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Search Results: 1 - 10 of 3244 matches for " Robin Hyde-DeRuyscher "
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Improved Bone Morphogenetic Protein-2 Retention in an Injectable Collagen Matrix Using Bifunctional Peptides
Paul T. Hamilton, Michelle S. Jansen, Sathya Ganesan, R. Edward Benson, Robin Hyde-DeRuyscher, Wayne F. Beyer, Joseph C. Gile, Shrikumar A. Nair, Jonathan A. Hodges, Hanne Gr?n
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070715
Abstract: To promote healing of many orthopedic injuries, tissue engineering approaches are being developed that combine growth factors such as Bone Morphogenetic Proteins (BMP) with biomaterial carriers. Although these technologies have shown great promise, they still face limitations. We describe a generalized approach to create target-specific modular peptides that bind growth factors to implantable biomaterials. These bifunctional peptide coatings provide a novel way to modulate biology on the surface of an implant. Using phage display techniques, we have identified peptides that bind with high affinity to BMP-2. The peptides that bind to BMP-2 fall into two different sequence clusters. The first cluster of peptide sequences contains the motif W-X-X-F-X-X-L (where X can be any amino acid) and the second cluster contains the motif F-P-L-K-G. We have synthesized bifunctional peptide linkers that contain BMP-2 and collagen-binding domains. Using a rat ectopic bone formation model, we have injected rhBMP-2 into a collagen matrix with or without a bifunctional BMP-2: collagen peptide (BC-1). The presence of BC-1 significantly increased osteogenic cellular activity, the area of bone formed, and bone maturity at the site of injection. Our results suggest that bifunctional peptides that can simultaneously bind to a growth factor and an implantable biomaterial can be used to control the delivery and release of growth factors at the site of implantation.
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A Wallis Product on Clovers
Trevor Hyde
Mathematics , 2012,
Abstract: We prove a generalization of the Wallis product for a sequence of real numbers related to arc lengths of clover curves. Our proof generalizes a common argument given for the original Wallis product using a sequence of definite integrals.
Laboratory confirmation of measles in elimination settings: experience from the Republic of the Marshall Islands, 2003
Hyde,Terri B; Nandy,Robin; Hickman,Carole J; Langidrik,Justina R; Strebel,Peter M; Papania,Mark J; Seward,Jane F; Bellini,William J;
Bulletin of the World Health Organization , 2009, DOI: 10.1590/S0042-96862009000200010
Abstract: objective: to highlight the complications involved in interpreting laboratory tests of measles immunoglobulin m (igm) for confirmation of infection during a measles outbreak in a highly vaccinated population after conducting a mass immunization campaign as a control measure. methods: this case study was undertaken in the republic of the marshall islands during a measles outbreak in 2003, when response immunization was conducted. a measles case was defined as fever and rash and one or more of cough, coryza or conjunctivitis. between 13 july and 7 november 2003, serum samples were obtained from suspected measles cases for serologic testing and nasopharyngeal swabs were taken for viral isolation by reverse transcriptase polymerase chain reaction (rt-pcr). findings: specimens were collected from 201 suspected measles cases (19% of total): of the ones that satisfied the clinical case definition, 45% were igm positive (igm+) and, of these, 24% had received measles vaccination within the previous 45 days (up to 45 days after vaccination an igm+ result could be due to either vaccination or wild-type measles infection). the proportion of igm+ results varied with clinical presentation, the timing of specimen collection and vaccination status. positive results on rt-pcr occurred in specimens from eight igm-negative and four igm+ individuals who had recently been vaccinated. conclusion: during measles outbreaks, limiting igm testing to individuals who meet the clinical case definition and have not been recently vaccinated allows for measles to be confirmed while conserving resources.
P2P Business Applications: Future and Directions  [PDF]
Pankaj Pankaj, Micki Hyde, James A. Rodger
Communications and Network (CN) , 2012, DOI: 10.4236/cn.2012.43029
Abstract: Since the launch of Napster in June 1999, peer-to-peer technology (P2P) has become synonymous with file sharing applications that are the bane of the recording industry due to copyright infringements and consequent revenue losses. P2P promised a revolution in business computing which has not arrived. It has become synonymous with illegal file sharing and copyright violations. Meanwhile the information systems industry has undergone a paradigm change, and we are supposedly living in a world of cloud computing and mobile devices. It is pertinent to examine if P2P, as a revolutionary technology, is still relevant and important today and will be in future. One has to examine this question in the context of the fact that P2P technologies have matured but have however had limited adoption outside file sharing in the consumer space. This paper provides a detailed analysis of P2P computing and offers some propositions to answer the question of the relevancy of P2P. It is proposed that P2P is still a relevant technology but may be reshaped in the coming years in a different form as compared to what exists today.
