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Search Results: 1 - 10 of 2162 matches for " Rafaela Priscila; "
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R&D Landscape for Breast Cancer through Patent Documents  [PDF]
Adelaide M. S. Antunes, Iolanda M. Fierro, Rafaela Di Sabato Guerrante, Priscila Rohem dos Santos, Flavia Maria Lins Mendes
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47A009
Abstract:

Cancer is a leading cause of death worldwide, and is estimated to be the cause of 13.1 million deaths in 2030. Breast cancer is the second cancer in the global mortality ranking, considering both sexes. Due to the burden of breast cancer worldwide, this paper aims to present an overview of the main R&D efforts focusing on breast cancer treatment. Patents were retrieved from the Derwent Innovations Index?, which has a specific code for pharmaceuticals related to breast cancer. A total of 423 patent documents filed in recent years were identified, of which 126 are exclusively for breast cancer, 169 for breast cancer and other cancers, and 128 are inventions related to the treatment of cancer and other diseases. The patent documents were classified into two large groups, the first of which had a predominance of claims for antibodies, proteins and polypeptides for use in medication production, while the second focuses on gene therapy, nucleotides and RNA. The country with the majority of priority patent applications was found to be the United States, followed by China and Japan.

Genetic variability among cassava accessions based on SSR markers
Ribeiro, Márcia de Nazaré Oliveira;Carvalho, Samuel Pereira de;Santos, Jo?o Bosco dos;Antonio, Rafaela Priscila;
Crop Breeding and Applied Biotechnology , 2011, DOI: 10.1590/S1984-70332011000300009
Abstract: the aim of this study was to characterize and estimate the genetic similarity among 93 cassava accessions. the dna amplification was performed with 14 microsatellite primers. the amplification products were separated by a polyacrylamide gel electrophoresis, showing a polymorphism formation, through which the accessions were discriminated against. the genetic similarity among accessions of cassava was estimated by the dice coefficient. cluster analysis was carried out using the upgma method. the polymorphic primers amplified a total of 26 alleles with 2-4 alleles per loci. the genetic similarity ranged from 0.16 to 0.96. the average values for observed and expected heterozygosity were 0.18 and 0.46, respectively. twenty genetic similarity clusters were determined, demonstrating diversity among accessions, suggesting the possibility of heterotic hybrid generation.
NOTE - Genetic variability among cassava accessions based on SSR markers
Márcia de Nazaré Oliveira Ribeiro,Samuel Pereira de Carvalho,Jo?o Bosco dos Santos,Rafaela Priscila Antonio
Crop Breeding and Applied Biotechnology , 2011,
Abstract: The aim of this study was to characterize and estimate the genetic similarity among 93 cassava accessions. The DNAamplification was performed with 14 microsatellite primers. The amplification products were separated by a polyacrylamide gelelectrophoresis, showing a polymorphism formation, through which the accessions were discriminated against. The genetic similarityamong accessions of cassava was estimated by the Dice coefficient. Cluster analysis was carried out using the UPGMA method. Thepolymorphic primers amplified a total of 26 alleles with 2-4 alleles per loci. The genetic similarity ranged from 0.16 to 0.96. Theaverage values for observed and expected heterozygosity were 0.18 and 0.46, respectively. Twenty genetic similarity clusters weredetermined, demonstrating diversity among accessions, suggesting the possibility of heterotic hybrid generation.
Genetics of common bean resistance to white mold
Flávia Fernandes Carneiro,Jo?o Bosco dos Santos,Paulo Roberto Carvalho Gon?alves,Rafaela Priscila Antonio
Crop Breeding and Applied Biotechnology , 2011,
Abstract: The objective of the research was to investigate the nature and magnitude of the genetic factors involved in theresistance of the common bean to white mold. The lines G122 (resistant) and M20 (susceptible) were crossed to yield F1 and F2generations and F2:3 progenies. The experiment was set up using the random block design with two replications, each of which wasevaluated twice with fungal inoculations being performed on 28 and 38 day-old plants using the straw test method. Six to eight daysafter inoculation evaluations were conducted on individual plants and at the level of means of progenies using a diagrammatic scaleranging from 1 to 9. The additive-dominance model adopted was efficient, and the genetic control of resistance was predominantlydue additive effects. Estimates of broad-sense heritability indicated that selection would be more efficient when based on the meansof progenies and when successive inoculations are employed.
