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Search Results: 1 - 10 of 3017 matches for " Ricarda Michaela Bauer "
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Vaccination against urinary tract infections caused by E. coli  [PDF]
Hartwig Wilhelm Bauer, Hira Shams, Ricarda Michaela Bauer
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.43A064

Uropathogenic Escherichia coli (UPEC) causes uncomplicated urinary tract infection (UTI) depicts a prevalent and potentially uncompromising infectious disease. In this analysis, we explained the functions of an immunoproteomics concept to vaccine development that has been successfully employed to recognize vaccine targets in other pathogenic bacteria. Pyelonephritis strains E. coli CFT073 are used for outer membrane isolation mimics urinary tract environment in which iron limitation, osmotic stress, human urine, and exposure to uroepithelial cells are included. During experiments of UTI, the antigens that induce the humoral immune response is to identified, two-dimensional gel electrophoresis are employed for the isolation of outer membrane protein and probed using pooled antisera from 20 CBA/J mice chronically infected with E. coli CFT073. 23 total outer membrane antigens, in which a unique iron compound receptor is included, are reacted with antisera and were identified by mass spectrometry. These antigens comprises of proteins with known functions in UPEC pathogenesis such as, ChuA, IroN, IreA, Iha, IutA, and FliC. These all information and data elaborate that these factors are associated with virulence during UTI are directed by antibody response. We also represents that the genes encoding ChuA, IroN, hypothetical protein c2482, and IutA are significantly more prevalent among UPEC strains than among fecal-commensal E. coli isolates. Therefore we concluded that, the outer membrane antigens are identified in this study are conserved, could be reflective part for the UTI vaccine generated to induce protective immunity against UPEC infections.

STAR: predicting recombination sites from amino acid sequence
Denis C Bauer, Mikael Bodén, Ricarda Thier, Elizabeth M Gillam
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-437
Abstract: We present STAR, Site Targeted Amino acid Recombination predictor, which produces a score indicating the structural disruption caused by recombination, for each position in an amino acid sequence. Example predictions contrasted with those of alternative tools, illustrate STAR'S utility to assist in determining useful recombination sites. Overall, the correlation coefficient between the output of the experimentally validated protein design algorithm SCHEMA and the prediction of STAR is very high (0.89).STAR allows the user to explore useful recombination sites in amino acid sequences with unknown structure and unknown evolutionary origin. The predictor service is available from http://pprowler.itee.uq.edu.au/star webcite.Recombinant DNA techniques, such as DNA shuffling, generate more diverse libraries than random mutagenesis with a relatively high fraction of functional proteins [1-4]. Like mutagenesis but unlike de novo protein design, recombination deals with native sequences whose effectiveness for some particular function is established. As protein design tools, recombinatorial techniques dramatically reduce the combinatorial space of possible sequences to an area which can be explored in vitro more easily.Site-directed (as opposed to random) recombination systematically reduces the amino acid sequence space for consideration by identifying specific sites in parental sequences at which their parts can be interchanged [2]. This paper develops and evaluates a method that uses machine learning to suggest recombination sites solely from the amino acid sequences of the parents. Alternative tools may be more precise but require either parents to be structurally resolved [5] or phylogenetically well-characterised [6].SCHEMA predicts structural disruption by gleaning contact maps of parents [5]. The principle of SCHEMA applies to recombination site identification (using SCHEMA's so-called S-profile) or to evaluate the folding potential of specific hybrids (using SCHEMA'
Gender Politics in Indonesia – Recent Developments: An Interview with Yuniyanti Chuzaifah
Ricarda Gerlach
ASEAS : ?sterreichische Zeitschrift für Südostasienwissenschaften , 2010,
