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Search Results: 1 - 10 of 2905 matches for " Rebecca Sutphen "
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Study of the Molecular Recognition of Aptamers Selected through Ovarian Cancer Cell-SELEX
Dimitri Van Simaeys,Dalia López-Colón,Kwame Sefah,Rebecca Sutphen,Elizabeth Jimenez,Weihong Tan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013770
Abstract: Ovarian cancer is the most lethal gynecological malignancy, and the ovarian clear cell carcinoma subtype (OCCA) demonstrates a particularly poor response to standard treatment. Improvements in ovarian cancer outcomes, especially for OCCA, could be expected from a clearer understanding of the molecular pathology that might guide strategies for earlier diagnosis and more effective treatment.
How Healthy Are We? A National Study of Well-Being at Midlife (Orville G. Brim, Carol D. Ryff, Ronald C. Kessler, Editors)
Sussan K. Sutphen
Preventing Chronic Disease , 2004,
Abstract: Every human being is the author of his own health or disease. Siddhartha Gautama, The Buddha, 563 483 BC Many Americans might agree with this statement, but if asked to rate their own physical, mental, and health beliefs, what would their responses be? How would they respond at midlife? How Healthy Are We? A National Study of Well-Being at Midlife answers these questions. In 1990, The John D. and Catherine T. MacArthur Foundation established the Research Network on Successful Midlife Development (MIDMAC), directed by one of the book s editors, Orville Brim. The multidisciplinary network was tasked with examining adults aged 40 to 60 as part of the foundation s series of studies on midlife development. MIDMAC identified the following goals: Establish specific indicators for a successful midlife. Establish a factual basis for the course of midlife. Identify factors that may influence the course of midlife development. Identify strategies that individuals may use to deal with midlife challenges. MIDMAC developed a national survey known as MIDUS (Midlife Development in the United States) (available at http://midmac.med.harvard.edu/research.html*) to help meet these goals. In How Healthy Are We?, Brim and colleagues present a collection of articles that summarize MIDUS survey findings.
Measurement of Phospholipids May Improve Diagnostic Accuracy in Ovarian Cancer
Lian Shan, Y. Ann Chen, Lorelei Davis, Gang Han, Weiwei Zhu, Ashley D. Molina, Hector Arango, James P. LaPolla, Mitchell S. Hoffman, Thomas Sellers, Tyler Kirby, Santo V. Nicosia, Rebecca Sutphen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046846
Abstract: Background More than two-thirds of women who undergo surgery for suspected ovarian neoplasm do not have cancer. Our previous results suggest phospholipids as potential biomarkers of ovarian cancer. In this study, we measured the serum levels of multiple phospholipids among women undergoing surgery for suspected ovarian cancer to identify biomarkers that better predict whether an ovarian mass is malignant. Methodology/Principal Findings We obtained serum samples preoperatively from women with suspected ovarian cancer enrolled through a prospective, population-based rapid ascertainment system. Samples were analyzed from all women in whom a diagnosis of epithelial ovarian cancer (EOC) was confirmed and from benign disease cases randomly selected from the remaining (non-EOC) samples. We measured biologically relevant phospholipids using liquid chromatography/electrospray ionization mass spectrometry. We applied a powerful statistical and machine learning approach, Hybrid huberized support vector machine (HH-SVM) to prioritize phospholipids to enter the biomarker models, and used cross-validation to obtain conservative estimates of classification error rates. Results The HH-SVM model using the measurements of specific combinations of phospholipids supplements clinical CA125 measurement and improves diagnostic accuracy. Specifically, the measurement of phospholipids improved sensitivity (identification of cases with preoperative CA125 levels below 35) among two types of cases in which CA125 performance is historically poor - early stage cases and those of mucinous histology. Measurement of phospholipids improved the identification of early stage cases from 65% (based on CA125) to 82%, and mucinous cases from 44% to 88%. Conclusions/Significance Levels of specific serum phospholipids differ between women with ovarian cancer and those with benign conditions. If validated by independent studies in the future, these biomarkers may serve as an adjunct at the time of clinical presentation, to distinguish between women with ovarian cancer and those with benign conditions with shared symptoms and features.
