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Search Results: 1 - 10 of 228 matches for " Rania Bakry "
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Anti-HBc and HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen  [PDF]
Hosny Badrawy, Rania Bakry
American Journal of Molecular Biology (AJMB) , 2013, DOI: 10.4236/ajmb.2013.31008
Abstract: Occult HBV infection is defined as the presence of hepatitis B virus (HBV) DNA in blood or liver tissues in patients negative for Hepatitis B surface Antigen (HBsAg). Those patients may or may not be positive for HBV antibodies. The objective of this study is to determine the presence or absence of HBV DNA in the serum samples from HBsAg negative blood donors. In addition we aimed to assess the magnitude of occult HBV infection and to reduce the risk of HBV infection. Over a period of one year a total of 7340 blood units were collected at blood transfusion center in our locality for the prevalence of HBV infection and 180 HBsAg negative blood specimens were randomly selected for anti-HBcIgM, anti-HBs antibody and HBV DNA. Ninety seven out of 7340 collected blood units were positive for HbsAg (1.3%).The randomly selected 180 tested donors revealed 7 (3.8%) positive for antiHBc IgM and 34 (18.8%) were positive for anti-HBs antibodies. Four out of 7 positive for anti-HBc IgM were also positive for anti-HBs and 2/180 (1.1%) specimens were positive for HBV DNA by PCR. Anti-HBc antibody should be tested routinely at any blood transfusion center and if they were positive regardless of anti-HBs titer, the blood should be discarded. Also HBV DNA is preferable to be performed to all blood donors to present completely safe blood transfusion.
Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study
Eman Mosad, Hosny B Hamed, Rania M Bakry, Azza M Ezz-Eldin, Nesrine M Khalifa
Journal of Hematology & Oncology , 2008, DOI: 10.1186/1756-8722-1-17
Abstract: All bone marrow samples of eighty patients diagnosed as CD 10 positive B-ALL in South Egypt Cancer Institute were evaluated by fluorescence in situ hybridization (FISH) for t(12;21) in newly diagnosed cases and after morphological complete remission as a minimal residual disease (MRD). We determined the prognostic significance of TEL-AML1 fusion represented by disease course and survival.TEL-AML1 fusion gene was positive in (37.5%) in newly diagnosed patients. There was a significant correlation between TEL-AML1 fusion gene both at diagnosis (r = 0.5, P = 0.003) and as a MRD (r = 0.4, P = 0.01) with favorable course. Kaplan-Meier curve for the presence of TEL-AML1 fusion at the diagnosis was associated with a better probability of overall survival (OS); mean survival time was 47 ± 1 month, in contrast to 28 ± 5 month in its absence (P = 0.006). Also, the persistence at TEL-AML1 fusion as a MRD was not significantly associated with a better probability of OS; the mean survival time was 42 ± 2 months in the presence of MRD and it was 40 ± 1 months in its absence. So, persistence of TEL-AML1 fusion as a MRD had no additive prognostic value over its measurement at diagnosis in terms of predicting the probability of OS.For most patients, the presence of TEL-AML1 fusion gene at diagnosis suggests a favorable prognosis. The present study suggests that persistence of TEL-AML1 fusion as MRD has no additive prognostic value.Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. Cure of many of these children is difficult to predict and is considered an individual response of the patient to chemotherapy. It is likely that this clinical heterogeneity reflects a diverse pathogenesis of leukemia. The molecular basis of childhood ALL is largely unknown. Furthermore, it is likely that significant advance in the treatment of childhood ALL will be dependent on a better understanding of the molecular events that cause the disease [1,2].A recurrent t(12;21)(p13:
Spectrophotometric Determination of Captopril and Penicillamine through the Use of Ligand Exchange Complexation Reactions
Saied Belal,Abdel-Fattah El-Walily,Omayma Abdel-Razak,Rania Bakry
International Journal of Biomedical Science , 2011,
Abstract: Two spectrophotmetric methods based on combined redox - ligand exchange reactions were developed for the determination of captopril and penicillamine in pure form and in their dosage forms. The first method is based on attenuating the absorbance of a ternary complex: silver (I) - bromopyrogallol red - phenanthroline in a buffer solution of pH6-8. The method has the concentration ranges 2-10 μg mL-1 and 0.5-1.75 μg mL-1 for captopril and penicillamine respectively, and the detection limits 7.1 × 10-2 and 5.7 × 10-2 μg mL-1 for captopril and penicillamine respectively. The second method is based on decreasing the absorbance of a chloroformic solution of copper (II) - oxine chelate when shaken with the drug solution in buffer medium of pH 8. The drugs were determined in the concentrations 30-90 μg mL-1 and 30-100 μg mL-1 for captopril and penicillamine respectively, and the detection limits 0.94 and 1.76 μg mL-1 for captopril and penicillamine respectively. The proposed methods were applied in the analysis of both compounds in their pharmaceutical preparations, and results were favorably compared with reference spectrophotometric methods regarding accuracy and precision.
Clinical Relevance of CDH1 and CDH13 DNA-Methylation in Serum of Cervical Cancer Patients
Abida Abudukadeer,Rania Bakry,Georg Goebel,Irene Mutz-Dehbalaie,Andreas Widschwendter,Günther K. Bonn,Heidi Fiegl
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13078353
Abstract: This study was designed to investigate the DNA-methylation status of E-cadherin ( CDH1) and H-cadherin ( CDH13) in serum samples of cervical cancer patients and control patients with no malignant diseases and to evaluate the clinical utility of these markers. DNA-methylation status of CDH1 and CDH13 was analyzed by means of MethyLight-technology in serum samples from 49 cervical cancer patients and 40 patients with diseases other than cancer. To compare this methylation analysis with another technique, we analyzed the samples with a denaturing high performance liquid chromatography (DHPLC) PCR-method. The specificity and sensitivity of CDH1 DNA-methylation measured by MethyLight was 75% and 55%, and for CDH13 DNA-methylation 95% and 10%. We identified a specificity of 92.5% and a sensitivity of only 27% for the CDH1 DHPLC-PCR analysis. Multivariate analysis showed that serum CDH1 methylation-positive patients had a 7.8-fold risk for death (95% CI: 2.2–27.7; p = 0.001) and a 92.8-fold risk for relapse (95% CI: 3.9–2207.1; p = 0.005). We concluded that the serological detection of CDH1 and CDH13 DNA-hypermethylation is not an ideal diagnostic tool due to low diagnostic specificity and sensitivity. However, it was validated that CDH1 methylation analysis in serum samples may be of potential use as a prognostic marker for cervical cancer patients.
Applying MILP for 27-Level CMLIs to Obtain Low THD Values over Wide Voltage Range  [PDF]
Mahmoud El-Bakry
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54032
Abstract:

