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Search Results: 1 - 7 of 7 matches for " Rawiwan Imerbsin "
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Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)
Geoffrey S Dow, Montip Gettayacamin, Pranee Hansukjariya, Rawiwan Imerbsin, Srawuth Komcharoen, Jetsumon Sattabongkot, Dennis Kyle, Wilbur Milhous, Simon Cozens, David Kenworthy, Anne Miller, Jim Veazey, Colin Ohrt
Malaria Journal , 2011, DOI: 10.1186/1475-2875-10-212
Abstract: In 2005, the radical curative efficacy of tafenoquine combinations was investigated in Plasmodium cynomolgi-infected na?ve Indian-origin Rhesus monkeys. In the first cohort, groups of two monkeys were treated with a three-day regimen of tafenoquine at different doses alone and in combination with a three-day chloroquine regimen to determine the minimum curative dose (MCD). In the second cohort, the radical curative efficacy of a single-day regimen of tafenoquine-mefloquine was compared to that of two three-day regimens comprising tafenoquine at its MCD with chloroquine or artemether-lumefantrine in groups of six monkeys. In a final cohort, the efficacy of the MCD of tafenoquine against hypnozoites alone and in combination with chloroquine was investigated in groups of six monkeys after quinine pre-treatment to eliminate asexual parasites. Plasma tafenoquine, chloroquine and desethylchloroquine concentrations were determined by LC-MS in order to compare doses of the drugs to those used clinically in humans.The total MCD of tafenoquine required in combination regimens for radical cure was ten-fold lower (1.8 mg/kg versus 18 mg/kg) than for monotherapy. This regimen (1.8 mg/kg) was equally efficacious as monotherapy or in combination with chloroquine after quinine pre-treatment to eliminate asexual stages. The same dose of (1.8 mg/kg) was radically curative in combination with artemether-lumefantrine. Tafenoquine was also radically curative when combined with mefloquine. The MCD of tafenoquine monotherapy for radical cure (18 mg/kg) appears to be biologically equivalent to a 600-1200 mg dose in humans. At its MCD in combination with blood schizonticidal drugs (1.8 mg/kg), the maximum observed plasma concentrations were substantially lower than (20-84 versus 550-1,100 ng/ml) after administration of 1, 200 mg in clinical studies.Ten-fold lower clinical doses of tafenoquine than used in prior studies may be effective against P. vivax hypnozoites if the drug is deployed in
Determination of silver nanoparticle release from antibacterial fabrics into artificial sweat
Kornphimol Kulthong, Sujittra Srisung, Kanittha Boonpavanitchakul, Wiyong Kangwansupamonkon, Rawiwan Maniratanachote
Particle and Fibre Toxicology , 2010, DOI: 10.1186/1743-8977-7-8
Abstract: A growing interest in nanotechnology has lead to the increased production and application of nanoparticles worldwide. They are incorporated into various categories of consumer products, including cosmetics, textiles, electronics and medicines [1,2]. Silver nanoparticles are potent and broad-spectrum antibacterial agents with activity against diverse species within both Gram-positive and Gram-negative bacteria [3]. They show a good antibacterial property with their large surface area to volume ratio, which provides a better contact with the microorganism [4]. Silver nanoparticles have been applied in diverse consumer products, such as clothes, socks and laboratory gowns, as well as in medical products, such as surgical gowns and dressing bandages, which are claimed to have the ability to inhibit bacterial growth [5,6]. Concerning their safety, the Environmental Protection Agency (EPA) published a notice for public review and a filed petition, open to comment by concerned parties. That petition requested EPA to classify and regulate all products containing nanoscale silver as pesticides by taking regulatory actions under the Federal Insecticides, Fungicide and Rodenticide Act (FIFRA), as well as analyze the potential human health and environmental risks of nanoscale silver [7]. However, those issues will potentially affect many stakeholders and, therefore, need public response and comment.Exposure to these materials during manufacturing and application can occur via ingestion, inhalation and dermal contact. In humans, it is well known that long-term ingestion of silver compounds can cause irreversible skin discoloration or Argyria [8]. The permissible exposure limit recommended by the National Institute for Occupational Safety and Health is 0.01 mg/m3 for all forms of silver [9]. However, in rats, inhalation of silver nanoparticles caused adverse effects to the liver, kidney and lungs as well as the silver being observed to accumulate in several tissues [10,11], and t
Successful clinical outcomes following decentralization of tertiary paediatric HIV care to a community-based paediatric antiretroviral treatment network, Chiangrai, Thailand, 2002 to 2008
Rawiwan Hansudewechakul,Thananda Naiwatanakul,Abraham Katana,Worawan Faikratok
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.2.17358
