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Search Results: 1 - 10 of 139507 matches for " Rakesh K Chandode "
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Generation, annotation, and analysis of ESTs from midgut tissue of adult female Anopheles stephensi mosquitoes
Deepak P Patil, Santosh Atanur, Dhiraj P Dhotre, D Anantharam, Vineet S Mahajan, Sandeep A Walujkar, Rakesh K Chandode, Girish J Kulkarni, Pankaj S Ghate, Abhishek Srivastav, Kannayakanahalli M Dayananda, Neha Gupta, Bhakti Bhagwat, Rajendra R Joshi, Devendra T Mourya, Milind S Patole, Yogesh S Shouche
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-386
Abstract: We obtained 7061 and 8306 ESTs from the sugar-fed and P. yoelii infected mosquito midgut tissue libraries, respectively. ESTs from the combined dataset formed 1319 contigs and 2627 singlets, totaling to 3946 unique transcripts. Putative functions were assigned to 1615 (40.9%) transcripts using BLASTX against UniProtKB database. Amongst unannotated transcripts, we identified 1513 putative novel transcripts and 818 potential untranslated regions (UTRs). Statistical comparison of annotated and unannotated ESTs from the two libraries identified 119 differentially regulated genes. Out of 3946 unique transcripts, only 1387 transcripts were mapped on the A. gambiae genome. These also included 189 novel transcripts, which were mapped to the unannotated regions of the genome. The EST data is available as ESTDB at http://mycompdb.bioinfo-portal.cdac.in/cgi-bin/est/index.cgi webcite.3946 unique transcripts were successfully identified from the adult female A. stephensi midgut tissue. These data can be used for microarray development for better understanding of vector-parasite relationship and to study differences or similarities with other malaria vectors. Mapping of putative novel transcripts from A. stephensi on the A. gambiae genome proved fruitful in identification and annotation of several genes. Failure of some novel transcripts to map on the A. gambiae genome indicates existence of substantial genomic dissimilarities between these two potent malaria vectors.Anopheles stephensi is a major malaria vector in the Indian subcontinent [1]. Rapid urbanization and development in the region has stimulated a corresponding increase in their population resulting in frequent malaria outbreaks [2]. Although, recent malaria epidemics occurred at higher frequencies, mortality was considerably low. For example during 2003, of the reported 1.78 million cases, only 1006 deaths were recorded in India [3].Absence of an efficient vaccine [4], evolution of drug-resistance in the parasites [5]
Erratum to “Inflammation and Its Role in Prostate Cancer” [Journal of Cancer Therapy 5 (2014) 836-844]  [PDF]
Rakesh K. Mishra, Ashutosh K. Tewari
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.61011
Abstract:

Inflammation is associated with various cancers, and plays a significant role in prostate cancer genesis including initiation, promotion, malignant conversion, invasion, and metastasis. While several studies posit an important role of inflammation in prostate growth, the exact mechanisms are not known. The extant basic and clinical research in the area, trying to unravel the etiology of prostatic inflammation and its signaling pathway, may help to develop novel therapeutic interventions against prostate cancer development triggered by inflammation.

Erratum to “Inflammation and Its Role in Prostate Cancer” [Journal of Cancer Therapy 5 (2014) 836-844]  [PDF]
Rakesh K. Mishra, Ashutosh K. Tewari
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.61011
Abstract:

Inflammation is associated with various cancers, and plays a significant role in prostate cancer genesis including initiation, promotion, malignant conversion, invasion, and metastasis. While several studies posit an important role of inflammation in prostate growth, the exact mechanisms are not known. The extant basic and clinical research in the area, trying to unravel the etiology of prostatic inflammation and its signaling pathway, may help to develop novel therapeutic interventions against prostate cancer development triggered by inflammation.

Inflammation and Its Role in Prostate Cancer  [PDF]
Rakesh K. Mishra, Ashutosh K. Tewari
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.59092
Abstract:

Infections and inflammatory responses are linked to 20% - 300% of all deaths from cancer worldwide. Inflammatory responses play crucial roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Several studies point to an important role of inflammation in prostate growth, although the contribution of inflammation to benign prostate cancer is not completely understood. The basic and clinical research in the area, trying to understand the etiology of prostatic inflammation and its signaling pathway may help to develop the novel therapeutic interventions against prostate cancer development triggered by inflammation.

