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Search Results: 1 - 10 of 3303 matches for " Rabia Hamid "
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Dietary Lectins as Disease Causing Toxicants
Rabia Hamid,Akbar Masood
Pakistan Journal of Nutrition , 2009,
Abstract: Lectins are carbohydrate binding proteins present in most plants, especially seeds and tubers like cereals, potatoes and beans. It is now well established that many lectins are toxic, inflammatory, resistant to cooking and digestive enzymes and present in much of our food and sometimes cause "food poisoning." The global pattern of varying prevalence of diseases such as coeliac disease, autoimmune diseases, rheumatoid arthritis, obesity, cardiovascular disease and insulin dependant diabetes mellitus, suggests that some dietary factor specific to plant foods could initiate these diseases. Of the food lectins, grain/cereal lectins, dairy lectins and legume lectins are the most common ones associated with aggravation of inflammatory and digestive diseases in the body and improvement of these diseases and/or symptoms when avoided. Recent research has suggested that these lectins may effectively serve as a vehicle allowing foreign proteins to invade our natural gut defenses and cause damage well beyond the gut, commonly in joints, brain, skin and various body glands. With continued exposure of the gut by these toxic food lectins a persistent stimulation of the body’s defense mechanism in a dysfunctional manner occurs, which manifests as an autoimmune disease. If the lectins in diet are causative in initiating all these diseases, it should be possible to identify the responsible constituents and modify or remove them so as to make the diet healthier. Here we present a brief account of lectin toxicity research and show how these proteins have become the focus of intense interest for biologists.
Receptor modification as a therapeutic approach against viral diseases
Rabia Farid,,Mohammad Haroon Khan,Hamid Rashid
Bioinformation , 2012,
Abstract: Poliovirus causes flaccid paralysis through the destruction of motor neurons in the CNS. Susceptibility to its infection is mainly due to the interaction in between the surface capsid proteins and its receptors on the host cell surface, important for binding, penetration and other necessary events during early infection. Receptor modification is a new approach to treat viral diseases by the modification of target proteins structure. Binding domains are modified in an effective way to make it difficult for the virus to recognize it. In this study, tolerant and intolerant induced mutations in the poliovirus receptor, VP1 and VP2 were identified and substituted in the seed sequence to get the modified versions. Substitutions causing changes in initial folding were short listed and further analyzed for high level folding, physiochemical properties and interactions. Highest RMSD values were observed in between the seed and the mutant K90F (3.265 ) and Q130W (3.270 ) respectively. The proposed substitutions were found to have low functional impact and thus can be further tested and validated by the experimental researchers. Interactions analyses proved most of the substitutions having decreased affinity for both the VP1 and VP2 and thus are of significant importance against poliovirus. This study will play an important role for bridging computational biology to other fields of applied biology and also will provide an insight to develop resistance against viral diseases. It is also expected that same approach can also be applicable against other viruses like HCV, HIV and other in near future
Evaluation of antimicrobial activity of a lectin isolated and purified from Indigofera heterantha  [PDF]
Sakeena Qadir, Ishfak Hussain Wani, Shaista Rafiq, Showkat Ahmad Ganie, Akbar Masood, Rabia Hamid
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.411133
Abstract:

Indigofera heterantha commonly called indigo bush is a member of leguminoseae family found in the Himalayan region of Kashmir. A lectin has been isolated from the seeds of Indigofera heterantha by the purification procedure involving anion exchange chromatography on DEAE-cellulose followed by gel filtration chromatography on Sephadex G 100. Molecular characterization of the lectin was done by gel filtration and SDS-PAGE. Activity of the lectin was checked by hemagglutination assay and the sugar specificity by sugar inhibition tests. The antimicrobial activity of the purified lectin was carried out by Agar disc diffusion using appropriate standards. On the ion exchange column, the bound protein when eluted with 0-0.5 M NaCl gradient emerged as three peaks—peak I, peak II and peak III out of which only peak II showed the hemagglutinating activity. The lectin further resolved into two peaks G1 and G2 on gel filtration, with the lectin activity residing in G1, corresponding to a molecular weight of 70 KDa. The purified lectin named as Indigofera heterantha Lectin (IHL) produced a single band on SDS PAGE (18 KDa), revealing the tetrameric nature of the lectin. It agglutinated human erythrocytes (A, B, AB, and O). Hemagglutination was inhibited by D-galactose, Dmannose and D-arabinose. The lectin is reasonably thermostable showing full activity within a temperature range of 30°C to 90°C. pH stability of the lectin falls in the range of 2-9. IHL demonstrated a remarkable antibacterial activity against the pathogenic bacteria Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. IHL also inhibited the growth

