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Search Results: 1 - 10 of 12941 matches for " Raffaello Di Camillo "
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The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors
M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino, Edoardo Alesse
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-172
Abstract: TSGs often locate at chromosomal regions, which are frequently deleted and/or methylated in tumors. High levels of 17p13 somatic alterations have been showed in several tumors, distal and independent of the p53 locus [1-4].Our group has identified KCTD11 as an immediate-early gene induced by neurogenic signals [5] and encoding a novel adaptor of Cullin3 ubiquitin E3 ligase complex targeting Histone Deacetylase 1 [6]. Importantly, KCTD11 is a novel TSG that inhibits cell growth and is mapping on human chromosome 17p13.2, whose expression is frequently lost in human MB [4].To analyze whether the down-regulation of KCTD11 represents a specific feature of MB, as well to other cancers, we performed a wide screening for KCTD11 expression, analyzing 177 human tumor samples and 177 normal matching samples, representing 18 different cancer types. Normal tissues, including larynx, esophagus, stomach, colon-rectum, urinary bladder, lung, breast, gallbladder and endometrium, exhibited a nuclear KCTD11 positive immunohistochemical staining between 40 to 78% (Fig. 1B), whereas the matching tumor samples showed a significant reduction of 0 to 18% of nuclear KCTD11 staining (Fig. 1A and 1B). Reduced KCTD11 expression was not observed in thyroid and kidney tumor tissues vs normal suggesting a tumorigenic specific role of KCTD11 for the above mentioned tissues (Fig. 1A and 1B and data not shown). Moreover KCTD11 was undetected both in normal and cancer tissues from liver, lymph-node and exocrine pancreas (data not shown). Together, these findings clearly indicated that selective tissues expressing KCTD11 have down-regulated this gene during tumorigenesis.To understand the transcriptional regulation of KCTD11, we identified and analyzed the promoter region. Human KCTD11 proximal promoter is a 623 bp region (Fig. 2A). It turned out to be a TATA- and CAAT-less promoter. The transcription start site (TSS) was previously identified [4] (Fig. 2A). Using the TRANSFACT software, we identifie
El argumento de "Lo Uno sobre lo múltiple" en el Tratado sobre las Ideas de Aristóteles
Di Camillo,Silvana Gabriela;
Synthesis (La Plata) , 2010,
Abstract: in this paper we attempt to offer, first, an analysis of the one over many argument, as it is provided by aristotle in his lost essay on ideas, in order to see what light it shed on the distinction between platonic ideas and aristotelian universals. secondly, we wonder about the validity of the reconstructed version of plato's argument and we conclude that aristotle does not distort plato's thought. finally, we stress what aristotle's criticism reveals, not only about the main differences between his own universals and the platonic idea, but also about his debts to platonic theories.
El problema del status ontológico del universal en Aristóteles
Di Camillo,Silvana;
Synthesis (La Plata) , 2004,
Abstract: this paper aims to pose the objective reference problem of the universals in aristotle. first, i shall consider his earliest view in book i of on ideas essay, where he seems to admit the existence of "common things' ( koiná ) (i). then, i shall reconstruct the porfirian view of aristotelian universal, just as considered in his commentary on the categories , as one property identically shared by many particulars (ii). finally, i shall explore the arguments aristotle displays in metaphysics z, 13-14 against universal substantiality (iii). i shall defend that the aporíai he finds in plato leads him little by little to confirm there is nothing real that makes reference to the universal term, with the pernicious consequences this view brings for his conception of science as true, universal knowledge.
