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Search Results: 1 - 10 of 204781 matches for " Ramón Scull Lizama "
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Citotoxicidad de extractos de plantas medicinales sobre la línea celular de carcinoma de pulmón humano A549
Díaz García,Alexis; Rodríguez Sánchez,Hermis; Scull Lizama,Ramón;
Revista Cubana de Farmacia , 2011,
Abstract: objectives: to evaluate the effect of 10 cuban medicinal plant extracts on the human lung tumor cell line a549. methods: the effect of the plant extracts on tumor cells was determined by a colorimetric assay using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) at concentrations ranging from 3,9-250 μg/ml for 72 hours and the mean cytotoxic concentration was calculated for each of them. results: the ethanolic extracts of parthenium hysterophorus, bixa orellana, momordica charantia and cucurbita maxima showed mean cytotoxic concentrations under 100 μg/ml. except for p. hysterophorus, the others are used in traditional medicine to fight cancer. the remaining extracts from cecropia peltata, melia azedarach, annona glabra, artemisia absintium, lepidium virginicum and bidens pilosa did not show significant cytotoxic effects. conclusions: the plant extracts for cancer treatment in traditional medicine showed cytotoxic effect on the tumor cell lines. ethnobotanical data represent an important tool for medicinal plants screening in the quest for new compounds to treat cancer.
Plantas medicinales de uso tradicional en Pinar del Río: Estudio etnobotánico. I
Scull Lizama,Ramón; Miranda Martínez,Migdalia; Infante Lantigua,Raúl E;
Revista Cubana de Farmacia , 1998,
Abstract: the results of a survey carried out among the inhabitants from 7 localities in the province of pinar del rio that allowed to establish the traditional use of 112 medicinal plants, which are used in 27 different affectations, are presented. the scientific names of each species, their family grouping, their taxonomic representativity, as well as the properties that are attributed to them according to the zone under study, are given. the results agree partially with those obtained by other investigators in different zones of the country.
Contribución al estudio de Cissus sicyoides L. (bejuco-ubí)
Scull Lizama,Ramón; Miranda Martínez,Migdalia; Caballero Pérez,Omelio;
Revista Cubana de Farmacia , 2000,
Abstract: the micromorphological description of cissus sicoydes l. (ipecacuanha) is presented and the preliminary phytochemical composition is summarized. aminoacids, fatty compounds and flavonoids, which have not been previously reported in bibliography, are detected in the whole aerial part of the plant. it is proved that the type of drying does not alter the compositon of the drug and guidelines are set on its stability. it is also demonstrated that the plant does not have toxic or antiviral effects against the virus of influenza a in victoria h3n2 and wsn (h1n1) strains for the conditons under which the study was developed.
Evaluación antileishmanial in vitro de extractos provenientes de Citrus limetta, Cucurbita maxima y Rhoeo spathacea
García Parra,Marley; Monzote Fidalgo,Lianet; Montalvo álvares,Ana Margarita; Scull Lizama,Ramón;
Revista Cubana de Medicina Tropical , 2008,
Abstract: background: leishmaniosis covers a group of infectious diseases caused by leishmania genus hemoflagellate organisms. at present, this disease is prevailing in 88 tropical countries worldwide; it is estimated that 1.5 to 2 million new cases will occur every year. the control of the disease is deficient, mainly because there is no effective vaccine available. although several drugs for treatment exist, all of them require parenteral way of administration, delayed and costly therapies and cause high toxicity. the tropical disease program of the world health organization considers plant research as an essential priority for leishmania treatment. objective: to evaluate the antileishmanial action of extracts from citrus limetta, cucurbita maxima y rhoeo spathacea. methods: aleishmania amazonensis strain, the causative agent of cutaneous leishmaniosis, was used in this paper. the extract effect on the stagings of promastigot and amastigot of the parasite as well as on the peritoneal macrophages from balb/c mouse was determined to assess its possible toxicity. results: curcubita maxima y rhoeo spathacea showed higher percentage of growth inhibition in promastigots. good anti-leishmanial activity was also observed against amastigots, whereas its citotoxicity was moderate, with a selectivity index of 3. conclusions: curcubita maxima y rhoeo spathacea extracts were the only ones that had anti-leishmanial activity.
Plantas medicinales de uso tradicional en Pinar del Río: Estudio etnobotánico. I
Ramón Scull Lizama,Migdalia Miranda Martínez,Raúl E Infante Lantigua
Revista Cubana de Farmacia , 1998,
Abstract: Se presentan los resultados de una encuesta realizada a los pobladores de 7 localidades de la provincia de Pinar del Río, la cual permitió establecer el uso tradicional de 112 plantas medicinales, que son empleadas en 27 afecciones diferentes. Se relacionan los nombres científicos de cada especie, su agrupación en familia, su representabilidad taxonómica, así como las propiedades que les son atribuidas en la zona de estudio. Los resultados concuerdan parcialmente con los obtenidos por otros investigadores en diferentes zonas del país. The results of a survey carried out among the inhabitants from 7 localities in the province of Pinar del Rio that allowed to establish the traditional use of 112 medicinal plants, which are used in 27 different affectations, are presented. The scientific names of each species, their family grouping, their taxonomic representativity, as well as the properties that are attributed to them according to the zone under study, are given. The results agree partially with those obtained by other investigators in different zones of the country.