Strong Signature of Natural Selection within an FHIT Intron Implicated in Prostate Cancer Risk
Yan Ding, Garrett Larson, Guillermo Rivas, Cathryn Lundberg, Louis Geller, Ching Ouyang, Jeffrey Weitzel, John Archambeau, Jerry Slater, Mary B. Daly, Al B. Benson, John M. Kirkwood, Peter J. O'Dwyer, Rebecca Sutphen, James A. Stewart, David Johnson, Magnus Nordborg, Theodore G. Krontiris
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003533
Abstract: Previously, a candidate gene linkage approach on brother pairs affected with prostate cancer identified a locus of prostate cancer susceptibility at D3S1234 within the fragile histidine triad gene (FHIT), a tumor suppressor that induces apoptosis. Subsequent association tests on 16 SNPs spanning approximately 381 kb surrounding D3S1234 in Americans of European descent revealed significant evidence of association for a single SNP within intron 5 of FHIT. In the current study, re-sequencing and genotyping within a 28.5 kb region surrounding this SNP further delineated the association with prostate cancer risk to a 15 kb region. Multiple SNPs in sequences under evolutionary constraint within intron 5 of FHIT defined several related haplotypes with an increased risk of prostate cancer in European-Americans. Strong associations were detected for a risk haplotype defined by SNPs 138543, 142413, and 152494 in all cases (Pearson's χ2 = 12.34, df 1, P = 0.00045) and for the homozygous risk haplotype defined by SNPs 144716, 142413, and 148444 in cases that shared 2 alleles identical by descent with their affected brothers (Pearson's χ2 = 11.50, df 1, P = 0.00070). In addition to highly conserved sequences encompassing SNPs 148444 and 152413, population studies revealed strong signatures of natural selection for a 1 kb window covering the SNP 144716 in two human populations, the European American (π = 0.0072, Tajima's D = 3.31, 14 SNPs) and the Japanese (π = 0.0049, Fay & Wu's H = 8.05, 14 SNPs), as well as in chimpanzees (Fay & Wu's H = 8.62, 12 SNPs). These results strongly support the involvement of the FHIT intronic region in an increased risk of prostate cancer.
Pricing Currency Call Options  [PDF]
Rebecca Abraham
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.811148
Abstract: This paper presents a theoretical model to price foreign currency call options. Currency options are employed in international trade to reduce the risk of loss due to the reduction of revenues obtained in depreciating foreign currency for an exporter, or the escalation of expense from appreciating foreign currency for an importer. Other users include banks and hedge funds who engage in currency speculation. Given the fluctuation of option prices over time, the model describes the distribution of foreign currency as a Weiner process for macroeconomically constrained foreign currencies followed by a Laplace distribution for unconstrained currencies. In a departure from existing currency option models, this model expresses foreign currencies as dependent upon the change in macroeconomic variables, such as inflation, interest rates, and government deficits. The distribution of currency calls is described as a Levy process in the context of an option trader’s risk preferences to account for the multiple discontinuities of a jump process. The paper concludes with three models of price functions of the Weiner process for Euro-related currency options, a Weiner process for stable currency options, and a Levy-Khintchine process for volatile currency calls.
The Valuation of Currency Put Options  [PDF]
Rebecca Abraham
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.811165
Abstract: Investors who seek to profit from depreciating currencies may invest in put options. Upon option exercise, the currency is sold at a high price, and then purchased at the lower future currency value, resulting in a gain for the put buyer. A series of such transactions yields a stream of income for the put investor. Alternatively, the investor could short sell the currency, reaping gains from the difference between the high short sale price and the low future purchase price. This paper derives the theoretical formulations for combined short sale and puts purchase strategies for the US dollar, the Euro, the Australian dollar and the New Zealand dollar, and the Mexican peso. Utility functions are based upon an assumption of declining risk aversio with negative rescale factors and positive threshold factors in a hyperbolic cosine distribution. This distribution intersects with the cosine distribution of short sale prices on the U. S. dollar, the lognormal distribution of short sale prices on the Euro, the Weiner process for shorts on the Australian dollar and the New Zealand dollar, and the Laplace currency distribution for peso shorts. Similar utility functions intersect with Levy-Khintchine jump processes to provide put option prices for each type of foreign currency.
