oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 600 )

2018 ( 910 )

2017 ( 909 )

2016 ( 1265 )

Custom range...

Search Results: 1 - 10 of 548341 matches for " Regina C.M. Succi "
All listed articles are free for downloading (OA Articles)
Page 1 /548341
Display every page Item
Altera??es metabólicas da síndrome lipodistrófica do HIV
Valente, Angélica M.M.;Reis, André F.;Machado, Daisy M.;Succi, Regina C.M.;Chacra, Antonio R.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2005, DOI: 10.1590/S0004-27302005000600004
Abstract: the introduction of highly active antiretroviral therapy (haart) has reduced morbidity and mortality in patients infected with the human immunodeficiency virus (hiv). however, prolonged treatment with combination regimens can be difficult to sustain because of problems with adherence and toxic effects. treatment with antiretroviral agents - protease inhibitors in particular - has uncovered a syndrome of abnormal fat redistribution, impaired glucose metabolism, insulin resistance and dyslipidemia, collectively termed lipodystrophy syndrome (slhiv). nowadays, no clinical guidelines are available for the prevention or treatment of slhiv, and its cause have yet to be totally elucidated. this review emphasizes the clinical features and the data from previous studies about the slhiv taking into account that a better understanding of this syndrome for hiv specialists, cardiologists and endocrinologists is fundamental for the disease control.
Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal
Fatema A. Legrand, Douglas F. Nixon, Christopher P. Loo, Erika Ono, Joan M. Chapman, Maristela Miyamoto, Ricardo S. Diaz, Amélia M.N. Santos, Regina C.M. Succi, Jacob Abadi, Michael G. Rosenberg, Maria Isabel de Moraes-Pinto, Esper G. Kallas
PLOS ONE , 2006, DOI: 10.1371/journal.pone.0000102
Abstract: Background In utero transmission of HIV-1 occurs on average in only 3%–15% of HIV-1-exposed neonates born to mothers not on antiretroviral drug therapy. Thus, despite potential exposure, the majority of infants remain uninfected. Weak HIV-1-specific T-cell responses have been detected in children exposed to HIV-1, and potentially contribute to protection against infection. We, and others, have recently shown that the removal of CD4+CD25+ T-regulatory (Treg) cells can reveal strong HIV-1 specific T-cell responses in some HIV-1 infected adults. Here, we hypothesized that Treg cells could suppress HIV-1-specific immune responses in young children. Methodology/Principal Findings We studied two cohorts of children. The first group included HIV-1-exposed-uninfected (EU) as well as unexposed (UNEX) neonates. The second group comprised HIV-1-infected and HIV-1-EU children. We quantified the frequency of Treg cells, T-cell activation, and cell-mediated immune responses. We detected high levels of CD4+CD25+CD127? Treg cells and low levels of CD4+ and CD8+ T cell activation in the cord blood of the EU neonates. We observed HIV-1-specific T cell immune responses in all of the children exposed to the virus. These T-cell responses were not seen in the cord blood of control HIV-1 unexposed neonates. Moreover, the depletion of CD4+CD25+ Treg cells from the cord blood of EU newborns strikingly augmented both CD4+ and CD8+ HIV-1-specific immune responses. Conclusions/Significance This study provides new evidence that EU infants can mount strong HIV-1-specific T cell responses, and that in utero CD4+CD25+ T-regulatory cells may be contributing to the lack of vertical transmission by reducing T cell activation.
Auditoria dos programas de preven??o de perdas auditivas em Curitiba (PPPA)
Cavalli, Regina C.M.;Morata, Thais C.;Marques, Jair M.;
Revista Brasileira de Otorrinolaringologia , 2004, DOI: 10.1590/S0034-72992004000300013
Abstract: aim: the objective of this study is to examine if the hearing loss prevention practices in industries located in the greater curitiba area are meeting legal requirements and scientific recommendations. study design: transversal cohort. material and method: a questionnaire prepared by the american national institute for occupational safety and health, niosh, in 1996, for auditing hearing loss prevention programs (hlpp) was used as an instrument for data collection. this instrument has 89 questions, divided in eight themes about the following aspects of hlpp programs: training and education, supervisor involvement, noise measurement, engineering and administrative controls, monitoring audiometry, record keeping, referrals, hearing protections devices and administrative aspects. the data was collected through interviews with occupational physicians, engineers and/or safety technicians. the industries were divided in two groups: one composed of industries with hlpps and another without hlpps. conclusion: no significant difference was observed between groups and both meet, in part, the legal requirements for hearing loss prevention. questions about practices that exceed the legal requirements indicated that industries with hlpps dedicated greater efforts to hearing loss prevention. through the data analysis, we could identify the strengths and weaknesses of the hlpp programs in this region of brazil. this information can lead to the proposal of more effective preventive measures and legislation revisions.
