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Search Results: 1 - 10 of 408705 matches for " Regina M Reilly "
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Pore dilation occurs in TRPA1 but not in TRPM8 channels
Jun Chen, Donghee Kim, Bruce R Bianchi, Eric J Cavanaugh, Connie R Faltynek, Philip R Kym, Regina M Reilly
Molecular Pain , 2009, DOI: 10.1186/1744-8069-5-3
Abstract: Abundantly expressed in sensory neurons, TRPV1, TRPA1 and TRPM8 are involved in sensory function, pain and neurogenic inflammation [1]. The function of these ion channels has been attributed to their ability to pass certain ion species across the plasma membrane. Once activated, TRPV1, TRPA1 and TRPM8 are permeable to small cations such as Ca2+, K+, Na+; hence, channel activation simultaneously depolarizes the plasma membrane and raises intracellular Ca2+, which subsequently triggers a variety of physiological processes. By analogy to voltage-gated K+ channels, it is assumed that ion selectivity of TRP channels should be an invariant signature to the respective channel. However, this notion has been challenged recently. When activated, TRPV1 exhibits time and agonist-dependent changes in ion selectivity [2]. In fact, TRPV1 undergoes pore dilation and allows permeation of large organic cations, including spermine (202.3 Da), NMDG (195.2 Da), Yo-Pro (376 Da), gentamycin (477.6 Da) and QX-314 [3-7]. Here we explored whether TRPA1 and TRPM8 undergo pore dilation by examining Yo-Pro uptake and changes in ion selectivity upon channel activation.Yo-Pro is a divalent cation impermeable to the plasma membrane. However, under certain conditions, it can enter cells, bind nucleic acids and emit fluorescence. Hence the uptake of Yo-Pro has been used previously as an indicator of pore dilation [2,8,9]. In HEK293-F cells transiently expressing rat TRPA1, allyl isothiocyanate (AITC) evoked robust increases in intracellular Ca2+ (Fig. 1A). Concomitantly, AITC also induced Yo-Pro uptake in a concentration-dependent manner (Fig. 1B). At higher concentrations of AITC (100 or 300 μM), the increase in fluorescence was immediately noticeable and continued to increase for about 50 min. In addition, AITC also induced Ca2+ influx and Yo-Pro uptake in cells expressing human TRPA1 and mouse TRPA1, but not in untransfected cells (data not shown). In cells expressing human TRPM8, menthol activat
Locally closed sets and LC-continuous functions
M. Ganster,I. L. Reilly
International Journal of Mathematics and Mathematical Sciences , 1989, DOI: 10.1155/s0161171289000505
Abstract: In this paper we introduce and study three different notions of generalized continuity, namely LC-irresoluteness, LC-continuity and sub-LC-continuity. All three notions are defined by using the concept of a locally closed set. A subset S of a topological space X is locally closed if it is the intersection of an open and a closed set. We discuss some properties of these functions and show that a function between topological spaces is continuous if and only if it is sub-LC-continuous and nearly continuous in the sense of Ptak. Several examples are provided to illustrate the behavior of these new classes of functions.
On potential energies and constraints in the dynamics of rigid bodies and particles
Oliver M. O'reilly,Arun R. Srinivasa
Mathematical Problems in Engineering , 2002, DOI: 10.1080/10241230215286
Abstract: A new treatment of kinematical constraints and potential energies arising in the dynamics of systems of rigid bodies and particles is presented which is suited to Newtonian and Lagrangian formulations. Its novel feature is the imposing of invariance requirements on the constraint functions and potential energy functions. These requirements are extensively used in continuum mechanics and, in the present context, one finds certain generalizations of Newton's third law of motion and an elucidation of the nature of constraint forces and moments. One motivation for such a treatment can be found by considering approaches where invariance requirements are ignored. In contrast to the treatment presented in this paper, it is shown that this may lead to a difficulty in formulating the equations governing the motion of the system.
Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia
Kelly M Reilly, David F Kisor
OncoTargets and Therapy , 2009, DOI: http://dx.doi.org/10.2147/OTT.S4770
Abstract: ofile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia Review (4655) Total Article Views Authors: Kelly M Reilly, David F Kisor Published Date August 2009 Volume 2009:2 Pages 219 - 228 DOI: http://dx.doi.org/10.2147/OTT.S4770 Kelly M Reilly1, David F Kisor2 1Department of Pharmacy Practice, 2Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, Ohio Northern University, Ada, Ohio, USA Abstract: Nelarabine is the prodrug of 9-β-arabinofuranosylguanine (ara-G) and is therapeutically classified as a purine nucleoside analog. Nelarabine is converted to ara-G by adenosine deaminase and transported into cells by a nucleoside transporter. Ara-G is subsequently phosphorylated to ara-G triphosphate (ara-GTP), thereby initiating the therapeutic effect by inhibiting DNA synthesis. Nelarabine has been extensively studied in regards to its pharmacokinetics, and the data have demonstrated that ara-GTP preferentially accumulates in malignant T-cells. Clinical responses to nelarabine have been demonstrated in various T-cell malignancies and appear to correlate with a relatively high intracellular concentration of ara-GTP compared to nonresponders. Therefore, this unique drug feature of nelarabine accounts for clinical utilization in treating adult and pediatric patients with relapsed or refractory T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma. Neuropathy is the most predominant adverse effect associated with nelarabine and the incidence correlates with the dose administered. Myelosuppression has been observed, with thrombocytopenia and neutropenia as the most common hematologic complications. This article reviews the pharmacology, mechanism of action, and pharmacokinetic properties of nelarabine, as well as nelarabine's clinical efficacy in T-ALL, T-LBL, and other hematologic malignancies. The toxicity profile, dosage, and administration, and areas of ongoing and future research, are also presented.
