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Search Results: 1 - 10 of 22385 matches for " Roberto Scarpato "
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Hydroperoxides and cytokines as biomarkers in detecting atherosclerosis predisposition in cigarette smokers  [PDF]
Valter Lubrano, Michela Ballardin, Vincenzo Longo, Moreno Paolini, Roberto Scarpato
Modern Research in Inflammation (MRI) , 2012, DOI: 10.4236/mri.2012.11002
Abstract: Objectives: Smoking increases oxidative modification of LDL, associated with lower HDL plasma levels, systemic inflammatory response and endothelial dysfunction. We tested the hypothesis that the risk status for coronary atherosclerosis disease (CAD) of cigarettes smokers might be identified by means of serum oxidative levels and vascular inflammation determination. Design and Methods: Oxidative stress levels, cytokines, and the metabolic status were investigated on 499 subjects admitted to our institute. The association between biomarkers and smoking habits in the presence/absence of disease and with the number of vessel affected, was studied. Results: Oxidative stress and inflammatory levels (p < 0.001) were strongly induced by smoking habits. Serum values of the subjects categorised as CAD, non CAD and healthy subjects differed significantly (p < 0.001) only for the degree of oxidative stress. Glycaemia was able to affect C-reactive protein serum levels with a positive association (p < 0.05). The analysis of the study population indicated that serum oxidative stress levels significantly increased with increasing number of vessels affected (p < 0.01). When statistical analysis was performed separately in both smoking groups, smokers did not show any particular difference for both oxidative stress and inflammation markers between the two groups of cardiovascular patients (CAD and non CAD) and the control group, while for non smokers, the differences were evident. Conclusion: These findings indicate that the considered biomarkers, especially oxidative stress, can be useful to predict the biological damage caused by cigarette smoking, as well as to identify subjects characterised by a higher risk of cardiovascular event, but cannot evaluate the presence of disease in subjects with smoking habit.
Apresenta o
Marta Scarpato
Cadernos CEDES , 2001, DOI: 10.1590/s0101-32622001000100001
Abstract:
Dan?a educativa: um fato em escolas de S?o Paulo
Scarpato, Marta Thiago;
Cadernos CEDES , 2001, DOI: 10.1590/S0101-32622001000100004
Abstract: the educational dance taught in the private schools of s?o paulo, based on the theories of rudolf laban and célestin freinet. the results show the progress in the development of the students: bodily and intellectual autonomy, socialization, cooperation, responsability and advance in learning. this article questions the appropriate dance style in the school environment and points out the scarnecess of trained teachers to develop similar work.
Dan a educativa: um fato em escolas de S o Paulo
Scarpato Marta Thiago
Cadernos CEDES , 2001,
Abstract: A Dan a Educativa, desenvolvida em escolas particulares de S o Paulo, está inserida na Grade Curricular da Educa o Infantil, fundamentada nas idéias convergentes de Rudolf Laban e Célestin Freinet. Os resultados apontam os progressos no desenvolvimento do educando: autonomia corporal e intelectual, socializa o, coopera o, responsabilidade e avan o na aprendizagem. Questiona qual o estilo de dan a mais apropriado na área da educa o e ressalta a necessidade de professores habilitados para desenvolverem trabalhos similares.
Food quality, consumer perception and preferences: an analysis on olive oil
Margherita Maria Pagliuca,Debora Scarpato
Electronic Journal of Applied Statistical Analysis , 2011,
Abstract: With high competition pressure and a saturated market, food quality has become an increasingly important means of competition on the market. Quality concept focuses on customer needs and expectations. A powerful and indispensable tool to understand the intrinsic quality of foods and to translate customer needs into product is sensory analysis. In this study we have chosen to focus the analysis on olive oil, given its importance in the present competitive scenario and also for the renewed and growing interest that this product has in nutrition. The aims of this work were twofold: firstly, to see whether the consumers have an adequate knowledge of the specific qualities of olive oil and also the perceived quality in regard to origin; and secondly, to analyze consumer preferences in order to identify sensory characteristics most important to the acceptability of five olive oils products.
Chromosome aberrations, valued as frequency of spontaneous micronuclei, in subjects with suspected presclerodermic Raynaud’s phenomenon
G. Porciello,R. Scarpato,F. Storino,F. Cagetti
Reumatismo , 2011, DOI: 10.4081/reumatismo.2003.28
Abstract: Objective: To evaluate the prevalence of spontaneous chromosome damage in cultured peripheral lymphocytes of subjects with suspected presclerodermic Raynaud’s phenomenon (RP), by means of molecular cytogenetic analysis. Methods: We studied 20 suspected presclerodermic RP, 20 idiopathic RP and 25 healthy subjects. As marker of chromosome alteration we used the micronucleus assay. All subjects were also classified as ANA-, ACA+ or Scl70+. To identify the mechanism of MN formation, a MN fluorescence in situ hybridisation (FISH) analysis using a pancentromeric DNA probe was also performed. Results: Suspected presclerodermic RP subjects, showed significantly higher MN frequencies than idiopathic RP and controls (39±15.2 vs 10±2.1 and 9.8±3.5 respectively p<0.0001). Interestingly, subjects with idiopathic RP displayed MN frequency comparable to that of controls. Furthermore, ACA+ subjects showed the highest MN frequencies (44±8.1) as compared to subjects with different antibody pattern (26±7.1). Conclusions: Our results show the presence of higher levels of chromosomal damage in circulating lymphocytes of suspected presclerodermic RP. They also would suggest a key role of anti-centromere antibody in determining the observed cytogenetic anomalies. FISH analysis indicated that both aneuploidogenic and clastogenic events contribute to the formation of MN observed in suspected presclerodermic RP.
