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Search Results: 1 - 10 of 2865 matches for " Raymond Pieters "
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Gemma Blok, Ziek of zwak. Geschiedenis van de verslavingszorg (2011)
Toine Pieters
Studium : Tijdschrift voor Wetenschaps- en Universiteits-Geschiedenis , 2011,
Rienk Vermij, David de Wied. Toponderzoeker in polderland
Toine Pieters
BMGN : Low Countries Historical Review , 2010,
Continuous cohomology of the isometry group of hyperbolic space realizable on the boundary
Hester Pieters
Mathematics , 2015,
Abstract: We prove that the continuous cohomology of $\text{Isom}^+(\mathbb{H}^n)$ can be calculated using the complex of measurable maps on the boundary of hyperbolic space. This implies in particular that for $\text{Isom}^+(\mathbb{H}^n)$ the comparison map from continuous bounded cohomology to continuous cohomology is injective in degree $3$. We furthermore prove a stability result for the continuous bounded cohomology of $\text{Isom}(\mathbb{H}^n)$ and $\text{Isom}(\mathbb{H}_{\mathbb{C}}^n)$.
Spectral Compensation for Linear-Logarithmic Flow Cytometry Acquisitions  [PDF]
Nickolaas van Rodijnen, Math Pieters, Marius Nap
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.79063
Abstract: Compensating for fluorescence overlap in multiparameter flow cytometry datasets, of which one parameter is linear distributed and at least one parameter is logarithmic distributed, leads usually to extreme high compensation values. We investigated this phenomenon with an adapted flow cytometry model, of which the two parameters can easily be converted from linear to logarithmic and vice versa. With the adapted model, spectral compensation was performed both for linear-logarithmic and linear-linear parameter distribution. The results of the flow cytometry model were validated with a real world example which was also compensated twice. The results of the two experiments show that the compensation values equal to the theoretically expected value when both parameters are linear distributed. However, the compensation value exceeds 100% when one of the two parameters is logarithmic distributed. In addition, we found that spectral compensation of differently distributed parameters leads to deformation of the compensated events. With the adapted flow cytometry model presented in this paper it is shown how to correctly compensate flow cytometry acquisitions with different distributed parameters.
Contribution of Classic and Alternative Effector Pathways in Peanut-Induced Anaphylactic Responses
Joost J. Smit, Karina Willemsen, Ine Hassing, Danielle Fiechter, Gert Storm, Louis van Bloois, Jeanette H. W. Leusen, Maarten Pennings, Dietmar Zaiss, Raymond H. H. Pieters
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028917
Abstract: Food allergy affects approximately 5% of children and is the leading cause of hospitalization for anaphylactic reactions in westernized countries. However, the pathways of anaphylaxis in food allergy are still relatively unknown. We investigated the effector pathways of allergic and anaphylactic responses of different strains of mice in a clinical relevant model of peanut allergy. C3H/HeOuJ, C57BL/6 and BALB/c mice were sensitized by intragastric peanut extract and challenged by intragastric or intraperitoneal injection of peanut. Peanut-specific T cell responses, IgE, IgG1 and IgG2a and mucosal mast cell degranulation were induced to different extent in C3H/HeOuJ, C57BL/6 and BALB/c mice. Interestingly, anaphylactic symptoms after systemic challenge were highest in C3H/HeOuJ followed by C57BL/6 but were absent in BALB/c mice. Mechanistic studies showed that the food allergic systemic anaphylaxis was dependent on platelets, FcRγ and mast cells, and partially dependent on platelet activating factor and monocytes/macrophages, depending on mouse strain. These data demonstrate that in three mouse strains, components of the classic and alternative anaphylactic cascade are differently expressed, leading to differential outcomes in parameters of allergic disease and food induced systemic anaphylaxis.
HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression
Douglas Conrad, Angela Wang, Raymond Pieters, Ferdinando Nicoletti, Katia Mangano, Anna M van Heeckeren, Steven K White, James M Frincke, Christopher L Reading, Dwight Stickney, Dominick L Auci
Journal of Inflammation , 2010, DOI: 10.1186/1476-9255-7-52
Abstract: In mice, oral treatment with HE3286 (40 mg/kg) significantly (p < 0.05) decreased neutrophil counts and exudate volumes (~50%) in carrageenan-induced pleurisy, and myeloperoxidase in lipopolysaccharide-induced lung injury. HE3286 (40 mg/kg) was not found to be profoundly immune suppressive in any of the classical animal models of immune function, including those used to evaluate antigen specific immune responses in vivo (ovalbumin immunization). When mice treated for two weeks with HE3286 were challenged with K. pneumoniae, nearly identical survival kinetics were observed in vehicle-treated, HE3286-treated and untreated groups.HE3286 represents a novel, first-in-class anti-inflammatory agent that may translate certain benefits of β-AET observed in rodents into treatments for chronic inflammatory pulmonary disease.Chronic obstructive pulmonary disease (COPD), a term most often used to describe chronic bronchitis and emphysema [1,2] is an inflammatory disease of the lungs marked by a loss of elastic recoil, an increased resistance to airflow and decreased expiratory flow rate leading to dyspnea [3]. Chronic bronchitis, emphysema and cystic fibrosis (CF), all forms of COPD, share many features including a progressive airway remodeling driven by chronic inflammation [4-7]. COPD is a major cause of morbidity and mortality in industrialized countries and novel treatments are urgently needed because many patients respond poorly to conventional therapies [8-10]. Even in responders, narrow therapeutic windows and a myriad of unwanted side effects, including immune suppression are treatment limiting [9-12]. We have suggested that suitable agents may be found within the adrenal metabolome [13].Dehydroepiandrosterone (DHEA) is an abundant adrenal steroid and a precursor in the biosynthesis of androgens, estrogens and other anti-inflammatory immune regulating steroids [14,15]. From studies reporting aberrant metabolism of adrenal steroids in CF patients [16,17] we surmised that
Gesondheidassessering van visgemeenskappe blootgestel aan varkplaasuitvloeisel in die Vaalrivier, Suid-Afrika
Wihan Pheiffer,Rialet Pieters
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie , 2012, DOI: 10.4102/satnt.v31i1.344
Inflammatory Stimuli Reprogram Macrophage Phagocytosis to Macropinocytosis for the Rapid Elimination of Pathogens
Somdeb BoseDasgupta,Jean Pieters
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1003879
Abstract: Following an infectious challenge, macrophages have to be activated in order to allow efficient clearance of infectious pathogens, but how macrophage activation is coupled to increased clearance remains largely unknown. We here describe that inflammatory stimuli induced the reprogramming of the macrophage endocytic machinery from receptor-mediated phagocytosis to macropinocytosis, allowing the rapid transfer of internalized cargo to lysosomes in a receptor-independent manner. Reprogramming occurred through protein kinase C-mediated phosphorylation of the macrophage protein coronin 1, thereby activating phosphoinositol (PI)-3-kinase activity necessary for macropinocytic uptake. Expression of a phosphomimetic form of coronin 1 was sufficient to induce PI3-kinase activation and macropinocytosis even in the absence of inflammatory stimuli. Together these results suggest a hitherto unknown mechanism to regulate the internalization and degradation of infectious material during inflammation.
In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential - the RAPTES project
Maaike Steenhof, Ilse Gosens, Maciej Strak, Krystal J Godri, Gerard Hoek, Flemming R Cassee, Ian S Mudway, Frank J Kelly, Roy M Harrison, Erik Lebret, Bert Brunekreef, Nicole AH Janssen, Raymond HH Pieters
Particle and Fibre Toxicology , 2011, DOI: 10.1186/1743-8977-8-26
Abstract: PM was sampled at eight sites: three traffic sites, an underground train station, as well as a harbor, farm, steelworks, and urban background location. Coarse (2.5-10 μm), fine (< 2.5 μm) and quasi ultrafine PM (qUF; < 0.18 μm) were sampled at each site. Murine macrophages (RAW 264.7 cells) were exposed to increasing concentrations of PM from these sites (6.25-12.5-25-50-100 μg/ml; corresponding to 3.68-58.8 μg/cm2). Following overnight incubation, MTT-reduction activity (a measure of metabolic activity) and the release of pro-inflammatory markers (Tumor Necrosis Factor-alpha, TNF-α; Interleukin-6, IL-6; Macrophage Inflammatory Protein-2, MIP-2) were measured. The oxidative potential and the endotoxin content of each PM sample were determined in a DTT- and LAL-assay respectively. Multiple linear regression was used to assess the relationship between the cellular responses and PM characteristics: concentration, site, size fraction, oxidative potential and endotoxin content.Most PM samples induced a concentration-dependent decrease in MTT-reduction activity and an increase in pro-inflammatory markers with the exception of the urban background and stop & go traffic samples. Fine and qUF samples of traffic locations, characterized by a high concentration of elemental and organic carbon, induced the highest pro-inflammatory activity. The pro-inflammatory response to coarse samples was associated with the endotoxin level, which was found to increase dramatically during a three-day sample concentration procedure in the laboratory. The underground samples, characterized by a high content of transition metals, showed the largest decrease in MTT-reduction activity. PM size fraction was not related to MTT-reduction activity, whereas there was a statistically significant difference in pro-inflammatory activity between Fine and qUF PM. Furthermore, there was a statistically significant negative association between PM oxidative potential and MTT-reduction activity.The response of
A Characterization of the Optimal Management of Heterogeneous Environmental Assets under Uncertainty  [PDF]
Frank Raymond
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.25093
Abstract: The application herein involves the optimal management of renewable and nonrenewable resources within the context of a stochastic model of optimal control. By characterizing the two dimensional Bellman solution, three rules with respect to resource management are established. Within the context of coastal development, this analysis may help to explain why renewable resources may become increasingly vulnerable to random external shocks as nonrenewable resources are depleted. Although existence of an optimal closed form solution to the multi-sector Bellman model remains an open mathematical question, this analysis offers a characterization which can be applied to other scenarios in economics or finance in which two assets following stochastic processes interact.
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