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Search Results: 1 - 10 of 1441 matches for " Ramon Charco "
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Right-sided diaphragmatic rupture after blunt trauma. An unusual entity
Ramon Vilallonga, Vicente Pastor, Laura Alvarez, Ramon Charco, Manel Armengol, Salvador Navarro
World Journal of Emergency Surgery , 2011, DOI: 10.1186/1749-7922-6-3
Abstract: Traumatic injuries of the diaphragm remain an entity of difficult diagnosis despite having been recognised early in the history of surgery. Sennertus, in 1541, performed an autopsy in one patient who had died from herniation and strangulation of the colon through a diaphragmatic gap secondary to a gunshot wound received seven months earlier [1]. However, these cases remain rare, and difficult to diagnose and care for. This has highlighted some of the aspects related to these lesions, especially when they are caused by blunt trauma and injuries of the right diaphragm [1,2].We report the case of a man of 36 years of age, thrown from a height of 12 meters and was referred to our centre. The patient arrived conscious and oriented, and we began manoeuvring the management of the patient with multiple injuries according to the guidelines of the ATLS (Advanced Trauma Life Support) recommended by the American College of Surgeons. The patient had an unstable pelvic fracture (type B2) with hemodynamic instability and respiratory failure. Patient's Injury Severity Score (ISS) was 38. Pelvis and chest X-rays were performed which confirmed the pelvic fracture and pathological elevation of the right hemidiaphragm was observed (Figure 1). We proceeded to stabilise the pelvic fracture and replace fluids, improving hemodynamic status. The patient continued with respiratory failure. For this reason, a chest tube was placed and Computerised Tomography (CT) was performed (Figure 2), showing a ruptured right hemidiaphragm, including chest drain in the right hepatic lobe and occupation of the lesser sac by blood. The patient underwent surgery, finding a right hemidiaphragm transverse rupture with a hepatothorax and an intrahepatic thoracic tube. We performed the suture of the diaphragm and liver packing, moved the patient to the intensive care unit, and after 48 hours, the liver packing was removed without problems. The patient evolved favourably.Currently, traumatic injuries of the diaph
Waning Sovereignty? The Kindred Myths of “Origins” and “Vanishing” of the State  [PDF]
Ramon Maiz
Open Journal of Political Science (OJPS) , 2017, DOI: 10.4236/ojps.2017.73032
Abstract: This article discusses, from an historical-neo-institutionalist and relational-strate- gic perspective, the postmodern thesis of the end of the state due to the increasing processes of world globalization. The main hypothesis is that the arguments which predict the structural crisis or the disappearance of the State in the age of neo-liberal globalization have their roots in a theoretically and historically implausible concept of sovereignty that ignores and distorts central aspects of statehood and state-building in terms of both institutional structure and political action. The myth of the “origins” of the State in Medieval or Renaissance times shares with the postmodern vision of the “vanishing” of the state, the same underlying misconception of the scope and limits of the state power. Sovereignty (the monopolization of political power) was always a claim, a desiderata, a contested andunfinished political project not an accomplished empirical fact.
Non-anatomical intestinal transplantation Trasplante intestinal en posición no anatómica
R. Charco,C. Malagelada,L. Llopart,J. Bueno
Revista Espa?ola de Enfermedades Digestivas , 2009,
Abstract: Introduction: intestinal transplantation is the only long-range treatment option for patients with intestinal failure. We report an exceptional case of isolated intestinal transplantation with the implant in a non-anatomical position. Clinical case: the patient was a thirty-eight-year-old man (60 kg weight, 180 cm height, 18.3 body mass index) with intestinal failure and home parenteral nutrition due to a short-bowel syndrome for which intestinal transplantation was indicated. The patient had a vascular malformation with the cava vein located left to the aorta, and the intestine was implanted with a 180o rotation around the mesenteric axis, so that the implant's superior mesenteric artery and vein matched the recipient's cava and aorta. Postoperative follow-up was excellent and the patient was discharged after six weeks with a 10-kg gain in body weight. Discussion: this non-anatomical intestinal implantation of the small bowel, previously unreported, offers technical advantages over other options. Adequate intestinal function represents a unique model to prove the viability of intestinal implants in a non-anatomical position. Introducción: el trasplante intestinal es el único tratamiento eficaz a largo plazo de los pacientes con fallo intestinal. Se presenta un caso clínico excepcional de trasplante intestinal aislado en posición no anatómica. Caso clínico: se trata de un varón de 38 a os de edad con fallo intestinal y nutrición parenteral domiciliaria por un síndrome de intestino corto al que se le indicó un trasplante intestinal. Fue incluido en lista de espera con un peso de 60 kg, 180 cm de altura y 18,3 de índice de masa corporal. El receptor presentaba una trasposición de los grandes vasos con la vena cava situada a la izquierda de la arteria aorta por lo que el intestino se implantó con una rotación del injerto de 180o sobre su eje mesentérico, con el objetivo de que la vena y la arteria mesentérica superior del injerto coincidieran con la vena cava y la arteria aorta del receptor. El paciente presentó excelente postoperatorio y fue dado de alta a las 6 semanas con un aumento de peso de 10 kg. Discusión: esta implantación no anatómica del intestino, previamente no referida en la literatura, ofrece ventajas técnicas sobre otras alternativas. La adecuada función intestinal constituye un modelo único que prueba la viabilidad del intestino implantado en posición no anatómica.
