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Search Results: 1 - 10 of 413727 matches for " Rita de Cássia Oliveira da Costa Mattos "
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Environmental Exposure Associated with Oxidative Stress Biomarkers in Children and Adolescents Residents in Brazilian Western Amazon  [PDF]
Beatriz Fátima Alves de Oliveira, Leandro Vargas Barreto de Carvalho, Dennys de Souza Mour?o, Rita de Cássia Oliveira da Costa Mattos, Hermano Albuquerque de Castro, Paulo Artaxo, Washington Leite Junger, Sandra Hacon
Journal of Environmental Protection (JEP) , 2018, DOI: 10.4236/jep.2018.94023
Abstract: Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this study, we evaluate the relationship between genetic, demographic, social, environmental, and health factors and redox imbalance biomarkers in a group of children and adolescents environmentally exposed to atmospheric pollutants and mercury in the Brazilian Western Amazon. This is a cross-sectional study of the relationship between demographic, genetic, and socioenvironmental factors and serum concentrations of redox imbalance biomarkers (thiol groups, malondialdehyde, and glutathione S-transferase [GST]) in children and adolescents living in the municipality of Porto Velho, Rond?nia. The investigated factors were hierarchically organized into groups of variables and their relationship with redox imbalance biomarkers was estimated by a multiple linear regression model. Children and adolescents with asthma, with C-reactive protein values, with the polymorphic variant GSTP1, and exposed to indoor air pollution presented lower thiol serum concentrations when compared to those categorized in their respective reference groups. GST activity and malondialdehyde serum concentrations were positively related to weekly fish consumption and exposure to PM2.5. This study showed that enzymatic GST activity and malondialdehyde serum concentrations are positively associated with environmental factors, especially air pollution (β = 8.64 U/L for GST and β = 0.244 μmol/L for MDA in high exposure group; p-value < 0.01); while serum thiol concentrations presented an inversely proportional relationship with markers of general health status, such asthma (median: 0.45 mmol/L vs. 0.48 mmol/L; p-value < 0.05), acute inflammation (β = -0.25 mmol/L; p-value < 0.01), and positively with genetic factor (β = 0.12 mmol/L for Val/Val; p-value < 0.05).
Indicadores para Centros de Referência em Saúde do Trabalhador: proposi??o de um sistema de acompanhamento de servi?os de saúde
Jacques,Camila Corrêa; Milanez,Bruno; Mattos,Rita de Cássia Oliveira da Costa;
Ciência & Saúde Coletiva , 2012, DOI: 10.1590/S1413-81232012000200011
Abstract: this research proposes a framework of indicators to monitor the activities of the occupational health reference centers (cerest). cerest are structural elements of the national network of comprehensive attention to workers' health (renast) and are coordinated by the general coordination of occupational health of the ministry of health (cgsat). in order to build this framework, we first elaborated a list of indicators based on the norms that govern cerest's responsibilities. as a strategy to build a participative approach, a likert scale questionnaire was sent to 173 cerest coordinators, who were asked to evaluate this preliminary list of indicators. after the return of the questionnaires (48,6%), the answers were analyzed, considering the cerest scope (state or regional), date of accreditation and location. indicators with approval rate higher than 75% were included in the proposed framework. this instrument consisted in 12 indicators for state cerest and 13 indicators for regional cerest. it is expected that the procedures proposed in this research and the framework itself might encourage the government to create a monitoring system for renast as well as for health services in general.
