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Search Results: 1 - 10 of 35139 matches for " Ransome van der Hoeven "
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Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans
Ransome van der Hoeven,Katie C. McCallum,Melissa R. Cruz,Danielle A. Garsin
PLOS Pathogens , 2011, DOI: 10.1371/journal.ppat.1002453
Abstract: Infected animals will produce reactive oxygen species (ROS) and other inflammatory molecules that help fight pathogens, but can inadvertently damage host tissue. Therefore specific responses, which protect and repair against the collateral damage caused by the immune response, are critical for successfully surviving pathogen attack. We previously demonstrated that ROS are generated during infection in the model host Caenorhabditis elegans by the dual oxidase Ce-Duox1/BLI-3. Herein, an important connection between ROS generation by Ce-Duox1/BLI-3 and upregulation of a protective transcriptional response by SKN-1 is established in the context of infection. SKN-1 is an ortholog of the mammalian Nrf transcription factors and has previously been documented to promote survival, following oxidative stress, by upregulating genes involved in the detoxification of ROS and other reactive compounds. Using qRT-PCR, transcriptional reporter fusions, and a translational fusion, SKN-1 is shown to become highly active in the C. elegans intestine upon exposure to the human bacterial pathogens, Enterococcus faecalis and Pseudomonas aeruginosa. Activation is dependent on the overall pathogenicity of the bacterium, demonstrated by a weakened response observed in attenuated mutants of these pathogens. Previous work demonstrated a role for p38 MAPK signaling both in pathogen resistance and in activating SKN-1 upon exposure to chemically induced oxidative stress. We show that NSY-1, SEK-1 and PMK-1 are also required for SKN-1 activity during infection. Evidence is also presented that the ROS produced by Ce-Duox1/BLI-3 is the source of SKN-1 activation via p38 MAPK signaling during infection. Finally, for the first time, SKN-1 activity is shown to be protective during infection; loss of skn-1 decreases resistance, whereas increasing SKN-1 activity augments resistance to pathogen. Overall, a model is presented in which ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling.
Cold Acid Postmortem Blood Most Probably Formed Pinkish-Red Heme-Madder Lake on Madder-Dyed Shroud of Turin  [PDF]
Adrie A. M. van der Hoeven
Open Journal of Applied Sciences (OJAppS) , 2015, DOI: 10.4236/ojapps.2015.511070
Abstract: The Turin Shroud was extensively scientifically investigated in 1978. In its pinkish red bloodstains, normal features of human blood were found, but also seemingly anomalous ones. In the present study, hitherto unnoticed details of the data are presented, Shroud data and more modern reference data are compared, and the results of a few experiments with linen, madder dye and blood are shown. It turns out that the Shroud’s ‘anomalous’ data are strong consistent evidence that its bloodstains contain acid heme-madder lake, of which the heme derived from cold acid postmortem blood and the madder had been applied to the Shroud at manufacture. It implies that the bloodstains were formed on the Shroud before the still not reproduced body-image was. Several other ‘red-color’ hypotheses for the Shroud’s bloodstains are discussed and dismissed.
Empleo, desigualdad y globalización: una preocupación continua
van der Hoeven,Rolph;
Cuadernos de Administración (Universidad del Valle) , 2010,
Abstract: this article deals the issue of global economic crisis and its strong impact on the population. shows concern for the effects of the crisis, mainly through increases in unemployment, which generates greater social inequality as people are forced to work informally, a fact that goes against labor stability and human development. through a look at the position assumed by several authors who handle financial issues, is that public policies arising from different periods have not been a satisfactory answer to balance socioeconomic inequalities because it has not been possible to achieve economic growth result in a more equitable income distribution, capable of generate a true human development. alternatives are contemplated to promote employment growth, from fiscal and monetary toward the industrial and commercial, as are some positions to face the effects of globalization.
Deconstructing Rotterdam's modern city centre Перестройка современного центра Роттердама
Frank van der Hoeven
Project Baikal , 2013,
Abstract: In the 20th century, the Dutch city of Rotterdam was radically transformed from a historic town into a modern city, becoming the selfacclaimed 'city of architecture', home to international architectural design offices, publishers and institutions. Although it is already 60 years after the destruction of the Rotterdam inner city, the city still struggles to be the vibrant, rigorous urban environment it needs to be in order to attract the so-called creative class. This article provides a contextual overview of the transformations of a number of key public spaces that are symbolic for the challenges the city faces. After the post-war reconstruction the city continuous to transform beyond modernism. В XX веке голландский город Роттердам радикально трансформировался, превратившись из исторического в современный, провозгласив себя городом архитектуры и став родным домом для множества архитектурных фирм, издательств и учреждений. Несмотря на то что прошло уже 60 лет со времени разрушения центральной части Роттердама, город по сей день стремится сохранить живую, строго организованную среду, которая бы привлекала творческую интеллигенцию. В статье предлагается контекстуальный обзор трансформаций главных общественных пространств, играющих знаковую роль в решении тех задач, которые стоят перед городом. Пройдя послевоенную реконструкцию, город продолжает изменяться, выходя за рамки модернизма.