Genetics of common bean resistance to white mold
Carneiro, Flávia Fernandes;Santos, Jo?o Bosco dos;Gon?alves, Paulo Roberto Carvalho;Antonio, Rafaela Priscila;Souza, Thaís Paula de;
Crop Breeding and Applied Biotechnology , 2011, DOI: 10.1590/S1984-70332011000200009
Abstract: the objective of the research was to investigate the nature and magnitude of the genetic factors involved in the resistance of the common bean to white mold. the lines g122 (resistant) and m20 (susceptible) were crossed to yield f1 and f2 generations and f2:3 progenies. the experiment was set up using the random block design with two replications, each of which was evaluated twice with fungal inoculations being performed on 28 and 38 day-old plants using the straw test method. six to eight days after inoculation evaluations were conducted on individual plants and at the level of means of progenies using a diagrammatic scale ranging from 1 to 9. the additive-dominance model adopted was efficient, and the genetic control of resistance was predominantly due additive effects. estimates of broad-sense heritability indicated that selection would be more efficient when based on the means of progenies and when successive inoculations are employed.
Estimates of genetic parameters for fruit yield and quality in custard apple progenies
Silva, Paulo Sérgio Lima e;Antonio, Rafaela Priscila;Mariguele, Keny Henrique;Silva, Kathia Maria Barbosa e;Lima, Lidiane Kely de;Silva, Júlio César do Vale;
Revista Brasileira de Fruticultura , 2007, DOI: 10.1590/S0100-29452007000300027
Abstract: apparently, there are no custard apple cultivars defined for the northeastern region of brazil. the establishment of breeding programs aimed at the selection of types from productive locations for later cloning is desirable. this work's objective was to evaluate the yield (during the first three crops) and quality (first crop) of fruits from 20 half-sibling custard apple tree progenies, selected from home orchards. an additional objective was to estimate genetic parameters for the traits evaluated. a micro sprinkling-irrigated experiment was conducted in mossoró-rn, brazil, as random blocks with five replications. in characteristics evaluated for periods longer than a year (diameter, height and mean weight of fruits, number of fruits ha-1 and fruit yield (kg ha-1), and a split-plot design was adopted, with progenies considered as plots and annual cropping seasons as subplots. the best progenies in terms of fruit yield (a3 and a4) are not necessarily the best for fruit dimensions and fruit mean weight (a2, fe4, jg1, jg2, sm1, sm7, and sm8). these progenies show great potential to be used in future studies on crosses or on vegetative propagation. in this regard, progeny jg2 should be highlighted as promising in terms of yield and fruit size. the progenies are not different with regard to percentages (in relation to mean fruit mass) of pericarp, endocarp, seeds, and receptacle, in the fruit, and fruit volume, number of seeds/fruit, and total soluble solids content in the fruit pulp, but progeny fe4 presents higher total titratable acidity in the fruit pulp. narrow-sense heritability estimates were relatively high for all characteristics in which there was variability between progenies, with higher values for number of fruits ha-1 (80 %) and fruit yield (78 %). relatively high coefficients of genotypic variation (around 20%) were observed for number of fruits ha-1 and fruit yield, with lower values for the other characteristics. there were positive genotypic and phenoty
Comparing breast feeding practices in baby friendly and non-accredited hospitals in Salvador, Bahia
Ortiz, Priscilla Nunes;Rolim, Rafaela Borges;Souza, Mateus Freire Lima e;Soares, Poliana Louzada;Vieira, Tatiana de Oliveira;Vieira, Graciete Oliveira;Lyra, Priscila Pinheiro Ribeiro;Silva, Luciana Rodrigues;
Revista Brasileira de Saúde Materno Infantil , 2011, DOI: 10.1590/S1519-38292011000400007