3D analytical and numerical modelling of the regional topography influence on the surface deformation due to underground heat source
Ladislav Brimich, María Charco, Igor Kohút, José Fernández
Contributions to Geophysics and Geodesy , 2011, DOI: 10.2478/v10126-011-0010-3
Abstract: Thermo-elastic strains and stresses play a considerable role in the stress state of the lithosphere and its dynamics, especially at pronounced positive geothermal anomalies. Topography has a significant effect on ground deformation. In this paper we describe two methods for including the topographic effects in the thermo-viscoelastic model. First we use an approximate methodology which assumes that the main effect of the topography is due to distance from the source to the free surface and permits to have an analytical solution very attractive for solving the inverse problem. A numerical solution using Finite Element Method (FEM) is also computed. The numerical method allows to include the local shape of the topography in the modelling. In the numerical model the buried magmatic body is represented by a finite volume thermal source. The temperature distribution is computed by the higher-degree FEM. For analytical as well as numerical model solution only the forces of thermal origin are considered. The comparison of the results obtained using both analytical and numerical techniques shows the qualitative agreement of the vertical displacements. In the numerical values small differences were obtained. The results show that for the volcanic areas with an important relief the perturbation of the thermo-viscoelastic solution (deformation and total gravity anomaly) due to the topography can be quite significant. In consequence, neglecting topography could give erroneous results in the estimated source parameters.
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments
Ramon Grima
BMC Systems Biology , 2009, DOI: 10.1186/1752-0509-3-101
Abstract: Starting from a master equation description of enzyme reaction kinetics and assuming metabolic steady-state conditions, we derive novel mesoscopic rate equations which take into account (i) the intrinsic molecular noise due to the low copy number of molecules in intracellular compartments (ii) the physical nature of the substrate transport process, i.e. diffusion or vesicle-mediated transport. These equations replace the conventional macroscopic and deterministic equations in the context of intracellular kinetics. The latter are recovered in the limit of infinite compartment volumes. We find that deviations from the predictions of classical kinetics are pronounced (hundreds of percent in the estimate for the reaction velocity) for enzyme reactions occurring in compartments which are smaller than approximately 200 nm, for the case of substrate transport to the compartment being mediated principally by vesicle or granule transport and in the presence of competitive enzyme inhibitors.The derived mesoscopic rate equations describe subcellular enzyme reaction kinetics, taking into account, for the first time, the simultaneous influence of both intrinsic noise and the mode of transport. They clearly show the range of applicability of the conventional deterministic equation models, namely intracellular conditions compatible with diffusive transport and simple enzyme mechanisms in several hundred nanometre-sized compartments. An active transport mechanism coupled with large intrinsic noise in enzyme concentrations is shown to lead to huge deviations from the predictions of deterministic models. This has implications for the common approach of modeling large intracellular reaction networks using ordinary differential equations and also for the calculation of the effective dosage of competitive inhibitor drugs.The inside of a cell is a highly complex environment. In the past two decades, detailed measurements of the chemical and biophysical properties of the cytoplasm have es
Use of intravenous antiarrhythmics to identify concealed Brugada syndrome
Ramon Brugada
Trials , 2000, DOI: 10.1186/cvm-1-1-045
Abstract: Over the past 50 years, the survival and quality of life of patients with cardiac disease has improved tremendously. Despite continued progress in technology and drug therapy, it seems that progress may have reached a plateau. The majority of our patients suffer from structural heart diseases, such as atherosclerosis and primary myocardial disease, that often progress despite our best efforts.The situation is completely different, however, when cardiac arrest strikes a healthy young person with no previous medical history. In this case, there is pressure not only on the patient and physician but also on family members, as there is a higher likelihood that the patient is suffering from a genetically determined disease predisposing to sudden death. It is at this point that there is a clash between the bench and the bedside, with physicians and family demanding a genetic test that will provide a definite diagnosis. The advances in molecular cardiology and genetics have been spectacular if one thinks that it has been only 10 years since the identification of the first gene predisposing to a familial cardiac disease. It is expected that our knowledge of cardiac disease will grow exponentially in the next few years thanks to the advances in the Human Genome Project. The reality, though, is that the technology has not yet evolved enough to be able to complete a genetic screen in a few days.Among the different diseases which are genetically determined, Brugada syndrome has benefited tremendously from the developments in molecular biology. The diagnosis is based on a clinical-electrocardiographic criteria consisting of syncopal or aborted sudden death episodes occurring in patients with a structurally normal heart, who also present with a characteristic ECG pattern of right bundle branch block and ST segment elevation in leads V1 to V3. The episodes of syncope and sudden death (aborted) are caused by fast polymorphic ventricular tachycardias [1].The first case series showing