Comparison of Fine Needle Aspiration Cytology and Thyroid Scan in Solitary Thyroid Nodule
Rabia Basharat,Mulazim Hussain Bukhari,Shahzad Saeed,Tahira Hamid
Pathology Research International , 2011, DOI: 10.4061/2011/754041
Abstract: Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules (STN) presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan (TS). These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients (80%) having cold nodule were labeled as suspicious 10 patients (20%) had hot nodule. On FNAC 23 patients (46%) had benign lesion, 22 patients (44%) had indeterminate lesion and 5 patients (10%) had malignant lesions. On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules. 1. Introduction Thyroid nodular (TN) lesions are a common clinical problem in the world. These are more common in women and in areas of iodine deficiency. Exposure to ionizing radiation in childhood and adolescence increases the risk of solitary thyroid nodule and thyroid carcinoma. In the United States, 4 to 7% of the adult population has a palpable thyroid nodule [1]. A solitary thyroid nodule is a palpable swelling in thyroid gland that has otherwise a normal appearance [2]. The majority of thyroid nodules are asymptomatic and only about 5 percent of all palpable nodules are found to be malignant. A variety of tests have been employed to separate benign from malignant thyroid nodules [2, 3]. These tests include isotope scanning and fine needle aspiration cytology. Combined use of isotope scanning, fine needle aspiration cytology, and histopathology of thyroid offers the best diagnostic strategy [4]. Isotope scanning was generally used to
Role of Knowledge in Supporting Growth across Indian States: A Co-Integration and Causality Approach  [PDF]
Arindam Banik, Rabia Khatun
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.33045
Abstract: This paper uses cointegration and vector error-correction models to analyse the causal relationship between education and development across select Indian states using annual data from 1980-81 to 2008-09. Expenditure on education per capita is used as the proxy for education, while State domestic product per capita is the proxy for development. The empirical results provide some evidence of bi-directional causality in Indian States such as Kerala, Karnataka, Andhra Pradesh, Maharashtra and Tamil Nadu. There is also evidence of causation running from per capita expenditure on education to per capita State domestic product in either the short or long run in states such as Bihar, Arunachal Pradesh, Uttar Pradesh, West Bengal, Punjab, Orissa, Madhya Pradesh, Gujarat, Rajasthan, Haryana and Punjab. Thus, there is some indication that the observed positive correlation across states between expenditure on education and growth reflects primarily the influence of government effective intervention in the education sector.
The Role of Morphology and Short Vowelization in Reading Morphological Complex Words in Arabic: Evidence for the Domination of the Morpheme/Root-Based Theory in Reading Arabic  [PDF]
Salim Abu-Rabia
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.34074
Abstract: This study investigated the reading accuracy of 59 adult highly skilled native Arabic readers in reading morphological complex Arabic words in 6 reading conditions: Isolated words with short vowelization, isolated words without short vowelization, sentences with roots with short vowelization, sentences with roots without short vowelization, sentences without priming roots with short vowelization and sentences without priming roots without short vowelization. The results indicated that roots and short vowelization were good facilitators for these adults highly skilled readers in their reading accuracy of morphological complex Arabic words. The results are discussed in the light of the role of roots as autonomous semantic entities and that the complex morphology of Arabic needs short vowelization for accuracy in reading.
Ethno-Botanic Treatments for Paralysis (Falij) in the Middle East  [PDF]
Aref Abu-Rabia
Chinese Medicine (CM) , 2012, DOI: 10.4236/cm.2012.34025
Abstract:

The goal of this paper is to describe beliefs and treatments for specific forms of Paralysis (falij) and other nervous disorders in the Middle East. Themes to be investigated include, the traditional medicinal practices used to treat Paralysis, as well as their curative methods using traditional herbal medicine. This paper is based on first and secondary sources; interviews with traditional healers, as well as patients who suffered from these disorders. The author found 152 plants species belonging to 58 families (see Appendix) that treat paralysis and other nervous disorders. The most significant plants species are found in the six families of herbs: Labiatae, Compositae, Umbelliferae, Papilionaceae, Liliaceae, and Solanaceae.

Key Plants in Fighting Cancer in the Middle East  [PDF]
Aref Abu- Rabia
Chinese Medicine (CM) , 2015, DOI: 10.4236/cm.2015.62014
Abstract: This article is derived from a broader study of ethno-botany, medical anthropology and alternative medicine in Middle Eastern countries, which has been conducted during the past two decades. It presents examples of different edible and medicinal plants and their uses by different communities (urban, peasant and Bedouin) in the treatment of diseases and various medical disorders. Alongside, the article reviews current knowledge concerning plants and cancer prevention and treatment. The article shows that people of these countries use various parts of the plant in a host of manners-fresh and soft, cooked or dried, as both food and medicine. These plants—part of the natural fauna of the Middle Eastern countries—grow in the wild and are cultivated. The author found that the most significant plants used were in the following families: Compositae, Gramineae, Labiatae, Lamiaceae, Liliaceae, Malvaceae, Oleaceae, Ranunculaceae, Umbelliferae, and Urticaceae.
Penitence, Confession, and the Power of Submission in Late Medieval Women's Religious Communities
Rabia Gregory
Religions , 2012, DOI: 10.3390/rel3030646
Abstract: This article argues that depictions of penance and confession in late medieval "Sisterbooks," which were written by women religious for communal use, show that medieval women understood religious authority to be enhanced through submission and service to community members. These collections of the lives and reminiscences of deceased sisters and father confessors construct idealized piety and religious authority through public acts of obedience and submission which built a reputation for sanctity, not just for the individual penitent, but for her entire community. Thus in the Sisterbooks, obedience to a confessor or spiritual director for both male and female penitents shifts the locus of spiritual authority from the confessor to the penitent and her community through communal observation and evaluation. These medieval Christian women understood the relationships between confessors and confessants as one which conferred power and authority to the penitent, complicating Foucault's influential claim that the sacrament of confession granted all power to the confessor who heard sins in secret. In the Sisterbooks, interactions between women religious and their confessors are depicted as relational, complex, and constantly in flux.
D’un pays à un autre ou les enjeux du passage dans Les Yeux baissés de Tahar Ben Jelloun
Rabia Redouane
Synergies Pologne , 2005,
Abstract:
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