Citotoxicidad de extractos de plantas medicinales sobre la línea celular de carcinoma de pulmón humano A549 Cytotoxicity of medicinal plant extracts on the human lung carcinoma cell line A549
Alexis Díaz García,Hermis Rodríguez Sánchez,Ramón Scull Lizama
Revista Cubana de Farmacia , 2011,
Abstract: OBJETIVO: evaluar el efecto de 10 extractos de plantas medicinales sobre el crecimiento de la línea celular humana de carcinoma de pulmón A549. METODOS: el efecto de los extractos sobre la células tumorales se midió a través de un ensayo colorimétrico mediante el empleo del bromuro de 3-(4,5-dimetil-tiazol-2-yl)-2,5-difenil tetrazolio a concentraciones entre 3,9-250 μg/mL durante 72 h y se calculó la concentración citotóxica media para cada uno. RESULTADOS: del total de los extractos evaluados solo cuatro (Parthenium hysterophorus, Bixa orellana, Momordica charantia y Cucurbita maxima) evidenciaron concentraciones citotóxicas medias inferiores a 100 μg/mL. Excepto Parthenium hysterophorus, las restantes se emplean en la medicina tradicional para el tratamiento del cáncer. Los extractos de Cecropia peltata, Melia azedarach, Annona glabra, Artemisia absintium, Lepidium virginicum y Bidens pilosa no mostraron efectos citotóxicos significativos. CONCLUSIONES: Los extractos de plantas que se emplean en la medicina tradicional para el tratamiento del cáncer, mostraron citotoxicidad sobre las células tumorales. El conocimiento etnobotánico representa una herramienta importante en la selección de plantas medicinales, en la búsqueda de nuevos compuestos para el tratamiento del cáncer. OBJECTIVES: to evaluate the effect of 10 Cuban medicinal plant extracts on the human lung tumor cell line A549. METHODS: the effect of the plant extracts on tumor cells was determined by a colorimetric assay using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) at concentrations ranging from 3,9-250 μg/mL for 72 hours and the mean cytotoxic concentration was calculated for each of them. RESULTS: the ethanolic extracts of Parthenium hysterophorus, Bixa orellana, Momordica charantia and Cucurbita maxima showed mean cytotoxic concentrations under 100 μg/mL. Except for P. hysterophorus, the others are used in traditional medicine to fight cancer. The remaining extracts from Cecropia peltata, Melia azedarach, Annona glabra, Artemisia absintium, Lepidium virginicum and Bidens pilosa did not show significant cytotoxic effects. CONCLUSIONS: the plant extracts for cancer treatment in traditional medicine showed cytotoxic effect on the tumor cell lines. Ethnobotanical data represent an important tool for medicinal plants screening in the quest for new compounds to treat cancer.
Contribución al estudio de Cissus sicyoides L. (bejuco-ubí)
Ramón Scull Lizama,Migdalia Miranda Martínez,Omelio Caballero Pérez
Revista Cubana de Farmacia , 2000,
Abstract: Se presenta la descripción micromorfológica de Cissus sicyoides L. (bejuco-ubí) y se resume la composición fitoquímica preliminar, donde se detecta la existencia de aminoácidos, compuestos grasos y flavonoides en toda la parte aérea de la planta, los cuales no habían sido informados con anterioridad en la bibliografía. Se demuestra que el tipo de secado no altera la composición de la droga y se marcan pautas sobre la estabilidad de ésta. Se comprueba que la planta no posee efectos tóxicos ni antivirales contra el virus de la influenza A en cepas victoria H3N2 y WSN (H1N1), para las condiciones en que se desarrolló el estudio. The micromorphological description of Cissus sicoydes L. (ipecacuanha) is presented and the preliminary phytochemical composition is summarized. Aminoacids, fatty compounds and flavonoids, which have not been previously reported in bibliography, are detected in the whole aerial part of the plant. It is proved that the type of drying does not alter the compositon of the drug and guidelines are set on its stability. It is also demonstrated that the plant does not have toxic or antiviral effects against the virus of influenza A in victoria H3N2 and WSN (H1N1) strains for the conditons under which the study was developed.