Silvana Gabriela Di Camillo
Philósophos : Revista de Filosofia , 2011, DOI: 10.5216/phi.v15i1.8545
Abstract: O recurso à exposi o crítica das doutrinas anteriores é um procedimento metodológico usual em Aristóteles. Mas a característica distintiva do Livro I da Metafísica é que, ao invés de estabelecer uma nova doutrina, o exame dos predecessores serve para confirmar os próprios conceitos aristotélicos, os quais ele usa para avaliar os êxitos e os erros das doutrinas analisadas. Essa imposi o de conceitos próprios lhe valeu a acusa o de ter uma compreens o histórica distorcida. Com a análise detalhada das críticas da teoria plat nica das Idéias na Metafísica I, 9, pretendemos mostrar: a) que as críticas de manipula o e distor o das opini es dos seus antecessores ofuscam o grau em que as suas próprias posi es emergem de uma análise crítica do pensamento anterior; e b) que a imposi o de conceitos próprios n o é uma distor o, mas uma proposta de solu o para os problemas que as teorias anteriores deixaram sem solu o. The use of critical exposition of previous doctrines is a methodological procedure usual in Aristotle. But the distinctive characteristic of Book I of the Metaphysics is that, rather than to establish a new doctrine, a review of predecessors serves to confirm the own concepts to be used in the evaluation of the doctrines examined. This imposition of own terms has cost him the charge of distorting historical understanding. With the detailed analysis of the criticisms of Plato's theory of Ideas in Metaphysics I, 9, we intend to show a) that the criticism of manipulation and distortion of his predecessors' views overshadow the degree to which Aristotle's own positions emerge from a critical review of previous thought and b) that the imposition of own terms does not suppose a distortion but a proposal of solution to the problems that previous theories have left unresolved.
Dependency Structure and Scaling Properties of Financial Time Series Are Related
Raffaello Morales,T. Di Matteo,Tomaso Aste
Quantitative Finance , 2013, DOI: 10.1038/srep04589
Abstract: We report evidence of a deep interplay between cross-correlations hierarchical properties and multifractality of New York Stock Exchange daily stock returns. The degree of multifractality displayed by different stocks is found to be positively correlated to their depth in the hierarchy of cross-correlations. We propose a dynamical model that reproduces this observation along with an array of other empirical properties. The structure of this model is such that the hierarchical structure of heterogeneous risks plays a crucial role in the time evolution of the correlation matrix, providing an interpretation to the mechanism behind the interplay between cross-correlation and multifractality in financial markets, where the degree of multifractality of stocks is associated to their hierarchical positioning in the cross-correlation structure. Empirical observations reported in this paper present a new perspective towards the merging of univariate multi scaling and multivariate cross-correlation properties of financial time series.
Non stationary multifractality in stock returns
Raffaello Morales,T. Di Matteo,Tomaso Aste
Quantitative Finance , 2012, DOI: 10.1016/j.physa.2013.08.037
Abstract: We perform an extensive empirical analysis of scaling properties of equity returns, suggesting that financial data show time varying multifractal properties. This is obtained by comparing empirical observations of the weighted generalised Hurst exponent (wGHE) with time series simulated via Multifractal Random Walk (MRW) by Bacry \textit{et al.} [\textit{E.Bacry, J.Delour and J.Muzy, Phys.Rev.E \,{\bf 64} 026103, 2001}]. While dynamical wGHE computed on synthetic MRW series is consistent with a scenario where multifractality is constant over time, fluctuations in the dynamical wGHE observed in empirical data are not in agreement with a MRW with constant intermittency parameter. We test these hypotheses of constant multifractality considering different specifications of MRW model with fatter tails: in all cases considered, although the thickness of the tails accounts for most of anomalous fluctuations of multifractality, still cannot fully explain the observed fluctuations.
Dynamical Hurst exponent as a tool to monitor unstable periods in financial time series
Raffaello Morales,T. Di Matteo,Ruggero Gramatica,Tomaso Aste
Quantitative Finance , 2011, DOI: 10.1016/j.physa.2012.01.004
Abstract: We investigate the use of the Hurst exponent, dynamically computed over a moving time-window, to evaluate the level of stability/instability of financial firms. Financial firms bailed-out as a consequence of the 2007-2010 credit crisis show a neat increase with time of the generalized Hurst exponent in the period preceding the unfolding of the crisis. Conversely, firms belonging to other market sectors, which suffered the least throughout the crisis, show opposite behaviors. These findings suggest the possibility of using the scaling behavior as a tool to track the level of stability of a firm. In this paper, we introduce a method to compute the generalized Hurst exponent which assigns larger weights to more recent events with respect to older ones. In this way large fluctuations in the remote past are less likely to influence the recent past. We also investigate the scaling associated with the tails of the log-returns distributions and compare this scaling with the scaling associated with the Hurst exponent, observing that the processes underlying the price dynamics of these firms are truly multi-scaling.