Experience with molecular and cytogenetic diagnosis of fragile X syndrome in Brazilian families
Mingroni-Netto, Regina C.;Pavanello, Rita C.M.;Otto, Paulo A.;Vianna-Morgante, Angela M.;
Brazilian Journal of Genetics , 1997, DOI: 10.1590/S0100-84551997000400028
Abstract: we report on the cytogenetic and dna analysis of 55 families with the fragile x (fmr-1 locus) mutation (318 individuals and 15 chorionic villi samples). a total of 129 males were investigated, 54 mentally normal and 75 presenting mental retardation. among the 54 normal males, 11 had the premutation, and none expressed the fragile site. the full mutation was detected in 73 retarded males, and 14 (18%) presented a premutation along with the full mutation (mosaics). all of them manifested the fragile site. the frequencies of fragile site expression correlated positively with the sizes of the expansion of the cgg repeats (d). among 153 normal females, 85 were found to be heterozygous for the premutation and 15 had the full mutation. in the premutated females the fragile site was not observed or it occurred at frequencies that did not differ from those observed in 53 noncarriers. cytogenetic analysis was thus ineffective for the diagnosis of premutated males or females. among the 51 heterozygotes for the full mutation, 36 (70%) had some degree of mental impairment. as in males, a positive correlation was detected between the frequencies of fragile site manifestation and the size of the expansion. however, the cytogenetic test was less effective for the detection of fully mutated females, than in the case of males, since 14% false negative results were found among females. segregation analysis confirmed that the risk of mental retardation in the offspring of heterozygotes increases with the length of d. the average observed frequency of mental retardation in the offspring of all heterozygotes was 30%. there was no indication of meiotic drive occurring in female carriers, since the number of individuals who inherited the mutation did not differ from the number of those inheriting the normal allele. no new mutations were detected in the 55 genealogies studied here.
Experience with molecular and cytogenetic diagnosis of fragile X syndrome in Brazilian families
Mingroni-Netto Regina C.,Pavanello Rita C.M.,Otto Paulo A.,Vianna-Morgante Angela M.
Brazilian Journal of Genetics , 1997,
Abstract: We report on the cytogenetic and DNA analysis of 55 families with the fragile X (FMR-1 locus) mutation (318 individuals and 15 chorionic villi samples). A total of 129 males were investigated, 54 mentally normal and 75 presenting mental retardation. Among the 54 normal males, 11 had the premutation, and none expressed the fragile site. The full mutation was detected in 73 retarded males, and 14 (18%) presented a premutation along with the full mutation (mosaics). All of them manifested the fragile site. The frequencies of fragile site expression correlated positively with the sizes of the expansion of the CGG repeats (D). Among 153 normal females, 85 were found to be heterozygous for the premutation and 15 had the full mutation. In the premutated females the fragile site was not observed or it occurred at frequencies that did not differ from those observed in 53 noncarriers. Cytogenetic analysis was thus ineffective for the diagnosis of premutated males or females. Among the 51 heterozygotes for the full mutation, 36 (70%) had some degree of mental impairment. As in males, a positive correlation was detected between the frequencies of fragile site manifestation and the size of the expansion. However, the cytogenetic test was less effective for the detection of fully mutated females, than in the case of males, since 14% false negative results were found among females. Segregation analysis confirmed that the risk of mental retardation in the offspring of heterozygotes increases with the length of D. The average observed frequency of mental retardation in the offspring of all heterozygotes was 30%. There was no indication of meiotic drive occurring in female carriers, since the number of individuals who inherited the mutation did not differ from the number of those inheriting the normal allele. No new mutations were detected in the 55 genealogies studied here.
Seguridad y Calidad en Medicina Intensiva
Romero,C.M.;
Medicina Intensiva , 2009,
