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Search Results: 1 - 10 of 609371 matches for " Rosa Lía;Castro "
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An Integrated ISFET pH Microsensor on a CMOS Standard Process  [PDF]
Francisco López-Huerta, Rosa María Woo-Garcia, Miguel Lara-Castro, Johan Jair Estrada-López, Agustín Leobardo Herrera-May
Journal of Sensor Technology (JST) , 2013, DOI: 10.4236/jst.2013.33010
Abstract: We present the design and integration of a nine-pH microsensor array on a single silicon substrate with its own signal readout circuit, integrated in a 0.6-μm commercial standard complementary metal oxide semiconductor (CMOS) process. An ion sensitive field effect transistor (ISFET) has been used as pH microsensor and an instrumentation amplifier as the read-out circuit. The ISFET structure is conformed by the channel length and ratio of MOS transistor, gate extended and the selective membrane, for which silicon nitride (Si3N4) is employed as an ion selective element. The complete design includes shielding around the pH microsensor and the readout circuit to avoid leakage of current to the substrate. The readout circuit is composed by three operational amplifiers and resistances that form the instrumentation amplifier, with a ±2.5 V bias has a 50 dB gain, power supply rejection ratio (PSSR) of 120 dB and common mode rejection ratio (CMRR) of 127 dB. The complete system is integrated in a 1.12 mm2 silicon area; it presents a 59 mV/pH linearity, within a concentration range of 2 to 12 of pH level, making it a good alternative for biological or medical applications.
Validation of commonly used reference genes for sleep-related gene expression studies
Kil S Lee, Tathiana A Alvarenga, Camila Guindalini, Monica L Andersen, Rosa MRPS Castro, Sergio Tufik
BMC Molecular Biology , 2009, DOI: 10.1186/1471-2199-10-45
Abstract: Neither TSD nor PSD affected the expression stability of all tested genes in both tissues indicating that b-actin, B2M, GAPDH and HPRT are appropriate reference genes for the sleep-related gene expression studies. In order to further verify these results, the relative expression of brain derived neurotrophic factor (BDNF) and glycerol-3-phosphate dehydrogenase1 (GPD1) was evaluated in brain and blood, respectively. The normalization with each of four reference genes produced similar pattern of expression in control and sleep deprived rats, but subtle differences in the magnitude of expression fold change were observed which might affect the statistical significance.This study demonstrated that sleep deprivation does not alter the expression stability of commonly used reference genes in brain and blood. Nonetheless, the use of multiple reference genes in quantitative RT-PCR is required for the accurate results.Sleep is a complex phenotype that involves several neurochemical and physiological processes. It is known to perform restorative functions and to facilitate memory consolidation [1,2]. Although sleep is essential for overall well-being and optimal physical and psychological functioning, chronic sleep restriction is frequently experienced due to contemporary social and domestic responsibilities, medical conditions and sleep disorders [3]. Sleep restriction alters sleep architecture primarily by decreasing the duration of the REM (rapid eye movement) sleep stage, also known as paradoxical sleep (PS) [3]. Therefore, approaches that reduce or abolish PS have been used to simulate chronic sleep restriction.Persistent sleep debt impairs neurobehavioral functions [3,4] and increases the risk for chronic diseases such as cardiovascular disorders [5], erectile dysfunction [6] and diabetes [7]. Thus, careful characterization of the effects of sleep deprivation not only improves our knowledge about the complex sleep process but also contributes to elucidation of the mecha
Caracteriza??o molecular de popula??es de Butia capitata (Arecaceae) do Sul do Brasil através de marcadores AFLP
Buttow, Miriam Valli;Castro, Caroline Marques;Schwartz, Elisane;Tonietto, Adilson;Barbieri, Rosa Lía;
Revista Brasileira de Fruticultura , 2010, DOI: 10.1590/S0100-29452010005000001
Abstract: the butia genus (arecaceae) is a small genus with subtropical species distributed in south america widely used as an ornamental plant. besides, its fruits are appreciated for its unique flavor and aroma. but in some regions in rio grande do sul state natural populations suffer with progress of building and rural activities. the aim of this study, therefore, was characterizing eight populations of butia capitata through aflp markers. by analysis of molecular variance was possible to verify that 83.68% of genetic variability is attributed to variation among populations and 13.67% is attributed to differences among populations within regions. in the pair-wise analysis, differences between 15 populations were significant, with an average of 14.72% of molecular variation attributed to differences between populations. this result indicates the presence of genetic variability distributed among all populations, without subdivision arising from geographical isolation.
