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Search Results: 1 - 10 of 12293 matches for " Rafael Ximenes Goncalves "
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AVO Didactic Analysis from Simplified Modeling of Seismic Data in Libra Oil Field of the Pre-Salt Region, Brazil  [PDF]
Kaio da Silva Pimentel Figueiredo, Kaendra Williams Temoteo, Rafael Ximenes Goncalves, Yasmim Monteiro Cordeiro, Rogério Manhaes Soares, Hans Schmidt Santos, Claudiomar Rodrigues Franco, Felipe Barbosa Venancio de Freitas, Christyne Barros de Sá
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105788
In this study, a certain zone of Libra oil field of the pre-salt region was se-lected to be analyzed for didactic purposes in order to simulate AVO re-sponses. The region was modeled using seismic data, setting up a typical oil system with source rock (shale), reservoir rock (sandstone), and seal rock (salt). Thus, a set of parameters such as seismic wave velocity, density and Poisson’s ratio for the studied zone was proposed. The AVO analysis allowed the classification of reflectors and the distinction of the geology for sandstones saturated with both water and gas.
Infec??o por Chlamydia trachomatis e Neisseria gonorrhoeae em mulheres atendidas em servi?o de planejamento familiar
Fernandes, Arlete Maria dos Santos;Daher, Gustavo;Nuzzi, Rafael Ximenes do Prado;Petta, Carlos Alberto;
Revista Brasileira de Ginecologia e Obstetrícia , 2009, DOI: 10.1590/S0100-72032009000500006
Abstract: purpose: to study infection prevalence by chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng), among adolescent and young women in a family planning outpatient clinic. methods: a total of 230 women up to 24 years old and history of up to four sexual partners have been followed-up for 48 months, with urine collection to search ct and ng, by the polymerase chain reaction method at the 1st, 12nd, 24th, 36th and 48th months. the variables studied were age group, schooling, marital status, number of gestations, abortions and children alive, age at the onset of sexual life, previous and present use of condom, previous use of intrauterine device, number of sexual partners in the previous six months and follow-up time. bivariate analysis of variables according to positive tests for ct and ng, and multiple analyses by logistic regression were done. results: the ratio of infections by ct was 13.5% and by ng, 3%. two women presented both tests as positive. the previous intrauterine device use was associated with positive tests for ng. conclusions: the prevalence of infections by ct and ng was higher among the age group studied and the screening of young women must be taken into consideration in our services, to control the dissemination of sexually transmitted diseases and prevention of sequels.
Detec??o do DNA de Chlamydia trachomatis em espondiloartropatias e artrite reumatóide
Navarrete Fernandez, Rafael;Ximenes, Ant?nio Carlos;Costa Alves, Maria de Fátima;
Revista Brasileira de Reumatologia , 2005, DOI: 10.1590/S0482-50042005000500003
Abstract: chlamydia trachomatis is the bacteria responsible for the most prevalent sexually transmitted disease worldwide. most of the infections in men and women is asymptomatic and when undiagnosed and untreated may reach the joints causing not only arthritis, but also other acknowledged complications related to the female reproductive system. objective: to investigate c. trachomatis dna in the urine and synovial fluid from patients with spondyloarthropathies (spa) and rheumatoid arthritis (ra) and evaluate serum anti-c. trachomatis igg and igm antibodies. methods: the population consisted of 15 patients with spondyloarthropathies, being 9 with undifferentiated spondyloarthropathy (us) and 6 with reactive arthritis (rea) (group i), and 15 patients with rheumatoid arthritis (ra) (group ii). the chlamydial dna was assessed in synovial fluid and urine samples of all patients by amplicor (roche, swiss) pcr. the anti-chlamydial igg and igm antibodies were quantified through indirect imunofluorescence (iif), while 15 patients of group i were typed for hla-b27 by the use of flow citometry. sociodemographical data and all information on sexual behaviour and presence of symptoms were collected through a (questionnaire in the form of) an interview. results: c. trachomatis dna was found in only one synovial fluid sample from patient with rea (6,7%). in two patients with ra, chlamydial dna was identified in the urine sample (13,3%). the anti-chlamydial igg antibodies were present in eight patients of the population studied; being three patients from group i (20%), and five from group ii (33,3%). the greatest titer of this antibody 1/256 was associated with the presence of chlamydial dna in a patient from group ii. the igm antibody was not detected in any of the samples from both groups. four individuals from group ii (26,7%) were hla-b27 positive and its presence was related to sacroiliitis. conclusions: the results in this study show that in patients with spondyloarthropathies and rhe
Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom
Ximenes Rafael M,Alves Renata S,Pereira Ticiana P,Araújo Renata M
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-139
Abstract: Background Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region of Brazil and used in folk medicine to treat snakebite. Its leaves are said to be anti-inflammatory. Secretory phospholipases A2 are important toxins found in snake venom and are structurally related to those found in inflammatory conditions in mammals, as in arthritis and atherosclerosis, and for this reason can be valuable tools for searching new anti-phospholipase A2 drugs. Methods HP-2 and piratoxin-III (PrTX-III) were purified through chromatographic techniques. The effect of HP-2 in the enzymatic activity of PrTX-III was carried out using 4-nitro-3-octanoyloxy-benzoic acid as the substrate. PrTX-III induced platelet aggregation was inhibited by HP-2 when compared to aristolochic acid and p-bromophenacyl bromide (p-BPB). In an attempt to elucidate how HP-2 interacts with PrTX-III, mass spectrometry, circular dichroism and intrinsic fluorescence analysis were performed. Docking scores of the ligands (HP-2, aristolochic acid and p-BPB) using PrTX-III as target were also calculated. Results HP-2 inhibited the enzymatic activity of PrTX-III (IC50 11.34 ± 0.28 μg/mL) although it did not form a stable chemical complex in the active site, since mass spectrometry measurements showed no difference between native (13,837.34 Da) and HP-2 treated PrTX-III (13,856.12 Da). A structural analysis of PrTX-III after treatment with HP-2 showed a decrease in dimerization and a slight protein unfolding. In the platelet aggregation assay, HP-2 previously incubated with PrTX-III inhibited the aggregation when compared with untreated protein. PrTX-III chemical treated with aristolochic acid and p-BPB, two standard PLA2 inhibitors, showed low inhibitory effects when compared with the HP-2 treatment. Docking scores corroborated these results, showing higher affinity of HP-2 for the PrTX-III target (PDB code: 1GMZ) than aristolochic acid and p-BPB. HP-2 previous incubated with the platelets inhibits the aggregation induced by untreated PrTX-III as well as arachidonic acid. Conclusion HP-2 changes the structure of PrTX-III, inhibiting the enzymatic activity of this enzyme. In addition, PrTX-III platelet aggregant activity was inhibited by treatment with HP-2, p-BPB and aristolochic acid, and these results were corroborated by docking scores.
Adenosin deaminasa como molécula coestimuladora y marcador de inmunidad celular
Pérez-Aguilar,Mary Carmen; Goncalves,Loredana; Ibarra,Alba; Bonfante-Cabarcas,Rafael;
Investigación Clínica , 2010,
Abstract: adenosine deaminase (ada) is an enzyme of purine metabolism which has been the subject of much interest because the congenital defect of this enzyme causes severe combined immunodeficiency syndrome. one of the three isoforms of the enzyme (ecto-ada) is capable of binding to the glycoprotein cd26 and adenosine receptors a1 and a2b. ada-cd26 interaction produces a costimulatory signal in the events of t cell activation and secretion of ifn-g, tnf-a and il-6. during this activation, the enzyme activity is regulated positively by il-2 and il-12 and negatively by il-4, based on the mechanism of translocation. diverse studies suggest that seric and plasmatic levels of ada rise in some diseases caused by microorganisms infecting mainly the macrophages and in hypertensive disorders, which may represent a compensatory mechanism resulting from increased adenosine levels and the release of hormones and inflammatory mediators estimulated by hipoxia
Uso da camara de ar em cirurgia ortopédica: aplica??es, vantagens e desvantagens
Goncalves, Jose Carlos Barbl;Fernandes, Yvens Barbosa;Silva, Rafael Barreto;Cipoli, Fernando;
Coluna/Columna , 2009, DOI: 10.1590/S1808-18512009000400011
Abstract: objective: this paper aimed at promoting the use of the inner tube as a systematic device in orthopedic surgery, such as body holder and protector of bony projections, especially in long-term spine surgeries. methods: this was a prospective non-randomized study, carried out from 2002 to 2007, with 264 orthopedic procedures. results: we found that, regardless the time of surgery, there were no areas of pressure around bony prominences or injury of peripheral nerves in the postoperative follow-up. conclusion: those results could recommend the inner tube as an excellent option like a frame in orthopedic surgery. it is an inexpensive device, easy to obtain, and without known complications.
