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Search Results: 1 - 10 of 335960 matches for " Rif S El-Mallakh "
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Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures
Martin E Brown, Rif S El-Mallakh
Therapeutics and Clinical Risk Management , 2010, DOI: http://dx.doi.org/10.2147/TCRM.S6382
Abstract: le of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures Review (4296) Total Article Views Authors: Martin E Brown, Rif S El-Mallakh Published Date March 2010 Volume 2010:6 Pages 103 - 109 DOI: http://dx.doi.org/10.2147/TCRM.S6382 Martin E Brown, Rif S El-Mallakh 1Department of Neurology, 2Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA Abstract: Eslicarbazepine is a new dibenzazepine antiepileptic agent. It is a high affinity antagonist of the voltage-gated sodium channel. It is closely related to both carbamazepine and oxcarbazepine. Eslicarbazepine has similar affinity to inactivated sodium channels (channels in just activated neurons) as carbamazepine, and greater efficacy in animal models of seizure than oxcarbazepine. In human placebo-controlled trials of a single daily dose of eslicarbazepine added to other anti-epileptic agents, significant seizure reductions occurred with 800 and 1200 mg daily, with nearly half of the patients experiencing a greater than 50% reduction in seizure frequency. Adverse events (AEs) occurred in over 50% of patients receiving therapeutic doses of eslicarbazepine (compared to 31.4%–44.7% of placebo-treated subjects), but were generally mild or moderate. Eight to 19.6% of eslicarbazepine treated patients discontinued due to AEs (compared to 3.9%–8.5% of placebo-treated subjects). In these patients receiving combination anticonvulsant therapy, the most common AEs were dizziness, nausea and vomiting, somnolence, and diplopia. Eslicarbazepine is an effective and reasonably well-tolerated adjunct in patients with suboptimal control of their partial seizures.
Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures
Martin E Brown,Rif S El-Mallakh
Therapeutics and Clinical Risk Management , 2010,
Abstract: Martin E Brown, Rif S El-Mallakh1Department of Neurology, 2Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USAAbstract: Eslicarbazepine is a new dibenzazepine antiepileptic agent. It is a high affinity antagonist of the voltage-gated sodium channel. It is closely related to both carbamazepine and oxcarbazepine. Eslicarbazepine has similar affinity to inactivated sodium channels (channels in just activated neurons) as carbamazepine, and greater efficacy in animal models of seizure than oxcarbazepine. In human placebo-controlled trials of a single daily dose of eslicarbazepine added to other anti-epileptic agents, significant seizure reductions occurred with 800 and 1200 mg daily, with nearly half of the patients experiencing a greater than 50% reduction in seizure frequency. Adverse events (AEs) occurred in over 50% of patients receiving therapeutic doses of eslicarbazepine (compared to 31.4%–44.7% of placebo-treated subjects), but were generally mild or moderate. Eight to 19.6% of eslicarbazepine treated patients discontinued due to AEs (compared to 3.9%–8.5% of placebo-treated subjects). In these patients receiving combination anticonvulsant therapy, the most common AEs were dizziness, nausea and vomiting, somnolence, and diplopia. Eslicarbazepine is an effective and reasonably well-tolerated adjunct in patients with suboptimal control of their partial seizures.Keywords: eslicarbazepine, licarbazepine, voltage-gated sodium channel, partial-onset seizures, epilepsy
Current and Emerging Therapies for the Management of Bipolar Disorders
Rif S. El-Mallakh, Ahmed Z. Elmaadawi, Yonglin Gao, Kavita Lohano and R. Jeannie Roberts
Journal of Central Nervous System Disease , 2012, DOI: 10.4137/JCNSD.S4441
Abstract: Bipolar disorder is a complex condition to treat because agents that may be effective for a specific phase may not be effective for other phases, or may even worsen the overall course of the illness. Over the last decade there has been an increase in research activity in the treatment of bipolar illness. There are now several agents that are well established for the treatment of acute mania (lithium, divalproex, carbamazepine, nearly all antipsychotics), acute bipolar depression (lamotrigine, quetiapine, olanzapine/fluoxetine combination), and relapse prevention (lithium, lamotrigine, divalproex, most second generation antipsychotics). There are also novel treatments that are being studied for all three phases. These include eslicarbazepine, cariprazine, MEM-1003, memantine, tamoxifen and pentazocine for acute mania; pramipexole, modafinil, armodafinil, divalproex, lurasidone, agomelatine, cariprazine, lisedexamfetamine, riluzole, RG-2417, bifeprunox, ropinirole, GSK1014802, and magnetic stimulation for bipolar depression; and asenapine, lurasidone, and cariprazine for relapse prevention. Additionally, there are accumulating data that antidepressants, particularly serotoninergic ones, are not particularly effective in acute bipolar depression and may worsen the course of the illness.