Review: Holike, Christine (2008), Islam und Geschlechterpolitiken in Indonesien – Der Einzug der Scharia in die regionale Gesetzgebung Buchbesprechung: Holike, Christine (2008), Islam und Geschlechterpolitiken in Indonesien – Der Einzug der Scharia in die regionale Gesetzgebung
Ricarda Gerlach
Journal of Current Southeast Asian Affairs , 2009,
Abstract: Book Review of Holike, Christine (2008), Islam und Geschlechterpolitiken in Indonesien – Der Einzug der Scharia in die regionale Gesetzgebung, Berlin: regiospectra Verlag; ISBN 978-3-940132-04-8, 101 Seiten Buchbesprechung der Monografie: Holike, Christine (2008), Islam und Geschlechterpolitiken in Indonesien – Der Einzug der Scharia in die regionale Gesetzgebung, Berlin: regiospectra Verlag; ISBN 978-3-940132-04-8, 101 Seiten
Quiet Crash Sites: Antun Mara i ’s Cro Car Crash Chronicle, after War/hol and Usput spomenici/ Sideroad Monuments and Aernout Mik’s Refraction
Ricarda Vidal
Altre Modernità , 2010,
Abstract: With the beginning of modernity death has been pushed to the margins of society. Indeed, for many, the only time they are confronted with death outside their immediate circle of friends or family is the chance encounter with the traffic accident, which is by now the most frequent form of public death in Western society. But while we try to deny death by institutionalising it and banning it from the everyday, the crowds who flock to the sites of accidents and violent deaths manifest our undiminished need to know about death. This essay examines our paradoxical attitude to accident sites, their attraction and repulsion, by looking at three artworks: Antun Maracic's photographic cycles Cro Car Crash Chronicle, after War/hol (2001-2) and Usput spomenici/ Sideroad Monuments (1999-2002) and Aernout Mik's video installation Refraction (2005). Maracic's two photo cycles are compendium works: Cro Car Crash Chronicle consists of a series of black-and-white press photographs of car crashes, and Sideroad Monuments focuses on crosses and memorials which mark the deaths of traffic victims. Mik's Refraction consists of a tripartite installation of a looped silent video of a large-scale traffic accident. In all three works the crash and the crash site are stylised into an aesthetic experience and the gallery becomes a place for the contemplation and acceptance of the fact of death.
Das Imperium als Thema der Russischen Geschichte
Vulpius, Ricarda
Zeitenblicke , 2007,
Aberrations of the Cervical Carotid Artery Which May Be Dangerous in Pharyngeal Surgery—A Computed Tomographic Study  [PDF]
Johannes Gossner, Ricarda Manka, Joerg Larsen
Advances in Computed Tomography (ACT) , 2013, DOI: 10.4236/act.2013.21006

Background: There are recognised variations in the anatomical course of the cervical portion of the internal carotid artery. An aberrant vessel with direct contact to the pharyngeal wall could easily be injured during pharyngeal surgery or may appear as a pharyngeal pseudo mass. Previous anatomical studies predominantly involved older patients. The prevalence of such variations which are at risk of injury during pharyngeal surgery has thus not been established in a general patient population. Material and Methods: The course of the internal carotid artery in relation to the oro and hypopharyngeal walls was retrospectively evaluated bilaterally by simple visual inspection and measurement of the smallest distance between the respective vessels and the adjacent mucosal surface of the pharyngeal wall in 138 consecutive contrast-enhanced computed tomography scans of the neck. Results: 11/138 (7.9%) of patients demonstrated relevant cervical carotid artery aberrations, comprising medial kinking of a vessel with asymmetry of the adjacent pharyngeal lumen and/or an intimate submucous course in the pharyngeal wall with no identifiable separating fat plane. This prevalence increased with age. Simple visual inspection correlated well with the measurement of the smallest distance between an artery and the pharyngeal wall, which was statistically significant (p < 0.0001). Conclusions: The prevalence of about 8% in a general patient population is higher than previously recorded in anatomical studies. Prevalence increases with age. Otorhinolaryngologists should be aware of such variation as a risk factor for haemorrhagic complications during pharyngeal surgery and as a differential diagnosis of pharyngeal mass lesions, especially in older patients. Modern contrast-enhanced CT allows identification and characterisation of any surgically relevant variant vascular anatomy in the pre-operative work-up.

