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Search Results: 1 - 10 of 3216 matches for " Robin Choo "
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Determinants of Health-Related Quality of Life (HRQoL) in the Multiethnic Singapore Population – A National Cohort Study
Melvin Khee-Shing Leow, Konstadina Griva, Robin Choo, Hwee-Lin Wee, Julian Thumboo, E. Shyong Tai, Stanton Newman
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067138
Abstract: Background HRQoL is an important outcome to guide and promote healthcare. Clinical and socioeconomic factors may influence HRQoL according to ethnicity. Methodology A multiethnic cross-sectional national cohort (N = 7198) of the Singapore general population consisting of Chinese (N = 4873), Malay (N = 1167) and Indian (N = 1158) adults were evaluated using measures of HRQoL (SF-36 version 2), family functioning, health behaviours and clinical/laboratory assessments. Multiple regression analyses were performed to identify determinants of physical and mental HRQoL in the overall population and their potential differential effects by ethnicity. No a priori hypotheses were formulated so all interaction effects were explored. Principal Findings HRQoL levels differed between ethnic groups. Chinese respondents had higher physical HRQoL (PCS) than Indian and Malay participants (p<0.001) whereas mental HRQoL (MCS) was higher in Malay relative to Chinese participants (p<0.001). Regressions models explained 17.1% and 14.6% of variance in PCS and MCS respectively with comorbid burden, income and employment being associated with lower HRQoL. Age and family were associated only with MCS. The effects of gender, stroke and musculoskeletal conditions on PCS varied by ethnicity, suggesting non-uniform patterns of association for Chinese, Malay and Indian individuals. Conclusions Differences in HRQoL levels and determinants of HRQoL among ethnic groups underscore the need to better or differentially target population segments to promote well-being. More work is needed to explore HRQoL and wellness in relation to ethnicity.
AN ADULT PATIENT WITH CONGENITAL HEART DISEASE
CHOO WS
Malaysian Family Physician , 2010,
Abstract:
Self-Reported Pain Intensity with the Numeric Reporting Scale in Adult Dengue
Joshua G. X. Wong, Victor C. Gan, Ee-Ling Ng, Yee-Sin Leo, Siew-Pang Chan, Robin Choo, David C. Lye
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096514
Abstract: Background Pain is a prominent feature of acute dengue as well as a clinical criterion in World Health Organization guidelines in diagnosing dengue. We conducted a prospective cohort study to compare levels of pain during acute dengue between different ethnicities and dengue severity. Methods Demographic, clinical and laboratory data were collected. Data on self-reported pain was collected using the 11-point Numerical Rating Scale. Generalized structural equation models were built to predict progression to severe disease. Results A total of 499 laboratory confirmed dengue patients were recruited in the Prospective Adult Dengue Study at Tan Tock Seng Hospital, Singapore. We found no statistically significant differences between pain score with age, gender, ethnicity or the presence of co-morbidity. Pain score was not predictive of dengue severity but highly correlated to patients’ day of illness. Prevalence of abdominal pain in our cohort was 19%. There was no difference in abdominal pain score between grades of dengue severity. Conclusion Dengue is a painful disease. Patients suffer more pain at the earlier phase of illness. However, pain score cannot be used to predict a patient’s progression to severe disease.
Packed Supercritical Fluid Chromatography for the Analyses and Preparative Separations of Palm Oil Minor Components  [PDF]
Mei Han Ng, Yuen May Choo
American Journal of Analytical Chemistry (AJAC) , 2015, DOI: 10.4236/ajac.2015.68062
Abstract: This paper depicts a brief review on the applications of packed supercritical fluid chromatography (SFC) in palm oil analyses and purifications from early 1990s to date. Packed SFC has been used for the analyses of various palm oil components. The analytical separations have also been scaled up to preparative scale that leads to the recovery of high value components from palm oil. This review encompasses both analytical and preparative SFC in the oil palm processing.
Aging and the decline in health  [PDF]
Robin Holliday
Health (Health) , 2010, DOI: 10.4236/health.2010.26092
Abstract: The biological reasons for aging are now understood. Aging is the result of multiple stochastic events in molecules, cells, tissues and organs. These together produce the aged phenotype, senescence and ultimately death. Many of these changes can be directly linked to specific age-associated disease. However, there are also age-related changes that are not pathological. It can be said that aging has multiple causes, or is instead due to a general loss of molecular fidelity, that is, an increase in disorder. The complexity of organism means that they develop as ordered structures by obtaining energy from the environment. These ordered structures must be maintained by a wide variety of mechanisms which also depend on energy resources. Eventually these mechanisms fail, and senescence sets in. It is known that the efficiency of maintenance is correlated directly with the lifespan of different mammalian species. Also, these lifespans are inversely correlated with fecundity or reproductive potential. There is a trade off between investment of resources in maintenance of the body, or soma, and investment in reproduction.
