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Search Results: 1 - 10 of 12102 matches for " Roche Pierre-Hugues "
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Surgical Management of Lumbar and Thoracolumbar Spinal Fractures: Indications, Surgical Technique and Evaluation on a Series of 64 Patients Treated with Percutaneous Posterior Osteosynthesis Combined with Kyphoplasty or Anterior Arthrodesis  [PDF]
Romuald Kouitcheu, Drogba Landry, N’da Hermann Adonis, Diallo Moussa, Melot Anthony, Troude Lucas, Roche Pierre-Hugues
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.81007
Abstract:

Introduction: Fractures of the lumbar spine and thoracolumbar junction are common in spinal trauma. The aim of this work is to analyze the nature of the indications, the morbidity as well as the results of these treatment regimens. Patients and Methods: A retrospective, single-center study, based on a review of 64 patients with lumbar spine and thoracolumbar junction fractures (T10-L2) without neurological disorders, was collected in the neurosurgery department of the North Hospital and University Hospital (CHU), Marseille over a period of 2 years from January 2015 to December 2016. Posterior percutaneous osteosynthesis were more or less associated with kyphoplasty preceded anterior arthrodesis. Clinical and radiological endpoints were collected at least 6 months later. Results: The mean follow-up was 9.5 months (6 - 24). The clinical evaluation found a mean VAS at last follow-up at 14/100 (0 - 30) and an average Oswestry score at the last follow-up at 88%. The initial average vertebral kyphosis went from 13° to 4° at the last follow-up with a correction loss of 1°, an absolute gain of 8°. No postoperative neurological complications were noted in our series. Conclusion: The implementation of a two-step therapeutic strategy with anterior reconstruction in Magerl’s lumbar spine or A3.3 thoracolumbar junction fractures allows effective and long-lasting correction of lumbar lordosis and thoracic kyphosis, and obtaining a balanced spine in the sagittal plane. Our functional results are close to normal, with low morbidity and a low complication rate.

Enhanced Characterization of the Smell of Death by Comprehensive Two-Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry (GCxGC-TOFMS)
Jessica Dekeirsschieter, Pierre-Hugues Stefanuto, Catherine Brasseur, Eric Haubruge, Jean-Fran?ois Focant
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039005
Abstract: Soon after death, the decay process of mammalian soft tissues begins and leads to the release of cadaveric volatile compounds in the surrounding environment. The study of postmortem decomposition products is an emerging field of study in forensic science. However, a better knowledge of the smell of death and its volatile constituents may have many applications in forensic sciences. Domestic pigs are the most widely used human body analogues in forensic experiments, mainly due to ethical restrictions. Indeed, decomposition trials on human corpses are restricted in many countries worldwide. This article reports on the use of comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCxGC-TOFMS) for thanatochemistry applications. A total of 832 VOCs released by a decaying pig carcass in terrestrial ecosystem, i.e. a forest biotope, were identified by GCxGC-TOFMS. These postmortem compounds belong to many kinds of chemical class, mainly oxygen compounds (alcohols, acids, ketones, aldehydes, esters), sulfur and nitrogen compounds, aromatic compounds such as phenolic molecules and hydrocarbons. The use of GCxGC-TOFMS in study of postmortem volatile compounds instead of conventional GC-MS was successful.