Evaluación antileishmanial in vitro de extractos provenientes de Citrus limetta, Cucurbita maxima y Rhoeo spathacea In vitro anti-leishmanial evaluation of extracts from Citrus limetta, Cucurbita maxima y Rhoeo spathacea
Marley García Parra,Lianet Monzote Fidalgo,Ana Margarita Montalvo álvares,Ramón Scull Lizama
Revista Cubana de Medicina Tropical , 2008,
Abstract: INTRODUCCIóN: la leishmaniosis comprende un grupo de enfermedades infecciosas causadas por organismos hemoflagelados del género Leishmania. Hoy día, esta enfermedad prevalece en 88 países tropicales alrededor del mundo y existe un estimado de 1,5 a 2 millones de nuevos casos por a o. Su control es deficiente, principalmente al no contar con una vacuna eficaz. Aunque existen varios fármacos para su tratamiento, todos requieren una administración parenteral, tratamientos muy largos, costosos, y causan una alta toxicidad al organismo. El programa de enfermedades tropicales de la Organización Mundial de la Salud considera la investigación de plantas como una esencial prioridad para el tratamiento de Leishmania. OBJETIVO: evaluar la actividad antileishmanial de extractos provenientes de Citrus limetta, Cucurbita maxima y Rhoeo spathacea. MéTODOS: en este trabajo se utilizó una cepa de Leishmania amazonensis agente causal de la leishmaniosis cutánea. Se determinó la actividad de los extractos frente a los estadios de promastigote y amastigote del parásito, así como frente a macrófagos peritoneales de ratón BALB/c, para valorar su posible toxicidad. RESULTADOS: los extractos provenientes de Curcubita maxima y Rhoeo spathacea fueron los que mostraron un mayor porcentaje de inhibición del crecimiento frente a promastigotes. Frente a amastigotes también mostraron una buena actividad antileishmanial, mientras que su citotoxicidad fue moderada con un índice de selectividad de 3. CONCLUSIONES: solo los extractos de Curcubita maxima y Rhoeo spathacea fueron los que mostraron una actividad antileishmanial. BACKGROUND: leishmaniosis covers a group of infectious diseases caused by Leishmania genus hemoflagellate organisms. At present, this disease is prevailing in 88 tropical countries worldwide; it is estimated that 1.5 to 2 million new cases will occur every year. The control of the disease is deficient, mainly because there is no effective vaccine available. Although several drugs for treatment exist, all of them require parenteral way of administration, delayed and costly therapies and cause high toxicity. The tropical disease program of the World Health Organization considers plant research as an essential priority for Leishmania treatment. OBJECTIVE: to evaluate the antileishmanial action of extracts from Citrus limetta, Cucurbita maxima y Rhoeo spathacea. METHODS: aLeishmania amazonensis strain, the causative agent of cutaneous leishmaniosis, was used in this paper. The extract effect on the stagings of promastigot and amastigot of the parasite as well as on the
Propiedades antiprotozoarias de aceites esenciales extraídos de plantas cubanas
Monzote Fidalgo,Lianet; Sariego Ramos,Idalia; Montalvo álvarez,Ana M.; Garrido Lorente,Nidia; Scull Lizama,Ramón; Abreu Payrol,Juan;
Revista Cubana de Medicina Tropical , 2004,
Abstract: the antiprotozoan activity of the essential oil extracted from artemisa abrotanum, chenopodium ambrosioides, pinus caribaea, piper aduncum and piper auritum, was evaluated. the evaluated oils did not show activity against l. amozonensis; however, the oil extracted from c. ambrosoides showed a promising activity against trichomonas vaginalis with a minimum inhibitory concentration of 25 mg/ml.
Actividad inhibidora del crecimiento in vitro de Plasmodium falciparum de extractos de algas del género Laurencia
Mendiola Martínez,Judith; Hernández,Hilda; Acu?a,Deyanira; Esquivel,Macario; Scull Lizama,Ramón; Abreu Payrol,Juan;
Revista Cubana de Medicina Tropical , 2005,
Abstract: several terpenoids have been identified in the genus laurencia showing antimalarial activity; however it is a genus of great chemical complexity worldwide. the majority of these substances have been extracted from collections made in philippines and brazil. in order to know the presence of antimalarial activity in organisms of this genus from the north west coast of cuba, we prepared extracts in ethanol with the whole plant of specimens of l obtusa and l. corallopsis and evaluated the inhibition produced by them against growth of plasmodium falciparum, strain f32. the minimum inhibitory concentrations against p. falciparum determined for laurencia extracts were in the range of 44 and 162 μg/ml, and values of median inhibitory concentrations were between 14.82 and 51.3 μg/ml. the results are similar to those obtained for extracts from medicinal plants. the extracts did not improve chloroquine results. l. obtusa extracts gave strong reactions to the assays for terpenoids and for lactonic/coumarine compounds, but we also detected the presence of alkaloids, free reducing sugars, saponins and flavonoids. several molecules could contribute to the observed antiplasmodial activity of the extracts, so research is in progress for the isolation and purification of new active principles.
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