Adenosin deaminasa en el síndrome de inmunodeficiencia combinada severa Adenosine deaminase in severe combined immunodeficiency syndrome
Mary Carmen Pérez-Aguilar,Loredana Goncalves,Rafael Bonfante-Cabarcas
Investigación Clínica , 2012,
Abstract: La Adenosin deaminasa es una enzima del metabolismo de las purinas cuya función es transformar la adenosina en inosina y la desoxiadenosina en desoxiinosina. La unión de ecto-ADA1 a la superficie celular a través de CD26 contribuye a la regulación de citocinas y estimula la proliferación de células T mediante la activación de CD45. La deficiencia de esta enzima genera el síndrome de inmunodeficiencia combinada severa, caracterizado por la acumulación de metabolitos de adenina y desoxiadenosina, los cuales tienen efectos tóxicos sobre los linfocitos, afectando así la síntesis de ADN y en consecuencia la expansión clonal. Un diagnóstico temprano de esta inmunodeficiencia es esencial ya que reduce notablemente la morbilidad y mortalidad asociada con infecciones recurrentes. Los avances recientes en biología molecular y genética han conducido a la identificación de los defectos genéticos de muchas de las inmunodeficiencias primarias y al desarrollo de herramientas de diagnóstico y tratamiento prometedoras Adenosine deaminase is an enzyme of the purine metabolism whose function is to convert adenosine to inosine and deoxyadenosine to deoxyinosine. The ecto-ADA1 binding to the cell surface through CD26 contributes to the regulation of cytokines and stimulates the proliferation of T cells by activating CD45. The deficiency of this enzyme generates the severe combined immunodeficiency syndrome, characterized by the accumulation of deoxyadenosine and adenine metabolites, which have toxic effects on lymphocytes, affecting DNA synthesis and consequently, clonal expansion. Early diagnosis of this immunodeficiency is essential, as it significantly reduces morbidity and mortality associated with recurrent infections. Recent advances in molecular biology and genetics have led to the identification of genetic defects of many primary immunodeficiencies and the development of promising diagnostic tools and treatment
Adenosin deaminasa como molécula coestimuladora y marcador de inmunidad celular Adenosine deaminase as costimulatory molecule and marker of cellular immunity
Mary Carmen Pérez-Aguilar,Loredana Goncalves,Alba Ibarra,Rafael Bonfante-Cabarcas
Investigación Clínica , 2010,
Abstract: La adenosin deaminasa (ADA), es una enzima del metabolismo de las purinas que ha sido objeto de mucho interés debido a que el defecto congénito de esta enzima causa el síndrome de inmunodeficiencia combinada severa. Una de las tres isoformas de la enzima (ecto-ADA) es capaz de unirse a la glicoproteína CD26 y a los receptores de adenosina A1 y A2B. La interacción ADA-CD26 produce una se al coestimuladora en los eventos de activación de las células T y en la secreción de IFN-g, TNF-a e IL-6. Durante dicha activación la actividad de la enzima está regulada de manera positiva por IL-2 e IL-12 y negativamente por IL-4, basado en un mecanismo de translocación. Diversos estudios se alan que los niveles séricos y plasmáticos de ADA se elevan en algunas enfermedades causadas por microorganismos que infectan principalmente a los macrófagos; así como en trastornos hipertensivos, lo cual podría representar un mecanismo compensatorio como consecuencia de la elevación de los niveles de adenosina y la liberación de mediadores hormonales e inflamatorios estimulados por la hipoxia Adenosine deaminase (ADA) is an enzyme of purine metabolism which has been the subject of much interest because the congenital defect of this enzyme causes severe combined immunodeficiency syndrome. One of the three isoforms of the enzyme (ecto-ADA) is capable of binding to the glycoprotein CD26 and adenosine receptors A1 and A2B. ADA-CD26 interaction produces a costimulatory signal in the events of T cell activation and secretion of IFN-g, TNF-a and IL-6. During this activation, the enzyme activity is regulated positively by IL-2 and IL-12 and negatively by IL-4, based on the mechanism of translocation. Diverse studies suggest that seric and plasmatic levels of ADA rise in some diseases caused by microorganisms infecting mainly the macrophages and in hypertensive disorders, which may represent a compensatory mechanism resulting from increased adenosine levels and the release of hormones and inflammatory mediators estimulated by hipoxia
Cinecoronariografia com gadolínio em pacientes com alergia grave ao contraste iodado
Meireles, George César Ximenes;Kreimer, Sérgio;Marchiori, Gilberto Guilherme Ajjar;Galon, Micheli Zanotti;Scanavacca, Rafael;
Revista Brasileira de Cardiologia Invasiva , 2012, DOI: 10.1590/S2179-83972012000300018
Abstract: the use of iodinated contrast media is contraindicated in some patients due to serious life-threatening adverse events. in such cases, there are reports that gadolinium (gadobutrol), which is commonly employed in magnetic resonance imaging, may be used as contrast media for coronary angiography. we report two cases with a history of severe allergy to iodinated contrast agent who underwent coronary angiography with gadolinium. the procedures were well tolerated, the amount of contrast media did not exceed 0.3-0.4 ml/kg and the images obtained were of acceptable quality for diagnostic purposes.
Capital social, redes sociais e inova??es produtivas
Ximenes, Tereza;
Ambiente & Sociedade , 2008, DOI: 10.1590/S1414-753X2008000200012
Abstract: successful experiences in motivating local populations show the importance of organizing people and training them to develop innovative projects. it also reveals that communities in which people interact more frequently with each other and where social networks, on a whole, are well integrated, are more likely to overcome their limitations and to take advantage of their opportunities. this in return favors the development of strategies and collective tactics, increasing the power of choice and decision of the community members.
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