Detection of delirium by nurses among long-term care residents with dementia
Philippe Voyer, Sylvie Richard, Lise Doucet, Christine Danjou, Pierre-Hugues Carmichael
BMC Nursing , 2008, DOI: 10.1186/1472-6955-7-4
Abstract: In this prospective study (N = 156), nurse ratings of delirium were compared to researcher ratings of delirium. This procedure was repeated for 6 delirium symptoms. Sensitivity, specificity, positive and negative predictive values were computed. Logistic regressions were conducted to identify factors associated with delirium that is undetected by nurses.Despite a high prevalence of delirium in this cohort (71.5%), nurses were able to detect the delirium in only a minority of cases (13%). Of the 134 residents not identified by nurses as having delirium, only 29.9% of them were correctly classified. Detection rates for the 6 delirium symptoms varied between 39.1% and 58.1%, indicating an overall under-recognition of symptoms of delirium. Only the age of the residents (≥ 85 yrs) was associated with undetected delirium (OR: 4.1; 90% CI: [1.5–11.0]).Detection of delirium is a major issue for nurses that clearly needs to be addressed. Strategies to improve recognition of delirium could result in a reduction of adverse outcomes for this very vulnerable population.Delirium is defined as a mental disorder of acute onset with a fluctuating course, characterized by disturbances in consciousness, attention, orientation, memory, thought, perception and behaviour [1]. It is a common problem among elderly patients admitted to acute and long-term care (LTC) facilities, with its prevalence ranging from 9.6% to 89% [2-4]. The wide variation in these estimates is likely related to methodological issues such as differences in the population under study, the type of clinical settings in question and the criteria used for diagnosis. For example, higher prevalence was found in cohorts composed of hospitalized elderly patients with pre-existing cognitive impairment [5,6].It is now recognised that delirium in older patients is associated with numerous negative outcomes. Consequences for elderly patients who develop delirium include decline in their functional and cognitive status as well as
Hydrocephalies and Vestibular Schwannoma of Great Size: Therapeutic Strategies: About a Series of 32 Cases  [PDF]
Moussa Diallo, Romuald Kouitcheu, Lucas Troude, Anthony Melot, Jean-Marc Kaya, Adamou Touta, Samuel Malca, Pièrre-Hugues Roche
Case Reports in Clinical Medicine (CRCM) , 2018, DOI: 10.4236/crcm.2018.75034
Abstract: Introduction: The association hydrocephalus and vestibular schwannoma (VS) has been known for a long time. However, there is no therapeutic consensus, especially the place of drainage of cerebrospinal fluid (CSF). We report the result of our experience on the management of this pathology from a group of patients with a high volume VS (Koos IV) and operated consecutively. After reflections based on current literature data, we propose a therapeutic decisional algorithm. Materials and Methods: This is an analytical, retrospective study of 171 patients operated on KOOS IV vestibular schwannoma from January 2003 to December 2016 at the Marseille University Hospital Center. Of these, 32 patients with hydrocephalus and stage IV vestibular schwannoma were included. Radio-diagnostic criteria for hydrocephalus were based on Evans’ index, cortical furrow status, and the presence of trans-ependymal resorption. Our sample was divided into 2 groups. The first consisted of patients first operated on their hydrocephalus and secondarily treated with schwannoma surgery (group I); patients who underwent surgical resection of their first-line tumor were group II. Epidemiological, clinical, radiological, therapeutic and monitoring data were analyzed. The comparison of the quantitative variables was made by Fisher’s test. Results: During our study period (13 years), 171 cases of stage IV SV had been operated. The association between hydrocephalus and SV stage IV of Koos accounted for 18.7%. The average age of our patients was 53 years with a sex ratio of 0.7. The clinical picture was primarily composed of otological signs (90.6%), headache (56.3%) and cerebellar involvement (43.8%). The average diameter of VS inponto-cerebellar angle (PCA) was 31.5 mm. The treatment consisted of placing a first shunt of the CSF in 34.4% (group I). The ventriculoperitoneal shunt (VPS) was performed in 90.9% of cases. The first surgical removal of the tumor (group II) involved 65.6% of the patients. The postoperative tumor residue averaged 0.76 cc. The Evans index was evaluated on average at 0.33 in each of the 2 groups postoperatively. The average follow-up time for patients was 51 months. Eight cases of complications were recorded during the study. Secondly, in group II, VPS was performed in 9.5% (2 cases). Conclusion: Hydrocephalus is a condition commonly associated with stage IV vestibular schwannoma. The first optimal surgical excision of the tumor seems to be the treatment of choice for this pathological association. The success of the surgery is very
Stereoselective Inhibition of the hERG1 Potassium Channel
Liliana Sintra Grilo,Pierre-Alain Carrupt,Hugues Abriel
Frontiers in Pharmacology , 2010, DOI: 10.3389/fphar.2010.00137
Abstract: A growing number of drugs have been shown to prolong cardiac repolarization, predisposing individuals to life-threatening ventricular arrhythmias known as Torsades de Pointes. Most of these drugs are known to interfere with the human ether à-gogo related gene 1 (hERG1) channel, whose current is one of the main determinants of action potential duration. Prolonged repolarization is reflected by lengthening of the QT interval of the electrocardiogram, as seen in the suitably named drug-induced long QT syndrome. Chirality (presence of an asymmetric atom) is a common feature of marketed drugs, which can therefore exist in at least two enantiomers with distinct three-dimensional structures and possibly distinct biological fates. Both the pharmacokinetic and pharmacodynamic properties can differ between enantiomers, as well as also between individuals who take the drug due to metabolic polymorphisms. Despite the large number of reports about drugs reducing the hERG1 current, potential stereoselective contributions have only been scarcely investigated. In this review, we present a non-exhaustive list of clinically important molecules which display chiral toxicity that may be related to hERG1-blocking properties. We particularly focus on methadone cardiotoxicity, which illustrates the importance of the stereoselective effect of drug chirality as well as individual variations resulting from pharmacogenetics. Furthermore, it seems likely that, during drug development, consideration of chirality in lead optimization and systematic assessment of the hERG1 current block with all enantiomers could contribute to the reduction of the risk of drug-induced LQTS.