Bounded elements of C*-inductive locally convex spaces
Giorgia Bellomonte,Salvatore Di Bella,Camillo Trapani
Mathematics , 2013,
Abstract: The notion of bounded element of C*-inductive locally convex spaces (or C*-inductive partial *-algebras) is introduced and discussed in two ways: the first one takes into account the inductive structure provided by certain families of C*-algebras; the second one is linked to natural order of these spaces. A particular attention is devoted to the relevant instance provided by the space of continuous linear maps acting in a rigged Hilbert space.
Effects of 200cH medications on mice bone marrow cells and macrophages
Carolina de Oliveira,Ana Paula R. Abud,Eneida Da Lozzo,Raffaello Di Bernardi
International Journal of High Dilution Research , 2011,
Abstract: Paracelsus once wrote: "All things are poison and nothing is without poison, only the dose permits something not to be poisonous." Latter Hahnemann formulated the law of similars, preparations which cause certain symptoms in healthy individuals if given in diluted form to patients exhibiting similar symptoms will cure it. Highly diluted natural complexes prepared according to Hahnemann ¢a a ¢s ancient techniques may represent a new form of immunomodulatory therapy. The lack of scientific research with highly diluted products led us to investigate the in vivo and in vitro actions of commonly used medications. Here we describe the results of experimental studies aimed at verifying the effects of Mercurius solubilis, Atropa Belladonna, Lachesis muta and Bryonia alba. All medications were at 200cH dilution. Animals were maintained for 7 days and were allowed to drink the medications, which were prepared in a way that the final dilution and agitation (200cH) was performed in drinking water. The medication bottle was changed and sucussed every afternoon. Co-culture of non treated mice bone marrow cells and in vitro treated peritoneal macrophages were also performed. After animal treatment the bone marrow cells were immunophenotyped with hematopoietic lineage markers on a flow cytometer. We have determined CD11b levels on bone marrow cells after culture and co-culture with treated macrophages and these macrophages were processed to scanning electron microscopy. We have observed by morphological changes that macrophages were activated after all treatments. Mercurius solubilis treated mice showed an increase in CD3 expression and in CD11b on nonadherent bone marrow cells after co-culture with in vitro treatment. Atropa Belladonna increased CD45R and decreased Ly-6G expression on bone marrow cells after animal treatment. Lachesis muta increased CD3, CD45R and, CD11c expression and decreased CD11b ex vivo and in nonadherent cells from co-culture. Bryonia alba increased Ly-6G, CD11c and CD11b expression ex vivo and when in co-culture CD11b was increased in adherent cells as well as decreased in nonadherent cells. With these results we have demonstrated that highly diluted medications act on immune cells activating macrophages, and changing the expression profile of hematopoietic lineage markers. Highly diluted medications are less toxic and cheaper than other commonly used medications and based on our observations, it is therefore conceivable that this medications which are able to act on bone marrow and immune cells may have a potential therapeutic use in clinica
A Boolean Approach to Linear Prediction for Signaling Network Modeling
Federica Eduati,Alberto Corradin,Barbara Di Camillo,Gianna Toffolo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012789
Abstract: The task of the DREAM4 (Dialogue for Reverse Engineering Assessments and Methods) “Predictive signaling network modeling” challenge was to develop a method that, from single-stimulus/inhibitor data, reconstructs a cause-effect network to be used to predict the protein activity level in multi-stimulus/inhibitor experimental conditions. The method presented in this paper, one of the best performing in this challenge, consists of 3 steps: 1. Boolean tables are inferred from single-stimulus/inhibitor data to classify whether a particular combination of stimulus and inhibitor is affecting the protein. 2. A cause-effect network is reconstructed starting from these tables. 3. Training data are linearly combined according to rules inferred from the reconstructed network. This method, although simple, permits one to achieve a good performance providing reasonable predictions based on a reconstructed network compatible with knowledge from the literature. It can be potentially used to predict how signaling pathways are affected by different ligands and how this response is altered by diseases.
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