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Search Results: 1 - 10 of 328259 matches for " Riyaz S Patel "
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MicroRNA Expression Profile in CAD Patients and the Impact of ACEI/ARB
Martina Weber,Meredith B. Baker,Riyaz S. Patel,Arshed A. Quyyumi,Gang Bao,Charles D. Searles
Cardiology Research and Practice , 2011, DOI: 10.4061/2011/532915
Abstract: Coronary artery disease (CAD) is the largest killer of males and females in the United States. There is a need to develop innovative diagnostic markers for this disease. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in important cellular processes, and we hypothesized that the miRNA expression profile would be altered in whole blood samples of patients with CAD. We performed a microarray analysis on RNA from the blood of 5 male subjects with CAD and 5 healthy subjects (mean age 53 years). Subsequently, we performed qRT-PCR analysis of miRNA expression in whole blood of another 10 patients with CAD and 15 healthy subjects. We identified 11 miRNAs that were significantly downregulated in CAD subjects (<.05). Furthermore, we found an association between ACEI/ARB use and downregulation of several miRNAs that was independent of the presence of significant CAD. In conclusion, we have identified a distinct miRNA signature in whole blood that discriminates CAD patients from healthy subjects. Importantly, medication use may significantly alter miRNA expression. These findings may have significant implications for identifying and managing individuals that either have CAD or are at risk of developing the disease.
Progeria
Mohamed Riyaz S,Jayachandran S
Indian Journal of Dental Research , 2009,
Abstract: Hutchinson Gilford Progeria Syndrome (HGPS) is a rare, sporadic, autosomal dominant syndrome that involves premature ageing and death at early age due to myocardial infarction or stroke. A 30-year-old male with clinical and radiologic features highly suggestive of HGPS is presented here with description of differential diagnosis, dental considerations and review of literature.
Regional Disparities, Inclusive Growth and Educational Development in Karnataka
G. S. Premakumara,Riyaz Ahmad
Trends in Information Management , 2010,
Abstract: Inclusive growth policy is an attempt to bring the backward sectors, classes, castes, tribes, women, and marginal people into main stream economy. It is necessary to understand the problem of exclusion to have better inclusive policy. The paper is an effort to analyze the regional disparities in educational development of Karnataka as a back drop to inclusive growth policy. It is revealed that out of four regions selected for study Gulbarga is the backward region in field of education. In comparison to other regions, the literacy rate is quite low and drop-out rate is quite high. However, educational programmes introduced by the government have increased the enrollments in the region but students are not able to complete their education fully with high drop-out rate.
Focal dermal hypoplasia (Goltz syndrome)
Riyaz Najeeba,Riyaz A,Chandran Rajesh,Rakesh S
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: A 7-year-old girl born of non-consanguineous marriage was evaluated for facial dysmorphism. She had multiple skeletal anomalies like hypoplasia of the right mandible, narrow nasal bridge with broad tip and unilateral notching of the right ala nasi, concomitant squint and low set ears. She also had generalized hypopigmented, atrophic linear macules, multiple papillomas, fat herniations, umbilical hernia, hypoplastic nails, cicatricial alopecia, mild mental retardation, ′lobster-claw′ hand and osteopathia striata of long bones, pointing to a diagnosis of Goltz syndrome. The unusual features noted were absence of the left first rib and aortic regurgitation.
