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Viral Latency in Blood and Saliva of Simian Foamy Virus-Infected Humans
Rejane Rua, Edouard Betsem, Antoine Gessain
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077072
Abstract: Simian foamy viruses (SFV) are widespread retroviruses among non-human primates (NHP). SFV actively replicate in the oral cavity and can be transmitted to humans through NHP bites, giving rise to a persistent infection. We aimed at studying the natural history of SFV infection in human. We have analyzed viral load and gene expression in 14 hunters from Cameroon previously shown to be infected with a gorilla SFV strain. Viral DNA could be detected by quantitative polymerase chain reaction (q-PCR) targeting the pol-in region, in most samples of peripheral blood mononuclear cells (PBMCs) (7.1 ± 6.0 SFV DNA copies/105 PBMCs) and saliva (2.4 ± 4.3 SFV DNA copies/105 cells) derived from the hunters. However, quantitative real-time reverse-transcription polymerase chain reaction (RT)-qPCR revealed the absence of SFV viral gene expression in both PBMCs and saliva, suggesting that SFV was latent in the human samples. Our study demonstrates that a latent infection can occur in humans and persist for years, both in PBMCs and saliva. Such a scenario may contribute to the putative lack of secondary human-to-human transmissions of SFV.
Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia
Li Zhou, Rejane Rua, Thomas Ng, Valentina Vongrad, Yung S Ho, Carolyn Geczy, Kenneth Hsu, Bruce J Brew, Nitin K Saksena
BMC Infectious Diseases , 2009, DOI: 10.1186/1471-2334-9-192
Abstract: To study activation and infiltration patterns of macrophages, CD8+ T cells in relation to HIV in diverse CNS areas of patients with and without dementia. 46 brain regions from two rapidly progressing severely demented patients and 53 regions from 4 HIV+ non-dementia patients were analyzed. Macrophage and CD8+ T cell infiltration of the CNS in relation to HIV was assessed using immuno-histochemical analysis with anti-HIV (P24), anti-CD8 and anti-CD68, anti-S-100A8 and granzyme B antibodies (cellular activation). Statistical analysis was performed with SPSS 12.0 with Student's t test and ANOVA.Overall, the patterns of infiltration of macrophages and CD8+ T cells were indiscernible between patients with and without dementia, but the co-localization of macrophages and CD8+ T cells along with HIV P24 antigen in the deeper midline and mesial temporal structures of the brain segregated the two groups. This predilection of infected macrophages and CD8+ T cells to the middle part of the brain was unique to both HAD patients, along with unique nature of provirus gag gene sequences derived from macrophages in the midline and mesial temporal structures.Strong predilection of infected macrophages and CD8+ T cells was typical of the deeper midline and mesial temporal structures uniquely in HAD patients, which has some influence on neurocognitive impairment during HIV infection.Human immunodeficiency virus type 1 (HIV-1) is associated with the development of neurological complications in many infected individuals, most especially a broad spectrum of motor impairments and cognitive deficits. Approximately 80-90% of autopsied cases of HIV-1-infected people demonstrated neuropathological changes [1-4]. The histopathology of HIV-associated dementia (HAD) is characterized by brain infiltration of mononuclear cells, formation of multinucleated giant cells, astrogliosis, and neuronal damage sometimes with neuronal loss [5,6]. The underlying mechanisms of HAD leading to neurological disor
First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia
Li Zhou, Eve Diefenbach, Ben Crossett, Sieu L Tran, Thomas Ng, Helen Rizos, Rejane Rua, Bin Wang, Amit Kapur, Kaushal Gandhi, Bruce J Brew, Nitin K Saksena
Molecular Neurodegeneration , 2010, DOI: 10.1186/1750-1326-5-27
Abstract: Here, we have analyzed total proteins from the frontal cortex of 9 HAD and 5 HIV non-dementia patients. Using 2-Dimensional differential in-gel electrophoresis (2-DIGE) to analyze the brain tissue proteome, 76 differentially expressed proteins (p < 0.05; fold change>1.25) were identified between HAD and HIV non-dementia patients, of which 36 protein spots (based on 3D appearance of spots on the images) were chosen for the mass spectrometry analysis. The large majority of identified proteins were represented in the energy metabolic (mitochondria) and signal transduction pathways. Furthermore, over 90% of the protein candidates are common to both HAD and other non-viral neurodegenerative disease, such as Alzheimer's disease. The data