Influência de fatores socioecon?micos na contamina??o por agrotóxicos, Brasil
Oliveira-Silva,Jefferson José; Alves,Sérgio R; Meyer,Armando; Perez,Frederico; Sarcinelli,Paula de Novaes; Mattos,Rita de Cássia O da Costa; Moreira,Josino C;
Revista de Saúde Pública , 2001, DOI: 10.1590/S0034-89102001000200005
Abstract: objective: the indiscriminate use of pesticides has been contributing for the environmental quality degradation, as well as it increases the occupational exposures to these products, determining a serious public health problem in rural areas. the purpose of this study was to evaluate the exposures of rural workers of rio de janeiro state to anticholinesterasic pesticides, through the analyses of the acetylcholinesterase from red cells (ache) and plasmatic butyrilcholinesterase (bche) levels. social-economic factors, such as the educational level of these workers, can strongly influence this situation, reason why the impact of some social-economic indicators and practices of pesticides' use in the human contamination status for rural areas were also evaluated. methods: the evaluation of rural workers exposure to pesticides was performed to a random sample of 55 workers among the 300 inhabitants of the study area ? five communities of magé county, rj. the ache and bche activities were determined to these workers. the enzymatic activities were evaluated according to the ellman's method modified by oliveira-silva. social-economic and pesticides use data were collected by a structured interview. the possible role of social-economic and pesticide use indicators as determinants of the worker's contamination was estimated by multivariate statistic techniques, using the enzymatic activity as the dependent variable and the social-economics pesticides use indicators as independent variables. results and conclusions: the data showed distinct results concerning the incidence of excessive exposure, according to the enzymatic indicator used. in the studied sample, a result of 3.0 % was found for the bche values, and 41.8 %, according to ache. individuals with at least one positive enzymatic indicator result were considered as "intoxicated". when these data were compared to the social-economic and pesticides use factors, it was showed the importance of educational level in the prev
Avalia??o dos fatores de risco relacionados à exposi??o ao chumbo em crian?as e adolescentes do Rio de Janeiro
Mattos,Rita de Cássia Oliveira da Costa; Carvalho,Márcia Aparecida Ribeiro de; Mainenti,Helena Ramirez Domingos; Xavier Junior,Ely Caetano; Sarcinelli,Paula de Novaes; Carvalho,Leandro Barreto Vargas de; Borges,Renato Mar?ullo; Quitério,Simone Lorena; Nogueira,Simone Mitri; Costa,Isabele Campos; Alves,Maria de Fátima Malizia;
Ciência & Saúde Coletiva , 2009, DOI: 10.1590/S1413-81232009000600011
Abstract: the importance of atmospheric lead in environmental global contamination is receiving increasing scientific attention. the main exposure monitoring approach is biological, but the environmental one has a key role, since the environment is the major source of exposure. the study aimed to identify the contamination sources and potential risk factors of the exposure in a 64 subject group formed by 0-16 years-old children from an economically deprived community in rio de janeiro. lead concentrations in soil, water, dust and air were determined and neurological and carcinogenic risk factors for ingestion and inhalation were calculated. blood samples were collected and used in the analysis of pb-b, ala-d% and ala-d genotyping. the observed neurological risk factor was 549 times higher than reference dose for dust and 554 times higher in the case of ingestion. the carcinogenic risk factor for ingestion was about 4 times. mean pb-b was 5.6μg/dl and 40% of the children presented pb-b levels above the 6μg/dl cutoff value. mean ala-d% was 40.3% and a correlation between pb-b and ala-d% was observed. alad1-2 genotype was identified in 10% of the children. the results will allow the understanding of our reality, supporting public health and environment organizations to carry out control actions and all-encompassing environmental surveillance.
Aplica o de metodologias FTIR de transmiss o e fotoacústica à caracteriza o de materiais altamente energéticos: parte II
Mattos Elizabeth da Costa,Viganó Itamar,Dutra Rita de Cássia Lazzarini,Diniz Milton Faria
Química Nova , 2002,
Abstract: Materials obtained during the synthesis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) were characterized by Fourier transform infrared (FTIR) transmission spectroscopy and/or Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS). By these techniques the spectrometric alterations that occurred during the process were observed. The characterized species during the synthesis of HMX were alpha-HMX, beta-HMX, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and HMX/RDX mixtures. The FTIR-PAS was verified to be a promising technique of great usefulness of the characterization of highly energetic materials because it is fast, simple and requires no sample preparation unlike Fourier transform infrared transmission technique (KBr pellet). The FTIR-PAS analysis showed that with small sample quantity is possible to distinguish between thealpha-HMX and beta-HMX and to detect even in a qualitative way different HMX / RDX ratios.
Determina??o quantitativa de TNT e HNS por TG e FT-IR
Silva, Gilson da;Mattos, Elizabeth da Costa;Dutra, Rita de Cássia Lazzarini;Diniz, Milton Faria;Iha, Koshun;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000600029
Abstract: 2,4,6-trinitrotoluene (tnt) is an energetic material that shows scarce crystalline properties that can be improved by addition of 2,2',4,4',6,6'-hexanitrostilbene (hns) in the crystallization process. hns is a very important high explosive used in a variety of military, aerospace and industrial formulations owing to its suitable properties. it is an insensitive and thermal stable explosive that can be produced from 2,4,6-trinitrotoluene (tnt). the purpose of this work is the quantitative determination of hns and tnt in explosives by thermogravimetric analysis (tg) and fourier transform infrared spectroscopy (ft-ir).
Aplica??o de metodologias FTIR de transmiss?o e fotoacústica à caracteriza??o de materiais altamente energéticos: parte II
Mattos, Elizabeth da Costa;Viganó, Itamar;Dutra, Rita de Cássia Lazzarini;Diniz, Milton Faria;Iha, Koshun;
Química Nova , 2002, DOI: 10.1590/S0100-40422002000500003
Abstract: materials obtained during the synthesis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (hmx) were characterized by fourier transform infrared (ftir) transmission spectroscopy and/or fourier transform infrared photoacoustic spectroscopy (ftir-pas). by these techniques the spectrometric alterations that occurred during the process were observed. the characterized species during the synthesis of hmx were a-hmx, b-hmx, hexahydro-1,3,5-trinitro-1,3,5-triazine (rdx) and hmx/rdx mixtures. the ftir-pas was verified to be a promising technique of great usefulness of the characterization of highly energetic materials because it is fast, simple and requires no sample preparation unlike fourier transform infrared transmission technique (kbr pellet). the ftir-pas analysis showed that with small sample quantity is possible to distinguish between thea-hmx and b-hmx and to detect even in a qualitative way different hmx / rdx ratios.
