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Search Results: 1 - 10 of 327517 matches for " Randal S. Weber "
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Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
Garden Adam S,Kies Merrill S,Morrison William H,Weber Randal S
Radiation Oncology , 2013, DOI: 10.1186/1748-717x-8-21
Abstract: Background We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches. Methods Demographics, treatments and outcomes of patients diagnosed with Stage 3- 4B squamous carcinoma of the oropharynx, between 2000 – 2007 were tabulated and analyzed. Results The cohort consisted of 1046 patients. The 5- year actuarial overall survival, recurrence-free survival and local-regional control rates for the entire cohort were 78%, 77% and 87% respectively. More advanced disease, increasing T-stage and smoking were associated with higher rates of local-regional recurrence and poorer survival. Conclusions Patients with locally advanced oropharyngeal cancer have a relatively high survival rate. Patients’ demographics and primary tumor volume were very influential on these favorable outcomes. In particular, patients with small primary tumors did very well even when treatment was not intensified with the addition of chemotherapy.
MicroRNA Profiling of Salivary Adenoid Cystic Carcinoma: Association of miR-17-92 Upregulation with Poor Outcome
Yoshitsugu Mitani, Dianna B. Roberts, Hanadi Fatani, Randal S. Weber, Merrill S. Kies, Scott M. Lippman, Adel K. El-Naggar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066778
Abstract: Background Salivary adenoid cystic carcinoma (ACC) is a rare relentlessly progressive malignant tumor. The molecular events associated with ACC tumorigenesis are poorly understood. Variable microRNAs (miRNA) have been correlated with tumorigenesis of several solid tumors but not in ACC. To investigate the association of miRNAs with the development and/or progression of ACC, we performed a comparative analysis of primary ACC specimens and matched normal samples and a pooled salivary gland standard and correlated the results with clinicopathologic factors and validated selected miRNAs in a separate set of 30 tumors. Methods MiRNA array platform was used for the identification of target miRNAs and the data was subjected to informatics and statistical interrelations. The results were also collected with the MYB-NFIB fusion status and the clinicopathologic features. Results Differentially dysregulated miRNAs in ACC were characterized in comparison to normal expression. No significant differences in miRNA expression were found between the MYB-NFIB fusion positive and -negative ACCs. Of the highly dysregulated miRNA in ACC, overexpression of the miR-17 and miR-20a were significantly associated with poor outcome in the screening and validation sets. Conclusion Our study indicates that the upregulation of miR-17-92 may play a role in the biology of ACC and could be potentially targeted in future therapeutic studies.
Periorbital Post-Inflammatory Hyperpigmentation after Fractionated CO2 Laser Resurfacing in Asians  [PDF]
Randal Tanh Hoang Pham, Ingerlisa Mattoch, Sterling S. Baker
Modern Plastic Surgery (MPS) , 2015, DOI: 10.4236/mps.2015.52002
Abstract: Background: Most data on laser resurfacing have come from studies of people with Fitzpatrick skin types 1 - 3; however, the world’s population is comprised mostly of Fitzpatrick skin types 4 - 6, which are more susceptible to post-inflammatory hyperpigmentation (PIH). Objective: For the purpose of expanding the expertise of plastic surgeons treating patients with darker skin types, this study examined the incidence of PIH in Asians who underwent laser resurfacing, including a histologic arm on fractional ablative resurfacing. Methods & Materials: The clinical study included six subjects of Vietnamese origin who underwent single-depth fractionated CO2 laser resurfacing. The histologic study involved a seventh subject. The MiXto SX® laser with a new scanning handpiece was used, along with magnifying loupes to assess ablative depth after each of three laser passes performed. Photographs were taken at various postoperative intervals. Results: All six clinical subjects showed cosmetic improvement in skin texture and tone with no post-inflammatory hyperpigmentation. In the histologic study, H&E stained sections revealed uniform diathermy. Conclusion: It is possible to significantly reduce PIH in darker skinned subjects through use of a new scanning handpiece and a technique using loupes to assess the depth of ablative resurfacing. The histologic study confirms these findings.
