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Search Results: 1 - 10 of 610 matches for " Rami Kantor "
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The HIV-1 Non-subtype B Workgroup: An International Collaboration for the Collection and Analysis of HIV-1 Non-subtype B Data
Kantor Rami,Shafer Robert W,Katzenstein David
Journal of the International AIDS Society , 2005, DOI: 10.1186/1758-2652-7-1-71
Abstract:
Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis
Philip A Chan,Austin Huang,Rami Kantor
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.2.17701
Abstract: Introduction: Tenofovir-containing regimens have demonstrated potential efficacy as pre-exposure prophylaxis (PrEP) in preventing HIV-1 infection. Transmitted drug resistance mutations associated with tenofovir, specifically the reverse transcriptase (RT) mutation K65R, may impact the effectiveness of PrEP. The worldwide prevalence of transmitted tenofovir resistance in different HIV-1 subtypes is unknown. Methods: Sequences from treatment-na ve studies and databases were aggregated and analyzed by Stanford Database tools and as per the International AIDS Society (IAS-USA) resistance criteria. RT sequences were collected from GenBank, the Stanford HIV Sequence Database and the Los Alamos HIV Sequence Database. Sequences underwent rigorous quality control measures. Tenofovir-associated resistance mutations included K65R, K70E, T69-insertion and ≥3 thymidine analogue mutations (TAMs), inclusive of M41L or L210W. Results: A total of 19,823 sequences were evaluated across diverse HIV-1 subtypes (Subtype A: 1549 sequences, B: 9783, C: 3198, D: 483, F: 372, G: 594, H: 41, J: 69, K: 239, CRF01_AE: 1797 and CRF02_AG: 1698). Overall, tenofovir resistance prevalence was 0.4% (n=77/19,823, 95% confidence interval or CI: 0.3 to 0.5). K65R was found in 20 sequences (0.1%, 95% CI: 0.06 to 0.15). Differences in the prevalence of K65R between HIV-1 subtypes were not statistically significant. K70E and ≥3 TAMs were found in 0.015% (95% CI: 0.004 to 0.04) and 0.27% (95% CI: 0.2 to 0.4) of sequences, respectively. Conclusions: Prevalence of transmitted K65R and other tenofovir resistance mutations across diverse HIV-1 subtypes and recombinants is low, suggesting minimal effect on tenofovir-containing PrEP regimens.
HIV-2 diagnosis and quantification in high-risk patients
Philip A Chan, Sarah E Wakeman, Timothy Flanigan, Susan Cu-Uvin, Erna Kojic, Rami Kantor
AIDS Research and Therapy , 2008, DOI: 10.1186/1742-6405-5-18
Abstract: HIV-2, the second AIDS-causing virus, is found predominantly in the Portuguese speaking countries of West Africa, with the highest rates of infection in Guinea-Bissau [1]. The prevalence of HIV-2 in the United States is extremely low [2], and the current guidelines recommend testing for HIV-2 only in the case of an indeterminate western blot or in patients with known links to West Africa [2,3]. While this screening practice may make sense for the majority of U.S. cities where the percentage of the population of West African descent is decidedly small, cities with a significant immigrant community from infected regions should consider increased surveillance. We present the case of a patient of Cape Verdean descent with likely PML in the setting of HIV-2, and discuss the difficulties of diagnosing HIV-2 in the United States.A 48 year-old male with a past medical history significant only for cataracts was admitted to our hospital with weakness, difficulty walking, and confusion that began one day prior to admission. In addition to the neurological symptoms, the patient had experienced a flu-like illness three to four weeks earlier accompanied by a ten to fifteen pound weight loss. The patient was afebrile with mental status changes and abnormal cerebellar findings on neurological exam including a wide-based gait, ataxia, dysmetria on finger-to-nose, and difficulty with rapid alternating hand movements. On further history, the patient took no medications and was born in Cape Verde, immigrating to the United States six years earlier. While he admitted to having multiple recent female sexual partners, he denied any drug use or any male sexual partners. His wife and five children remained in Cape Verde. His history raised the possibility of acute HIV infection or an AIDS-related illness.An initial HIV enzyme immunoassay (EIA) was performed in the emergency room and returned positive (Bayer ADVIA Centaur HIV-1/O/2 EHIV EIA). Other laboratory tests were normal, aside from a
Application of the Analytical Hierarchy Process (AHP) to Multi-Criteria Analysis for Contractor Selection  [PDF]
Mohammed Balubaid, Rami Alamoudi
American Journal of Industrial and Business Management (AJIBM) , 2015, DOI: 10.4236/ajibm.2015.59058
Abstract: One of the key activities of any client is contractor selection. Without a suitable and precise method for selecting the best contractor, the completion of a project will likely be affected. In this study, we examine the use of the analytical hierarchy process (AHP) as a decision-support model for contractor selection. This model can assist project management teams in identifying contractors who are most likely to deliver satisfactory outcomes in a selection process that is not based simply on the lowest bid. In this study, an AHP-based model is tested using a hypothetical scenario in which candidate contractors are evaluated. Six criteria for the primary objective are evaluated. The criteria used for contractor selection in the model are identified, and the significance of each criterion is determined using a questionnaire. Comparisons are made by ranking the aggregate score of each candidate based on each criterion, and the candidate with the highest score is deemed the best. This study contributes to the construction sector in two ways: first, it extends the understanding of selection criteria to include degrees of importance, and second, it implements a multi-criteria AHP approach, which is a new method for analyzing and selecting the best contractor.