Tandem mass spectrometry data quality assessment by self-convolution
Keng Choo, Wai Tham
BMC Bioinformatics , 2007, DOI: 10.1186/1471-2105-8-352
Abstract: The proposed method measures the qualities of MS data sets based on the symmetric property of b- and y-ion peaks present in a MS spectrum. Self-convolution on MS data and its time-reversal copy was employed. Due to the symmetric nature of b-ions and y-ions peaks, the self-convolution result of a good spectrum would produce a highest mid point intensity peak. To reduce processing time, self-convolution was achieved using Fast Fourier Transform and its inverse transform, followed by the removal of the "DC" (Direct Current) component and the normalisation of the data set. The quality score was defined as the ratio of the intensity at the mid point to the remaining peaks of the convolution result. The method was validated using both theoretical mass spectra, with various permutations, and several real MS data sets. The results were encouraging, revealing a high percentage of positive prediction rates for spectra with good quality scores.We have demonstrated in this work a method for determining the quality of tandem MS data set. By pre-determining the quality of tandem MS data before subjecting them to protein identification algorithms, spurious protein predictions due to poor tandem MS data are avoided, giving scientists greater confidence in the predicted results. We conclude that the algorithm performs well and could potentially be used as a pre-processing for all mass spectrometry based protein identification tools.Mass spectrometry (MS) is a common analytical technique used to identify unknown compounds, quantify known materials, and elucidate the molecular structure and chemical composition of organic and inorganic substances. A mass spectrometer is an instrument used to measure the mass-to-charge ratio of individual molecules that have been converted into electrically charged molecules, or ions [1]. These ions are filtered and ordered from a lower to higher mass-to-charge ratio (m/z) before passing through an ion detector in the instrument [2]. In the field of pr
Menstruation angina: a case report
Wai Kah Choo
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-6618
Abstract: A case of menstruation angina is reported in order to raise awareness of this association. A 47-year-old South Asian woman presented with recurrent chest pains in a monthly fashion coinciding with her menstruations. Each presentation was associated with troponin elevation. Angioplasty failed to resolve her symptoms but she eventually responded to hormonal therapy.The possibility of menstruation angina should always be taken into account in any female patients from puberty to menopause presenting with recurrent chest pains. This can allow an earlier introduction of hormonal therapy to arrest further myocardial damage.While some live through menstrual cycles as part and parcel of their lives, the cyclical fluctuation of sex hormones disturbs the lives of many others. To date, menstruation has established effects on migraine, epilepsy, asthma, irritable bowel syndrome and diabetes [1].The few suffering from 'menstruation angina' or 'catamenial angina' may not have earned the attention they deserve. Research into the relationship between coronary events and menstrual cycles is still in its infancy, but preliminary trials have so far shown compelling evidence.A 47-year-old South Asian woman presented with a 3-month history of recurrent left-sided chest pains. Initially, her pains were non-exertional and were relieved by massages and antacids. The onset of her pains usually coincided with the second or third day of her menstruation each month and usually lasted up to 4 days. Rests frequently eased her pains, hence she did not seek medical attention.She eventually presented to our Emergency Department in the fourth month. She had sudden onset sharp chest pain, 10/10 in intensity, which radiated up to her jaw and travelled down to her arms. The pain was non-exertional and sublingual nitrates did not help. She also complained of diaphoresis, hot flushes and persistent lethargy. This presentation coincided with the second day of her menstruation.Aside from a raised Body Mass
Doubly stochastic right multipliers
Choo-Whan Kim
International Journal of Mathematics and Mathematical Sciences , 1984, DOI: 10.1155/s016117128400051x
Abstract: Let P(G) be the set of normalized regular Borel measures on a compact group G. Let Dr be the set of doubly stochastic (d.s.) measures on G —G such that (As —Bs)= (A —B), where s ¢ G, and A and B are Borel subsets of G. We show that there exists a bijection ¢ ” between P(G) and Dr such that ¢ ’1=m ¢ — , where m is normalized Haar measure on G, and (x,y)=(x,xy ¢ ’1) for x,y ¢ G. Further, we show that there exists a bijection between Dr and Mr, the set of d.s. right multipliers of L1(G). It follows from these results that the mapping ¢ ’T defined by T f= ¢ —f is a topological isomorphism of the compact convex semigroups P(G) and Mr. It is shown that Mr is the closed convex hull of left translation operators in the strong operator topology of B[L2(G)].
Access to Malay manuscripts
Ding Choo Ming
Bijdragen tot de Taal-, Land- en Volkenkunde , 1987,
Abstract:
Information seeking in organizations: epistemic contexts and contests
Chun Wei Choo
Information Research: an international electronic journal , 2007,
Abstract: Introduction. Organizations seek and use information to understand and enact their worlds. Information constitutes what the organization 'knows' about its environment and its tasks, and thus creates a basis for action. However, the link between information, knowledge, and action is problematic and not well understood. Method. We consider three case studies that highlight different aspects of the interaction between information and knowledge in organizations. The first case compares information seeking and use in the due diligence processes of a government agency and a venture capital firm. The second case surfaces the epistemic properties of information seeking in the preparation of country studies by the staff of a German bank. The third case recollects the experience of large-scale information sharing among copier technicians of a multinational office products company. Analysis. These case studies suggest that organizations behave as epistemic communities with distinct epistemic and information cultures that influence how information is sought and utilized, and how beliefs are formed and re-formed. Conclusion. . To understand information behaviour in organizations is to understand how organizations are simultaneously information-seeking and belief-forming social systems, where information is shaped by epistemic practices as much as beliefs are the outcomes of information seeking and use.
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