Current and Emerging Therapies for the Management of Bipolar Disorders
Rif S. El-Mallakh,Ahmed Z. Elmaadawi,Yonglin Gao,Kavita Lohano
Journal of Central Nervous System Disease , 2011,
Abstract:
Magnetization dynamics in Co2$MnGe/Al2$O3$/Co tunnel junctions grown on different substrates
M. Belmeguenai,H. Tuzcuoglu,F. Zighem,S-M. Chérif,Y. Roussigné,P. Moch,K. Westerholt,A. El Bahoui,C. Genevois,A. Fnidiki
Physics , 2013, DOI: 10.1166/sl.2013.3064
Abstract: We study static and dynamic magnetic properties of Co2MnGe (13 nm)/Al2O3 (3 nm)/Co (13 nm) tunnel magnetic junctions (TMJ), deposited on various single crystalline substrates (a-plane sapphire, MgO(100), Si(111)). The results are compared to the magnetic properties of Co and of Co$_{2}$MnGe single films lying on sapphire substrates. X-rays diffraction always shows a (110) orientation of the Co$_{2}$MnGe films. Structural observations obtained by high resolution transmission electron microscopy confirmed the high quality of the TMJ grown on sapphire. Our vibrating sample magnetometry measurements reveal in-plane anisotropy only in samples grown on a sapphire substrate. Depending on the substrate, the ferromagnetic resonance spectra of the TMJs, studied by the microstrip technique, show one or two pseudo-uniform modes. In the case of MgO and of Si substrates only one mode is observed: it is described by magnetic parameters (g-factor, effective magnetization, in-plane magnetic anisotropy) derived in the frame of a simple expression of the magnetic energy density; these parameters are practically identical to those obtained for the Co single film. With a sapphire substrate two modes are present: one of them does not appreciably differ from the observed mode in the Co single film while the other one is similar to the mode appearing in the Co$_{2}$MnGe single film: their magnetic parameters can thus be determined independently, using a classical model for the energy density in the absence of interlayer exchange coupling.
Transmission electron microscopy and ferromagnetic resonance investigations of tunnel magnetic junctions using Co2MnGe Heusler alloy as magnetic electrodes
M. Belmeguenai,C. Genevois,F. Zighem,Y. Roussigné,S-M. Chérif,K. Westerholt,A. El Bahoui,A. Fnidiki,P. Moch
Physics , 2013, DOI: 10.1016/j.tsf.2013.11.090
Abstract: HRTEM, nano-beam electronic diffraction, energy dispersive X-rays scanning spectroscopy, Vibrating Sample Magnetometry (VSM) and FerroMagnetic Resonance (FMR) techniques are used in view of comparing (static and dynamic) magnetic and structural properties of Co2MnGe (13 nm)/Al2O3 (3 nm)/Co (13 nm) tunnel magnetic junctions (TMJ), deposited on various single crystalline substrates (a-plane sapphire, MgO(100) and Si(111)). They allow for providing a correlation between these magnetic properties and the fine structure investigated at atomic scale. The Al2O3 tunnel barrier is always amorphous and contains a large concentration of Co atoms, which, however, is significantly reduced when using a sapphire substrate. The Co layer is polycrystalline and shows larger grains for films grown on a sapphire substrate. The VSM investigation reveals in-plane anisotropy only for samples grown on a sapphire substrate. The FMR spectra of the TMJs are compared to the obtained ones with a single Co and Co2MnGe films of identical thickness deposited on a sapphire substrate. As expected, two distinct modes are detected in the TMJs while only one mode is observed in each single film. For the TMJ grown on a sapphire substrate the FMR behavior does not significantly differ from the superposition of the individual spectra of the single films, allowing for concluding that the exchange coupling between the two magnetic layers is too small to give rise to observable shifts. For TMJs grown on a Si or on a MgO substrate the resonance spectra reveal one mode which is nearly identical to the obtained one in the single Co film, while the other observed resonance shows a considerably smaller intensity and cannot be described using the magnetic parameters appropriate to the single Co2MnGe film.