An Approach to Diagnostic Criteria for the Definition of Slight Cognitive Impairment Aproximación a los criterios diagnósticos para la definición de deterioro cognitivo leve
Julio Armas Castro,Mayra Rosa Carrasco García,Sussette Angell Valdés,Yanet López Mena
MediSur , 2009,
Abstract: For years the term slight cognitive impairment has been used in literature as a transitional stage between normal aging and a slight Alzheimer’s disease and in conversion studies it has been associated to quantitative and qualitative alterations that support that support the hypothesis that slight cognitive impairment constitutes an early stage of dementia in most of the patients. In this search the most updated diagnostic criteria on the topic have been reviewed looking for both a diagnostic consensus among the multiple and heterogeneous symptoms of this disorder and a clear, concise and uniform criterion that allow to reach a right definition and diagnosis of patients with slight cognitive impairment. El término deterioro cognitivo leve se ha usado en la literatura durante varios a os como un estado de transición entre el envejecimiento normal y una enfermedad de Alzheimer muy leve, se asocia además a alteraciones cuantitativas y cualitativas, en estudios de conversión, que apoyan la hipótesis de que se trata de estadios iniciales de demencia en una gran proporción de casos. En este trabajo se realiza una revisión de los principales criterios diagnósticos que se emplean en la actualidad para llegar a un consenso diagnóstico dentro de la heterogeneidad de síntomas y definir con criterios claros, concretos y uniformes a los pacientes con deterioro cognitivo leve.
Caracteriza??o molecular de variedades crioulas de abóboras com marcadores microssatélites
Priori, Daniela;Barbieri, Rosa Lía;Castro, Caroline M;Oliveira, Antonio C de;Vilella, Juliana CB;Mistura, Claudete C;
Horticultura Brasileira , 2012, DOI: 10.1590/S0102-05362012000300024
Abstract: among the five cultivated species of pumpkins, cucurbita pepo has the highest variability for fruit characteristics, such as color, shape and size. the active germplasm bank of cucurbitaceae from embrapa clima temperado (brazil) has 61 accessions of this species, all of them landraces grown in southern brazil. these landraces are part of regional culture, in gastronomy (preparation of traditional dishes) for crafts and ornaments. the aim of this study was to evaluate genetic variability within and among landraces of c. pepo cultivated in rio grande do sul state, by microsatellite markers. ten accessions of c. pepo landraces with different shapes and sizes of fruit, and colors and textures of fruit skin were evaluated. genomic dna was extracted individually from five plants of each accession. forty microsatellite loci were analyzed, and 34 amplified. in total 100 alleles were found (one to five alleles per locus). from the analysed loci, 85.3% were polymorphic, showing the presence of genetic variability among the accessions. the analysis of molecular variance showed that 45.39% of genetic variability is attributed to differences within accessions, and 54.60% is attributable to variation among accessions. thus, despite the presence of genetic variability within accessions, the largest proportion of variability in c. pepo is distributed among the accessions. the genetic variability found within accessions can be due to the allogamy, the exchange of landraces seeds between the farmers and also by cultivation of more than one cucurbita landrace in the same area.
Knowledge associated with the use of medicinal plants by farmers elderly residents in a nursing home
Anelise Miritz Borges, Caroline Vasconcellos Lopes, Lenice de Castro Muniz de Quadros, Rita Maria Heck, Rosa Lía Barbieri
Revista de Enfermagem UFPE On Line , 2010,
Abstract: Objective: to identify medicinal plants used by elderly farmer living in an long stay institution in a city in Rio Grande do Sul state and rescue knowledge associated with them. Method: it is a qualitative, exploratory and descriptive study, conducted in a home for elderly in S o Louren o do Sul, Rio Grande do Sul state, Brazil. Seven subjects participate in the study. The instruments used were semi-structured interviews and observation of plants with photographic record. Data collection occurred in June 2009. Results: Considering the seven interviewees, four were women and three men, with the age of 63 to 91 years old, with spent time in the institution from 3 months to 12 years. They reported the use of twenty-four medicinal plants. Regarding the transmission of knowledge about medicinal plants prevailed not diffusion of knowledge, corresponding to four subjects. Only two said they use to teach what they know about the plans to others. In addition, an elder said spread their knowledge when it is addressed, otherwise it does not. Conclusion: we believe that the acquisition of knowledge on the use of medicinal plants for therapeutic purposes occurs throughout life, causing therefore an accumulation of valuable knowledge in the elderly. Descriptors: phytotherapy; nursing; homes for the aged.
