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Search Results: 1 - 10 of 343230 matches for " Ricardo S. Diaz "
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Estimating the length of the first antiretroviral therapy regiment durability in S?o Paulo, Brazil
Medeiros, Roseane;Diaz, Ricardo S.;Castelo Filho, Adauto;
Brazilian Journal of Infectious Diseases , 2002, DOI: 10.1590/S1413-86702002000600005
Abstract: brazil was the first country to provide unrestricted, cost-free access to antiretroviral (arv) medicine for aids treatment. however, there is little data about the benefits of such a policy for these patients. we evaluated the duration of benefit obtained with the introduction of arvs, defined as the durability of the first arv regiment. we reviewed the medical charts of patients attended from 1996-2000, at the outpatient clinics of the federal university of s?o paulo, brazil. a total of 120 drug-naive hiv-1 infected patients were eligible to participate in the study. about half of the individuals (53%) presented with disease symptoms; 59% of them had cd4 count below 200 cells/mm3. mean estimated duration of the benefit of therapy was 14.1 months. the most used regimen in this cohort was zidovudine/3tc/indinavir (26%), followed by zidovudine/ddi (17%), and zidovudine/3tc/nelfinavir (13%). the most frequent cause of interruption of therapy was gastrointestinal intolerance. use of treatment regimens with three drugs was more effective than with two drugs, but only for patients with cd4<200 cells/mm3 or cv>100,000 copies rna/ml. however, the use of triple therapy was associated with a significantly higher probability of reaching maximum viral suppression, during a longer period (p<0.05).the patients enrolled in the study benefitted from therapy for a limited time, after the introduction of double or triple antiretroviral therapy. the incidence of adverse events was significantly associated with loss of the benefits provided by the initial therapeutic regimen.
DISE O DE UN ENLACE WI-FIAUTóNOMO COMO UNA SOLUCIóN DE CONECTIVIDAD PARA ZONAS RURALES.
óSCAR GUALDRóN G.,JOSE RUGELES U.,RICARDO DIAZ S.
Scientia Et Technica , 2011,
Abstract: Este documento describe la experiencia de dise o, implementación y pruebas de campo de un enlace de largo alcance, alimentado con energía solar, utilizando radios Wi-Fi modificando parámetros de su MAC. El sistema es una alternativa para la conectividad de zonas rurales. Se utilizó el simulador RadioMobile durante el proceso de dise o. Se evaluó el desempe o del sistema entre dos estaciones separadas 10.22 Km alcanzándose una tasa promedio de transferencia en TCP de 13.8 Mbps. El sistema se dise ó para permitir una operación continua de 24 horas durante 3 días con bajos niveles de radiación solar.
Estimating the length of the first antiretroviral therapy regiment durability in S o Paulo, Brazil
Medeiros Roseane,Diaz Ricardo S.,Castelo Filho Adauto
Brazilian Journal of Infectious Diseases , 2002,
Abstract: Brazil was the first country to provide unrestricted, cost-free access to antiretroviral (ARV) medicine for AIDS treatment. However, there is little data about the benefits of such a policy for these patients. We evaluated the duration of benefit obtained with the introduction of ARVs, defined as the durability of the first ARV regiment. We reviewed the medical charts of patients attended from 1996-2000, at the outpatient clinics of the Federal University of S o Paulo, Brazil. A total of 120 drug-naive HIV-1 infected patients were eligible to participate in the study. About half of the individuals (53%) presented with disease symptoms; 59% of them had CD4 count below 200 cells/mm3. Mean estimated duration of the benefit of therapy was 14.1 months. The most used regimen in this cohort was Zidovudine/3TC/Indinavir (26%), followed by Zidovudine/DDI (17%), and Zidovudine/3TC/Nelfinavir (13%). The most frequent cause of interruption of therapy was gastrointestinal intolerance. Use of treatment regimens with three drugs was more effective than with two drugs, but only for patients with CD4<200 cells/mm3 or CV>100,000 copies RNA/mL. However, the use of triple therapy was associated with a significantly higher probability of reaching maximum viral suppression, during a longer period (p<0.05).The patients enrolled in the study benefitted from therapy for a limited time, after the introduction of double or triple antiretroviral therapy. The incidence of adverse events was significantly associated with loss of the benefits provided by the initial therapeutic regimen.