Energy solutions for polymer aqueous solutions in two dimension
Chérif Amrouche,El-Hacene E. H Ouazar
Mathematics , 2007,
Abstract: The aim of this article is to study a nonlinear system modeling a Non-Newtonian fluid of polymer aqueous solutions. We are interested here in the existence of weak solutions for the stationary problem in a bounded plane domain or in two-dimensional exterior domain. Due to the third order of derivatives in the non-linear term, it's difficult to obtain solution satisfying energy inequality. But with a good choice of boundary conditions, an adapt special basis and the use of the good properties of the trilinear form associated to the non-linear term, we obtain energy solutions. The problem in bounded domain is treated and the more difficult problem on non bounded domain too.
ON AUTOMATIC SURJECTIVITY OF SOME ADDITIVE TRANSFORMATIONS
EL KETTANI,MUSTPHA ECH-CHéRIF; El BOUCHIBTI,EL HOUCINE;
Proyecciones (Antofagasta) , 2004, DOI: 10.4067/S0716-09172004000200004
Abstract: let x be an infinite dimensional banach space and let ?: b(x) → b(x) be a spectrum preserving additive transformation. we show that if the image of quasi-nilpotent operators contains all quasi-nilpotent operators, then ? is an automophism or an antiautomorphism of b(x)
ON AUTOMATIC SURJECTIVITY OF SOME ADDITIVE TRANSFORMATIONS
MUSTPHA ECH-CHéRIF EL KETTANI,EL HOUCINE El BOUCHIBTI
Proyecciones (Antofagasta) , 2004,
Abstract: Let X be an infinite dimensional Banach space and let : B(X) → B(X) be a spectrum preserving additive transformation. We show that if the image of quasi-nilpotent operators contains all quasi-nilpotent operators, then is an automophism or an antiautomorphism of B(X)
High-Field MRI Contribution in Tolosa-Hunt Syndrome (THS). Report of Two Cases and Review of Literature  [PDF]
Chérif Mohamadou Aidara, Philomène Kouna, Jennifer Nyangui Mapaga, Nfally Badji, Hamidou Deme, Abdoulaye Dione Diop, Abdoulaye Ndoye Diop, Sokhna Ba, El Hadj Niang
Open Journal of Radiology (OJRad) , 2018, DOI: 10.4236/ojrad.2018.83016
Abstract: Background: Tolosa Hunt Syndrome is an inflammatory condition of unknown etiology of the cavernous sinus and superior orbital fissure. Because of the difficulty in establishing histological evidence, his diagnosis is based on a set of arguments established by the International Headache Society. MRI allows indirect visualization of the granuloma and plays a key role in diagnosis and follow-up. Aim: To illustrate High-field MRI contribution in Tolosa-Hunt Syndrome (THS). Cases Presentation: Two patients, a 25-year-old female and a 40-year-old male were recruited in this retrospective case report study at the Radiology service of Fann University Hospital (Dakar Senegal). The first patient has been suffering from a right retro-orbital pain and diplopia for 2 months and the second from a painful oculomotor nerve palsy for 3 months. Blood tests, lumbar puncture, thyroid hormone levels and an infectious screen were done. Screening for converting enzymes, and serum antibodies were also done. They underwent a high field MRI (Siemens 1.5T) with T1, T2, FLAIR, T2*, diffusion B1000, TOF polygon, CISS 3D and T1 gadolinium sequences in the 3 planes space. No significant abnormality was detected in blood tests or CSF analysis. Screening for converting enzymes and serum antibodies screen were also negative. For each patient, MRI examinations showed a non tumoral thickening of the right cavernous sinus, suggesting a granulomatous involvement. Tolosa Hunt Syndrome was evoked firstly. They were put on corticotherapy at high doses with a spectacular regression of symptoms. The Criteria of the International Headache Society of THS were met in both patients. Conclusion: High-field MRI is a significant diagnostic tool in the assessment of painful ophthalmoplegia. It allows a direct visualization of the granuloma of the cavernous sinus and assesses its course throughout the disease.
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