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Search Results: 1 - 10 of 22365 matches for " Roberto Aquilano "
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The asymmetry of time and the cellular world. Is immortality possible?  [PDF]
Roberto O. Aquilano
Journal of Biophysical Chemistry (JBPC) , 2011, DOI: 10.4236/jbpc.2011.21007
Abstract: I analyze the flow of time in this article, both in gross and in microscopic processes, with a well defined arrow of time, but as the amount of energy involved in the microscopic processes is so small, it is more difficult to argue that the entropy increases, and therefore the direction of time becomes confusing and undefined at the molecular level. Therefore, is cell immortality possible?
On the Relativistic Stars  [PDF]
Silvia Morales, Roberto Aquilano
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.34046

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ??Announcement from Editorial Board

The following article has been retracted due to plagiarism. This paper published in Vol.3 No.4, April 2012, has been removed from this site.

Title: On the Relativistic Stars

Author: Silvia Morales, Roberto Aquilano

It has been brought to our attention that this paper appears exactly as it was published in Astroparticle Physics, vol. 32, 2009, 153. (\"On the nature of relativistic stars\" by Silvia Morales, Alejandra Zorzi, Roberto Aquilano)

Consequently, this paper has been retracted by Journal of Modern Physics.

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?JMP Editorial Board

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?April 30, 2015

The Time-Asymmetry and the Entropy Gap
Roberto Aquilano,Mario Castagnino
Physics , 2000, DOI: 10.1142/S021773239600076X
Abstract: The universe time-asymmetry is essentially produced by its low-entropy unstable initial state. Using quanlitative arguments, Paul Davies has demonstrated that the universe expansion may diminish the entropy gap, therefore explaining its low-entropy state, with respect to the maximal possible entropy at any time. This idea is implemented in a qualitative way\thinspace in a simple homogeneous model. Some rough coincidence with observational data are found
Addemdum to: ''The Mathematical Structure of Quantum Superspace as a Consequence of Time Asymmetry''
Roberto Aquilano,Mario Castagnino,Ernesto Eiroa
Physics , 2000, DOI: 10.1103/PhysRevD.59.087301
Abstract: In this paper we improve the results of sec. VI of paper [M. Castagnino, Phys. Rev. D 57, 750 (1998)] by considering that the main source of entropy production are the photospheres of the stars.
Entropy gap and time asymmetry II
Roberto Aquilano,Mario Castagnino,Ernesto Eiroa
Physics , 2000, DOI: 10.1142/S0217732300000876
Abstract: In this letter the paper [R. Aquilano, M. Castagnino, Mod. Phys. Lett A,11, 755 (1996)] is improved by considering that the main source of entropy production are the stars photospheres.
Glutathione: new roles in redox signaling for an old antioxidant
Katia Aquilano,Maria R. Ciriolo
Frontiers in Pharmacology , 2014, DOI: 10.3389/fphar.2014.00196
Abstract: The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
Quantification of Testosterone (t) by 8 Immunoassays and by Liquid Chromatography -Tandem mass Spectrometry (lc -msms) in Normal and Hirsute Women: A Multicenter Study Cuantificación de testosterona (t) por 8 inmunoensayos y por cromatografía líquida en tandem con espectrometría de masa (Lc ms/ms): En mujeres normales e hirsutas. Estudio multicéntrico
HE Scaglia,DR Aquilano,G Buccini,C Chichizola
Revista Argentina de Endocrinología y Metabolismo , 2012,
Abstract: Objective: To compare T results in normal and hirsute women, obtained by different laboratories employing the same or different methods, including an in-home RIA, and the gold standard method LC-MS/MS. In addition, T results were referred to a curve obtained by 6 different pools that had been prepared on the basis of LC-MS/MS results. Design: Prospective study Setting: Hormone Determination Laboratory, Hospital Italiano, La Plata, and private practice of each participant laboratory. Patient(s): Blood samples were obtained from 78 individuals sorted into 3 groups, namely, normal men (n:39), normal women (n:24) and hirsute women (n:15) Interventions(s): None Main Outcome Measure(s): To evaluate if the results obtained in each lab for each serum sample by the methods currently employed in our country are significantly different from those obtained by LC-MS/MS (Gold standard) Result(s) One out of the 24 NW showed high T values by LC - MS/MS. In each lab, except in 1 (Architect) T results of this serum sample were normal. Two out of the 15 hirsute patients showed normal T values (LC - MS/MS). Method and number of labs -shown between brackets- and percentages of normal T results (false negatives) are described for each method as follows: Chemiluminescence: Axsym - Abbott (Axn) - (3) 85, Architect - Abbott - (Arch); (2) 70; Immulite - Siemmens - (IMM); (2) 42; Electrochemiluminescence - Elecsys - Roche- ((EQL); (4) 52; Fluorescent enzymatic - Vidas - Bio-Merieux - (Vidas) (1) 69; Manual coated tube radioimmunoassay (RIA): RIA - Siemmens Coat-a-Count (RIA S); (3) 64; RIA - DSL Inc (RIA DSL); (1) 31; RIA - DIASource - (DiaS); (1) 31; and in-Home RIA (in-H) (1) 12. Statistically significant differences were obtained between different methods and against LC MS/MS. In-H method is the one that comes closest to 1 on the Weighted Deming regression and closest to zero on the SD intercept, (standard deviation of the constant in the straight line equation) indicating that the values match those obtained by LC - MS/MS. The values recorded by the various methods employed showed no significant modifications when plotted against a secondary standard curve. Conclusion(s) This indicates that the techniques in current use in our area underestimate hyperandrogenemia in these patients. Discrepancies are not due to the various calibration curves proposed in the corresponding commercial kits. The fact that the In-H technique affords finer results while employing a larger serum volume suggests that the disparities among the various commercial methods result from their limited sensiti