Analysis of the Origin and Evolutionary History of HIV-1 CRF28_BF and CRF29_BF Reveals a Decreasing Prevalence in the AIDS Epidemic of Brazil
Natalia Ristic,Jean Zukurov,Wagner Alkmim,Ricardo Sobhie Diaz,Luiz Mario Janini,Mario P. S. Chin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017485
Abstract: HIV-1 subtype B and subtype F are prevalent in the AIDS epidemic of Brazil. Recombinations between these subtypes have generated at least four BF circulating recombinant forms (CRFs). CRF28_BF and CRF29_BF are among the first two BF recombinants being identified in Brazil and they contributed significantly to the epidemic. However, the evolution and demographic histories of the CRFs are unclear.
Evolutionary Dynamics of HIV-1 BF and CB Recombinants and Its Parental Counterparts in South America
élcio Leal, Leonardo O. Martins, L. Mario Janini and Ricardo S. Diaz
Retrovirology: Research and Treatment , 2012,
Abstract: Analysis of the near full-length genomes revealed that the subtype F appeared in Brazilian HIV-1 epidemics at least 10 years after the subtype B. Notably, the BF recombinant emerged almost simultaneously with the introduction of subtype F in Brazil. Analysis of reverse transcriptase fragments indicated that the C subtype originated in the early 1990s, and the CB recombinant emerged 2 years after the appearance of subtype C. The high growth rate of BF recombinant possibly obscured the prevalence of the pure subtype F. In contrast, subtype C, although appearing 20 years after subtype B, was responsible for a well-defined epidemic. Nevertheless, the CB recombinant equally emerged rapidly after the introduction of the second parental (subtype C). Our results suggest that the outcome related to the recombinant profile are probably influenced by the capacity of the newly arriving subtype to establish a critical number of infections before it recombines with the previous circulating subtype.
Evolutionary Dynamics of HIV-1 BF and CB Recombinants and Its Parental Counterparts in South America
élcio Leal,Leonardo O. Martins,L. Mario Janini,Ricardo S. Diaz
Retrovirology: Research and Treatment , 2008,
Abstract: Analysis of the near full-length genomes revealed that the subtype F appeared in Brazilian HIV-1 epidemics at least 10 years after the subtype B. Notably, the BF recombinant emerged almost simultaneously with the introduction of subtype F in Brazil. Analysis of reverse transcriptase fragments indicated that the C subtype originated in the early 1990s, and the CB recombinant emerged 2 years after the appearance of subtype C. The high growth rate of BF recombinant possibly obscured the prevalence of the pure subtype F. In contrast, subtype C, although appearing 20 years after subtype B, was responsible for a well-defined epidemic. Nevertheless, the CB recombinant equally emerged rapidly after the introduction of the second parental (subtype C). Our results suggest that the outcome related to the recombinant profile are probably influenced by the capacity of the newly arriving subtype to establish a critical number of infections before it recombines with the previous circulating subtype.
CALIDAD DE LAS AGUAS SUPERFICIALES DE BAHíA MáLAGA, PACíFICO COLOMBIANO
Betancourt Portela Julián Mauricio,Sánchez Diaz Granados José Gregorio,Mejia Ladino Luz Marina,Cantera Jaime Ricardo
Acta Biológica Colombiana , 2011,
Abstract: El trabajo consistió en un plan de monitoreo que contó con una red de diez estaciones distribuidas en Bahía Málaga, y que fue realizado por muestreos trimestrales entre los a os 2005 y 2006. En esos muestreos se evaluó la calidad de las aguas superficiales mediante la medición de las variables físicoquímicas, microbiológicas, tóxicos orgánicos, hidrocarburos y organoclorados. La cercanía a la Bahía de Buenaventura y la influencia de algunos esteros como Luisico, Valencia, Los Monos y La Sierpe favorece el aporte de materiales biogénicos (N, P, Si) que sostienen la productividad primaria de Bahía Málaga, en la que aún no se evidencian riesgos ambientales por procesos de eutroficación. Los resultados muestran un buen estado la calidad de sus aguas y aportan elementos útiles para las autoridades locales, regionales y nacionales que actualmente gestionan el proceso de declaratoria de la bahía como área Marina Protegida.
