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Search Results: 1 - 10 of 69 matches for " Radka Platte "
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CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen
Jean E Abraham, Mel J Maranian, Kristy E Driver, Radka Platte, Bolot Kalmyrzaev, Caroline Baynes, Craig Luccarini, Mitul Shah, Susan Ingle, David Greenberg, Helena M Earl, Alison M Dunning, Paul DP Pharoah, Carlos Caldas
Breast Cancer Research , 2010, DOI: 10.1186/bcr2629
Abstract: This was a population based case-cohort study. We genotyped known functional variants (n = 7; minor allele frequency (MAF) > 0.01) and single nucleotide polymorphisms (SNPs) (n = 5; MAF > 0.05) tagging all known common variants (tagSNPs), in CYP2D6 in 6640 DNA samples from patients with invasive breast cancer from SEARCH (Studies of Epidemiology and Risk factors in Cancer Heredity); 3155 cases had received tamoxifen therapy. There were 312 deaths from breast cancer, in the tamoxifen treated patients, with over 18000 years of cumulative follow-up. The association between genotype and BCSS was evaluated using Cox proportional hazards regression analysis.In tamoxifen treated patients, there was weak evidence that the poor-metaboliser variant, CYP2D6*6 (MAF = 0.01), was associated with decreased BCSS (P = 0.02; HR = 1.95; 95% CI = 1.12-3.40). No other variants, including CYP2D6*4 (MAF = 0.20), previously reported to be associated with poorer clinical outcomes, were associated with differences in BCSS, in either the tamoxifen or non-tamoxifen groups.CYP2D6*6 may affect BCSS in tamoxifen-treated patients. However, the absence of an association with survival in more frequent variants, including CYP2D6*4, questions the validity of the reported association between CYP2D6 genotype and treatment response in breast cancer. Until larger, prospective studies confirming any associations are available, routine CYP2D6 genetic testing should not be used in the clinical setting.Tamoxifen has been the standard treatment for oestrogen receptor (ER)-positive breast cancer for more than three decades. Indications for its use [1] include: metastatic disease in women (pre- and post-menopausal) and men; adjuvant therapy in pre- and post-menopausal women with breast cancer (lymph node positive and negative); preventative therapy in women at high risk of breast cancer; ductal carcinoma in situ post-resection; and for the prevention of contra-lateral breast cancer. There are proven benefits ass
Baár, Monika: Historians and Nationalism. East-Central Europe in the Nineteenth Century. Oxford: Oxford University Press, 2010, 340 s., ISBN: 978-0-19-157385-9.
Radka Martincová
St?edoevropské Politické Studie , 2012,
Abstract: Book Review
Effect of long-term potassium fertilization on the chemical composition of Oriental tobacco
Journal of Central European Agriculture , 2012, DOI: 10.5513/jcea01/13.3.1078
Abstract: The effects of the different potassium rates (0, 75 and 450 kg K2O ha-1) on nutrient concentrations in the above-ground biomass and chemical characteristics of sun-cured tobacco have been studied in a stationary field trial. Annual fertilization with 75 kg K2O ha-1 was adequate to maintain soil K concentration near the initial value. It was found that yield of cured leaves was not significantly affected by rate of K application when oriental tobacco was grown on soils with high available soil K. With the increase of K fertilization rate the content of the potassium in leaves increased from 0.65 to 4.49%. The concentration of Ca and Mg in the leaves ranged from 2.03 to 5.23% and from 0.52 to 0.71%, respectively and decreased with increases in added potassium. No effect of K rates on nicotine and protein content was noted. Only the reducing sugars’ content tended to increase to 11.42% at the highest K rate. Fertilization with moderate potassium rates (75 kg K2O ha-1) on soils high in available K is necessary to maintain the good potassium reserves. When oriental tobacco was grown on alkaline soils with high available K and Ca, potassium fertilization improves K nutrition and therefore may favorably affect burning properties of tobacco.
The correlation between media and technology: The context of the gradual rise of new media
Radka Kohutova
Bodhi: An Interdisciplinary Journal , 2010, DOI: 10.3126/bodhi.v4i1.5810
Abstract: DOI: http://dx.doi.org/10.3126/bodhi.v4i1.5810 Bodhi 2010 4(1): 48-70
Blow-up criteria for the 3d cubic nonlinear Schr?dinger equation
Justin Holmer,Rodrigo Platte,Svetlana Roudenko
Mathematics , 2009,
Abstract: We consider solutions $u$ to the 3d nonlinear Schr\"odinger equation $i\partial_t u + \Delta u + |u|^2u=0$. In particular, we are interested in finding criteria on the initial data $u_0$ that predict the asymptotic behavior of $u(t)$, e.g., whether $u(t)$ blows-up in finite time, exists globally in time but behaves like a linear solution for large times (scatters), or exists globally in time but does not scatter. This question has been resolved (at least for $H^1$ data) if $M[u]E[u]\leq M[Q]E[Q]$, where $M[u]$ and $E[u]$ denote the mass and energy of $u$, and $Q$ denotes the ground state solution to $-Q+\Delta Q +|Q|^2Q=0$. Here, we prove a new sufficient condition for blow-up using an interpolation type inequality and the virial identity that is applicable to certain initial data satisfying $M[u]E[u]>M[Q]E[Q]$. Our condition is similar to one obtained by Lushnikov (1995) but our method allows for an adaptation to radial, infinite-variance initial data that can be stated conceptually: for real initial data, if a certain fraction of the mass is contained in the unit ball, then blow-up occurs. We also show analytically (if one takes the numerically computed value of $\|Q\|_{\dot H^{1/2}}$) that there exist Gaussian initial data $u_0$ with negative quadratic phase such that $\|u_0\|_{\dot H^{1/2}} < \|Q\|_{\dot H^{1/2}}$ but the solution $u(t)$ blows-up. We conclude with several numerically computed examples.