Diffusion in LanCoIn3n+2 phases studied by perturbed angular correlation
Randal Newhouse,Gary S. Collins
Physics , 2011,
Abstract: Jump frequencies of 111In/Cd tracer atoms were measured for a series of layered phases LanCoIn3n+2 using the technique of perturbed angular correlation of gamma rays (PAC). The frequencies were determined by analysis of nuclear quadrupole relaxation produced by fluctuating electric field gradients. Samples were synthesized having nominal values n= 1, 2, 3, 5 and \infty, with n=\infty corresponding to the L12 phase LaIn3. The phases form heuristically from LaIn3 by replacing every (n+1)th (100) mixed plane of La and In atoms with a plane of Co-atoms. For the n=1 phase, LaCoIn5, jump frequencies were too small to detect. Two signals were observed, one for indium atoms next to the Co-planes and the other for more distant indium atoms. No relaxation was observed for atoms next to the Co-planes, indicating that there is no diffusion across the Co-planes. With increasing n, jump rates for the other In-atoms increased toward values observed for LaIn3. Jump frequency activation enthalpies for n= 3 and 5 were observed to be the same as for n=\infty, suggesting the same diffusion mechanism. However, the jump-frequency prefactors were found to be smaller for small n, which is attributed to reductions in the connectivity of the diffusion sublattice. We conclude that diffusion in the layered phases is remarkably similar to diffusion in LaIn3 once the reduced connectivity is taken into account.
Gene order data from a model amphibian (Ambystoma): new perspectives on vertebrate genome structure and evolution
Jeramiah J Smith, S Randal Voss
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-219
Abstract: Ambystoma has experienced a rate of genome rearrangement that is substantially lower than mammalian species but similar to that of chicken and fish. Overall, we found greater conservation of genome structure between Ambystoma and tetrapod vertebrates, nevertheless, 57% of Ambystoma-fish orthologs are found in conserved syntenies of four or more genes. Comparisons between Ambystoma and amniotes reveal extensive conservation of segmental homology for 57% of the presumptive Ambystoma-amniote orthologs.Our analyses suggest relatively constant interchromosomal rearrangement rates from the euteleost ancestor to the origin of mammals and illustrate the utility of amphibian mapping data in establishing ancestral amniote and tetrapod gene orders. Comparisons between Ambystoma and amniotes reveal some of the key events that have structured the human genome since diversification of the ancestral amniote lineage.Amphibians (salamanders, frogs, and cecilians) arise from a branch of the vertebrate evolutionary tree that is juxtaposed between aquatic fishes and more terrestrial amniotes (Figure 1). This phylogenetic location therefore positions amphibians to provide important comparative perspective for reconstructing character changes that have occurred during vertebrate evolution. For example, the amphibian perspective is essential for understanding molecular, developmental, and morphological changes of appendages that are associated with the transformation of obligatorily aquatic fish to terrestrial tetrapods [1-4]. In addition, because amphibians are the most basal tetrapod lineage, the amphibian perspective is essential for understanding the evolution of amniote characteristics among the "higher vertebrate" groups. Although many studies have exploited the phylogenetic position of amphibians for comparative perspective, very few comparisons have been made at the genome level. Here we present results from the first broad-scale comparison of genome structure between an amphibian
Diffusion in binary and pseudo-binary L12 indides, stannides, gallides and aluminides of rare-earth elements as studied using perturbed angular correlation of 111In/Cd
Randal Newhouse,Justine Minish,Gary S. Collins
Physics , 2011,
Abstract: Diffusional jumps can produce fluctuating electric field gradients at nuclei of jumping atoms. Using perturbed angular correlation of gamma rays (PAC), jumps of probe atoms cause nuclear quadrupole relaxation that can be fitted to obtain the mean jump frequency. An overview is given of the application of this approach to highly ordered intermetallic compounds having the L12 (Cu3Au) crystal structure. New results are then presented for jump frequencies of 111In/Cd probe atoms in pseudo-binary L12 compounds of the forms In3(La1-xPrx) and (In1-xSnx)3La. For the mixed rare-earth system, jump frequencies are found to scale with composition between jump frequencies of the end-member phases In3La and In3Pr. However, for the mixed sp-element system, a large decrease in jump frequency is observed as Sn atoms substitute for In-atoms. This difference in behavior appears to depend on whether atomic disorder is on the diffusion sublattice (In-Sn substitution), as opposed to a neighboring sublattice (La-Pr substitution), whether or not there is a difference in diffusion mechanism between end-member phases, and/or whether or not there is a valence difference between the mixing atoms. All three conditions apply for only (In1-xSnx)3La.