Inser??o das ciências básicas no currículo integrado do curso de Medicina da Universidade Estadual de Londrina
Vargas, Lúcia Helena Mendon?a;Colus, Ilce Mara de Syllos;Linhares, Rosa Elisa Carvalho;Salom?o, Tereza Maria Sandis;Marchese, Maurício de Castro;
Revista Brasileira de Educa??o Médica , 2008, DOI: 10.1590/S0100-55022008000200004
Abstract: the medical school of the state university of londrina established an integrated curriculum using problem based learning (pbl) as teaching strategy in the thematic modules of the medical course. although according to the literature problem based learning enhances the understanding and retention of basic sciences concepts, some authors fear that these basic concepts are not sufficiently emphasized in this methodology. the objective of this study is to evaluate the participation of basic sciences in the integrated curriculum of the londrina state university medical school. to this purpose a semi-structured questionnaire was elaborated for evaluating the participation of teachers of the basic areas in the different activities making part of the current curriculum. there was an increase of 36% in the participation of basic science teachers in relation to the previous curriculum. it was verified that basic sciences teachers participated in activities of the integrated curriculum during the first four but mainly during the first two years. efforts should be made for achieving a more intense integration of basic sciences and clinical practice throughout the course.
Miastenia grave ocular
Estevéz Miranda,Yaimir; Naranjo Fernández,Rosa M; Méndez Sánchez,Teresita de J; Castro Pérez,Pedro D; Rúa Martínez,Raúl;
Revista Cubana de Oftalmolog?-a , 2010,
Abstract: myasthenia gravis is an autoimmune illness of the neuromuscular joint that is characterized by the variability of the muscular weakness that worsens or caused by exercising of the muscle or the involved muscular groups; resting helps in improving the condition of the muscle. the first description of the illness dates back to 1672, but its linking to a thymus disorder was not discovered until 1901. this illness is not very frequent, affects equally to all the races, and it does not predominate in any particular geographic region. this paper presented a male patient aged 28 years who went to the ophthalmologic service at "ramón pando ferrer" cuban institute of ophthalmology because he suffered from double vision, slight palpebral ptosis in his right eye that became worse as the day went by. after the questions asked to the patient and the analysis of the clinical picture, it was suspected that the patient was affected by myasthenia gravis, and then he was referred to the clinician and the neurologist. the studies based on the neuroimaging analysis, the tomography and the electroencephalogram did not show any alteration. it was decided to evaluate the case with the assistance of the neurophthalmology service in our center and the institute of neurology; the diagnosis was confirmed.
Defectos refractivos en estudiantes de la Escuela “Pedro D. Murillo”
Estévez Miranda,Yaimir; Naranjo Fernández,Rosa M; Pons Castro,Lucy; Méndez Sánchez,Teresita de J; Rúa Martínez,Raúl; Dorrego Oduardo,Milagros;
Revista Cubana de Oftalmolog?-a , 2011,
Abstract: objectives: to characterize the refractive defects in children of school age in “pedro murillo” school in educational center ciudad libertad. methods: a descriptive study and cross-sectional study was carried out to knowing the refractive disorders in elementary school children in “pedro murillo” school marianao municipality, la havana, in the from september 2010 to february, 2011. the universe was formed by 422 students. a complete ophthalmologic exam was performed on 844 eyes. they were distributed according to the refractive defect and their degree of severity, age, gender and the frequency of the amblyopia. results: the astigmatism was the most frequent ametropia for 63.4 %, the compound myopic astigmatism prevailed. of the studied ametropias their mild form prevailed for 83 %. the frequency of amblyopia was 3.7 % in students. conclusions: the observed refractive defects were within the expected figures with respect to the international reports on this topic.
Miscelánea sobre escultura genovesa en Espa a
López Torrijos, Rosa,Nicolau Castro, Juan
Archivo Espa?ol de Arte , 2001,
Abstract: El estudio de obras italianas que de manera ininterrumpida fue llegando a Espa a se viene haciendo desde hace ya muchos a os. Pero se han estudiado preferentemente los grandes conjuntos sepulcrales o retablísticos tallados en mármol y se ha prestado menor atención a la escultura religiosa devocional que también llegó en gran cantidad y que ejercerá su influencia entre los artistas de la manera tradicional. En este aspecto las zonas italianas para nosotros más interesantes han sido Génova y Napóles desde donde, por los más diversos conductos, nos llegó un elevado número de piezas. Como una breve aportación más al catálogo genovés pretendemos con estas líneas dar a conocer unas piezas que no tienen, tal vez, más en común que el conservarse en distintos lugares de la Comunidad castellano-manchega.…
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