The 27-level cascaded multilevel inverter (CMLI) is a popular CMLI, since it can produce an output voltage with nearly sinusoidal wave form and may be realized as a trinary asymmetric CMLI that consists of only three H-bridges. A new approach using a mixed integer linear programming (MILP) model is applied, that can determine the switching angles of this CMLI that minimize the values of any undesired harmonics. The model is applied first to determine the number of harmonics to be minimized to obtain least percentage total harmonic distortion (%THD) utilizing the 13 positive levels of the inverter. The obtained result is then included in the model and it is solved for different values of the output voltage. Single phase and three phase cases are investigated. The results show very low values of %THD and low order harmonics over wide voltage range till the 91st harmonic in both cases, which agree with the IEEE standards 519-1992 for voltage distortion limits till 161 kv.

Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis
Nihal A Fathi, Azza M Ezz-Eldin, Eman Mosad, Rania M Bakry, Hosny B Hamed, Sahar Ahmed, Marwa Mahmoud, Hebat-Allah G Rashed, Fatma Abdullah
International Archives of Medicine , 2008, DOI: 10.1186/1755-7682-1-20
Abstract: Sixty patients with RA were examined. Radiographic changes were evaluated by (Larsen score) and disease activity was measured by disease activity score 28 (DAS28). The markers analyzed were: erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptides (anti-CCP2) and HLA-DRB1 alleles typed by PCR.In this study, anti-CCP antibodies, CRP, RF and AKA were detected in 83.3%, 56.7%, 71.7% and 52% of patients respectively. HLA-DRB1*01 was found in 45% of patients and 35% of them had one or two HLA-DRB1*04 alleles. According to DRB1*04 subtypes, (DRB1* 0405) was present in of 80% them. For prediction of grade of activity, the independent predictors were anti-CCP (OR 19.6), and DRB1*04 positive allele (OR 5.1). The combination of DRB1*04 + anti-CCP antibodies gave increase in the specificity and positive predictive value to 92% and 90 respectively. As regards to the prediction of radiological joint damage, the independent predictors were HLA-DRB1*04, HLA-DRB1*01, RF, and CRP > 18 (OR 5.5, 4.5, 2.5, 2.0 respectively).Our findings suggest that anti-CCP2 is superior to RF for the detection of RA and provided predictive information on joint destruction and disease activity. The presence of RA associated antibodies (ACCP or RF) and/or the SE genes are indicative for a poorer radiological outcome and higher grade of activity.Rheumatoid arthritis (RA) is an inflammatory disease of unknown cause. The course of rheumatoid arthritis is ranging from mild to aggressive forms, the latter being very difficult to cope with. It has been shown that early diagnosis and treatment reduce joint destruction, and improve survival [1]. Risk factors have been identified in groups of patients with different outcomes such as baseline radiographic joint changes, presence of rheumatoid factor (RF), specific human leukocyte antigens (HLA); HLA-DRB1 genotypes, high disease activity, high disability scores, and high levels of acute phase protei
Capillary Electrophoresis Coupled To Mass Spectrometry for Forensic Analysis
Christian W. Huck, Verena Huck-Pezzei, Rania Bakry, Stefan Bachmann, Muhammad Najam-ul-Haq, Matthias RainerGünther K. Bonn
The Open Chemical Engineering Journal , 2007, DOI: 10.2174/1874123100701010030]
Abstract: In this review the most important techniques, which are developed to hyphenate capillary electrophoresis to mass spectrometry (CE-MS), suitable for forensic analysis, are summarized. Analytes of interest are divided into four main parts, namely, compounds with amine containing side chains, compounds with N-containing saturated ring structures, other heterocycles and peptides. Sample pre-treatments and direct injection modes used in CE-MS for forensic analysis are briefly discussed from critical point of view. Special emphasis is placed to point out the advantages of mass spectrometric detection compared to UV- and laser- induced fluorescence (LIF) detections.
