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Triplet chemotherapy with paclitaxel, gemcitabine, and cisplatin as second-line therapy for advanced urothelial carcinoma  [PDF]
Hideki Takeshita, Koji Chiba, Sachi Kitayama, Shingo Moriyama, Rika Omura, Akira Noro
Modern Chemotherapy (MC) , 2013, DOI: 10.4236/mc.2013.21001
Abstract: Background: Methotrexate, vinblastine, doxorubicin, and cisplatin regimen, and gemcitabine and cisplatin regimen are widely used for advanced or metastatic urothelial carcinomas (UCs). However, a standard treatment for patients who fail these firstline chemotherapies is unavailable. We examined the efficacy and safety of secondline paclitaxel, gemcitabine, and cisplatin (PCG) chemotherapy in Japanese patients. Methods: Between 2004 and 2010, 25 patients with metastatic UCs who failed to respond to platinumbased regimens were treated with PCG. They received intravenous paclitaxel (60 mg/m2) and gemcitabine (1000 mg/m2) on days 1 and 8, and cisplatin (70 mg/m2) on day 2 of every 21 day course. We retrospectively collected patients’ clinical and pathological data and evaluated adverse effects and survivals. Results: Patients underwent 95 PCG cycles in all (average, 3.8 cycles per patient). One patient (4%) achieved complete response, 5 (20%) showed partial response, 8 (42%) had disease stabilization, and 5 (26%) had disease progression. Median overall survival was 8.5 months. Neutropenia and thrombocytopenia of grade ≥ 3 were observed in 68% and 56% of patients, respectively. No treatment related death occurred. Multivariate analysis revealed that hemoglobin levels < 10 g/dL and estimated glomerular filtration rate < 60 mL/(min1.73 m2) were significant risk factors for overall survival. Conclusion: PCG chemotherapy in the secondline setting potentially contributed to good prognosis in selected patients with relatively significant but tolerable toxicity.
Performance Prospects of Fully-Depleted SOI MOSFET-Based Diodes Applied to Schenkel Circuit for RF-ID Chips  [PDF]
Yasuhisa Omura, Yukio Iida
Circuits and Systems (CS) , 2013, DOI: 10.4236/cs.2013.42024

The feasibility of using the SOI-MOSFET as a quasi-diode to replace the Schottky-barrier diode in the Schenkel circuit is examined by device simulations primarily and experiments partly. Practical expressions of boost-up efficiency for d. c. condition and a. c. condition are proposed and are examined by simulations. It is shown that the SOI-MOSFET-based quasi-diode is a promising device for the Schenkel circuit because high boost-up efficiency can be gained easily. An a. c. analysis indicates that the fully-depleted condition should hold to suppress the floating-body effect for GHz-level RF applications of a quasi-diode.

Proposal of High-Temperature-Operation Tolerant SOI MOSFET and Preliminary Study on Device Performance Evaluation
Yasuhisa Omura
Active and Passive Electronic Components , 2011, DOI: 10.1155/2011/850481
Abstract: We propose a high-temperature-operation (HTOT) SOI MOSFET and show preliminary simulation results of its characteristics. It is demonstrated that HTOT SOI MOSFET operates safely at 700?K with no thermal instability because of its expanded effective bandgap. It is shown that its threshold voltage is higher than that of the conventional SOI MOSFET because its local thin Si regions offer an expanded effective band gap. It is shown that HTOT SOI MOSFET with 1-nm-thick local-thin Si regions is almost insensitive to temperature for (427?C). This confirms that HTOT SOI MOSFET is a promising device for future high-temperature applications. 1. Introduction The long-term goal in integrated circuits is to lower the dimensionality of MOS transistors in order to increase the function-density and also the speed of extremely large-scale silicon-integrated circuits [1]. The necessity of the silicon-on-insulator (SOI) MOSFET is clear, given its merits of high-speed operation and low-power operation with fewer short-channel effects [2]. However, its off-leakage current is significant, even in thin SOI MOSFETs in the sub-100-nm regime [3]. The author recently proposed the tunneling barrier junction (TBJ) SOI MOSFET that offers suppressed off-leakage current [4, 5]. It has been shown that the TBJ SOI MOSFET suffers from low drive current if used at low temperatures as intended [6]. It has been demonstrated, however, that the thin SOI MOSFET is a promising device for applications that work at 300?C [1]. Its off-leakage current is still a serious problem and prevents its use at higher temperatures. When analyzing high-temperature-operation, it is anticipated that we do not need full quantum-mechanical simulations even for a thin SOI MOSFET because the influence of various carrier scattering events on the transport in the channel region is crucial; so-called thermalization is dominant in the Si material. This paper applies the semiclassical transport model to assess the feasibility of SOI MOSFET in achieving high-temperature operation. This paper introduces the High-Temperature-Operation Tolerant (HTOT) SOI MOSFET and shows preliminary simulation results of its characteristics. A commercial 2D device simulator [7] is used to simulate the drain current characteristics throughout the study. 2. Device Structure and Simulations A schematic of HTOT SOI MOSFET is shown in Figure 1(a). The device has an n+-Si gate, a thin n-type body, two thin p-type bodies, and two local-thin Si regions; it is assumed that the top SOI layer surface has (001) orientation. The gate oxide layer is
Metastable supersymmetry breaking vacua from conformal dynamics
Omura, Yuji
High Energy Physics - Phenomenology , 2008, DOI: 10.1063/1.3051996
Abstract: We study the scenario that conformal dynamics leads to metastable supersymmetry breaking vacua. At a high energy scale, the superpotential is not R-symmetric, and has a supersymmetric minimum. However, conformal dynamics suppresses several operators along renormalization group flow toward the infrared fixed point. Then we can find an approximately R-symmetric superpotential, which has a metastable supersymmetry breaking vacuum, and the supersymmetric vacuum moves far away from the metastable supersymmetry breaking vacuum. We show a 4D simple model. Furthermore, we can construct 5D models with the same behavior, because of the AdS/CFT dual.