Abstract: Introduction: Most paediatric antiretroviral treatments (ARTs) in Thailand are limited to tertiary care hospitals. To decentralize paediatric HIV treatment and care, Chiangrai Prachanukroh Hospital (CRH) strengthened a provincial paediatric HIV care network by training community hospital (CH) care teams to receive referrals of children for community follow-up. In this study, we assessed factors associated with death and clinical outcomes of HIV-infected children who received care at CRH and CHs after implementation of a community-based paediatric HIV care network. Methods: Clinical records were abstracted for all children who initiated ART at CRH. Paired Wilcoxon signed rank tests were used to assess CD4% and virological change among all children. Cox proportional hazard models were used to assess factors associated with death. Treatment outcomes (CD4%, viral load (VL) and weight-for-age Z-score (WAZ)) were compared between CRH and CH children who met the criteria for analysis. Results: Between February 2002 and April 2008, 423 HIV-infected children initiated ART and 410 included in the cohort analysis. Median follow-up for the cohort was 28 months (interquartile range (IQR)=12 to 42); 169 (41%) children were referred for follow-up at CH. As of 31 March 2008, 42 (10%) children had died. Baseline WAZ (< 2 (p=0.001)) and baseline CD4% (<5% (p=0.015)) were independently associated with death. At 48 months, 86% of ART-na ve children in follow-up had VL<400 copies/ml. For sub-group analysis, 133 children at CRH and 154 at CHs were included for comparison. Median baseline WAZ was lower in CH children than in CRH children (p=0.001); in both groups, WAZ, CD4% and VL improved after ART with no difference in rate of WAZ and CD4% gain (p=0.421 and 0.207, respectively). Conclusions: Children at CHs had more severe immunological suppression and low WAZ at baseline. Community- and tertiary care-based paediatric ART follow-ups result in equally beneficial outcomes with the strengthening of a provincial referral network between tertiary and community care. Nutrition interventions may benefit children in community-based HIV treatment and care.
地球学报 , 2012, DOI: 10.3975/cagsb.2012.s1.04
Abstract: NansutureinnorthernThailand,representingacomplexzonewithcomplexgeologyandstructures,hasbeenselectedforairbornegeophysicalinvestiga-tions.ThesuturehasbeenwidelyacceptedasanearlyTriassiccollisionzonebetweenShan-ThaiandIndo-chinamicrocontinentalblocks.Ourfielddatasuggesttheoccurrenceofamélangezoneinresponsetocom-pressiontectonics.Moreover,previouspetrochemicalandfieldinvestigationssuggestthattheNansuturemayhavebeenformedasaresultofasubductionzone.
Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand
Anake Kijjoa,Rawiwan Wattanadilok,Werner Herz,Nair Campos,Maria S?o José Nascimento,Madalena Pinto
Marine Drugs , 2007, DOI: 10.3390/md502006
Abstract: The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells.
Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand
Rawiwan Wattanadilok,Pichan Sawangwong,Cátia Rodrigues,Honorina Cidade,Madalena Pinto,Eugenia Pinto,Artur Silva,Anake Kijjoa
Marine Drugs , 2007, DOI: 10.3390/md502040
Abstract: A new compound maleimide-5-oxime was isolated, together with 3,4- dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(-) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.
High virologic response rate after second-line boosted protease inhibitor-based antiretroviral therapy regimens in children from a resource limited setting
Thanyawee Puthanakit, Gonzague Jourdain, Piyarat Suntarattiwong, Kulkanya Chokephaibulkit, Umaporn Siangphoe, Tulathip Suwanlerk, Wasana Prasitsuebsai, Virat Sirisanthana, Pope Kosalaraksa, Witaya Petdachai, Rawiwan Hansudewechakul, Narit Waranawat, Jintanat Ananworanich
AIDS Research and Therapy , 2012, DOI: 10.1186/1742-6405-9-20
Abstract: A retrospective chart review was conducted at 8 Thai sites of children who switched to PI –based regimens due to failure of NNRTI –based regimens. Primary endpoints were HIV RNA?<?400 copies/ml and CD4 change over 48?weeks.Data from 241 children with median baseline values before starting PI-based regimens of 9.1?years for age, 10% for CD4%, and 4.8 log10 copies/ml for HIV RNA were included; 104 (41%) received a single ritonavir-boosted PI (sbPI) with 2 NRTIs and 137 (59%) received double-boosted PI (dbPI) with/without NRTIs based on physician discretion. SbPI children had higher baseline CD4 (17% vs. 6%, p?<?0.001), lower HIV RNA (4.5 vs. 4.9 log10 copies/ml, p?<?0.001), and less frequent high grade multi-NRTI resistance (12.4% vs 60.5%, p?<?0.001) than the dbPI children. At week 48, 81% had HIV RNA?<?400 copies/ml (sbPI 83.1% vs. dbPI 79.8%, p?=?0.61) with a median CD4 rise of 9% (+7%vs.?+?10%, p?<?0.005). However, only 63% had HIV RNA?<?50 copies/ml, with better viral suppression seen in sbPI (76.6% vs. 51.4%, p 0.002).Second-line PI therapy was effective for children failing first line NNRTI in a resource-limited setting. DbPI were used in patients with extensive drug resistance due to limited treatment options. Better access to antiretroviral drugs is needed.
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