Lecture Notes of Möbuis Transformation in Hyperbolic Plane  [PDF]
Rania B. M. Amer
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515215
Abstract:

In this paper, I have provided a brief introduction on M?bius transformation and explored some basic properties of this kind of transformation. For instance, M?bius transformation is classified according to the invariant points. Moreover, we can see that M?bius transformation is hyperbolic isometries that form a group action PSL (2, R) on the upper half plane model.

Effect of pulse drip irrigation and mulching systems on yield, quality traits and irrigation water use efficiency of soybean under sandy soil conditions  [PDF]
Abdelraouf Ramadan Eid, Bakry Ahmed Bakry, Moamen Hamed Taha
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.45036
Abstract:

Two field experiments were carried out during growing seasons 2010 and 2011, it executed in research farm of national research center in Nubaryia region, Egypt to study the effect of pulse drip irrigation and mulching systems for saving water, increasing and improving yield of soybean. The study factors were, pulse drip irrigation technology (adding of daily water requirements on 4 times, 8 times, 12 times compared with adding of daily water requirements on 1 time) and mulching systems (covering the soil with black plastic mulch “BPM”, rice straw mulch “RSM” and the control treatment was soil surface without mulch “WM”). The following parameters were studied to evaluate the effect of pulse drip irrigation and mulching systems: 1) Soil moisture distribution in root zone, 2) Growth characters of soybean plant, 3) Yield of soybean, 4) Irrigation water use efficiency of soybean “IWUE soybean”, and 5) Oil content and oil yield, 6) Protein content and protein yield, 7) Economical parameter. According to the economical view and the results of statistical analysis for effect of pulse drip irrigation and mulching systems on yield, quality traits and IWUE soybean indicated that, applying the irrigation requirements on 8 pulses/day with using BPM is the best conditions because under these conditions was occurred the highest value of yield, quality traits and IWUE soybean and there was significant deference between this case and other treatments. Where, pulse irrigation technique increase from water movement in horizontal direction than vertical direction hence improve from soil moisture distribution and wetted soil volume in root zone and using BPM decrease from evaporation process rate from soil surface hence decreasing of salts accumulation in addition to decreasing of weed growth in the root zone. All traits at AIR on 12 pulses/ day are decreased by increasing of pulses, this may be due to irrigation water was very small with every pulse at AIR on 12 pulses/day in addition increasing the total time of time-off, this mean, un-sufficient application for irrigation water to remove water stress in the root zone.

Symmetric diffusions with polynomial eigenvectors
Dominique Bakry
Mathematics , 2014,
Abstract: We describe symmetric diffusion operators where the spectral decomposition is given through a family of orthogonal polynomials. In dimension one, this reduces to the case of Hermite, Laguerre and Jacobi polynomials. In higher dimension, some basic examples arise from compact Lie groups. We give a complete description of the bounded sets on which such operators may live. We then provide a classification of those sets when the polynomials are ordered according to their usual degrees
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