Hedge Fund Investing or Mutual Fund Investing: An Application of Multi-Attribute Utility Theory  [PDF]
Rebecca Abraham
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.94042
Abstract: This paper contrasts high-risk, hedge fund trading, with low-risk, mutual fund trading, in terms of their differing utility functions. We envision hedge funds, led by informed traders who use information to seek out investment opportunities, timing market conditions, with the expectation that prices will move in their favor. Directional hedge funds act to influence prices, while non-directional hedge funds do not act to influence prices. We present utility functions based on steeply-sloping Laplace distributions and hyperbolic cosine distributions, to describe the actions of directional hedge fund traders. Less steeply-sloping lognormal distributions, Coulomb wave functions, quadratic utility functions, and Bessel utility functions are used to describe the investing style of non-directional hedge fund traders. Flatter Legendre utility functions and inverse sine utility functions describe the modest profit-making aspirations of mutual fund traders. The paper’s chief contribution is to develop optimal prices quantitatively, by intersecting utility functions with price distributions. Price distributions for directional hedge fund returns are portrayed as sharp increases and decreases, in the form of jumps, in a discrete arrival Poisson-distributed process. Separate equations are developed for directional hedge fund strategies, including event-driven arbitrage, and global macro strategies. Non-directional strategies include commodity trading, risk-neutral arbitrage, and convertible arbitrage, with primarily lognormal pricing distributions, and some Poisson jumps. Mutual funds are perceived to be Markowitz portfolios, lying on the Capital Market Line, or the International Capital Market Line, tangent to the Efficient Frontier of minimum variance-maximum return portfolios.
Design and Implementation of a 3D Undersea Camera System
Xida Chen,Steve Sutphen,Paul Macoun,Yee-Hong Yang
Computer Science , 2015,
Abstract: In this paper, we present the design and development of an undersea camera system. The goal of our system is to provide a 3D model of the undersea habitat in a long-term continuous manner. The most important feature of our system is the use of multiple cameras and multiple projectors, which is able to provide accurate 3D models with an accuracy of a millimeter. By introducing projectors in our system, we can use many different structured light methods for different tasks. There are two main advantages comparing our system with using ROVs or AUVs. First, our system can provide continuous monitoring of the undersea habitat. Second, our system has a low hardware cost. Comparing to existing deployed camera systems, the advantage of our system is that it can provide accurate 3D models and provides opportunities for future development of innovative algorithms for undersea research.
The Fundamental Movement Skills of a Year 9 Group and a Gifted and Talented Cohort  [PDF]
Gillian Griffiths, Rebecca Billard
Advances in Physical Education (APE) , 2013, DOI: 10.4236/ape.2013.34035

Physical Education is often viewed as the place where Fundamental Motor Skills (FMS) are developed. These skills underpin the development of motor competence and perceived competence, therefore impacting on participation and physical literacy. Within education, Gifted and Talented (G & T) and inclusion agendas have been high profile yet research has shown that children across the world are not reaching expected levels of skill mastery at primary level (5 - 11 years). The aim of the research was therefore to investigate the levels of mastery at secondary level (11 - 16 years) and within a G & T cohort to establish their levels of mastery, and investigate how this may relate to their participation in physical activities. Forty five children, 19 years 9 pupils (13.24 ± 0.2 years) and 26 G & T pupils (13.24 ± 0.2 years) were evaluated performing a combination locomotor, manipulative (object control) and balance skills (n = 5). 5 trials of each skill were recorded and graded against the performance criteria by one experimenter. Mastery or near mastery were only achieved, if, in 4 out of the 5 trials, 5 of the 6 component criteria were present. If this was not attained non-mastery was designated. Results revealed that the G & T pupils had greater overall mastery of the 5 skills, however they did not master all skills. All G & T had significantly increased jumping and throwing skills, and males significantly increased kicking skills. In both groups the majority of participation outside the school curriculum was related to games activities and was dominated by invasion games however no males participated in “aesthetic” activity outside school. These results indicate that development of FMS may not be occurring in children at KS3 and there is both an invasion games bias and a gender bias in the activities accessed out of school.

Folk-Linguistic Attitudes in Eastern Massachusetts  [PDF]
Rebecca Day Babcock
Open Journal of Modern Linguistics (OJML) , 2014, DOI: 10.4236/ojml.2014.43035

Folk linguistics attempts to study people’s beliefs and attitudes about language through their metalinguistic statements, usually collected in a naturalistic setting. Data was collected in a semistructured focus group setting with 11 white, middle- and working-class participants from Eastern Massachusetts. Participants spoke freely about linguistic topics. The results showed that the group focused their discussion on the speech of politicians (former Boston Mayor Tom Menino to be exact), linguistic status markers, specific features (r- and g-dropping, broad /a/), regions (local Massachusetts regions and Tennessee), and ethnicity (Black and Hispanic). All topics were introduced by the participants, rather than by the researcher.

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