was further validated using specific antibodies to 4 proteins (CA2, GS, CKMT and CRMP2) by western blot (WB) in the same samples used for 2D-DIGE, with additional confirmation by immunohistochemitsry (IHC) using frontal lobe tissue from different HAD and HIV+ non-dementia patients. The validation for all 4 antibodies by WB and IHC was in concordance with the DIGE results, lending further credence to the current findings.These results suggest not only convergent pathogenetic pathways for the two diseases but also the possibility of increased Alzheimer's disease (AD) susceptibility in HAD patients whose life expectancy has been significantly increased by highly active antiretroviral therapy.HIV-1 associated dementia (HAD) is a common complication of HIV disease with a prevalence of at least 20% in advanced HIV infection in the pre-highly active antiretroviral therapy (HAART) era [1]. Even in patients taking HAART, milder forms of cognitive impairment remain common and functionally significant [2]. The reasons for the continued presence and development of HAD and its milder forms, despite effective HAART are not clear. Furthermore, due to the longevity of HIV patients after the advent of HAART, the prevalence of HAD has increased [3]. It has
Tem orixá no samba: Clara Nunes e a presen?a do candomblé e da umbanda na música popular brasileira
Bakke, Rachel Rua Baptista;
Religi?o & Sociedade , 2007, DOI: 10.1590/S0100-85872007000200005
Abstract: information about afro-brazilian religions (candomblé and umbanda) often reaches the general public through the phonographic industry, radio and television. brazilian popular music (mpb) is also an important source of information about these religions. for this reason this paper attempts to interpret the ways in which the values from these religions appear on mpb, having as an empirical field the artistic production of clara nunes (analyzes of lyrics, performances in concerts, video clips and appearances in tv shows, as well as the symbols chosen to disseminate her work, shown in lp covers and inner-sleeves).
Os princípios contabilísticos dos planos públicos: análise comparativa do POCP Português e do PGCP Espanhol
Rua,Susana Catarino;
Tékhne - Revista de Estudos Politécnicos , 2006,
Abstract: accounting principles, underlying assumptions or basic hypothesis are one of the elements of the conceptual framework, whose application is indispensable for the information to transmit a true and fair view of the financial, economical and budgetary situation of the entity. both the pocp and the pgcp followed closely the accounting principles determined in the enterprises plans, however taking into account the particularities of the governmental accounting, namely the aspects that distinguish the entities to which they apply. nevertheless, these public plans present differences concerning their accounting principles, in terms of denomination, wording and number of mentioned principles.
Los Estudios de Paleoantropología en el País Vasco.
C. de la Rua
Munibe Antropologia-Arkeologia , 1990,
Abstract: Se hace un breve repaso histórico de los estudios de Paleoantropología en el País Vasco, refiriéndonos al interés despertado por la población vasca en investigadores extranjeros, nacionales y locales, desde fines del siglo pasado. A partir del a o 1919, con las primeras publicaciones del equipo formado por Aranzadi, Barandiarán y Eguren, se inicia una etapa de auténtica orientación antropológica en los estudios de Prehistoria. En esta primera época hay que destacar la contribución de T. de Aranzadi quien, tras definir las características antropológicas de la población vasca actual y de los restos prehistóricos recuperados en sucesivas campa as arqueológicas (1919-1936), formula explícitamente una hipótesis sobre el origen y evolución de la población asentada en el territorio. Marcan el progreso de la Antropología Física en el País Vasco en las últimas décadas, las aportaciones de destacados investigadores (Basabe, Riquet, ...), la incorporación de esta disciplina en el ámbito universitario vasco y el desarrollo de nuevos enfoques metodológicos e interpretativos, con el intento de continuar la labor iniciada por la anterior generación de antropólogos, con una visión abierta y con base genética aplicada a las poblaciones pirenaicas. Por otro lado nos hemos planteado el doble propósito de recoger los estudios más importantes realizados sobre Antropología prehistórica vasca e intentar establecer una síntesis de los pobladores del País Vasco durante los diferentes períodos prehistóricos. Los escasos yacimientos arqueológicos donde se han conservado restos