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
Thomas M Morgan, John A House, Sharon Cresci, Philip Jones, Hooman Allayee, Stanley L Hazen, Yesha Patel, Riyaz S Patel, Danny J Eapen, Salina P Waddy, Arshed A Quyyumi, Marcus E Kleber, Winfried M?rz, Bernhard R Winkelmann, Bernhard O Boehm, Harlan M Krumholz, John A Spertus
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-127
Abstract: We examined 95 polymorphisms in 69 distinct gene regions identified in a GWAS for premature myocardial infarction for their association with post-ACS mortality among 811 whites recruited from university-affiliated hospitals in Kansas City, Missouri. We then sought replication of a positive genetic association in a large, racially diverse cohort of myocardial infarction patients (N = 2284) using Kaplan-Meier survival analyses and Cox regression to adjust for relevant covariates. Finally, we investigated the apparent association further in 6086 additional coronary artery disease patients.After Cox adjustment for other ACS risk factors, of 95 SNPs tested in 811 whites only the association with the rs6922269 in MTHFD1L was statistically significant, with a 2.6-fold mortality hazard (P = 0.007). The recessive A/A genotype was of borderline significance in an age- and race-adjusted analysis of the entire combined cohort (N = 3095; P = 0.052), but this finding was not confirmed in independent cohorts (N = 6086).We found no support for the hypothesis that the GWAS-identified variants in this study substantially alter the probability of post-ACS survival. Large-scale, collaborative, genome-wide studies may be required in order to detect genetic variants that are robustly associated with survival in patients with coronary artery disease.Genome-wide association studies (GWAS) have identified robust genetic associations in a variety of common diseases [1], including myocardial infarction (MI) [2-6]. The GWAS approach, with its emphasis on large sample sizes and inclusion of hundreds of thousands of genetic markers, has produced a degree of reproducibility that was generally lacking in earlier candidate gene studies of MI [7]. However, nine GWAS-identified genetic susceptibility markers, all meeting criteria for genome-wide statistical significance, collectively account for only 3% of the estimated heritability of early-onset myocardial infarction (MI), raising questions about t
Down Regulation of a Matrix Degrading Cysteine Protease Cathepsin L, by Acetaldehyde: Role of C/EBPα
Riyaz A. Mir,Shyam S. Chauhan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020768
Abstract: The imbalance between extra cellular matrix (ECM) synthesis and degradation is critical aspect of various hepatic pathologies including alcohol induced liver fibrosis. This study was carried out to investigate the effect of acetaldehyde on expression of an extra cellular matrix degrading protease cathepsin L (CTSL) in HepG2 cells.
ADAPTIVE CONTROL FOR TWO COLLABORATIVE ROBOTS HANDLING AN OBJECT WITHOUT VELOCITY FEEDBACK
Dr. E. Balasubramanian,Mr. S. Riyaz Ahammed
International Journal of Engineering Science and Technology , 2011,
Abstract: The kinematic and dynamic equations of manipulators as well as rigid object are presented. The system dynamics is obtained by combining the dynamics of manipulators and the object. In order to avoid the problems encountered due to the measurement of velocity signal, an adaptive control without velocity feedback is employed. This will help us to avoid the need for velocity sensors and ultimately reduces the cost. Stability analysis and corresponding simulations are carried out to show the performance of the controller.
Rosai-dorfman syndrome
Riyaz Najeeba,Khader Anza,Sarita S
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: Rosai-Dorfman syndrome is characterized by sinus histiocytosis with massive lymphadenopathy. A 25-year-old woman presented with multiple erythematous and yellowish papules on the forehead, cheeks, chin and thigh. She had massive generalized, firm, non-tender and non-matted lymphadenopathy and mild hepatomegaly. Her hemogram was normal. A skin biopsy showed collections of histiocytes with emperipolesis and plenty of plasma cells. A lymph node biopsy showed partial loss of architecture, dilated sinuses filled with histiocytes, which showed lymphocytophagocytosis, anisonucleosis and a clear cytoplasm. She was referred to an oncologist for further management.
Investigation of Asphaltene Deposition and Precipitation in Production Tubing  [PDF]
Abdolvahab Rastgoo, Riyaz Kharrat
International Journal of Clean Coal and Energy (IJCCE) , 2017, DOI: 10.4236/ijcce.2017.61002
Abstract: Asphaltenes are complex molecular entities, which together with resins, aromatic hydrocarbons and saturates forms the crude oil. Asphaltenes and resins are in the thermodynamic equilibrium at static reservoir condition. However, asphaltene can precipitate due to changes in thermodynamic condition. Asphaltene deposition in production tubings has been an outstanding problem with wide economic impact on the oil industry. Meanwhile, the use of real-time tools to monitor depositions along the well is of great difficulty. In this work, the asphaltene precipitation region in a single phase flow wellbore is predicted for an oil well of the Iranian oil field. Then, asphaltene deposition thickness along the well is predicted for three time intervals. The simulation results indicated that asphaltene thickness exceeded more than 50% of tubing radius; therefore, a reduction in flow rate, an increase in pressure drop and tubing blockage are expected. Moreover, it is shown the deposits thickness along the wellbore has approximately a skew normal distribution shape, which could be the result of increases in velocity and excess pressure drop.
Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity  [PDF]
Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel
Open Journal of Metal (OJMetal) , 2012, DOI: 10.4236/ojmetal.2012.23008
Abstract: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
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