Navigating the massive world of reddit: Using backbone networks to map user interests in social media
Randal S. Olson,Zachary P. Neal
Computer Science , 2013,
Abstract: In the massive online worlds of social media, users frequently rely on organizing themselves around specific topics of interest to find and engage with like-minded people. However, navigating these massive worlds and finding topics of specific interest often proves difficult because the worlds are mostly organized haphazardly, leaving users to find relevant interests by word of mouth or using a basic search feature. Here, we report on a method using the backbone of a network to create a map of the primary topics of interest in any social network. To demonstrate the method, we build an interest map for the social news web site reddit and show how such a map could be used to navigate a social media world. Moreover, we analyze the network properties of the reddit social network and find that it has a scale-free, small-world, and modular community structure, much like other online social networks such as Facebook and Twitter. We suggest that the integration of interest maps into popular social media platforms will assist users in organizing themselves into more specific interest groups, which will help alleviate the overcrowding effect often observed in large online communities.
Optimize Unsynchronized Garbage Collection in an SSD Array
Da Zheng,Randal Burns,Alexander S. Szalay
Computer Science , 2015,
Abstract: Solid state disks (SSDs) have advanced to outperform traditional hard drives significantly in both random reads and writes. However, heavy random writes trigger fre- quent garbage collection and decrease the performance of SSDs. In an SSD array, garbage collection of individ- ual SSDs is not synchronized, leading to underutilization of some of the SSDs. We propose a software solution to tackle the unsyn- chronized garbage collection in an SSD array installed in a host bus adaptor (HBA), where individual SSDs are exposed to an operating system. We maintain a long I/O queue for each SSD and flush dirty pages intelligently to fill the long I/O queues so that we hide the performance imbalance among SSDs even when there are few parallel application writes. We further define a policy of select- ing dirty pages to flush and a policy of taking out stale flush requests to reduce the amount of data written to SSDs. We evaluate our solution in a real system. Experi- ments show that our solution fully utilizes all SSDs in an array under random write-heavy workloads. It improves I/O throughput by up to 62% under random workloads of mixed reads and writes when SSDs are under active garbage collection. It causes little extra data writeback and increases the cache hit rate.
Combined Carbon Dioxide Laser Lateral Canthotomy and Femtosecond Laser-Assisted Cataract Surgery  [PDF]
Randal Tanh Hoang Pham
Modern Plastic Surgery (MPS) , 2013, DOI: 10.4236/mps.2013.34027
Abstract:

Purpose: The purpose of this study was to evaluate a new procedure aimed at lengthening the palpebral fissure to facilitate femtosecond laser-assisted cataract surgery in patients with small eyes. Method: A quick procedure using the CO2 laser was adapted for patients with small eyes undergoing laser-assisted cataract surgery using the Catalys system. The UniPulse CO2 laser (Nidek) was used for laser lateral canthotomy on patients with small palpebral fissures to allow fitting of the Liquid OpticTM Interface eyepiece. Results: Lateral canthotomies were performed on 19 women and 7 men (ages ranged from 45 to 93 years) with lower eyelid lengths equal to or shorter than 32 mm who then underwent femtosecond laser-assisted cataract surgery. A total of 33 eyelids received laser lateral canthotomy with the CO2 laser; only one eyelid had lateral canthotomy with cold-steel tenotomy scissors. Dockings were completed for all 34 eyes with eyelids receiving lateral canthotomies. The 33 eyes with eyelids that received laser canthotomy with the CO2 laser had successful femtosecond laser-assisted cataract surgery. The one eye with the eyelid that received cold-steel canthotomy could not have femtosecond laser-assisted cataract surgery despite successful docking because of pupillary constriction. The findings were statistically significant; Fisher Exact Test showed a p-value of 0.0294. Conclusion: Laser lateral canthotomy with CO2 laser is a safe and effective method to allow docking and completion of femtosecond laser-assisted cataract surgery.

On Merging Cover Inequalities for Multiple Knapsack Problems  [PDF]
Randal Hickman, Todd Easton
Open Journal of Optimization (OJOp) , 2015, DOI: 10.4236/ojop.2015.44014
Abstract:

This paper describes methods to merge two cover inequalities and also simultaneously merge multiple cover inequalities in a multiple knapsack instance. Theoretical results provide conditions under which merged cover inequalities are valid. Polynomial time algorithms are created to find merged cover inequalities. A computational study demonstrates that merged inequalities improve the solution times for benchmark multiple knapsack instances by about 9% on average over CPLEX with default settings.

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