Persistent work-life conflict and health satisfaction - A representative longitudinal study in Switzerland
Michaela K Knecht, Georg F Bauer, Felix Gutzwiller, Oliver H?mmig
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-271
Abstract: The study is based on a representative longitudinal database (Swiss Household Panel), covering a six-year period containing seven waves of data collection. The sample includes 1261 persons, with 636 men and 625 women. Data was analysed by multi-level mixed models and analysis of variance with repeated measures.In the overall sample, there was no linear increase or decrease of work-life conflict detected, in either its time-based or strain-based form. People with higher education were more often found to have a strong work-life conflict (time- and strain-based), and more men demonstrated a strong time-based work-life conflict than women (12.2% vs. 5%). A negative relationship between work-life conflict and health satisfaction over time was found. People reporting strong work-life conflict at every wave reported lower health satisfaction than people with consistently weak work-life conflict. However, the health satisfaction of those with a continuously strong work-life conflict did not decrease during the study period.Both time-based and strain-based work-life conflict are strongly correlated to health satisfaction. However, no evidence was found for a persistent work-life conflict leading to poor health satisfaction.The topic of reconciling work and family has become a prominent issue in the last decade in the society as well as in science. Society has undergone several major social changes, that increased the number of employees who face substantial domestic duties as well as work obligations [1]. Examples for such social developments and trends in labour market are the increasing number of women and mothers joining the workforce, working single parents, dual-income families etc. Hence, there has emerged a considerable branch of research at the interface of work and private life analysing problems of combining work and family.Since both life domains demand resources such as time or energy and these resources are scarce, participating in both domains can generate int
Work-life conflict and musculoskeletal disorders: a cross-sectional study of an unexplored association
Oliver H?mmig, Michaela Knecht, Thomas L?ubli, Georg F Bauer
BMC Musculoskeletal Disorders , 2011, DOI: 10.1186/1471-2474-12-60
Abstract: Survey data collected in 2007 among the workforces of four large companies in Switzerland were used for this study. The study population covered 6091 employees. As the exposure variable and hypothesized risk factor for MSD, WLC was measured by using a 10-item scale based on an established 18-item scale on work-family conflict. The outcome variables used as indicators of MSD were (low) back pain and neck/shoulder pain. Stress as the assumed intervening variable was assessed by a validated single-item measure of general stress perception. Correlation coefficients (r), standardized regression coefficients (β) and multiple adjusted odds ratios (OR) were calculated as measures of association.WLC was found to be quite strongly associated with MSD (β = .21). This association turned out to be substantially confounded by physical strain at work, workload and job autonomy and was considerably reduced but far from being completely eliminated after adjusting for general stress as another identified risk factor of MSD and a proven strong correlate of WLC (r = .44). A significant and relevant association still remained (β = .10) after having controlled for all considered covariates. This association could be fully attributed to only one direction of WLC, namely the work-to-life conflict. In subsequent analyses, a clear gradient between this WLC direction and both types of MSD was found, and proved to be consistent for both men and women. Employees who were most exposed to such work-to-life conflict were also most at risk and showed a fivefold higher prevalence rate (19%-42%) and also an up to sixfold increased relative risk (OR = 3.8-6.3) of suffering greatly from these types of MSD compared with the least exposed reference group showing very low WLC in this direction. Including stress in the regression models again reduced the strength of the association significantly (OR = 1.9-4.1), giving an indication for a possible indirect effect of WLC on MSD mediated by stress.Future rese
Efficacy of Influenza Vaccination and Tamiflu? Treatment – Comparative Studies with Eurasian Swine Influenza Viruses in Pigs
Ralf Duerrwald, Michael Schlegel, Katja Bauer, Théophile Vissiennon, Peter Wutzler, Michaela Schmidtke
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061597
Abstract: Recent epidemiological developments demonstrated that gene segments of swine influenza A viruses can account for antigenic changes as well as reduced drug susceptibility of pandemic influenza A viruses. This raises questions about the efficacy of preventive measures against swine influenza A viruses. Here, the protective effect of vaccination was compared with that of prophylactic Tamiflu? treatment against two Eurasian swine influenza A viruses. 11-week-old pigs were infected by aerosol nebulisation with high doses of influenza virus A/swine/Potsdam/15/1981 (H1N1/1981, heterologous challenge to H1N1 vaccine strain) and A/swine/Bakum/1832/2000 (H1N2/2000, homologous challenge to H1N2 vaccine strain) in two independent trials. In each trial (i) 10 pigs were vaccinated twice with a trivalent vaccine (RESPIPORC? FLU3; 28 and 7 days before infection), (ii) another 10 pigs received 150 mg/day of Tamiflu? for 5 days starting 12 h before infection, and (iii) 12 virus-infected pigs were left unvaccinated and untreated and served as controls. Both viruses replicated efficiently in porcine respiratory organs causing influenza with fever, dyspnoea, and pneumonia. Tamiflu? treatment as well as vaccination prevented clinical signs and significantly reduced virus shedding. Whereas after homologous challenge with H1N2/2000 no infectious virus in lung and hardly any lung inflammation were detected, the virus titre was not and the lung pathology was only partially reduced in H1N1/1981, heterologous challenged pigs. Tamiflu? application did not affect these study parameters. In conclusion, all tested preventive measures provided protection against disease. Vaccination additionally prevented virus replication and histopathological changes in the lung of homologous challenged pigs.
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