Use of carnauba based carrier for copper sprays reduces infection by Xanthomonas citri subsp. citri and Diaporthe citri in Florida commercial grapefruit groves  [PDF]
Jan Narciso, Wilbur Widmer, Christopher Ference, Mark Ritenour, Ricardo Diaz
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.37117
Abstract: Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc), is a bacterial disease of citrus and results in peel blemishes rendering fresh fruit unsalable. Xcc is most active in warm, wet Florida summers where tissues are infected during periods of active growth. Melanose, caused by Diaporthe citri, is common in citrus producing countries, but, like canker, is only important for fresh market fruit. To control canker and melanose, Florida growers spray trees with copper formulations (Cu), but these sprays are removed by strong rains and intense radiation of Florida summers. A study was undertaken in FL commercial grapefruit groves in 2009 and 2010 to assess the efficiency of a spray combining copper with a specially formulated, hydrating wax (WashGard?) (WG). Using a 21-day spray schedule for the season, fruit were sprayed with WG + Cu, Cu and Control (no spray). Fruit from trees sprayed with WG + Cu had approximately 10 and17% more canker free fruit in 2009 and 2010 respectively compared to trees sprayed with copper alone. Compared to control trees the canker free fruit incidence was increased by ≈10% in 2009 and 57% in 2010. For melanose there was 40% more disease free fruit (treated) over fruit from trees with no treatment in 2009 and approximately 20% more in 2010. Controlling infection with this spray significantly reduces citrus canker and melanose, increasing the percentage of marketable fruit.
High Human Herpesvirus 8 (HHV-8) Prevalence, Clinical Correlates and High Incidence among Recently HIV-1-Infected Subjects in Sao Paulo, Brazil
Mariana Dias Batista, Suzete Ferreira, Mariana M. Sauer, Helena Tomiyama, Maria Teresa Maidana Giret, Cláudio S. Pannuti, Ricardo S. Diaz, Ester C. Sabino, Esper G. Kallas
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005613
Abstract: Background Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi Sarcoma, which occurs especially in HIV-infected subjects. HHV-8 infection and its clinical correlates have not been well characterized in recently HIV-1-infected subjects, especially men who have sex with men (MSM). Methodology/ Principal Findings We assessed the HHV-8 seroprevalence, clinical correlates, and incidence after one year of follow-up in a cohort of 228 recently HIV-1-infected individuals, of whom 83.6% were MSM, using indirect immunofluorescence assay. The prevalence of HHV-8 infection at the time of cohort enrollment was 25.9% (59/228). In the univariate model, there were significant associations with male gender, black ethnicity, MSM practice, and previous hepatitis B virus and syphilis infections. In the multivariate model we could still demonstrate association with MSM, hepatitis B, and black ethnicity. No differences in mean CD4+ cell counts or HIV viral load according to HHV-8 status were found. In terms of incidence, there were 23/127 (18.1%) seroconversions in the cohort after 1 year. Conclusions HHV-8 is highly prevalent among recently HIV-1-infected subjects. Correlations with other sexually transmitted infections suggest common transmission routes.
Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil
Maria Teresa M. Giret,Jo?o Luiz Miraglia,Maria Cecília Araripe Sucupira,Anna Nishiya,José Eduardo Levi,Ricardo S. Diaz,Ester C. Sabino,Esper G. Kallas
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018407
Abstract: The results of previous studies elsewhere have indicated that GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus type 1 (HIV-1) due to similar transmission routes of both viruses. The aim of this study was to determine the prevalence, incidence density and genotypic characteristics of GBV-C in this population.
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