A note on weakly -continuous functions
M. Mr?evi?,I. L. Reilly
International Journal of Mathematics and Mathematical Sciences , 1989, DOI: 10.1155/s0161171289000025
Abstract: Recently a new class of functions between topological spaces, called weakly -continuous functions, has been introduced and studied. In this paper we show how an appropriate change of topology on the domain of a weakly -continuous function reduces it to a weakly continuous function. This paper examines some of the consequences of this result.
On potential energies and constraints in the dynamics of rigid bodies and particles
O'reilly Oliver M.,Srinivasa Arun R.
Mathematical Problems in Engineering , 2002,
Abstract: A new treatment of kinematical constraints and potential energies arising in the dynamics of systems of rigid bodies and particles is presented which is suited to Newtonian and Lagrangian formulations. Its novel feature is the imposing of invariance requirements on the constraint functions and potential energy functions. These requirements are extensively used in continuum mechanics and, in the present context, one finds certain generalizations of Newton's third law of motion and an elucidation of the nature of constraint forces and moments. One motivation for such a treatment can be found by considering approaches where invariance requirements are ignored. In contrast to the treatment presented in this paper, it is shown that this may lead to a difficulty in formulating the equations governing the motion of the system.
Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia
Kelly M Reilly,David F Kisor
OncoTargets and Therapy , 2009,
Abstract: Kelly M Reilly1, David F Kisor21Department of Pharmacy Practice, 2Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, Ohio Northern University, Ada, Ohio, USAAbstract: Nelarabine is the prodrug of 9-β-arabinofuranosylguanine (ara-G) and is therapeutically classified as a purine nucleoside analog. Nelarabine is converted to ara-G by adenosine deaminase and transported into cells by a nucleoside transporter. Ara-G is subsequently phosphorylated to ara-G triphosphate (ara-GTP), thereby initiating the therapeutic effect by inhibiting DNA synthesis. Nelarabine has been extensively studied in regards to its pharmacokinetics, and the data have demonstrated that ara-GTP preferentially accumulates in malignant T-cells. Clinical responses to nelarabine have been demonstrated in various T-cell malignancies and appear to correlate with a relatively high intracellular concentration of ara-GTP compared to nonresponders. Therefore, this unique drug feature of nelarabine accounts for clinical utilization in treating adult and pediatric patients with relapsed or refractory T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma. Neuropathy is the most predominant adverse effect associated with nelarabine and the incidence correlates with the dose administered. Myelosuppression has been observed, with thrombocytopenia and neutropenia as the most common hematologic complications. This article reviews the pharmacology, mechanism of action, and pharmacokinetic properties of nelarabine, as well as nelarabine's clinical efficacy in T-ALL, T-LBL, and other hematologic malignancies. The toxicity profile, dosage, and administration, and areas of ongoing and future research, are also presented.Keywords: nelarabine, T-cell acute lymphoblastic leukemia, 9-beta-D-arabinofuranosyl guanine, ara-G
Direct measurement of the maximum tunnel rate in a radio frequency single electron transistor operated as a microwave mixer
D. J. Reilly,T. M. Buehler
Physics , 2004, DOI: 10.1063/1.2093929
Abstract: By operating the radio frequency single electron transistor (rf-SET) as a mixer we present measurements in which the RC roll-off of the tunnel junctions is observed at high frequencies. Our technique makes use of the non-linear rf-SET transconductance to mix high frequency gate signals and produce difference-frequency components that fall within the bandwidth of the rf-SET. At gate frequencies >15GHz the induced charge on the rf-SET island is altered on time-scales faster than the inverse tunnel rate, preventing mixer operation. We suggest the possibility of utilizing this technique to sense high frequency signals beyond the usual rf-SET bandwidth.
用放射性磷检测大田小麦的衰老
M.,L.,Reilly,唐永金
麦类作物学报 , 1987, DOI: 10.7606/j.issn.1009-1041.1987.06.110
Abstract: 用游离态放射性磷半衰期的迅速释放表示小麦旗叶开始衰老的特征(Morris等,1985),就使~(32)P示踪成为研究衰老过程的一种有用手段.小麦抽穗时,不同品种的旗叶经放射性同位素处理后恢复的程度和速率大不相同(Reilly等,1984).初步的大田研究表明,选定处理时间是关键.处理太早,示踪元素会不令人满意地移向第二、三、四幼叶的居间分生组织;抽穗后处理,示踪元素就直接向正在发育的穗移动而不在叶片中形成稳固的基线;恰在抽穗之
Legal and Sociological Analyses on Telework at Home in Brazil  [PDF]
Márcia Regina Castro Barroso
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.26057
Abstract: This text is a small adaptation of our Master-degree’s dissertation, which had telework performed in Brazilian homes as its main goal. The research as a whole focused on both sociological and legal analyses of the aspects of telework, regarding flexible work schedules, legislation on distance work, hierarchical relationships, space and time organization of work utilizing telematic means, as well as perceptions of the actors involved with this activity. In this paper, the legal aspects of telework in Brazil will be emphasized.
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