The high frequency of spontaneous micronuclei observed in lymphocytes of systemic sclerosis patients: preliminary results
G. Porciello,R. Scarpato,F. Storino,F. Cagetti
Reumatismo , 2011, DOI: 10.4081/reumatismo.2002.36
Abstract: Objective: aim of the study is to assess the presence of spontaneous chromosome damage in patients affected by limited (lSSc) or diffuse (dSSc) Systemic Slerosis, using the micronucleus (MN) assay. Methods: we evaluated MN frequency in cultured peripheral lymphocytes of 18 SSc and in a group of 20 healthy controls. Patients were also classified as ACA+, Scl70+, FAN+ according to the presence of the specific anti-nuclear antibodies. We also explored the hypothesis that the extent of cytogenetic alteration might be related to the severity of the pathological condition and/or to the immunological profile. Results: compared to controls, the patient group as a whole showed significantly higher MN frequencies (10.8±4.5 vs. 27.8±13.7, p<0.001). No correlation was found between spontaneous chromosome damage and severity of the disease, being MN frequency 33.1±17.0 and 19.8±2.7 in lSSc and dSSc, respectively. Interestingly, ACA+ subjects displayed the highest MN frequency (36.9±15.0), as compared to patients with different antibody pattern (Scl70+, FAN+; 19.7±8.2). Conclusions: our results confirm the presence of chromosomal damage in circulating lymphocytes of SSc patients and would suggest a key role of antibodies to the centromere in determining the observed cytogenetic anomalies.
Bipolar Disorder: an impossible diagnosis
Faravelli Carlo,Gorini Amedei Silvia,Scarpato Maria Alessandra,Faravelli Luca
Clinical Practice and Epidemiology in Mental Health , 2009, DOI: 10.1186/1745-0179-5-13
Abstract: Following the recent debates on the discrepancy between the predominant weight of bipolar disorder (BPD) in the clinical reality and its relatively low prevalence figures emerging from epidemiological surveys, the present paper contends the ability of current operational diagnostic system to properly detect the clinical entity of bipolar disorder. As an episode of mania/hypomania is the necessary requirement for a diagnosis of bipolar disorder to be made, in this editorial we maintain that: a) the most severe forms of mania, characterized by cloudy consciousness, mood incongruent delusions, and physical symptoms are likely to escape DSM IV criteria, that are shaped around hypomania or mild mania; b) the impossibility to diagnose mania when this occurs during antidepressant treatments impedes diagnosing those cases whose natural illness pattern is Depression followed by Mania (known as DMI pattern); c) given that approximately 50% of cases have their onset of BPD with affective episodes other than mania/hypomania any prevalence figure necessarily underestimates BPD; d) the sub-threshold forms of BPD, well described in the concept of Bipolar Spectrum, are beyond the possibility to be recognized using operational diagnoses in spite of their utmost clinical relevance.
Integer Programming Formulations for Maximum Lifetime Broadcasting Problems in Wireless Sensor Networks  [PDF]
Roberto Montemanni
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.212111
Abstract: Approaches based on integer linear programming have been recently proposed for topology optimization in wireless sensor networks. They are, however, based on over-theoretical, unrealistic models. Our aim is to show that it is possible to accommodate realistic models for energy consumption and communication protocols into integer linear programming. We analyze the maximum lifetime broadcasting topology problem and we present realistic models that are also shown to provide efficient and practical solving tools. We present a strategy to substantially speed up the convergence of the solving process of our algorithm. This strategy introduces a practical drawback, however, in the characteristics of the optimal solutions retrieved. A method to overcome this drawback is discussed. Computational experiments are reported.
Innovation in the Financial Sector: Persistence and Schumpeterian Hypotheses  [PDF]
Roberto Napoli
Journal of Service Science and Management (JSSM) , 2008, DOI: 10.4236/jssm.2008.13023
Abstract: The paper analyses innovation features in the German financial sector. The first topic is persistence of innovation. Our research question is: Do innovators plan further innovation for the subsequent year? In addition, since the sector is so far poorly researched, very basic questions are investigated in the paper: the relationship between firm size and innovation (both linear and quadratic), as well as the impact of market structure on innovation (i.e. Schumpeterian and neo-Schumpeterian hypotheses). Finally, Suttons argument of R &amp;amp;amp;amp; D sunk costs is investigated as a possible explanation for persistence. Basing on the CIS IV survey, our empirical evidence is consistent with the results of similar researches carried out in different sectors.
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