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Search Results: 1 - 10 of 13696 matches for " Riccardo;Gomes "
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Tratamento medicamentoso da osteoartrose do joelho
Rezende, Márcia Uch?a de;Gobbi, Riccardo Gomes;
Revista Brasileira de Ortopedia , 2009, DOI: 10.1590/S0102-36162009000100002
Abstract: clinical treatment for osteoarthritis (oa) is very important and is based on patient's self care and guided by the physician. drug therapy is additional to losing weight, improving muscular strength, proprioception, flexibility and range of motion. between the available drugs for osteoarthritis' treatment, some are basically analgesics and do not interfere on disease's progression; some are anti-inflammatory with good analgesic power but with side effects that compromise their prolonged usage; and the structure modifying drugs that slow down the progression of oa. the medications are presented in topic, oral, intra-muscular, intra-venous and intra-articular forms. the hyaluronic acid has various presentations with good analgesic effect and some evidence of structure modifying property. there is ia evidence level for the use of diacerhein and of glucosamine to slow down the disease. still, more technology for diagnosis and therapy control of oa is necessary to define the efficacy of other drugs.
Business Cycles and Recessions in the OECD Area  [PDF]
Riccardo Fiorito
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.43A022

Recessions are less frequent (10%), more volatile and less persistent than negative business cycles are (50%). In this article, OECD annual data are used to provide a taxonomy of postwar recessions, showing in particular the frequency, the features and the number of countries involved in major episodes. We shall also implement a simple way for inserting positive (or negative) growth cases into standard business cycle analysis, stressing in particular the importance of recessions for stabilization policies. This applies mostly to fiscal policies that risk otherwise to be more pro-cyclical than normally required.

Researches on Methodologies to Verify Reduced Sensitivities of Venturia inaequalis in Field to Difenoconazole and First Indications of a Survey in Italy  [PDF]
Riccardo Fiaccadori
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.89138
Abstract: Resistance of Venturia inaequalis to the first IBS triazoles occurred in the 80’s in Italy and other countries. Successively number of applications sensibly decreased and problems of resistance to IBS generally disappeared. In 2010 suspects of resistance to the newer IBS difenoconazole, the actually most used IBS, appeared in several countries. In vitro tests the results confirmed the previous researches: the monoconidia from populations which were poorly controlled showed moderate reduced sensitivity respect to well controlled and wild-types. New in vivo tests were realized with preventive and curative applications on seedlings. No different activity among the three types of populations (poorly, well-controlled and wild-types) was found in preventive applications. On the contrary, in curative applications, wild-types and well controlled populations showed a visible and statistically significant activity respect to the poorly controlled. A survey of sensitivity to difenoconazole was carried out in two Italian apple areas in 2013-2015 and showed the presence of populations resistant to difenoconazole. Probably the cause of the resistance spread was the increase of the number of applications of this IBS in the last years. However the problem appears more complex because nowadays resistance regards about all fungicides and with a higher severity respect previous decades. An increase of virulence of V. inaequalis strains appears to be the cause of this situation also for the high presence of cultivars with high or moderate susceptibility to scab. Foreseeable remedies consist in
Persistence of Venturia inaequalis Populations Resistant to Strobilurins in the Field and in the Glasshouse  [PDF]
Riccardo Fiaccadori
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.94042
Abstract: The research was focused on the persistence of resistance of V. inaequalis to strobilurins from resistant populations occurring in the field. It was studied with two types of experiments: the first in apple orchards where resistance occurred in 2005 and employ of these fungicides was suspended from 2006 to 2011, realizing every year sensitivity/resistance assays on strobilurins. In the second was verified the sensitivity/resistance of the same 2015 populations, repeatedly multiplied (ten inoculations) in glasshouse on apple seedlings. Results showed that the resistance survived in orchards all the years of tests (six years), despite sensitivity fluctuations occurred on infected leaves due to sexual crosses, competition with sensible strains and soil management. In glasshouse, the level of resistance of all populations increased quickly in first inoculations and values remained high (EC50 > 10 mg·L-1) in all the following inoculations, until the last, the 10th. V. inaequalis resistant strains seemed to show high fitness: relevant persistence in the field, and a capacity of prevail on sensible ones in absence of factors of field variability.
Labor Market Policies in Matching Models: Do Externalities Matter?  [PDF]
Riccardo Tilli
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.94054
This paper analyzes the role played by five labor policy instruments (firing tax, hiring subsidies, taxation, unemployment benefits and tax structure) in a matching model with endogenous job destruction, when search externalities are not internalized and the market solution is inefficient. Since the theoretical model does not show univocal effects on equilibrium unemployment of some policy tools (such as hiring subsidies and firing tax), we propose a calibration and a numerical simulation of the model, in order to verify their real impact on unemployment and labor market structure. Results show that if, as is reasonable to assume, there are frictions on the labor market that generate search externalities, a labor market regulation becomes desirable and can be aimed at the internalization of externalities through an appropriate combination of labor policy instruments. In particular, our results have highlighted the crucial role of hiring subsidies and progressive taxation, not only for the achievement of the optimal solution, but also for supporting some forms of passive labor policies, mainly unemployment benefits and employment protection.
