oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 7 )

2018 ( 74 )

2017 ( 63 )

2016 ( 93 )

Custom range...

Search Results: 1 - 10 of 27388 matches for " Robert Squares "
All listed articles are free for downloading (OA Articles)
Page 1 /27388
Display every page Item
The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants
Lisa C Crossman, Virginia C Gould, J Maxwell Dow, Georgios S Vernikos, Aki Okazaki, Mohammed Sebaihia, David Saunders, Claire Arrowsmith, Tim Carver, Nicholas Peters, Ellen Adlem, Arnaud Kerhornou, Angela Lord, Lee Murphy, Katharine Seeger, Robert Squares, Simon Rutter, Michael A Quail, Mari-Adele Rajandream, David Harris, Carol Churcher, Stephen D Bentley, Julian Parkhill, Nicholas R Thomson, Matthew B Avison
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-4-r74
Abstract: The genome of the bacteremia-associated isolate S. maltophilia K279a is 4,851,126 bp and of high G+C content. The sequence reveals an organism with a remarkable capacity for drug and heavy metal resistance. In addition to a number of genes conferring resistance to antimicrobial drugs of different classes via alternative mechanisms, nine resistance-nodulation-division (RND)-type putative antimicrobial efflux systems are present. Functional genomic analysis confirms a role in drug resistance for several of the novel RND efflux pumps. S. maltophilia possesses potentially mobile regions of DNA and encodes a number of pili and fimbriae likely to be involved in adhesion and biofilm formation that may also contribute to increased antimicrobial drug resistance.The panoply of antimicrobial drug resistance genes and mobile genetic elements found suggests that the organism can act as a reservoir of antimicrobial drug resistance determinants in a clinical environment, which is an issue of considerable concern.The rise of antimicrobial drug resistance in bacteria is one of the biggest threats to healthcare provision in the developed world. Few new antimicrobial drugs are undergoing clinical trials, and almost none are effective against Gram-negative multi-drug resistant (MDR) pathogens [1]. A return to the pre-antibiotic era is a possibility, and for some infections is the current reality [2].Antimicrobial resistance in historically common pathogens is usually either acquired on a mobile genetic element or results from a mutation [3]. However, some opportunistic pathogens are intrinsically resistant to the actions of a number of antimicrobial classes. These tend to be of environmental origin, and their intrinsic drug resistance determinants either provide resistance to antibiotics produced by competitors, or represent broad-spectrum methods for removing toxic compounds or waste products that, by chance, protect against antimicrobials [3,4]. It is known that established opportuni
Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens
Mark W Silby, Ana M Cerde?o-Tárraga, Georgios S Vernikos, Stephen R Giddens, Robert W Jackson, Gail M Preston, Xue-Xian Zhang, Christina D Moon, Stefanie M Gehrig, Scott AC Godfrey, Christopher G Knight, Jacob G Malone, Zena Robinson, Andrew J Spiers, Simon Harris, Gregory L Challis, Alice M Yaxley, David Harris, Kathy Seeger, Lee Murphy, Simon Rutter, Rob Squares, Michael A Quail, Elizabeth Saunders, Konstantinos Mavromatis, Thomas S Brettin, Stephen D Bentley, Joanne Hothersall, Elton Stephens, Christopher M Thomas, Julian Parkhill, Stuart B Levy, Paul B Rainey, Nicholas R Thomson
Genome Biology , 2009, DOI: 10.1186/gb-2009-10-5-r51
Abstract: Comparisons of three P. fluorescens genomes (SBW25, Pf0-1, Pf-5) revealed considerable divergence: 61% of genes are shared, the majority located near the replication origin. Phylogenetic and average amino acid identity analyses showed a low overall relationship. A functional screen of SBW25 defined 125 plant-induced genes including a range of functions specific to the plant environment. Orthologues of 83 of these exist in Pf0-1 and Pf-5, with 73 shared by both strains. The P. fluorescens genomes carry numerous complex repetitive DNA sequences, some resembling Miniature Inverted-repeat Transposable Elements (MITEs). In SBW25, repeat density and distribution revealed 'repeat deserts' lacking repeats, covering approximately 40% of the genome.P. fluorescens genomes are highly diverse. Strain-specific regions around the replication terminus suggest genome compartmentalization. The genomic heterogeneity among the three strains is reminiscent of a species complex rather than a single species. That 42% of plant-inducible genes were not shared by all strains reinforces this conclusion and shows that ecological success requires specialized and core functions. The diversity also indicates the significant size of genetic information within the Pseudomonas pan genome.Pseudomonas fluorescens is a physiologically diverse species of opportunistic bacteria (gamma-proteobacteria) found throughout terrestrial habitats. The species contributes greatly to the turnover of organic matter and, while present in soil, is abundant on the surfaces of plant roots and leaves. Of the plant-colonizing strains, some, such as isolates SBW25 and Pf-5, positively affect plant health and nutrition [1-3]. The mechanistic bases of these effects remain unclear, but are known to include the production of plant growth hormones, the suppression of pathogens (especially fungi and oomycetes) detrimental to plant health via competitive and/or allelopathic effects, and the direct elicitation of plant defense res
Introduction to a Requirements Engineering Framework for Aeronautics  [PDF]
Robert Abo
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.39105
Abstract: This paper introduces a framework to produce and to manage quality requirements of embedded aeronautical systems, called the ‘Requirements Engineering Framework’ (REF). It aims at making the management of the requirement lifecycle easier, from the specification of the purchaser’s needs, to their implementation in the final products, and also their verification, while controlling costs. REF is based on the main standards of aeronautics, in particular RTCA DO-254, and RTCA DO-178B standards. An implementation of REF, using the IBM Rational DOORS and IBM Rational Change tools, is also presented in this paper.
Pricing Options in Jump Diffusion Models Using Mellin Transforms  [PDF]
Robert Frontczak
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.33037
Abstract:

