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Search Results: 1 - 10 of 325488 matches for " Rajani S. Nadgauda "
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Commiphora wightii (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat  [PDF]
Neeraj Jain, Rajani S. Nadgauda
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.46A009
Abstract:

The plants are the primary producers and an indispensible source of food and nutrition, medicine and fuel/biofuel. Unsustainable overharvesting and indiscriminate felling of plants due to ever increasing needs of population pressure are causes of great concern. The IUCN includes, the species facing a high risk of extinction in the wild as threatened, and “endangered” is one of the sub-categories under “threatened” category. Commiphora wightii (Arnott) Bhandari is an arid region plant, highly valued for its medicinally important guggul gum-resin as a source of guggulsterone. It is listed in IUCN’s Red Data List of threatened plants and now it is becoming endangered. Its population is fast depleting in its natural habitat, primarily due to over-exploitation, unsustainable and destructive methods of gum-extraction coupled with natural dry-arid habitat, slow growth and poor regeneration of the plant. Several other reasons have also been indicated for its declining population. Therefore, it demands severe measures for its conservation before we completely lose this important medicinal plant. A lot of research and study is underway but has vast scope for improvement, requiring efforts to supplement with such information that would aid transgenic development and breeding programmes for production and cultivation of improved varieties. The article presents the importance of this plant and its conservation in a nut-shell.

In Silico Mining of EST-SSRs in Jatropha curcas L. towards Assessing Genetic Polymorphism and Marker Development for Selection of High Oil Yielding Clones  [PDF]
Neeraj Jain, Ganesh B. Patil, Poonam Bhargava, Rajani S. Nadgauda
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.511167
Abstract:



In recent years, Jatropha curcas L. has gained popularity as a potential biodiesel plant. The varying oil content, reported between accessions belonging to different agroclimatic zones, has necessitated the assessment of the existing genetic variability to generate reliable molecular markers for selection of high oil yielding variety. EST derived SSR markers are more useful than genomic markers as they represent the transcriptome, thus, directly linked to functional genes. The present report describes the in silico mining of the microsatellites (SSRs) using J. curcas ESTs from various tissues viz. embryo, root, leaf and seed available in the public domain of NCBI. A total of 13,513 ESTs were downloaded. From these ESTs, 7552 unigenes were obtained and 395 SSRs were generated from 377 SSR-ESTs. These EST-SSRs can be used as potential microsatellite markers for diversity analysis, MAS etc. Since the Jatropha genes carrying SSRs have been identified in this study, thus, EST-SSRs directly linked to genes will be useful for developing trait linked markers.



Prospective Study on the Efficacy of Tamulosin in Medical Management of Distal Ureteric Stones
S Basnet,PM Shrestha,Rajani Shakya
Journal of Chitwan Medical College , 2013, DOI: 10.3126/jcmc.v3i1.8468
Abstract: A non-interventional prospective study was done in patients having single distal ureteral stone less than 10 mm to find the effectiveness of two weeks course of Tamsulosin 0.4 mg in the stone expulsion; the reduction of occurrence of ureteral, re-duction in rate of use of analgesic agents and the side effects of the drug. Thirty patients, having stone size ≤ 10.0 mm were revealed initially by patient’s symptoms and then confirmed by ultrasonography (USG) followed by Intravenous Urography (IVU) radiographic images. The expulsion rate of distal ureteral stones having size ≤ 10.0 mm was found to be 76.66 % (27 out of 30), with only 26.66 % of analgesic consumption, with decrease in colic episodes by 36.66 % and lesser evidence of side effects. The expulsion rate for stone size less than 7.0 mm is 36.72 % with mean of expulsion days as 5.90±1.92. The expulsion rate for stone size more than 7.0 mm is 63.33 % with mean of expulsion days as 9.33±27. The correlation between the size and expulsion days is statistically significant with p-value of 0.00057 (p = 0.01). The observed side effects were orthostatic hypotension (26.7 %), headache (13.3 %), dizziness (6.7 %), sore throat (6.7 %) followed by fatigue (3.3 %), abnormal ejaculation (3.3 %) and no any side effect was observed in 56.7 % patients. Considering the economic value and its effectiveness, the MET using Tamsulosin 0.4 mg can be the possible intervention for the medical treatment of distal ureteral stones having less than 10 mm stone size. Journal of Chitwan Medical College 2013; 3(1): 56-61 DOI: http://dx.doi.org/10.3126/jcmc.v3i1.8468
Automated Pulse-Based Diagnosis: Role of TIM Diagnostic Features  [PDF]
Rajani R. Joshi
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.710076
Abstract: Emanated from the idea of reinvestigating ancient medical system of Ayurveda—Traditional Indian Medicine (TIM), our recent study had shown significant applications of analysis of arterial pulse waveforms for non-invasive diagnosis of cardiovascular functions. Here we present results of further investigations analyzing the relation of pulse-characteristics with some clinical and pathological parameters and other features that are of diagnostic importance in Ayurveda.