Implica??es farmacogenéticas de polimorfismos da eNOS para drogas de a??o cardiovascular
Silva, Pamela Souza;Lacchini, Riccardo;Gomes, Valéria de Aguiar;Tanus-Santos, José Eduardo;
Arquivos Brasileiros de Cardiologia , 2011, DOI: 10.1590/S0066-782X2011000200017
Abstract: the pharmacogenetics is one of the most promising fields of medicine. the conclusion of the genome project allowed this field to start discovering complex factors modulating the response to drugs, and new technologies are close a great expansion of the area. the cardiovascular diseases are currently among the major causes of hospitalizations and death, and have been the target of a large part of genetic studies of complex diseases. parallel to the susceptibility to disease markers identification, it is necessary to investigate how different genetic profiles can change the responses to the currently used drugs. the biological system that controls the endothelial production of the nitric oxide has been one of the greatest targets in the pharmacological responses to the drugs used in the cardiovascular diseases therapy. this review aims at approaching the current knowledge on interaction among the genetic variations of enos and the pharmacological responses to the drugs used in the cardiovascular system.
Ensaios clínicos controlados e randomizados na ortopedia: dificuldades e limita??es
Malavolta, Eduardo Angeli;Demange, Marco Kawamura;Gobbi, Riccardo Gomes;Imamura, Marta;Fregni, Felipe;
Revista Brasileira de Ortopedia , 2011, DOI: 10.1590/S0102-36162011000400018
Abstract: randomized controlled clinical trials (rcts) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. steps such as patient selection, randomization and blinding are fundamental for conducting an rct, but some additional difficulties are presented in trials that involve surgical procedures, as in common in orthopedics. the aim of this article was to highlight and discuss some difficulties and possible limitations on rcts within the field of surgery.
Método de ensaio biomecanico para análise da isometricidade na reconstru o do ligamento patelofemoral medial Biomechanical access method for analyzing isometricity in reconstructing the medial patellofemoral ligament
David Sadigursky,Riccardo Gomes Gobbi,César Augusto Martins Pereira,José Ricardo Pécora
Revista Brasileira de Ortopedia , 2012, DOI: 10.1590/s0102-36162012000500010
Abstract: OBJETIVO: Apresentar um dispositivo biomecanico para o estudo da reconstru o do ligamento patelofemoral medial (LPFM) e sua isometricidade. MéTODOS: Foi desenvolvido um sistema biomecanico acessível, que permite a aplica o de for as fisiológicas e n o fisiológicas no joelho, através de um bra o mecanico e aplica o de pesos e contrapesos, possibilitando a execu o de diferentes estudos, além de ter um sistema de medidas bastante preciso de aferi o de distancias entre diferentes estruturas para análise dos experimentos. Este artigo descreve a montagem deste sistema, além de sugerir algumas aplica es práticas. Foram estudados seis joelhos de cadáveres. Os joelhos foram preparados em uma máquina de ensaios desenvolvida no Laboratório de Biomecanica do IOT HC FMUSP, que permitiu a avalia o dinamica do comportamento patelar, quantificando a sua lateraliza o entre 0 e 120 graus. A diferen a entre as distancias encontradas, com e sem carga, aplicada na patela foram agrupadas segundo o angulo de fixa o do enxerto (0°, 30°, 60° e 90°) e situa o do joelho (íntegro, reconstruído e lesado). RESULTADOS: Houve uma tendência em ocorrer menor desvio lateral em angulos de fixa o acima de 30 graus de flex o, principalmente entre os angulos entre 45° e 60° graus de flex o, após a reconstru o. Para os demais angulos n o houve significancia estatística. CONCLUS O: O método desenvolvido é uma ferramenta útil para os estudos da articula o patelofemoral, além de ter um sistema de medidas bastante preciso de aferi o de distancias entre diferentes estruturas e permitir a sua utiliza o em institui es com menos recursos disponíveis. OBJECTIVE: To present a biomechanical device for evaluating medial patellofemoral ligament (MPFL) reconstruction and its isometricity. METHODS: An accessible biomechanical method that allowed application of physiological and non-physiological forces to the knee using a mechanical arm and application of weights and counterweights was developed, so as to enable many different evaluations and have a very accurate measurement system for distances between different structures, for analysis on experiments. This article describes the assembly of this system, and suggests some practical applications. Six cadaver knees were studied. The knees were prepared in a testing machine developed at the Biomechanics Laboratory of IOT-HCFMUSP, which allowed dynamic evaluation of patellar behavior, with quantification of patellar lateralization between 0° and 120°. The differences between the distances found with and without load applied to the patella were g
Necrose avascular da cabe a femoral em pacientes HIV positivos: resultados iniciais do tratamento cirúrgico por substitui o articular ceramica-ceramica Avascular necrosis of the femoral head in HIV-infected patients: preliminary results from surgical treatment for ceramic-ceramic joint replacement