Empleo, desigualdad y globalización: una preocupación continua Employment, Inequality and Globalization: A Continuous Concern
Rolph van der Hoeven
Cuadernos de Administración (Universidad del Valle) , 2010,
Abstract: El presente artículo aborda el tema de la crisis económica mundial y su fuerte impacto sobre la población. Muestra la preocupación por los efectos de dicha crisis, principalmente en el incremento del desempleo, que genera mayores desigualdades sociales puesto que las personas se ven abocadas a trabajar de manera informal, hecho que va en contra de la estabilidad laboral y del desarrollo humano. A través de una mirada a la posición asumida por diversos autores que manejan el tema financiero, se encuentra que las políticas pùblicas surgidas de diferentes épocas no han sido una respuesta satisfactoria para equilibrar las desigualdades socioeconómicas dado que no ha sido posible lograr un crecimiento económico que redunde en una distribución del ingreso más equitativa, capaz de generar un verdadero desarrollo humano. Se contemplan algunas alternativas para promover el crecimiento del empleo, desde lo fiscal y lo monetario hasta lo industrial y lo comercial, al igual que se presentan algunas posiciones para enfrentar los efectos de la globalización. This article deals the issue of global economic crisis and its strong impact on the population. Shows concern for the effects of the crisis, mainly through increases in unemployment, which generates greater social inequality as people are forced to work informally, a fact that goes against labor stability and human development. Through a look at the position assumed by several authors who handle financial issues, is that public policies arising from different periods have not been a satisfactory answer to balance socioeconomic inequalities because it has not been possible to achieve economic growth result in a more equitable income distribution, capable of generate a true human development. Alternatives are contemplated to promote employment growth, from fiscal and monetary toward the industrial and commercial, as are some positions to face the effects of globalization.
C.H.E. de Wit, De Nederlandse revolutie van de achttiende eeuw 1780-1787. Oligarchie en proletariaat
H. van der Hoeven
BMGN : Low Countries Historical Review , 1975,
Abstract:
W. Verkade, Thorbecke als Oost-Nederlands patriot
H. van der Hoeven
BMGN : Low Countries Historical Review , 1976,
Abstract:
Opportunities for a Bio-based Economy in the Netherlands
Johan Sanders,Diederik Van der Hoeven
Energies , 2008, DOI: 10.3390/en1030105
Abstract: The shift to a bio-based economy for the Netherlands is not only required because of climate change, but also for industrial strategy reasons. Traditional strongholds of the Dutch economy like the Rotterdam harbour, the agricultural sector (including the greenhouse sector, and food and feed industries) and the petrochemical industry will be affected by the new economic realities, and it is precisely to these sectors that a bio-based economy will offer new opportunities.
Clinical value of an arterial pressure-based cardiac output measurement device
Joris Lemson, Johannes G van der Hoeven
Critical Care , 2008, DOI: 10.1186/cc6219
Abstract: However, the Bland Altman plot of APCO versus ICO shows a wide spread of data points with a percentage error of 42%. These large variations could lead to a completely different clinical management. Also, we disagree that a percentage error less than 28% is a conservative requirement. By using an error-gram, limits of precision of ±20% for both test and reference method give predicted limits of agreement of 28.3% [2]. These limits should be respected when an alternative cardiac output measurement technique is evaluated because limits of precision in excess of 20% for a single technique are not clinically acceptable.Furthermore, the authors state that they only consider a change in cardiac output of 30% or more clinically relevant. This is in contrast to daily clinical practice in which cardiac output changes of 10% to 15% are frequently used for making decisions regarding therapy. Also, they have calculated the change in cardiac output by dividing the delta cardiac output by the mean value before and after the change. In this way they have artificially decreased the relative change in cardiac output. Subsequently, in the plot showing the change in ICO versus the change in APCO, it can be observed that when changes in ICO of more than 15% are analyzed, in only 35% of the cases did the APCO also change 15% or more in the same direction. Moreover, in 45% of the cases the APCO changed in the opposite direction!Based on the results of this study, we think that APCO is not accurate in measuring absolute values of cardiac output, nor in tracking changes in cardiac output in a general intensive care population.William T McGeeFew data support the use of any therapy based on hemodynamic variables to improve outcome in intensive care unit (ICU) patients. In the recently completed FACTT trial, therapy based on cardiac output had no impact on patient outcome [3]. Other trials targeting cardiac output as a treatment variable have had disappointing results [4].In our study of ICU p
On the bit-complexity of sparse polynomial multiplication
Joris van der Hoeven,Grégoire Lecerf
Computer Science , 2009,
Abstract: In this paper, we present fast algorithms for the product of two multivariate polynomials in sparse representation. The bit complexity of our algorithms are studied in detail for various types of coefficients, and we derive new complexity results for the power series multiplication in many variables. Our algorithms are implemented and freely available within the Mathemagix software. We show that their theoretical costs are well-reflected in practice.
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