Directed cell migration in the presence of obstacles
Ramon Grima
Theoretical Biology and Medical Modelling , 2007, DOI: 10.1186/1742-4682-4-2
Abstract: We propose that cells can sense the presence of obstacles and avoid them because obstacles interfere with the chemical field. We build a model to test this hypothesis and find that this naturally enables efficient at-a-distance sensing to be achieved with no need for a specific and active obstacle-sensing mechanism. We find that (i) the efficiency of obstacle avoidance depends strongly on whether the chemotactic chemical reacts or remains unabsorbed at the obstacle surface. In particular, it is found that chemotactic cells generally avoid absorbing barriers much more easily than non-absorbing ones. (ii) The typically low noise in a cell's motion hinders the ability to avoid obstacles. We also derive an expression estimating the typical distance traveled by chemotactic cells in a 3D random distribution of obstacles before capture; this is a measure of the distance over which chemotaxis is viable as a means of directing cells from one point to another in vivo.Chemotactic cells, in many cases, can avoid obstacles by simply following the spatially perturbed chemical gradients around obstacles. It is thus unlikely that they have developed specialized mechanisms to cope with environments having low to moderate concentrations of obstacles.Directed cell motion is a common feature of many cells and micro-organisms; this movement can be induced by a number of factors including light (phototaxis), gravity (gravitotaxis) and various chemicals (chemotaxis). The last of these is the most pervasive natural form of taxis. The bacteria Escherichia coli and Salmonella typhimurium, the slime mould Dictyostelium discoideum, and neutrophils [1] are a few of the many well studied examples of chemotactic life-forms. Chemotaxis involves the detection of a local chemical gradient and the subsequent movement of the organism up (positive chemotaxis) or down (negative chemotaxis) the gradient. For example, Dictyostelium discoideum follows trails of folic acid secreted by its food source, bacte
Latinos(as) y la descolonización del imperio estadounidense en el siglo XXI
Tabula Rasa , 2007,
Abstract: despite appearances, the united states empire finds itself in an accelerated decay. there are many fights, such as anti-capitalist, anti-imperialist, and anti-patriarchic taking place in the interior of this empire, invisible to the peoples that live through the ominous consequences in latin america, africa, asia and middle east. this article presents the dilemmas that the united states empire faces related to the growth of the latin populations and the decolonialization from its interior. in a few decades, white people in the united states will be a demographic minority. current racial minorities will be the majorities; latinos will be the majority of the minority groups. the empire is struggling with new forms of apartheid (neoapartheid) and de-colonization of white supremacy. because of their strategic importance, the upcoming fights will be acute and defining for the future of all humanity.
Hacia un pluri-versalismo transmoderno decolonial
Tabula Rasa , 2008,
Abstract: this article discusses the concept of the universal in the western philosophical tradition and proposes other, decolonial ways to think about uni-versality as pluri-versality, based on the thinking of aimé cesaire, enrique dussel and the zapatistas. the first part discusses the concept of “universal” from descartes to marx, covering kant and hegel. the second part discusses the other concept of universal which is proposed by aimé cesaire from an afro-caribbean decolonial perspective. the third part analyzes the concept of universal implied in the notion of transmodernity proposed by enrique dussel. the fourth part discusses the difference between postmodernity and transmodernity using as an example the postmodern notion of hegemony proposed by laclau and the transmodern and pluriversal notion of politics proposed by the zapatistas in the other campaign. finally, the article discusses the implications of all this for the leftist debate about the vanguard party versus the rearguard movement.
Tachyon-Chaplygin inflation on the brane
Herrera, Ramon
High Energy Physics - Phenomenology , 2008, DOI: 10.1007/s10714-008-0703-8
Abstract: Tachyon-Brane inflationary universe model in the context of a Chaplygin gas equation of state is studied. General conditions for this model to be realizable are discussed. In the high-energy limit and by using an exponential potential we describe in great details the characteristic of this model. Recent observational data from the Wilkinson Microwave Anisotropy Probe experiment are employed to restrict the parameters of the model.
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