This paper is concerned with the valuation of options in jump diffusion models. The partial integro-differential equation (PIDE) inherent in the pricing problem is solved by using the Mellin integral transform. The solution is a single integral expression independent of the distribution of the jump size. We also derive analytical expressions for the Greeks. The results are implemented and compared to other approaches.

Australia’s Out-Dated Concern over Fishing Threatens Wise Marine Conservation and Ecologically Sustainable Seafood Supply  [PDF]
Robert Kearney
Open Journal of Marine Science (OJMS) , 2013, DOI: 10.4236/ojms.2013.32006
Abstract:

Seafood plays an important role in human nutrition and its increased consumption is actively recommended for sustenance and health benefits in both developing and developed countries. In parallel to this, the public receives confusing advice as to what seafood is sustainably produced and is frequently misled about the environmental impacts of fishing, especially in locations such as Australia where contemporary fishery management has a conservation and sustainability focus. It is recognised globally that Australia’s traditional fishery management driven by strict sustainability and biodiversity regulations, has achieved impressive results in managing both fish stocks and the effects of fishing on marine environments. Despite this, continued pressure from non-government organisations (NGOs) and a perpetuation of the misuse of management terms such as overfished is used to promote the misguided need for ever increasing fishing restrictions, most obviously in protected areas. This paper questions the motives of some NGOs and governments in Australia in pursuing additional restrictions on fishing which are mostly unnecessary and disproportionate to the sustainability requirements of other sources of food. This is done within the context of the global need for sustainable seafood supply and the need for effective marine conservation that addresses all threats to marine ecosystems in proportion to the magnitude of each threat.

Wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients—A perspective review  [PDF]
Robert LeMoyne
Advances in Parkinson's Disease (APD) , 2013, DOI: 10.4236/apd.2013.24021
Abstract: Parkinson’s disease is a growing medical concern as societies, such as the United States of America, become progressively aged. Therapy strategies exist for the amelioration of Parkinson’s disease symptoms, and the quantification of attributes, such as hand tremor, can provide valuable feedback. Wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients have been progressively advanced over the course of the past half-decade. In particular, wireless accelerometer nodes and smartphones, such as the iPhone, hold promise for optimizing therapy strategy by providing convenient quantified feedback. This perspective review addresses the current advances in wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients and forecasts for the near future.
A Study of Lateralized Cognitive Processes in Upper-Division Electrical Engineering Students’: Correlating Written Language Functions with Analytical Reasoning in Microelectronics  [PDF]
Robert Melendy
World Journal of Engineering and Technology (WJET) , 2014, DOI: 10.4236/wjet.2014.22008
Abstract: The human brain is asymmetrical in function, with each of its two hemispheres being somewhat responsible for distinct cognitive and motor tasks, to include writing. It stands to reason that engineering students who have established entrance into their upper-division programs will have demonstrated cognitive proficiency in math and logical operations, abstract and analytical reasoning and language usage, to include writing. In this study the question was asked: is there a correlation between an upper-division electrical engineering students’ analytical reasoning ability and their descriptive writing ability? Descriptive writing is taken here to mean a students’ ability to identify key physical aspects of a mathematical model and to express—in words—a concise and well-balanced description that demonstrates a deep conceptual understanding of the model. This includes more than a description of the variables or the particular application to an engineering problem; it includes a demonstrated recognition of the basic physics that govern the model, certain limitations (idealizations) inherent in the model, and an understanding of how to make practical experimental measurements to verify the governing physics in the model. A student at this level may demonstrate proficiency in their analytical reasoning skills and hence be capable of correctly solving a given problem. However, this does not guarantee that the same student is skilled in associating equations with their physical meaning on a deep conceptual level or in understanding physical limitations of the equation. Consequently, such a student may demonstrate difficulty in mapping their comprehension of the model into written language that demonstrates a sound conceptual understanding of the governing physics. The findings represent a sample of two independent class sections of Electrical and Computer Engineering junior’s first course in Microe-lectronic Devices and Circuits during fall semesters 2012 and 2013 at a private mid-size university in NW Oregon. A total of three exams were administered to each of the 2012/2013 groups. Correlations between exam scores that students achieved on their descriptive writing of microelectronics phenomena and their analytical problem-solving abilities were examined and found to be quite significant.
Foilized pouches can prevent the transmission of HIV from mother to child using multi-drug therapies  [PDF]
Robert Malkin
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.71007
Abstract: Children can become HIV positive (HIV+) from their mother during home birth. If the infant ingests antiretroviral (ARV), medications immediately after birth, the risk of transmission can be dramatically reduced. We have previously proposed the use of foilized, polyethylene-lined pouches to store ARV’s. Using the pouch, the mother receives the medication at an antenatal care visit, months before delivery, and if she delivers at home, tears open the pouch and drips the medication into her child’s mouth. In this work, we extend the use of the pouch to store a modern ARV, Lamivudine (3TC), often used in multi-drug regimens. Under laboratory conditions, pouches were filled with 3TC and stored at 25?C/60% relative humidity (RH) for twelve months. We found that the 3TC was stable throughout the year (maximum 5.6% of labeled concentration change). The preservatives were somewhat degraded by the act of repackaging the medicine, but sufficient preservatives remained to maintain the medication. The same impurities were identified in the 3TC stored in the pouches and the samples removed from the bottles indicating that the pouches do not introduce new impurities (impurities that are not already introduced by the bottle). We conclude that the pouch can preserve this modern ARV for up to twelve months.
Valuation of Mineral Resources in Selected Financial and Accounting Systems  [PDF]
Robert Uberman
Natural Resources (NR) , 2014, DOI: 10.4236/nr.2014.59045
Abstract:
The paper presents reviews of fundamental issues regarding valuation methodologies of mineral deposits: 1) recommended by mineral industry standards; 2) used for disclosures in financial statements and 3) adopted in national statistics. A discussion of historical developments of various regulations is supplemented by characteristics of key valuation methods. Differences and similarities are analysed and compared to current practices. A special attention is given to certain distinctive issues which are not shared by most of other types of assets like inclusion of decommissioning and rehabilitation costs or consequences of long duration of investment phase.
Hernia Societies—A Blessing or a Curse? Who Is Running Them? Ethical Surgeons or the Industry  [PDF]
Robert Bendavid
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.513103
Abstract:

The intended purpose of hernia societies is being lost. Originally, they were meant to be a venue for the dissemination of basic science, knowledge and sharing of acquired research, experiences by surgeons with the ultimate aim of improving a patient’s lot. Instead, they have become venues and brokerage houses where the plastics industry may advertise and sell products which have barely been tested or about which the truth was never entirely revealed. An FDA approval, sadly, is not assurance that all is well. We are discovering these facts through the courts and the lay press. We, as surgeons, are not told the whole truth to impart to patients who expect nothing less! Have any of us been complicit, knowingly or not?

 

Page 1 /27388
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.