CLIPS based decision support system for water distribution networks
K. Sandeep,K. Rakesh
Drinking Water Engineering and Science (DWES) & Discussions (DWESD) , 2011, DOI: 10.5194/dwes-4-37-2011
Abstract: The difficulty in knowledge representation of a water distribution network (WDN) problem has contributed to the limited use of artificial intelligence (AI) based expert systems (ES) in the management of these networks. This paper presents a design of a Decision Support System (DSS) that facilitates "on-demand'' knowledge generation by utilizing results of simulation runs of a suitably calibrated and validated hydraulic model of an existing aged WDN corresponding to emergent or even hypothetical but likely scenarios. The DSS augments the capability of a conventional expert system by integrating together the hydraulic modelling features with heuristics based knowledge of experts under a common, rules based, expert shell named CLIPS (C Language Integrated Production System). In contrast to previous ES, the knowledge base of the DSS has been designed to be dynamic by superimposing CLIPS on Structured Query Language (SQL). The proposed ES has an inbuilt calibration module that enables calibration of an existing (aged) WDN for the unknown, and unobservable, Hazen-Williams C-values. In addition, the daily run and simulation modules of the proposed ES further enable the CLIPS inference engine to evaluate the network performance for any emergent or suggested test scenarios. An additional feature of the proposed design is that the DSS integrates computational platforms such as MATLAB, open source Geographical Information System (GIS), and a relational database management system (RDBMS) working under the umbrella of the Microsoft Visual Studio based common user interface. The paper also discusses implementation of the proposed framework on a case study and clearly demonstrates the utility of the application as an able aide for effective management of the study network.
Growth of Boron Nitride Nanotubes Having Large Surface Area Using Mechanothermal Process  [PDF]
Sunil K. Singhal, Avanish K. Srivastava, Rakesh B. Mathur
World Journal of Nano Science and Engineering (WJNSE) , 2011, DOI: 10.4236/wjnse.2011.14018
Abstract: Nanostructures of boron nitride (BN) including nanotubes, nanofibers and nanosheets having a large surface area are very useful in storing hydrogen and other gases. In the present paper we report the synthesis and characterization of these nanostructures of BN using mechanothermal process. Under this process elemental boron powder is first ball milled to about 50 h in an inert atmosphere and then annealed at 1100℃ - 1250℃ for 6 h in the presence of NH3 gas. By this treatment nanotubes and other nanostructures of BN were synthesized. The diameter of BN nanotubes varied from 20 to 50 nm and most of them exhibited spindle or bamboo like morphology. Because of the large surface area, these nanotubes may be explored for a better hydrogen gas storage device as compared to the crystallized nanotubes. The main advantage of this technique is that the nanotubes can be grown in large quantity. A possible growth mechanism towards the evolution of such fascinating nano-objects of boron nitride has been discussed employing high-resolution transmission electron microscopy and photoluminescence.
Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
Rakesh K Kumar
Respiratory Research , 2002, DOI: 10.1186/rr198
Abstract: In a review published in 1995, Kumar and Lykke [3] discussed lymphocyte-macrophage-fibroblast as well as epithelial cell-fibroblast and reciprocal interactions in pulmonary fibrosis. We stated that " [i]njury to alveolar epithelial cells, especially type 2 pneumocytes, appears to be an important event in the genesis of pulmonary fibrosis. Both in vitro and in vivo studies suggest that failure to replace damaged type 1 epithelium by proliferation and differentiation of type 2 pneumocytes may be a determinant of whether or not progression to fibrosis ensues." The references cited at this point included not only the studies by Adamson and colleagues [4] to which Selman and Pardo refer, but also data from an animal model of resolving vs. non-resolving pneumonia [5].Furthermore, we discussed the alveolar epithelial changes in pulmonary fibrosis and pointed out that " [b]oth in animal experimental models and in the human disease, these cuboidal epithelial cells develop cytoplasmic extensions ('spikes') which protrude through the epithelial basement membrane. The spikes may become intimately associated with interstitial fibroblastic cells, a finding that is especially noticeable in 'usual interstitial pneumonitis' associated with epithelial hyperplasia. These observations strongly suggest that 'handshakes' between type 2 pneumocyte-like epithelial cells and fibroblasts might take place during the development of pulmonary fibrosis." This part of the review included references to numerous descriptions of such spikes in the 1980s literature, electron micrographs demonstrating the spikes both in IPF and in murine bleomycin-induced pulmonary fibrosis, and discussion of the potential role of epithelial cell-derived transforming growth factor-β (and other growth factors) in the induction of fibrosis.Although this review was not published in a respiratory sciences journal, it has been cited in standard textbooks [6,7], so one could reasonably argue that the concept of IPF as a dis
International Journal of Herbal Medicine (IJHM): A New Open-Access International Journal
Rakesh K Joshi
International Journal of Herbal Medicine , 2013,
Abstract: It is with pleasure that we introduce the first issue of online journal “International Journal of Herbal Medicine (IHJM)” a bimonthly publication of AkiNik Publications. The Journal is peer-reviewed, broad-spectrum and committed to the promotion of research and dissemination of knowledge in Phytochemistry, Pharmacognosy, Essential oil chemistry, Natural product chemistry, Botany, Biochemistry, Biotechnology, Marine research and related multidiscipline. IJHM also provides an advanced international forum for the development of technology of pharmaceutical sciences.
Variability and Accuracy of Target Displacement from Nonlinear Static Procedures
Rakesh K. Goel
ISRN Civil Engineering , 2011, DOI: 10.5402/2011/582426
Abstract:
Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?
Rakesh K. Kumar
Frontiers in Physiology , 2012, DOI: 10.3389/fphys.2012.00312
Abstract: Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteristic pathological features of human asthma and their relationship to AHR and examine some limitations of mouse models that are commonly used to investigate these relationships. We compare these conventional models with our mouse model of chronic asthma involving long-term low-level inhalational challenge and review studies of the relationship between inflammation/remodeling and AHR in this model and its derivatives, including models of an acute exacerbation of chronic asthma and of the induction phase of childhood asthma. We conclude that while extrapolating from studies in mouse models to AHR in humans requires cautious interpretation, such experimental work can provide significant insights into the pathogenesis of airway responsiveness and its molecular and cellular regulation.
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