Sensing Attributes of an Agile Information System  [PDF]
Pankaj Pankaj, Micki Hyde, Arkalgud Ramaprasad
Intelligent Information Management (IIM) , 2013, DOI: 10.4236/iim.2013.55016
Abstract: Information Systems (IS) agility is a current topic of interest in the IS industry. The study follows up on the work on the definition of the construct of IS agility which is defined as the ability of IS to sense a change in real time; diagnose it in real time; and select and execute an action in real time. It explores the attributes for sensing in an Agile Information System. A set of attributes was initially derived using the practitioner literature and then refined using interviews with practitioners. Their importance and validity were established using a survey of the industry. All attributes derived from this study were deemed pertinent for sensing in an agile information system. Dimensions underlying these attributes were identified using Exploratory Factor Analysis. This list of attributes can form the basis for assessing and establishing sensing mechanisms to increase IS agility.
Sex and Personality Differences in Job Value Preferences  [PDF]
Adrian Furnham, Geoff Trickey, Gillian Hyde
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.75069

One thousand four hundred and fifty-eight business executives completed the two Hogan assessment measures: the Motives, Values and Preferences Inventory (MVPI) (an inventory of ten core occupational values), and the Hogan Personality Inventory (HPI) (a measure of seven super-factor traits). There were seven sex differences on the values which factored into three interpretable factors labelled Science, Excitement and Virtue. Regression with the factor scores as the criterion variables and demography and the seven HPI scales as predictor variables showed a quarter to a half of the variance could be explained. The second factor Excitement was most clearly related to HPI scores. Implications for selection are considered.

Assessing the Potential for “Cultural Disruption” through Sharing Economy: A Case Study of a Time Bank in Helsinki  [PDF]
Tomas Tr?skman, Nathalie Hyde-Clarke
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.46012
Abstract: A better networked society has the potential to facilitate utopian ideals that embrace modes of sharing economy through the advent of the better utilization of community resources. Much has been expected of new digital communication spaces capable of linking individuals with each other outside the ambit of governments and mega-conglomerates. However, due to evolving corporate and marketing strategies, and national legal frameworks, there has been no clear demonstration of a truly alternative economic system. The recent interest in collaborative or sharing economy calls attention once more to this potential. This article presents and analyses a time-banking initiative, Stadin Aikapankki, in Helsinki, Finland. It explores the motivations behind the formation of this sharing economy community initiative, how it relates to and is expressed in terms of utopian aims and ideals, and whether this case study is able to maintain aspects of cultural disruption in the face of pressures from mainstream national actors.
Exploring the Benefits of an Agile Information System  [PDF]
Pankaj Chaudhary, Micki Hyde, James A. Rodger
Intelligent Information Management (IIM) , 2017, DOI: 10.4236/iim.2017.95007
Abstract: Information Systems (IS) agility is a current topic of interest in the IS industry. The study follows up on work on the definition of the construct of IS agility and attributes for sensing, diagnosis, and selection and execution in an agile IS. IS agility is defined as the ability of an IS to sense a change in real time; diagnose it in real time; and select and execute a response in real time. Architecting an agile IS is a complex and resource-intensive task, and hence examination of its benefits is highly desired and appropriate. This paper examines the benefits of an Agile Information System. Benefits of an agile IS were derived from related academic literature and then refined using practitioner literature and qualitative data. The benefits considered were the first order or direct benefits. These benefits were then empirically validated through a survey of IT practitioners. The results of the survey were analyzed and a rank order of the benefits was arrived at. An exploratory factor analysis was also done to find the common dimensions underlying the benefits. It is suggested that organizations can use the empirically validated benefits from this study to justify and jump-start their capital and labor expenditure to build agility into their Information System.
Aging and the decline in health  [PDF]
Robin Holliday
Health (Health) , 2010, DOI: 10.4236/health.2010.26092
Abstract: The biological reasons for aging are now understood. Aging is the result of multiple stochastic events in molecules, cells, tissues and organs. These together produce the aged phenotype, senescence and ultimately death. Many of these changes can be directly linked to specific age-associated disease. However, there are also age-related changes that are not pathological. It can be said that aging has multiple causes, or is instead due to a general loss of molecular fidelity, that is, an increase in disorder. The complexity of organism means that they develop as ordered structures by obtaining energy from the environment. These ordered structures must be maintained by a wide variety of mechanisms which also depend on energy resources. Eventually these mechanisms fail, and senescence sets in. It is known that the efficiency of maintenance is correlated directly with the lifespan of different mammalian species. Also, these lifespans are inversely correlated with fecundity or reproductive potential. There is a trade off between investment of resources in maintenance of the body, or soma, and investment in reproduction.
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