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Search Results: 1 - 10 of 3027 matches for " Roberta Zappacosta "
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Leishmania life cycle images in the cutaneous cytologic smear of an immunocompetent patient
Zappacosta Roberta,Claudi Roberta,Magnasco Salvatore,Dell′Osa Emma
Journal of Cytology , 2010,
Abstract: Cutaneous leishmania life cycle images on cytology smears are very rare. We report herein a gallery of cytologic images from a case of sporadic cutaneous leishmaniasis in a 61 year old man presenting with ulcerative skin lesion.
Stenotrophomonas maltophilia Virulence and Specific Variations in Trace Elements during Acute Lung Infection: Implications in Cystic Fibrosis
Arianna Pompilio, Domenico Ciavardelli, Valentina Crocetta, Ada Consalvo, Roberta Zappacosta, Carmine Di Ilio, Giovanni Di Bonaventura
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088769
Abstract: Metal ions are necessary for the proper functioning of the immune system, and, therefore, they might have a significant influence on the interaction between bacteria and host. Ionic dyshomeostasis has been recently observed also in cystic fibrosis (CF) patients, whose respiratory tract is frequently colonized by Stenotrophomonas maltophilia. For the first time, here we used an inductively mass spectrometry method to perform a spatial and temporal analysis of the pattern of changes in a broad range of major trace elements in response to pulmonary infection by S. maltophilia. To this, DBA/2 mouse lungs were comparatively infected by a CF strain and by an environmental one. Our results showed that pulmonary ionomic profile was significantly affected during infection. Infected mice showed increased lung levels of Mg, P, S, K, Zn, Se, and Rb. To the contrary, Mn, Fe, Co, and Cu levels resulted significantly decreased. Changes of element concentrations were correlated with pulmonary bacterial load and markers of inflammation, and occurred mostly on day 3 post-exposure, when severity of infection culminated. Interestingly, CF strain – significantly more virulent than the environmental one in our murine model - provoked a more significant impact in perturbing pulmonary metal homeostasis. Particularly, exposure to CF strain exclusively increased P and K levels, while decreased Fe and Mn ones. Overall, our data clearly indicate that S. maltophilia modulates pulmonary metal balance in a concerted and virulence-dependent manner highlighting the potential role of the element dyshomeostasis during the progression of S. maltophilia infection, probably exacerbating the harmful effects of the loss of CF transmembrane conductance regulator function. Further investigations are required to understand the biological significance of these alterations and to confirm they are specifically caused by S. maltophilia.
Prognostic Value of HPV E6/E7 mRNA Assay in Women with Negative Colposcopy or CIN1 Histology Result: A Follow-Up Study
Paolo Giorgi Rossi, Maria Benevolo, Amina Vocaturo, Donatella Caraceni, Lucia Ciccocioppo, Antonio Frega, Irene Terrenato, Roberta Zappacosta, Deborah French, Sandra Rosini
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057600
Abstract: Pap test, and especially HPV DNA test, identify a large group of women who do not have any clinically relevant lesions, i.e., CIN2+ (Cervical Intraepithelial Neoplasia grade 2 or worse), but who are at greater risk of getting lesions in the future. The follow up of these women needs new biomarkers with prognostic value. The objective of this study is to evaluate the prognostic value of E6/E7 mRNA over-expression assay (PreTect HPV-Proofer, Norchip) for 5 HR-HPV types (16, 18, 31, 33, and 45) for progression to CIN2+ after a negative colposcopy. This prospective study, conducted at four Italian centres, enrolled 673 women with either a negative colposcopy or a negative or CIN1 histology. The clinical end-point was histological confirmation of CIN2+. Women were classified at baseline according to mRNA results and managed according to local colposcopy protocols. At least one conclusive follow-up test was obtained for 347 women (25 months average lapse since recruitment, range 5–74). Only seven CIN2+ were detected during follow up, three among the 82 women positive for mRNA at baseline, two among the 250 negative (Fisher exact test, p = 0.02), and two among the 12 with an invalid test. Absolute CIN2+ risk was 6.7/1,000 person/years in the whole cohort. The absolute CIN2+ risk was 18.4/1,000 person/years and 3.6/1,000 person/years in mRNA-positive and mRNA-negative women, respectively. In conclusion, E6/E7 mRNA over-expression appears to be a good candidate as a prognostic biomarker to manage HR-HPV DNA-positive women with negative colposcopy or histology, particularly in order to decrease follow-up intensity in those who are negative.
Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
Bruno Zappacosta,Pierpaolo Mastroiacovo,Silvia Persichilli,George Pounis,Stefania Ruggeri,Angelo Minucci,Emilia Carnovale,Generoso Andria,Roberta Ricci,Iris Scala,Orazio Genovese,Aida Turrini,Lorenza Mistura,Bruno Giardina,Licia Iacoviello
Nutrients , 2013, DOI: 10.3390/nu5051531
Abstract: To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with “moderate” hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/Methods: We performed a 13 week open, randomized, double blind clinical trial on 149 free living persons with mild hyperhomocyteinemia, with daily 200 μg from a natural folate-rich diet, 200 μg [6 S]5-methyltetrahydrofolate (5-MTHF), 200 μg folic acid or placebo. Participants were stratified according to their MTHFR genotype. Results: Homocysteine (Hcy) levels were reduced after folate enriched diet, 5-MTHF or folic acid supplementation respectively by 20.1% ( p < 0.002), 19.4% ( p < 0.001) and 21.9% ( p < 0.001), as compared to baseline levels and significantly as compared to placebo ( p < 0.001, p < 0.002 and p < 0.001, respectively for enriched diet, 5-MTHF and folic acid). After this enriched diet and the folic acid supplementation, Hcy in both genotype groups decreased approximately to the same level, with higher percentage decreases observed for the TT group because of their higher pre-treatment value. Similar results were not seen by genotype for 5-MTHF. A significant increase in RBC folate concentration was observed after folic acid and natural folate-rich food supplementations, as compared to placebo. Conclusions: Supplementation with natural folate-rich foods, folic acid and 5-MTHF reached a similar reduction in Hcy concentrations.
Somatomedin C (IGF-1), Dehydroepiandrosterone Sulphate (DHEA-S) and Hcy Metabolism in Postmenopausal African Women
Cecilia Zuppi,Jacques Simpore,Bruno Zappacosta,Cinzia Carrozza
Journal of Medical Sciences , 2006,
Abstract: Biological aging implies a progressive decrease of endocrine and metabolic resources, which correspond to a reduction of working activity and caloric intake. The aim of this study was to measure DHEA-S and IGF-1 and products of methionine metabolism in 76 postmenopausal African women (50 to 100 years of age) compared to 22 adult African fertile women (30 to 45 years of age). Determination of plasma DHEA-S in elderly women gave a markedly low mean concentration and the same was observed for plasma IGF-1 (450.1±263.2 and 64.2±38.1 ng mL-1, respectively). The correlation between DHEA-S and IGF-1 was significantly positive only in 71-100 years women (r = 0.44, p<0.05). There was a significant decrease of plasma glutathione in all elderly women (3.5±0.4 μMol L-1), while the plasma homocysteine (Hcy) was markedly elevated (18.7±0.5 μMol L-1), whilst that of folic acid, Vit B12 and Vit B 6 levels were found in the normal range. A significant positive correlation between DHEA-S and plasma glutathione levels (r = 0.56, p<0.025) was found only in the 50-60 old years women group, while the correlation between IGF-1 and plasma glutathione was negative but not significant (r = -0.36, p = NS) in the same age group. In this study a low level of IGF-1 and DHEA-S in old humans is firstly considered as consequence of hypo-caloric alimentation, moderate physical activity and absence of psychophysics stress. Moreover a positive correlation between IGF-1 and DHEA-S in oldest age populations, ranging from 71 to 100 years, suggests that endocrine and metabolic systems must be maintained in a lower equilibrium to compensate the physiological reduction of the oxidant/antioxidant balance (low level of plasma glutathione).
An X-ray WHIM metal absorber from a Mpc-scale empty region of space
Luca Zappacosta,Fabrizio Nicastro,Yair Krongold,Roberto Maiolino
Physics , 2012, DOI: 10.1088/0004-637X/753/2/137
Abstract: We report a detection of an absorption line at ~44.8 {\AA} in a > 500 ks Chandra HRC-S/LETG X-ray grating spectrum of the blazar H 2356-309. This line can be identified as intervening CV-K{\alpha} absorption, at z\approx0.112, produced by a warm (log T = 5.1 K) intergalactic absorber. The feature is significant at a 2.9{\sigma} level (accounting for the number of independent redshift trials). We estimate an equivalent hydrogen column density of log N_H=19.05 (Z/Zsun)^-1 cm^-2. Unlike other previously reported FUV/X-ray metal detections of warm-hot intergalactic medium (WHIM), this CV absorber lies in a region with locally low galaxy density, at ~2.2 Mpc from the closest galaxy at that redshift, and therefore is unlikely to be associated with an extended galactic halo. We instead tentatively identify this absorber with an intervening Warm-Hot Intergalactic Medium filament possibly permeating a large-scale, 30 Mpc extended, structure of galaxies whose redshift centroid, within a cylinder of 7.5 Mpc radius centered on the line of sight to H 2356-309, is marginally consistent (at a 1.8{\sigma} level) with the redshift of the absorber.
