasis mansoni: revisited and reconsidered
Lambertucci, José Roberto;
Memórias do Instituto Oswaldo Cruz , 2010, DOI: 10.1590/S0074-02762010000400012
Abstract: acute schistosomiasis is a systemic hypersensitivity reaction against the migrating schistosomula and eggs. a variety of clinical manifestations appear during the migration of schistosomes in humans: cercarial dermatitis, fever, pneumonia, diarrhoea, hepatomegaly, splenomegaly, skin lesions, liver abscesses, brain tumours and myeloradiculopathy. hypereosinophilia is common and aids diagnosis. the disease has been overlooked, misdiagnosed, underestimated and underreported in endemic areas, but risk groups are well known, including military recruits, some religious congregations, rural tourists and people practicing recreational water sports. serology may help in diagnosis, but the finding of necrotic-exudative granulomata in a liver biopsy specimen is pathognomonic. differentials include malaria, tuberculosis, typhoid fever, kala-azar, prolonged salmonella bacteraemia, lymphoma, toxocariasis, liver abscesses and fever of undetermined origin. for symptomatic hospitalised patients, treatment with steroids and schistosomicides is recommended. treatment is curative in those timely diagnosed.
Treatment of schistosomiasis: gathering stones together
Lambertucci, J. R.;
Memórias do Instituto Oswaldo Cruz , 1995, DOI: 10.1590/S0074-02761995000200006
Abstract: in this paper the treatment of schistosomiasis is examined under the following headings: cercarial dermatitis, katayama fever, schistosomiasis in the immunosuppressed host and treatment of therapeutic failures.
Acute schistosomiasis: clinical, diagnostic and therapeutic features
Lambertucci, J. R.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1993, DOI: 10.1590/S0036-46651993000500003
Abstract: three distinct syndromes caused by schistosomiasis have been described: cercarial dermatitis or swimmer's itch, acute schistosomiasis or katayama fever, and chronic schistosomiasis. complications of acute schistosomiasis have also been reported. the absence of a serological marker for the acute stage has hindered early diagnosis and treatment. recently, an elisa test using klh (keyhole limpet haemocyanin) as antigen, has proved useful in differentiating acute from chronic schistosomiasis mansoni. clinical and experimental evidence indicate that steroids act synergistically with schistosomicides in the treatment of katayama syndrome. in this paper, clinical, diagnostic and therapeutic features of acute schistosomiasis are updated.
Complicated Massive Choledochal Cyst: A Case Report
CN Okoromah, MA Odelola, FZ Etukudo
Nigerian Journal of Clinical Practice , 2002,
Abstract: Choledochal cysts are rare congenital anomalies resulting from congenital dilatations of the common bile duct (CBD) and usually they present during infancy with cholestatic jaundice. This report is on a massive-sized choledochal cyst associated with massive abdominal distention, respiratory embarrassment, postprandial vomiting and intractable electrolyte imbalance leading to death within 48 hours after emergency surgery in a five-month old Infant. This form of presentation is considered unusual and notable. This case report is aimed at highlighting this unique presentation and reviewing literature on choledochal cyst. It is hoped that this report will prompt early recognition and attention to the potential complications of choledochal cyst, in order to forestall morbidity and mortality. We recommended evaluation of the in-hospital long-term postoperative outcomes of cases of choledochal cyst. KEY WORDS: Choledochal cyst., Massive dilatation, complications, Death. Nigerian Journal of Clinical Practice Vol.5(2) 2002: 150-152
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