Drilling Investigations on the Mechanics and Structure of Faults
Kentaro Omura
Scientific Drilling , 2007, DOI: 10.2204/iodp.sd.s01.22.2007
Preoperative concurrent chemotherapy with S-1 and radiotherapy for locally advanced squamous cell carcinoma of the oral cavity: Phase I trial
Hiroyuki Harada, Ken Omura
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-33
Abstract: Thirty patients, 15 each with stage III and IVA oral carcinoma, were enrolled. All patients received a total dose of 40-Gy. For the S-1 treatment, patients were given either the standard Japanese dose, calculated according to body surface area, or a reduced dose. Groups consisting of at least three patients were given S-1 according to one of 8 regimens.Hematologic toxicity was mild and reversible. The most common nonhematologic toxicity was mucositis. At level 8 that was the standard S-1 dose for 5 days per week for 4 weeks, dose-limiting toxicity was observed when 2 patients had grade 4 mucositis. This level was thus deemed the maximum tolerated dose for the regimen.The recommended dose of S-1 with concurrent radiotherapy was the reduced dose of S-1 given for 5 days per week, for 4 consecutive weeks. Preoperative S-1 and concurrent radiotherapy was well tolerate and feasible and warrants a phase II study.Today the treatment of primary oral squamous cell carcinoma includes various combinations of radiotherapy, chemotherapy and surgery. In literature searches, studies employing adjuvant strategies of radiotherapy after surgery outnumber those of preoperative concepts. Nevertheless, for about 20 years, preoperative therapy concepts have been established as the standard approach in some centers. Klug et al. summarized the results of the preoperative chemoradiotherapy for oral cancer [1]. He reported that 5-year survival rate determined by the meta-analysis of the 32 studies (1927 patients) was 62.6%, appearing to be remarkably good.Kirita et al. reported obtaining a clinical response rate of 97.9%, and a 5-year overall actuarial survival rate of 81.3%, by treating advanced oral cancer with preoperative concurrent cisplatin- or carboplatin-based intravenous chemotherapy and radiotherapy at a total dose of 40-Gy [2]. Iguchi et al. reported an overall response rate of 100% when treating oral and maxillary carcinoma with concurrent chemoradiotherapy, using a combination of
Clóvis Moura e a sociologia da práxis
Mesquita, érika;
Estudos Afro-Asiáticos , 2003, DOI: 10.1590/S0101-546X2003000300007
Abstract: this work contributes to a (re)thinking of the work and intellectual position of one of the greatest brazilian thinkers, clovis moura, a very important brazilian thinker of the negro social history. it analyzes this radical social scientist's academic career, and it shows, as well, a part of his life story that has contributed to his theoretical and practical ideas. and it also highlights his late acceptance among the academic circles.
Development and Prospect of Music Therapy in Japan
Rika Ikuno
Voices: A World Forum for Music Therapy , 2005,
Abstract: I have a strange sense that music therapy is something that never fits completely into an existing society, regardless of Western or Asian context. Just aiming at being accepted by society will only drive us to a dead end. Rather, music therapy could conceive the possibility of shaking (aspects of) an existing society and could suggest new (or deeper) values of music in relation to human-beings. For this purpose, we need to cultivate our insights about the culture-specific elements and the universal elements in all areas of clinical, academic, and professional practice. By doing so, we can accomplish "independence" in a true sense, including economic independence some day.
Fact Sheet of Music Therapy in Japan
Rika Ikuno
Voices: A World Forum for Music Therapy , 2005,
Abstract: Brief History of Japanese Music Therapy Development after World War II
Rika Ikuno
Voices: A World Forum for Music Therapy , 2005,
Abstract: On January 10th, 2005, The Asian Music Therapy Symposium was held in Senzoku Gakuen College of Music in Kawasaki, Japan, as the 80th anniversary of the school foundation. As a partial report on the symposium, I offer here an edited version of the paper I presented at the conference, a Fact Sheet on Music Therapy in Japan, and the discussion paper: "Things Asian Music Therapists should Learn" by Izumi Futamata (an experienced Japanese music therapist and a lecturer at Senzoku).
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