Journal of Central European Agriculture , 2006,
Abstract: In relation to determination of leaf area through linear measurements of leaf blade and mathematical coeffi cients in Burley tobacco individual values of correction coeffi cients have been determined by variety and in dependence of the leaf position.
Correlations in atomic systems: Diagnosing coherent superpositions
Radka Bach,Kazimierz Rzazewski
Physics , 2004, DOI: 10.1103/PhysRevLett.92.200401
Abstract: While investigating quantum correlations in atomic systems, we note that single measurements contain information about these correlations. Using a simple model of measurement -- analogous to the one used in quantum optics -- we show how to extract higher order correlation functions from individual "phtotographs" of the atomic sample. As a possible application we apply the method to detect a subtle phase coherence in mesoscopic superpostitions.
Correlation functions of cold bosons in an optical lattice
Radka Bach,Kazimierz Rzazewski
Physics , 2004, DOI: 10.1103/PhysRevA.70.063622
Abstract: We investigate the experiment of collapses and revivals of matter wave field in more detail. To this end we calculate the lowest-order correlation functions of the Bose field. We compare predictions of the total Fock state with the commonly used coherent state approximation. We also show how to observe an interference pattern for the celebrated Mott state.
Exploring the link between MORF4L1 and risk of breast cancer
Griselda Martrat, Christopher A Maxwell, Emiko Tominaga, Montserrat Porta-de-la-Riva, Núria Bonifaci, Laia Gómez-Baldó, Massimo Bogliolo, Conxi Lázaro, Ignacio Blanco, Joan Brunet, Helena Aguilar, Juana Fernández-Rodríguez, Sheila Seal, Anthony Renwick, Nazneen Rahman, Julia Kühl, Kornelia Neveling, Detlev Schindler, María J Ramírez, María Castellà, Gonzalo Hernández, EMBRACE, Douglas F Easton, Susan Peock, Margaret Cook, Clare T Oliver, Debra Frost, Radka Platte, D Gareth Evans, Fiona Lalloo
Breast Cancer Research , 2011, DOI: 10.1186/bcr2862
Abstract: Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk.A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to γ-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, Ptrend = 0.45 and 0.05, P2df = 0.51 and 0.14, respectively; and rs10519219, Ptrend = 0.92 and 0.72, P2df = 0.76 and 0.07, respectively.While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers.Genes that when mutated cause Fanconi anemia (FA) and/or influence bre
Oral Perceptions of Fat and Taste Stimuli Are Modulated by Affect and Mood Induction
Petra Platte, Cornelia Herbert, Paul Pauli, Paul A. S. Breslin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065006
Abstract: This study examined the impact of three clinical psychological variables (non-pathological levels of depression and anxiety, as well as experimentally manipulated mood) on fat and taste perception in healthy subjects. After a baseline orosensory evaluation, ‘sad’, ‘happy’ and ‘neutral’ video clips were presented to induce corresponding moods in eighty participants. Following mood manipulation, subjects rated five different oral stimuli, appearing sweet, umami, sour, bitter, fatty, which were delivered at five different concentrations each. Depression levels were assessed with Beck’s Depression Inventory (BDI) and anxiety levels were assessed via the Spielberger’s STAI-trait and state questionnaire. Overall, subjects were able to track the concentrations of the stimuli correctly, yet depression level affected taste ratings. First, depression scores were positively correlated with sucrose ratings. Second, subjects with depression scores above the sample median rated sucrose and quinine as more intense after mood induction (positive, negative and neutral). Third and most important, the group with enhanced depression scores did not rate low and high fat stimuli differently after positive or negative mood induction, whereas, during baseline or during the non-emotional neutral condition they rated the fat intensity as increasing with concentration. Consistent with others’ prior observations we also found that sweet and bitter stimuli at baseline were rated as more intense by participants with higher anxiety scores and that after positive and negative mood induction, citric acid was rated as stronger tasting compared to baseline. The observation that subjects with mild subclinical depression rated low and high fat stimuli similarly when in positive or negative mood is novel and likely has potential implications for unhealthy eating patterns. This deficit may foster unconscious eating of fatty foods in sub-clinical mildly depressed populations.
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