Ecosystem Responses in the Distribution of Black Clam (Villorita cyprinoides) Beds in Vembanad Estuary during Environmental Changes Using GIS and RS  [PDF]
Thankam Theresa Paul, Grinson George, A. Dennis, N. R. Athira, R. S. Biradar, Rajani Khandagale, K. G. Padmakumar
Journal of Geographic Information System (JGIS) , 2017, DOI: 10.4236/jgis.2017.93015
Abstract: The biomass and distribution of black clam (Villorita cyprinoides) in Vembanad, a tropical estuary located along the southwest coast of India varied significantly. Sampling was done in freshwater-dominated zone in the south (distal) and brackish water zone in the north (proximal), during pre and post monsoon seasons. Clam biomass was estimated from samples, collected from different stations during the study period. Water transparency and temperature were measured at the sample sites. Water samples were collected and analysed for salinity, dissolved oxygen (DO), pH and hardness. There was a significant difference in the clam biomass during the two seasons in the distal zone, and those collected from the distal and proximal zones during pre-monsoon season. The data were further analysed to determine the factors affecting the clam biomass distribution in the two zones and seasons. Factor analyses, comparing the distal zone during two seasons and zonal variations were similar to earlier observations. Step wise regression analyses found that dissolved oxygen (adjusted R2 = 0.3) is the only variable affecting clam survival during pre-monsoon period in the distal and proximal zones. A geographic map of the region obtained from the Indian satellite sensor LISS (Linear Image Self Scanner) was used along with in situ data to map the results using inverse distance weightage model.
Correlation of Membrane Binding and Hydrophobicity to the Chaperone-Like Activity of PDC-109, the Major Protein of Bovine Seminal Plasma
Rajeshwer S. Sankhala,Rajani S. Damai,Musti J. Swamy
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017330
Abstract: The major protein of bovine seminal plasma, PDC-109 binds to choline phospholipids present on the sperm plasma membrane upon ejaculation and plays a crucial role in the subsequent events leading to fertilization. PDC-109 also shares significant similarities with small heat shock proteins and exhibits chaperone-like activity (CLA). Although the polydisperse nature of this protein has been shown to be important for its CLA, knowledge of other factors responsible for such an activity is scarce. Since surface exposure of hydrophobic residues is known to be an important factor which modulates the CLA of chaperone proteins, in the present study we have probed the surface hydrophobicity of PDC-109 using bisANS and ANS. Further, effect of phospholipids on the structure and chaperone-like activity of PDC-109 was studied. Presence of DMPC was found to increase the CLA of PDC-109 significantly, which could be due to the considerable exposure of hydrophobic regions on the lipid-protein recombinants, which can interact productively with the nonnative structures of target proteins, resulting in their protection. However, inclusion of DMPG instead of DMPC did not significantly alter the CLA of PDC-109, which could be due to the lower specificity of PDC-109 for DMPG as compared to DMPC. Cholesterol incorporation into DMPC membranes led to a decrease in the CLA of PDC-109-lipid recombinants, which could be attributed to reduced accessibility of hydrophobic surfaces to the substrate protein(s). These results underscore the relevance of phospholipid binding and hydrophobicity to the chaperone-like activity of PDC-109.
A Study of Reproductive Morbidities among Women Reporting to Primary and Tertiary Care Centres in and around Delhi
S Rajani, HS Gaikwad, V Tripathi, S Salhan
International Journal of Health Research , 2011,
Abstract: Purpose: To assess reproductive morbidities among women reporting to a tertiary and a primary health centres in and around Delhi, India. Methods: 581 women (388 were from Safdarjung Hospital and 193 from the Primary Health Centre in Najafgarh) of all age groups who attended the gynecological out-patient departments at both centres were interviewed using a structured questionnaire comprising of questions relating to general socio-demographic information and the reasons for coming to the centre and examined. These were categorized into gynecological, obstetrical or contraceptive after obtaining a detailed history. Results: The frequency of reproductive morbidities in the present study was observed to be quite high with gynecological conditions being the most common (88.64%), followed by obstetric (65.93%) and contraceptive (11.53%) morbidities. Conclusion: Gynaecological conditions were the major reasons while the women visited the healthcare facilities. Early identification of RTIs and other types of morbidities needs to be encouraged through regular check-ups. The antenatal clinics also need to be strengthened in order to ensure better obstetric health care.
Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine
Soni S,Anandjiwala Sheetal,Patel G,Rajani M
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Leaf of Adhatoda vasica ( Vasaka ) is an important drug of Ayurveda, prescribed as an expectorant. Quinazoline alkaloids present in the leaves are established as active principles. In Ayurveda, its leaf juice ( Vasa swarasa ) is incorporated in many formulations. Classical method for extracting the juice ( swarasa ) from the leaf is an elaborate process, which involves subjecting a bolus of crushed fresh leaf to heat followed by squeezing out the juice. Commercially, to prepare the juice of Vasaka , manufacturers have been adopting different methods other than the traditional method. In an effort to evaluate these modified processes phytochemically to identify the process which gives juice of the quality that is obtained by traditional method, in terms of its alkaloid content, we prepared the leaf juice by traditional Ayurvedic method, its modification by steaming of leaf to simulate the traditional method and other methods adopted by some manufacturers. These juice samples were evaluated for the total alkaloid content by spectrophotometric method and vasicine content by thin layer chromatography densitometric method using high performance thin layer chromatography. The high performance thin layer chromatography method was validated for precision, repeatability and accuracy. The total alkaloid content varied from 0.3 mg/ml to 5.93 mg/ml and that of vasicine content varied from 0.2 mg/ml to 5.64 mg/ml in the juice samples prepared by different methods. The present study revealed that steaming of fresh leaves under 15 lb pressure yielded same quantity of juice as the traditional bolus method (25 ml/100 g leaf) and its total alkaloid content and vasicine content (4.05±0.12 and 3.46±0.06 mg/ml, respectively) were very high when compared to the other methods, though the traditional method was found to give the best quality juice with highest amount of total alkaloids (5.93±0.55 mg/ml) and vasicine (5.64±0.10 mg/ml) content .
Entrapment of ketorolac tromethamine in polymeric vehicle for controlled drug delivery
Paliwal S,Chauhan Rajani,Sharma Veena,Majumdar D
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: The most common method for applying a drug in to the eye is to formulate the drug in the form of an eye drop, but this method is not considered ideal for ocular delivery of drug because of poor bioavailability arising from precorneal loss processes, this loss of drug from the precorneal area is a net effect of drainage, tear secretion and noncorneal absorption. Following the above lead we tried to improve the ocular bioavailability by increasing the corneal contact time and the feasible way was to formulate a drug with mucoadhesive/viscosity imparting agents. The adhesive strength of various polymers on corneal surface was studied with the help of self modified Franz diffusion cell and freshly excised goat/bovine cornea. The polymers hydroxypropylmethylcellulose, carboxymethylcellulose sodium, Eudragit type E/RL/RS, Carbopol ETD 2020 and Carbopol 934 National Formulary were formulated with drug, ketorolac tromethamine. The adhesive strength of polymers on corneal surface and permeation characteristics of drug through cornea were investigated by using above said formulations. Eudragit type E/RL/RS did not show any improvement in mucoadhesion, but the formulations containing Carbopol ETD 2020 and Carbopol 934 national formulary showed good mucoadhesion on corneal surface in the concentration as low as 0.75%. The mucoadhesive strength was also evaluated using the combination of Carbopol acrylates/C 10-30 alkylacrylate with allylpentaerithrital and preservative benzalkonium chloride, which also resulted in good mucoadhesion with improved corneal permeation. Observations made in this study indicate the potentiality of the ophthalmic formulations containing mucoadhesive/viscosity imparting agents.
Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac
Thrivikrama Padur Tantry,Nandish S Vastrad,Prashanth Mohan,Rajani Kadri
Online Journal of Health & Allied Sciences , 2010,
Abstract: Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action. The efficacy and safety profile of ketorolac, yet another widely used post-operative analgesic is well documented. This study aims to compare the two analgesics. Aims and objectives: This study was conducted to compare the analgesic efficacy and other effects of butorphanol and ketorolac, administered intramuscularly, in post-operative patients who have undergone lower abdominal and pelvic surgeries. Materials and methods: 50 patients undergoing lower abdominal and pelvic surgeries under general or spinal anaesthesia were randomly divided into two Groups (25 each). At a particular level of post-operative pain, the patients Groups I and II were administered intramuscular ketorolac 30mg and butorphanol 2mg respectively. The analgesic effect was studied using Visual Analogue Scale (VAS) and the verbal category scale. Patients were monitored for the sedative action, respiratory status and other vital parameters for 300 minutes and for other adverse reactions over the next twelve hours. Observations: Butorphanol provided better analgesia within the first two hours of administration, while ketorolac was more effective at 4-5 hours. Better sedative action without any significant respiratory depressant effect was demonstrated with butorphanol. There were no clinically significant hemodynamic fluctuations or adverse reactions with butorphanol or ketorolac. Conclusions: Butorphanol provides better early analgesia as compared to ketorolac with a desirable and safe sedative effect in post-operative patients who have undergone lower abdominal and pelvic surgeries.
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