Henrique Amorim Cabrita,Alexandre Leme de Godoy Santos,Riccardo Gomes Gobbi,Ana Lúcia Munhoz Lima
Revista Brasileira de Ortopedia , 2012, DOI: 10.1590/s0102-36162012000500014
Abstract: OBJETIVOS: Avaliar os resultados funcionais iniciais e o índice de complica es precoces das artroplastias totais do quadril ceramica-ceramica em pacientes que convivem com o HIV e apresentam osteonecrose da cabe a femoral. MéTODO: Doze pacientes HIV+ com diagnóstico de osteonecrose da cabe a do fêmur incongruente foram avaliados através de critérios clínicos, laboratoriais, pela escala funcional WOMAC antes e após o tratamento com substitui o articular. RESULTADOS: Observamos que 83,3% dos indivíduos faziam uso de inibidores de protease, 75% apresentavam dislipidemia e 66,6% síndrome lipodistrófica, a melhora na evolu o no escore WOMAC foi estatisticamente significativa para seis e 12 meses de pós-operatório em compara o com o escore pré-operatório e n o observamos complica es secundárias a esse procedimento. CONCLUS O: A artroplastia total do quadril com implante de ceramica-ceramica para o tratamento da necrose avascular do quadril nessa parcela da popula o é op o cirúrgica adequada, apresenta melhora funcional inicial significativa e baixo índice de complica o precoce. OBJECTIVES: To evaluate the initial functional results and early complication rate of ceramic-ceramic total hip replacements among patients living with HIV who presented osteonecrosis of the femoral head. METHOD: Twelve HIV-positive patients with a diagnosis of osteonecrosis of the incongruent femoral head were evaluated using clinical and laboratory criteria and the WOMAC functional scale before and after treatment with joint replacement. RESULTS: We observed that 83.3% of the subjects were taking protease inhibitors, 75% had dyslipidemia and 66.6% had lipodystrophy syndrome. The improvement over the evolution of the WOMAC score was statistically significant at six and twelve months after the operation, in comparison with the preoperative score. We did not observe complications secondary to this procedure. CONCLUSION: Total hip arthroplasty with a ceramic-ceramic implant for treating avascular necrosis of the hip is an appropriate surgical option for this portion of the population. It provides a significant initial functional improvement and a low early complication rate.
Valor da avalia o radiográfica pré-operatória dos defeitos ósseos no joelho nas revis es de artroplastia Value of preoperative radiographic evaluations on knee bone defects for revision arthroplasty
Mauricio Masasi Iamaguchi,Camilo Partezani Helito,Riccardo Gomes Gobbi,Marco Kawamura Demange
Revista Brasileira de Ortopedia , 2012,
Abstract: OBJETIVO: Avaliar o valor da avalia o radiográfica pré-operatória nas revis es de artroplastias totais do joelho. MéTODOS: Trinta e um joelhos operados no período de 2006 a 2008 em uma série consecutiva de casos de cirurgia de revis o de artroplastia total de joelho foram analisados retrospectivamente. CRITéRIOS ANALISADOS: número de cunhas ou enxertos ósseos estruturados utilizados para preenchimento dos defeitos ósseos; localiza o das cunhas e enxertos ósseos utilizados e espessura média do polietileno utilizada. A classifica o AORI era estabelecida previamente através de radiografias pré-operatórias segundo critérios preestabelecidos. Após a análise, os joelhos foram divididos em quatro grupos (I, IIA, IIB e III). RESULTADOS: O número médio de cunhas ou enxertos ósseos utilizados em cada joelho variou de maneira crescente entre os grupos (grupo I: 1,33; grupo IIA: 2; grupo IIB: 4,33; grupo III: 4,83) (P = 0,0012). As localiza es mais comuns foram: medial na tíbia e posteromedial no fêmur. N o houve diferen a estatisticamente significante na espessura do polietileno utilizado. CONCLUS O: A classifica o AORI para defeitos ósseos no joelho baseada em radiografias pré-operatórias mostrou correla o crescente com a necessidade de utiliza o de cunhas e/ou enxertos estruturados na revis o de artroplastia total do joelho. Porém, até 46% dos joelhos dos grupos I e IIA apresentaram falhas ósseas de até 5mm n o diagnosticadas através das radiografias pré-operatórias. OBJECTIVE: To evaluate the value of preoperative radiographic evaluations for total knee arthroplasty (TKA) revision. METHODS: Thirty-one knees that were operated between 2006 and 2008, in a consecutive series of cases of TKA revision surgery were analyzed retrospectively. THE FOLLOWING CRITERIA WERE EVALUATED: number of wedges or structured bone grafts used for filling the bone defects; locations of the wedges and bone grafts used; and mean thickness of the polyethylene used. The AORI classification was previously established based on preoperative radiographs, using preestablished criteria. After the analysis, the knees were divided into four groups (I, IIA, IIB and III). RESULTS: The mean number of wedges or grafts used in each knee progressively increased among the groups (group I: 1.33; group IIA: 2; group IIB: 4.33; and group III: 4.83) (P = 0.0012). The commonest locations were medial in the tibia and posteromedial in the femur. There were no statistically significant differences in the thickness of the polyethylene used. CONCLUSION: The AORI classification for bone defects in the knee,
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