Cartografia e diplomacia: usos geopolíticos da informa??o toponímica (1750-1850)
Kantor, Iris;
Anais do Museu Paulista: História e Cultura Material , 2009, DOI: 10.1590/S0101-47142009000200004
Abstract: this paper explores the geopolitical dimensions of toponymy as registered in cartographic documents dating from the reforms pushed through by the consulate of marquis of pombal in the mid 18th century to the early decades of the 19th century, as the post-colonial imperial state established itself.
Minorías sexuales: sobre el paradigma de la Tolerancia y el paradigma de la Ciudadanía Plena
Kantor, Daniel;
Política y cultura , 2011,
Abstract: we propose two paradigms for analyzing the rights of sexual minorities within a juridical-political-social framework. the first paradigm arises from the idea of tolerance; whereas the second stems from the notion of full citizenship. the features of both paradigms have been gleaned from bills, laws and judicial cases concerning the right to association and the right to same-sex marriage. the article reviews the legal discourse and political implications of the aforementioned legal sources as well as some socio-historical issues concerning the struggle for equal rights of sexual minorities in argentina.
Usos diplomáticos da ilha-Brasil polêmicas cartográficas e historiográficas
Kantor, íris;
Varia Historia , 2007, DOI: 10.1590/S0104-87752007000100005
Abstract: this article analyses the formation of brazil's island myth and how it was represented in the xvi and xvii cartography. it also discusses how this myth was used and reused for diplomatic porpoises.
Minorías sexuales: sobre el paradigma de la Tolerancia y el paradigma de la Ciudadanía Plena
Daniel Kantor
Política y cultura , 2011,
Abstract: Proponemos dos formas paradigmáticas de concebir los derechos de las minorías sexuales en un marco jurídico-político y social general. El primer paradigma es una mirada a través del prisma de la "Tolerancia", el segundo desde la perspectiva de la "Ciudadanía Plena". Hemos deducido las características de ambos paradigmas a partir de proyectos de leyes, leyes y casos jurisprudenciales referentes al "Derecho de Asociación" y al "Derecho al Matrimonio entre Personas del Mismo Sexo". Revisamos el discurso jurídico y las implicancias políticas de las sentencias, y algunos aspectos histórico-sociales de las luchas por las reivindicaciones de las minorías sexuales en Argentina.
Globalization and the American Model of Urban Development: Making the Market
Paul Kantor
Métropoles , 2007,
Abstract: Ce travail discute de l’argument selon lequel le modèle de développement urbain américain serait le reflet d’une pénétration du niveau local par de nouvelles forces libérées par la globalisation économique. Bien que le modèle américain contienne de nombreuses caractéristiques néo-libérales, cette analyse dévoile le r le important joué par le gouvernement américain dans la constitution d’un système urbain radicalement décentralisé bien avant la nouvelle économie. Il montre également comment ce système est activement soutenu par une intervention croissante de l’Etat à tous les niveaux. La nouvelle économie ne saurait être confondue avec le modèle américain de développement. Au contraire, l’expérience urbaine américaine révèle bien le caractère essentiellement politique du processus de globalisation et le r le omniprésent des politiques publiques dans son fonctionnement. This survey questions whether the American model of urban development reflects penetration of the local state by new forces unleashed by economic globalization. Although the American model incorporates many neo-liberal features, this analysis describes how government in the USA actually played a key role in erecting a radically decentralized urban system in advance of the new economy. It also surveys how this system is actively sustained through growing state intervention at all governmental levels. The new economy should not be conflated with the American model of development. Rather, the American urban experience is suggestive of the essentially political character of the globalization process and the ubiquitous role of public policy in making it work.
Cartografia e diplomacia: usos geopolíticos da informa o toponímica (1750-1850)
Iris Kantor
Anais do Museu Paulista: História e Cultura Material , 2009,
Abstract: This paper explores the geopolitical dimensions of toponymy as registered in cartographic documents dating from the reforms pushed through by the consulate of Marquis of Pombal in the mid 18th century to the early decades of the 19th century, as the post-colonial imperial State established itself.
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