Respiratory syncytial virus infection in infants and correlation with meteorological factors and air pollutants
Vandini Silvia,Corvaglia Luigi,Alessandroni Rosina,Aquilano Giulia
The Italian Journal of Pediatrics , 2013, DOI: 10.1186/1824-7288-39-1
Abstract: Background Respiratory Syncytial Virus (RSV) is the most important cause of severe respiratory infections in infants with seasonal epidemics. Environmental factors (temperature, humidity, air pollution) could influence RSV epidemics through their effects on virus activity and diffusion. Methods We conducted a retrospective study on a paediatric population who referred to our Paediatric Emergency Unit in order to analyze the correlation between weekly incidence of RSV positive cases during winter season in Bologna and meteorological factors and air pollutants concentration. Results We observed a significant correlation between the incidence of RSV infections and the mean minimum temperature registered during the same week and the previous weeks. The weekly number of RSV positive cases was also correlated to the mean PM10 concentration of the week before. Conclusions RSV epidemic trend in Bologna (Italy) is related to the mean minimum temperature, and the mean PM10 concentration.
Caloric Restriction and the Nutrient-Sensing PGC-1 in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration
Daniele Lettieri Barbato,Sara Baldelli,Beatrice Pagliei,Katia Aquilano,Maria Rosa Ciriolo
International Journal of Cell Biology , 2012, DOI: 10.1155/2012/759583
Abstract: Mitochondrial activity progressively declines during ageing and in many neurodegenerative diseases. Caloric restriction (CR) has been suggested as a dietary intervention that is able to postpone the detrimental aspects of aging as it ameliorates mitochondrial performance. This effect is partially due to increased mitochondrial biogenesis. The nutrient-sensing PGC-1 is a transcriptional coactivator that promotes the expression of mitochondrial genes and is induced by CR. It is believed that many of the mitochondrial and metabolic benefits of CR are due to increased PGC-1 activity. The increase of PGC-1 is also positively linked to neuroprotection and its decrement has been involved in the pathogenesis of many neurodegenerative diseases. This paper aims to summarize the current knowledge about the role of PGC-1 in neuronal homeostasis and the beneficial effects of CR on mitochondrial biogenesis and function. We also discuss how PGC-1 -governed pathways could be used as target for nutritional intervention to prevent neurodegeneration. 1. Introduction Mitochondria are dynamic organelles fundamental for cell life. The central roles of mitochondria in metabolism place them at the center stage of global energy modulation. Indeed, these organelles are best known for producing ATP via oxidative phosphorylation (OXPHOS). In the matrix, tricarboxylic acid cycle (TCA) generates reduced carriers (NADH and FADH2), which donate electrons to the inner membrane-localized electron transport chain (ETC). In this way electrons derived from metabolites flow through the ETC generating intermembrane proton gradient (mitochondrial membrane potential), which fundamental for the activity of rotary turbine-like ATP synthase producing ATP from ADP [1]. Mitochondria contain a circular genome, mitochondrial DNA (mtDNA), which has been reduced during evolution through gene transfer to the nucleus. Even if mitochondria are characterized by an own genome encoding for 13 subunits of ETC, they strongly necessitate of many other nuclear encoded proteins (about 1000–1500) for the execution of their function [2]. Therefore, it is clear that mitochondria are not autonomous entities but strongly dependent on nuclear genome. Indeed, mitochondrial homeostasis is assured by a well-functioning bidirectional network of mitochondrial-nuclear communications (MN-C). MN-C control many cell activities including mitochondrial biogenesis, an intricate biological process consisting in the growth and division of preexisting mitochondria that requires the replication of the mtDNA and the synthesis and
Integer Programming Formulations for Maximum Lifetime Broadcasting Problems in Wireless Sensor Networks  [PDF]
Roberto Montemanni
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.212111
Abstract: Approaches based on integer linear programming have been recently proposed for topology optimization in wireless sensor networks. They are, however, based on over-theoretical, unrealistic models. Our aim is to show that it is possible to accommodate realistic models for energy consumption and communication protocols into integer linear programming. We analyze the maximum lifetime broadcasting topology problem and we present realistic models that are also shown to provide efficient and practical solving tools. We present a strategy to substantially speed up the convergence of the solving process of our algorithm. This strategy introduces a practical drawback, however, in the characteristics of the optimal solutions retrieved. A method to overcome this drawback is discussed. Computational experiments are reported.
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