Abstract: the safety and quality care are two attributes of the health care that are closely intertwined. quality is a feature of the system that delivers health care, thereby improving it, we need a proper reorganization teamwork. measurements of quality are intended to assess whether the process of health care reaches the desired objectives, while avoiding the processes that predispose to harm the patient. the critically ill patients are vulnerable to medical errors, and may experience side effects preventable, often associated with: medications, mechanical ventilation, and intravascular devices. the evidence currently available suggest that the safety and quality of care can be improved. in this article presents some of the strategies and interventions developed to optimize the processes of care in critically ill patients, and improve the safety culture in the icu.
Reimmunization after bone marrow transplantation: current recommendations and perspectives
Machado, C.M.;
Brazilian Journal of Medical and Biological Research , 2004, DOI: 10.1590/S0100-879X2004000100021
Abstract: autologous and allogeneic bone marrow transplantation (bmt) recipients lose immune memory of exposure to infectious agents and vaccines accumulated through a lifetime and therefore need to be revaccinated. diphtheria toxoid, tetanus toxoid, pertussis vaccine (children <7 years old), haemophilus influenzae type b conjugate, 23-valent pneumococcal polysaccharide, inactivated influenza vaccine, inactivated polio vaccine and live-attenuated measles-mumps-rubella vaccine are the currently recommended vaccines to be included in a vaccination program after bmt. for most of them, the best time to vaccinate, the number of vaccine doses and/or the duration of immunity after vaccination have not been established. vaccination protocols vary greatly among bmt centers, suggesting that the lack of sufficient data has not permitted the formulation of reliable recommendations. the use of other vaccines and the perspectives for different vaccination protocols are analyzed in this review.
A física de Aristóteles: uma constru??o ingênua?
Porto, C.M;
Revista Brasileira de Ensino de Física , 2009, DOI: 10.1590/S1806-11172009000400019
Abstract: in this work we make a brief exposition on aristotle's physics. we show how aristotelic science constitutes a complex export towards a rational understanding of material reality, completely integrated to an organic and comprehensive thought. we intended to show, above all, how physical and cosmological aristotelic elements come from philosophical tenets as much as from empirical observations characteristic of human experience belonging to that historic-cultural moment.
The Extent to Which Incentives Influence Primary School Teachers Job Satisfaction in Botswana
C.M. Mhozya
The Social Sciences , 2013,
Abstract: A descriptive survey using questionnaires, individual interviews and career histories of primary school teachers was conducted to investigate job satisfaction of teachers as regard to teacher incentives. The study also went further to find out whether there is any link between incentives and gender. Stratified sample from the population of primary school teachers from urban as well as rural areas in Botswana was used. Qualitative data analyses were presented through the use of frequency tables, calculation of percentages and cross tabulations. Information from all sources was triangulated. The study reveals that statistically significant number of teachers were of the view that their salaries were not enough as compared to their workloads. They clearly showed that there were no well set promotion procedures as all progressions depended solely on the school heads recommendation which were confidential and corrupt. The results also showed that teachers did not link, incentives with gender matters instead they ascribed their disadvantages to their poor qualification and hierarchical structures that limits their progression. Three recommendations were made on the basis of the findings.
Effects of Organic Manure Types on Root-Gall Nematode Disease and African Yam Bean Yield
C.M. Agu
Plant Sciences Research , 2013,
Abstract: Evaluation of the effects of different organic manures on root-gall nematode disease on African yam bean was conducted in a sandy loam soil naturally infested with a root-gall nematode, Meloidogyne incognita. The experiment was conducted in a randomized complete block design with four replications. African yam bean plant were treated with sawdust, municipal garbage, swine, compost, poultry and farmyard manures at 2.5 ton ha 1. Results showed that severe root galls occurred on plants treated with sawdust and rare galls on those treated with poultry and farmyard manures. Growth and yield characteristics of the plant were also affected by root-gall damage at the various organic manure treatments.
Page 1 /548341
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.