óseos humanos, dificultan el establecimiento de una síntesis antropológica de estos pobladores, por lo menos hasta finales del Pleistoceno. Los escasos restos de Lezetxiki, Axlor, Isturitz y Erralla, constituyen las únicas evidencias humanas del período Paleolítico en el País Vasco. Los conocimientos actuales sobre los cráneos hallados en la Cueva de Urtiaga (atribuidos al Magdaleniense y Aziliense) invalidan en gran medida la base argumental de la hipótesis sobre el origen de las características de la población vasca en épocas paleolíticas. A partir del Neolítico, los restos hallados en los yacimientos del País Vasco (Santimami e, Urtiaga, Atxeta,...) permiten verificar la existencia de algunos de los rasgos característicos de la población vasca, que asimismo se presentan en las estaciones dolménicas pirenaicas. En los yacimientos de regiones más meridionales del País, principalmente en la cuenca del Ebro, se observa a partir del Neo-Eneolítico, una cierta eterogeneidad en la población exhumada, con un
La fiesta de la "mamacha" candelaria de la comunidad de Ocobamba (Apurímac) en Lima
Teófilo Altamirano Rua
Anthropologica , 1989,
Abstract: El artículo no presenta resumen.
Susana Catarino Rua
Revista Universo Contábil , 2009,
Abstract: Com a reforma da Contabilidade Pública em Portugal, e consequentemente a implementa o de planos de contabilidade pública sectoriais, a contabilidade patrimonial ganhou importancia neste sistema contabilístico, sendo necessário definir a composi o e o valor do património de cada entidade pública. A classifica o dos elementos patrimoniais como activos tornou-se uma das preocupa es destas entidades, sendo necessário definir critérios precisos para o seu reconhecimento e valora o. Estes critérios juntamente com um conjunto de conceitos dos elementos das demonstra es financeiras fazem parte da estrutura conceptual t o necessária para a Contabilidade Pública em Portugal. Partindo do conceito de activo das empresas e dos seus critérios de reconhecimento, e atendendo às particularidades das entidades públicas poderemos definir um conceito de activo público bem como critérios para o seu reconhecimento e para a sua valora o, aos quais um elemento deverá necessariamente obedecer para que possa constar no balan o de uma determinada entidade pública, compondo dessa forma o seu património. As a result of the Governmental Accounting reform in Portugal, and consequently the implementation of sectorial governmental accounting plans, the patrimonial accounting received importance in this accounting system, being needed to define the elements and the value of the patrimony of each public entity. The classification of the patrimonial elements as assets became one of the concerns of those entities, being necessary to define accurate criteria for their recognition and measurement. These criteria, with a group of concepts of the elements of the financial statements, are part of the conceptual framework necessary for the Governmental Accounting in Portugal. From the concept of asset of the companies and from their recognition criteria, and considering the particularities of the public entities, we will be able to define a concept of public asset, as well as criteria, for its recognition and its measurement, to which an element must obey so as to be reported in the balance-sheet of a certain public entity, and in that way being part of its patrimony.
Focko Weberling (1926-2009)
Gabriel H. Rua
Boletín de la Sociedad Argentina de Botánica , 2009,
Numerical approximation of conditionally invariant measures via Maximum Entropy
Christopher Bose,Rua Murray
Mathematics , 2012,
Abstract: It is well known that open dynamical systems can admit an uncountable number of (absolutely continuous) conditionally invariant measures (ACCIMs) for each prescribed escape rate. We propose and illustrate a convex optimisation based selection scheme (essentially maximum entropy) for gaining numerical access to some of these measures. The work is similar to the Maximum Entropy (MAXENT) approach for calculating absolutely continuous invariant measures of nonsingular dynamical systems, but contains some interesting new twists, including: (i) the natural escape rate is not known in advance, which can destroy convex structure in the problem; (ii) exploitation of convex duality to solve each approximation step induces important (but dynamically relevant and not at first apparent) localisation of support; (iii) significant potential for application to the approximation of other dynamically interesting objects (for example, invariant manifolds).
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