Aspectos epidemiológicos e clínicos do escorpionismo na regi?o de Santarém, Estado do Pará, Brasil
Pardal, Pedro Pereira de Oliveira;Castro, Lívia Correa;Jennings, Erik;Pardal, Joseana Silva de Oliveira;Monteiro, Maria Rita de Cássia da Costa;
Revista da Sociedade Brasileira de Medicina Tropical , 2003, DOI: 10.1590/S0037-86822003000300006
Abstract: this is a descriptive and prospective study on epidemiological and clinical aspects of 72 scorpion accidents admitted to santarém municipal hospital, state of pará, brazil, from february 2000 to february 2001. only 8.3% brought the animal with them, identified as t. cambridgei. the majority of victims were male (83.3%). the mean age and the time of the medical help were respectively 33.6±18.3 years and 4.6±3.2 hours. the parts of the body most affected were the superior members (51.5%). local symptoms occurred in 91.7% cases and systemic manifestations in 98.6% of the accidents. the local symptoms included: paresthesia in 79.2% cases, pain in 52.8% and edema in 26.4%. among the systemic manifestations neurological disorders predominated in 97.2%, and the symptom of "electric shock" occurred in 88.9% patients. the most common neurological signs were: myoclonia (93%), dysmetria (86.1%), dysarthria (80.6%), and ataxia (70.8%). the accidents were classified as moderate in 76.4% without any serious cases. the specific anti-venom serum was not administered in 32.7% of the moderate cases, due to non-availability of the anti-venom serum at the time of attendance. the victims of scorpion envenomation notified at santarém, present a different clinical and regional behavior from previous reports in brazil and amazonia regions. the predominantly neurological picture has not previously been described in the brazilian literature.
In vitro studies of the anthelmintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae)
Nunomura, Rita de Cássia Saraiva;Silva, Ellen Cristina Costa da;Oliveira, Denilson Ferreira;Garcia, Adriana Mello;Boeloni, Jankerle Neves;Nunomura, Sergio Massayoshi;Pohlit, Adrian Martin;
Acta Amazonica , 2006, DOI: 10.1590/S0044-59672006000300006
Abstract: 1300 ppm (1.3 g / l), water and ethanol extracts prepared from stems or roots of picrolemma sprucei hook. f. were lethal (85-90 % mortality) in vitro to haemonchus contortus (barber pole worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. neosergeolide and isobrucein b were isolated in 0.0083 and 0.0070 % yield from dry, ground p. sprucei stems (0.89 kg). neosergeolide, isobrucein b and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to h. contortus at similar concentrations (81-86 ppm). the anthelmintic activity of p. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein b, has therefore been demonstrated for the first time.
Qualidade do queijo de leite de cabra tipo Coalho condimentado com cumaru (Amburana cearensis A.C. Smith)
Souza, Evandro Leite de;Costa, Ana Caroliny Vieira da;Garcia, Estefania Fernandes;Oliveira, Maria Elieidy Gomes de;Souza, Wandrick Hauss de;Queiroga, Rita de Cássia Ramos do Egypto;
Brazilian Journal of Food Technology , 2011, DOI: 10.4260/BJFT2011140300026
Abstract: this study aimed to carry out the physicochemical, microbiological and sensory characterization of coalho-like goat's milk cheese with added coumarou (amburana cearensis a.c. smith), manufactured in the cariri region, paraíba state, brazil. the average values obtained for moisture, protein, fat, fat in the dry extract, ash and acidity as lactic acid were 46.5; 23.9; 25.3; 47.5; 3.8 and 0.09%, respectively. all the samples analyzed presented total coliform counts > 2.4 x 103 mpn.g-1, while the faecal coliforms ranged between 0.3 x 101 - > 2.0 x 103 mpn.g-1. salmonella was not found in any of the samples. the mesophilic, fungal and coagulase-positive staphylococcal counts were between 3.7 x 104-5.6 x 108; 4.6 x 102-5.2 x 109; and > 101-8.0 x 105 cfu.g-1, respectively. the sensory tests showed good acceptance of the product assessed and satisfactory results for purchasing intent. the good acceptance of the cheeses evaluated showed the potential for increased consumption. however, the results of the microbiological analyses showed the need for better monitoring of the steps involved in its processing, in order to obtain a product with better microbiological quality.
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