Group Dynamics in On-Line and Face-to-Face Interactions: An Experimental Study on Learning Methods  [PDF]
Sergio Severino, Roberta Messina
Sociology Mind (SM) , 2011, DOI: 10.4236/sm.2011.12008
Abstract: Organizing in groups does not represent an objective definition, but rather a way to better understand the mean-ing of plurality. At the same time modern technologies modify perceptive and cognitive transformation. This re-search shows that on-line groups develop objective dynamics in face-to-face groups; it evaluates the quality of the University student services and studies the dynamics of the creation of face-to-face and on-line groups. Stu-dents were divided into experimental on-line (forum, chat, newsgroup) and face-to-face encounters (seminars, laboratories). The two level analyses show the defence mechanisms, the lack of socialization attitudes and the tolerance of differences that characterized on-line groups. The new technologies open new horizons and cogni-tive functions.
Hemispheric Asymmetry for Language Processing and Lateral Preference in Simultaneous Interpreters  [PDF]
Alice Mado Proverbio, Roberta Adorni
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.21002
Abstract: Neuroimaging studies showed that linguistic functions are less lateralized in polyglots than in monolinguals. However, there is not much agreement about the role of the two hemispheres in semantic and syntactic processing in bilinguals. In this study, 35 right-handed Italian speakers were shown 520 words and pseudo-words. The task consisted in detecting a given target letter by pressing a button with either the left or right hand. 19 simultaneous interpreters and 16 monolingual University students participated in the study. Interpreters performed the task in their native (L1) and second language (L2 = English); monolingual students only in L1. Response times to targets were recorded as a function of the hand used. RTs were faster to words than pseudo-words (word superiority effect). Results showed a significant right hand/LH advantage for the student group, and a complete lack of asymmetry for the interpreters both in L1 and L2. These data indicate a left-lateralization of linguistic functions in monolinguals and reduced lateralization in polyglots. The lack of lateralization in interpreters can be attributed either to their polyglottism, or to their prolonged practice of simultaneous interpreting strategies (e.g., dealing with two input channels; right ear/LH for listening to themselves interpret and left ear/RH for listening to the source language).
X-Ray Absorption By WHIM in the Sculptor Wall
David A. Buote,Luca Zappacosta,Taotao Fang,Philip J. Humphrey,Fabio Gastaldello,Gianpiero Tagliaferri
Physics , 2009, DOI: 10.1088/0004-637X/695/2/1351
Abstract: We present XMM RGS and Chandra LETG observations of the blazar, H 2356-309, located behind the Sculptor Wall, a large-scale galaxy structure expected to harbor high-density Warm-Hot Intergalactic Medium (WHIM). Our simultaneous analysis of the RGS and LETG spectra yields a 3-sigma detection of the crucial redshifted O vii K-alpha line with a column density (>~ 10^{16} cm^{-2}) consistent with similar large-scale structures produced in cosmological simulations. This represents the first detection of non-local WHIM from X-ray absorption studies where XMM and Chandra data are analyzed simultaneously and the absorber redshift is already known, thus providing robust evidence for the expected repository of the "missing baryons".
Effect of extracts from araticum (Annona crassiflora) on CCl4-induced liver damage in rats
Roesler, Roberta;
Ciência e Tecnologia de Alimentos , 2011, DOI: 10.1590/S0101-20612011000100012
Abstract: the influence of ethanolic extracts of annona crassiflora on the activities of hepatic antioxidant enzymes was examined. extracts of a. crassiflora seeds and peel were administered orally (50 mg of galic acid equivalents.kg-1) to wistar rats for 14 consecutive days followed by a single oral dose of carbon tetrachloride (ccl4, 2 g.kg-1). lipid peroxidation and the activities of hepatic catalase (cat), cytochromes p450 (cp450) and b5, glutathione peroxidase (gpx), glutathione reductase (gred), superoxide dismutase (sod), and the content of glutathione equivalents (gsh) were evaluated. the treatment with ccl4 increased lipid peroxidation, the level of gsh equivalents and the content of cytochrome b5 by 44, 140 and 32%, respectively, with concomitant reductions of 23, 34 and 39% in the activities of cat, sod, and cp450, respectively. the treatment with a. crassiflora seeds and peel extracts alone inhibited lipid peroxidation by 27 and 22%, respectively without affecting the cp450 content. the pretreatment with the a. crassiflora extracts prevented the lipid peroxidation, the increase in gsh equivalents and the decrease in cat activity caused by ccl4, but it had no effect on the ccl4-mediated changes in cp450 and b5 and sod. these results show that a. crassiflora seeds and peel contain antioxidant activity in vivo that could be of potential therapeutic use.
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