Caractérisation des défauts d'une surface sphérique par décomposition modale
Hugues Favreliere,Serge Samper,Pierre-Antoine Adragna
Computer Science , 2010,
Abstract: The [ISO 1101] standard specifies the form errors with geometrical tolerances using the zone concept.To complete this concept, we present a generic method which adapts to any geometry and allows to describe any kind of errors. Thus,we can dissociate the part errors according to reference categories: position, orientation,form, waviness and roughnesses. Starting from a cloud of poinds representing the error measurement, the "modal" method decompose, like Fourier series,this error in a sum of sorted errors according to the ircomplexity degree (a number of "wavinesses"). In addition, we propose to show, on a simple example, that according to error complexity to be characterized, an interpolation by the modal method allows to optimize the measuring strategy.
Modeling of 2D and 3D Assemblies Taking Into Account Form Errors of Plane Surfaces
Serge Samper,Pierre-Antoine Adragna,Hugues Favreliere,Maurice Pillet
Computer Science , 2010, DOI: 10.1115/1.3249575
Abstract: The tolerancing process links the virtual and the real worlds. From the former, tolerances define a variational geometrical language (geometric parameters). From the latter, there are values limiting those parameters. The beginning of a tolerancing process is in this duality. As high precision assemblies cannot be analyzed with the assumption that form errors are negligible, we propose to apply this process to assemblies with form errors through a new way of allowing to parameterize forms and solve their assemblies. The assembly process is calculated through a method of allowing to solve the 3D assemblies of pairs of surfaces having form errors using a static equilibrium. We have built a geometrical model based on the modal shapes of the ideal surface. We compute for the completely deterministic contact points between this pair of shapes according to a given assembly process. The solution gives an accurate evaluation of the assembly performance. Then we compare the results with or without taking into account the form errors. When we analyze a batch of assemblies, the problem is to compute for the nonconformity rate of a pilot production according to the functional requirements. We input probable errors of surfaces (position, orientation, and form) in our calculus and we evaluate the quality of the results compared with the functional requirements. The pilot production then can or cannot be validated.
Random effects compound Poisson model to represent data with extra zeros
Marie-Pierre Etienne,Eric Parent,Benoit Hugues,Bernier Jacques
Statistics , 2009,
Abstract: This paper describes a compound Poisson-based random effects structure for modeling zero-inflated data. Data with large proportion of zeros are found in many fields of applied statistics, for example in ecology when trying to model and predict species counts (discrete data) or abundance distributions (continuous data). Standard methods for modeling such data include mixture and two-part conditional models. Conversely to these methods, the stochastic models proposed here behave coherently with regards to a change of scale, since they mimic the harvesting of a marked Poisson process in the modeling steps. Random effects are used to account for inhomogeneity. In this paper, model design and inference both rely on conditional thinking to understand the links between various layers of quantities : parameters, latent variables including random effects and zero-inflated observations. The potential of these parsimonious hierarchical models for zero-inflated data is exemplified using two marine macroinvertebrate abundance datasets from a large scale scientific bottom-trawl survey. The EM algorithm with a Monte Carlo step based on importance sampling is checked for this model structure on a simulated dataset : it proves to work well for parameter estimation but parameter values matter when re-assessing the actual coverage level of the confidence regions far from the asymptotic conditions.
Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial [ISRCTN08745124]
Hugues Chevassus, Isabelle Mourand, Nathalie Molinier, Bruno Lacarelle, Jean-Frédéric Brun, Pierre Petit
BMC Pharmacology and Toxicology , 2004, DOI: 10.1186/1472-6904-4-3
Abstract: The study was designed as a double-blind, placebo-controlled, cross-over clinical trial. Diazepam (10 mg) and clonazepam (1 mg) were infused during 30 min to 15 male subjects with a mean age of 22 years (range: 20–29), after informed consent was given. Benzodiazepines were assayed by capillary gas chromatography with electron capture, insulin by radioimmunoassay and glucose by the enzymatic glucose oxidase method.Both benzodiazepines induced significant psychotropic effects. The acute insulin responses (AIR) were significantly and negatively correlated with the clonazepam plasma concentrations (r = -0.609, P < 0.05, n = 14). However, the mean AIR was not significantly different between the benzodiazepine-treated subjects and the controls. In addition, the parameters of glucose assimilation were significantly decreased as compared with placebo in the subgroup of 7 subjects with plasma clonazepam concentrations higher than 6.0 ng ml-1 (median and lower limit of effective therapeutic concentrations): 1.37 ± 0.3 versus 2.84 ± 0.60 × 10-2min-1 (P = 0.028) for the coefficient of glucose tolerance (Kg), 2.18 ± 0.29 versus 3.71 ± 0.89 × 10-4μUml-1min-1 (P = 0.018) for insulin sensitivity (Si) and 1.80 ± 0.39 versus 3.59 ± 0.71 × 10-2min-1 (P = 0.028) for glucose effectiveness at basal insulin (Sg). These parameters were not significantly modified when diazepam was administered; plasma levels of this drug however, were below the effective therapeutic concentrations (300 ng ml-1) from min 15 after the end of the perfusion.The present results suggest that a benzodiazepine, in particular clonazepam, may alter insulin secretion and insulin sensitivity after a single administration in healthy volunteers.Benzodiazepine drugs are widely prescribed, mainly for their anxiolytic and sedative properties. In addition to these psychotropic actions, different metabolic effects have also been reported but few clinical trials on that topic are available.A trend to increased glycemia without
SNPPicker: High quality tag SNP selection across multiple populations
Hugues Sicotte, David N Rider, Gregory A Poland, Neelam Dhiman, Jean-Pierre A Kocher
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-129
Abstract: SNPPicker optimizes the selection of tag SNPs from common bin-tagging programs to design custom genotyping panels. The application uses a multi-step search strategy in combination with a statistical model to maximize the genotyping success of the selected tag SNPs. User preference toward functional SNPs can also be taken into account as secondary criteria. SNPPicker can also optimize tag SNP selection for a panel tagging multiple populations. SNPPicker can optimize custom genotyping panels including all the assay-specific constraints of Illumina's GoldenGate and Infinium assays.A new application has been developed to maximize the success of custom multi-population genotyping panels. SNPPicker also takes into account user constraints including options for controlling runtime. Perl Scripts, Java source code and executables are available under an open source license for download at http://mayoresearch.mayo.edu/mayo/research/biostat/software.cfm webciteDespite the commercial availability of affordable genome wide genotyping panels, custom-designed SNPs panels are frequently used for high resolution genotyping studies focusing on specific genes or chromosomal regions. The design of custom SNP panels for genotyping studies aims to minimize the number of SNPs to genotype while maximizing the information content of the panel.The number of SNPs to genotype can be minimized by taking advantage of linkage disequilibrium (LD) between SNP alleles in the same population. A number of algorithms are available to assess LD between SNPs and select tag SNPs representative of groups of correlated SNPs called bins [1-5]. These bin-tagging algorithms use population specific sets of reference genotypes to compute bins and tag SNPs and report all possible tag SNP candidates for each bin. Note that Tagger, which reports the best tag SNP, also provides an exportable table of r2 values between SNPs that can be used to compute all tag SNPs candidates. Since these tag SNPs candidates are theore
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