Abstract: objectives: to compare compliance with steps 4 to 10 of "the steps to successful breastfeeding" in two hospitals accredited by the baby-friendly hospital initiative (bfhi group) with two not yet accredited hospitals in salvador. methods: a cross-sectional study was conducted with 100 women in bfhi-accredited hospitals and 103 women in non-bfhi-accredited hospitals by collecting data on their obstetric history, any breast feeding counseling received during antenatal care, and data on delivery and hospitalization. data were obtained by applying questionnaires and reviewing patients' medical charts. the chi-square test was used for bivariate variables and student's t test for continuous variables. results: statistically significant differences (p<0.05) were found between the bfhi-accredited group and the non-bfhi group with respect to steps 5 (77% vs 35.9%), 6 (81% vs 31%), 8 (77% vs 52.4%), and 9 (100% vs 94.2%). no differences were found between the two groups with respect to steps 4, 7 or 10. satisfactory compliance with the requirements of the baby-friendly hospital initiative in bfhiaccredited hospitals was found only with respect to steps 6, 7 and 9. conclusions: these results highlight the benefits of bfhi accreditation but emphasize the need for continuous and systematic evaluation in order to promote breastfeeding and provide support in bfhiaccredited maternity hospitals.
Cáncer gástrico, epidemiología y prevención
Sierra,Rafaela;
Acta Médica Costarricense , 2002,
Abstract: gastric cancer is one of the tumors with higher worldwide mortality. although the incidence rate has been declining, it is still a major public health problem still. epidemiological information and knowledge about this cancer is abundant. this is an up to date review about commonly accepted risk factors: helicobacter pylori infection, diet, genetic predisposition and socioeconomic status. we also stress the new questions and challenges that recent discoveries about this pathology entail. the ways to tackle this cancer are discussed using x rays and biological markers such as serum pepsinogens in high risk groups or populations.
Trabalho, temporalidade e representa??es sociais de gênero: uma análise da articula??o entre trabalho doméstico e assalariado
Cyrino, Rafaela;
Sociologias , 2009, DOI: 10.1590/S1517-45222009000100005
Abstract: this article examines the "work and gender" question through the relationship between housework and paid work, considering that one of the key factors to explain the unequal insertion of men and women in the labor market is related to the issue of reconciliation between work and family life. despite being a preliminary study, the author intends to develop a research hypothesis to be examined in further studies on the nature of the central role that the work usually plays in the lives of women. thus, the paper aims to contribute in some way to the advancement of researches on the complex relationships between career and family life.
Order out of Chaos? A Case Study in High Energy Physics
Rafaela Hillerbrand
Studia Philosophica Estonica , 2012,
Abstract: In recent years, computational sciences such as computational hydrodynamics or computational field theory have supplemented theoretical and experimental investigations in many scientific fields. Often, there is a seemingly fruitful overlap between theory, experiment, and numerics. The computational sciences are highly dynamic and seem a fairly successful endeavor---at least if success is measured in terms of publications or engineering applications. However, for theories, success in application and correctness are two very different things; and just the same may hold for "methodologies" like computer simulations. A lively debate on the epistemic status of computer simulations has thus emerged within the philosophy of science. This paper discusses possible problems when computer simulation and laboratory experiment are intertwined. In present experiments, stochastic methods in the form of Monte Carlo simulations are often involved in generating experimental data. It is questioned as to how far a realistic stance can be maintained when such stochastic elements are involved. Taking experiments in high energy physics as a study case, this paper contends that using these types of entangled material and numerical experiments as a source of new phenomena or for theory testing must presuppose a certain understanding of causality and thus binds us at least to a weak form of realism.
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