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Search Results: 1 - 10 of 30271 matches for " RR.;Santos "
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Reproductive cycle of Macrobrachium amazonicum females (Crustacea, Palaemonidae)
Sampaio, CMS.;Silva, RR.;Santos, JA.;Sales, SP.;
Brazilian Journal of Biology , 2007, DOI: 10.1590/S1519-69842007000300022
Abstract: macrobrachium amazonicum is considered a favorite brazilian species of freshwater prawn for cultivation as a result of its quick development and because it is easy to maintain in captivity. the aim of this work is to describe the sexual cycle stages and determine maturation age of the female m. amazonicum, which was collected monthly from june, 2002 to may, 2003 in the jaguaribe river, itai?aba, ceará. a monthly sample of water was also collected to determine the following parameters: temperature, dissolved oxygen, ph and salinity. a monthly sample of females was selected among the individuals caught, to determine the total weight (wt), carapace length (lc) and abdomen+telson length (la+t) and to register the number of non-ovigerous females (nof) and ovigerous females (of). determining ovarian maturation stages of m. amazonicum was done in a laboratory by observing macroscopic characters such as coloring, size, location and appearance of ovarians examined by transparent carapace. the first maturation age was determined from the relative frequency of the total length (lt) of young and adult females. the environmental parameters of the jaguaribe river did not hold any influence in the number of individuals collected. a total of 1,337 prawns were sampled, 513 males (38.4%) and 824 females (61.6%). the proportion between males and females in the studied population was of 1:1.6. among the collected females, 492 (50.7%) did not carry eggs in their abdomens (nof) and 332 (40.3%) carried eggs in their abdomens (of). there was no record of intact females. non-ovigerous females with mature ovaries were recorded throughout all the months of collection. the female ovaries were classified as immature (im), rudimentary (ru), intermediary (in) and mature (m). m. amazonicum females reach their first sexual maturity between 4.5 and 5.5 cm of total length.
Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery
Coelho-Castelo AAM,Trombone AP,Rosada RS,Santos RR
Genetic Vaccines and Therapy , 2006, DOI: 10.1186/1479-0556-4-1
Abstract: In order to assess a new strategy of DNA vaccine for a more complete understanding of its action in immune response, it is important to determine the in vivo biodistribution fate and antigen expression. In previous studies, our group focused on the prophylactic and therapeutic use of a plasmid DNA encoding the Mycobacterium leprae 65-kDa heat shock protein (Hsp65) and achieved an efficient immune response induction as well as protection against virulent M. tuberculosis challenge. In the present study, we examined in vivo tissue distribution of naked DNA-Hsp65 vaccine, the Hsp65 message, genome integration and methylation status of plasmid DNA. The DNA-Hsp65 was detectable in several tissue types, indicating that DNA-Hsp65 disseminates widely throughout the body. The biodistribution was dose-dependent. In contrast, RT-PCR detected the Hsp65 message for at least 15 days in muscle or liver tissue from immunized mice. We also analyzed the methylation status and integration of the injected plasmid DNA into the host cellular genome. The bacterial methylation pattern persisted for at least 6 months, indicating that the plasmid DNA-Hsp65 does not replicate in mammalian tissue, and Southern blot analysis showed that plasmid DNA was not integrated. These results have important implications for the use of DNA-Hsp65 vaccine in a clinical setting and open new perspectives for DNA vaccines and new considerations about the inoculation site and delivery system.
Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
Silva, Ara;Morais, SM;Marques, MMM;Lima, DM;Santos, SCC;Almeida, RR;Vieira, IGP;Guedes, MIF;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2011, DOI: 10.1590/S1678-91992011000400007
Abstract: in recent years, the search for natural plant products to fight viral diseases has been increasing. in this work, two spondias species, namely s. mombin and s. tuberosa, found in ceará state (brazil), and their main phenolic components were evaluated against dengue virus. in vitro antiviral tests were performed against type-2 dengue virus by the mtt method and standard cytopathic effect reduction assay in c6/36 cells. cytotoxicity was also evaluated by mtt. the presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by hplc analysis. both spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with ic50 of 362.68 μg/ml and 500 μg/ml, respectively.
Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering
Tonelli FM, Santos AK, Gomes KN, Loren on E, Guatimosim S, Ladeira LO, Resende RR
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S33612
Abstract: rbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering Review (2861) Total Article Views Authors: Tonelli FM, Santos AK, Gomes KN, Loren on E, Guatimosim S, Ladeira LO, Resende RR Published Date August 2012 Volume 2012:7 Pages 4511 - 4529 DOI: http://dx.doi.org/10.2147/IJN.S33612 Received: 05 May 2012 Accepted: 14 June 2012 Published: 14 August 2012 Fernanda MP Tonelli,1 Anderson K Santos,1 Katia N Gomes,2 Eudes Loren on,2 Silvia Guatimosim,3 Luiz O Ladeira,2 Rodrigo R Resende1 1Cell Signaling and Nanobiotechnology Laboratory, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil; 2Nanomaterials Laboratory, Department of Physics, Federal University of Minas Gerais, Belo Horizonte, Brazil; 3Intracellular Cardiomiocyte Signaling Laboratory, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil Abstract: In recent years, significant progress has been made in organ transplantation, surgical reconstruction, and the use of artificial prostheses to treat the loss or failure of an organ or bone tissue. In recent years, considerable attention has been given to carbon nanotubes and collagen composite materials and their applications in the field of tissue engineering due to their minimal foreign-body reactions, an intrinsic antibacterial nature, biocompatibility, biodegradability, and the ability to be molded into various geometries and forms such as porous structures, suitable for cell ingrowth, proliferation, and differentiation. Recently, grafted collagen and some other natural and synthetic polymers with carbon nanotubes have been incorporated to increase the mechanical strength of these composites. Carbon nanotube composites are thus emerging as potential materials for artificial bone and bone regeneration in tissue engineering.
Prescribing Pattern Among Medical Interns at the Rural Health Centres of a Medical College, Manipal, Karnataka
Pati RR
Indian Journal of Community Medicine , 2004,
Prevalence and Pattern of Disability in a Rural Community in Karnataka
Pati RR
Indian Journal of Community Medicine , 2004,
The parasellar dura mater and adjacent dura: a microsurgical and light microscopic study in fetal materials
Vucetic RR
Neuroanatomy , 2005,
Abstract: The parasellar dura mater should be distinguished from the adjacent dura because the cavernous sinus, the internal carotid artery, and certain cranial nerves passes through it. The purpose of this study is to demonstrate the difference between the structure of the parasellar and the adjacent dura mater. The study was held with 80 fetuses at a gestational age of 20-40 weeks. Microdissection and histological investigation was performed without decalcification. The results are as follows: The meningeal layer of the parasellar dura mater was thicker from that of the adjacent dura, but their periosteal layers had similar thickness. The meningeal layer of the cranial dura mater had a multilayered structure, and also two types of lamellas have been found, the compact and the loose lamellas. Four compact and four loose lamellas of the meningeal layer of the parasellar dura mater have been shown by dissection and histological method. Through these lamellas are passing the cranial nerves III, IV, V1, V2, V3, VI and their vessels. Through the fourth loose lamellae pass the parasellar portion of the internal carotid artery. In the third and fourth loose lamellas there are venous spaces arranged around the internal carotid artery, which form the cavernous sinus. The compact lamellas are thinner but firmer in comparison to loose lamellas. On the other hand, three compact and three loose lamellas have been found in the meningeal layer of the adjacent dura mater. Neither evident vessels nor nerves have been noticed between these lamellas.
Hypertonie 2010: Was ist neu?
Wenzel RR
Journal für Hypertonie , 2011,
Abstract: Gesundheitspolitisch zeigen die neuen Daten von 2010, dass kardiovaskul re Pr vention schon in der Kindheit und Jugend beginnen muss. Insbesondere die Früherkennung einer Hypertonie hat auf das sp tere überleben der betroffenen Menschen einen wichtigen Einfluss. Eine Pay for performance -Regelung macht in der Hypertonie keinen Sinn, es sollte eher über ffentlichkeitsarbeit die Vigilanz bezüglich der Hypertonie und deren Therapie erh ht werden. Was mache ich ab 2011 bei meinen Patienten anders? Eine sch rfere Blutdruckeinstellung auf 130 135 mmHg systolisch macht zumindest beim Diabetiker vermutlich wenig Sinn, insbesondere wenn ich den Koronarstatus des Patienten nicht kenne. Allerdings gibt es durch die sch rfere Blutdrucksenkung einen gewissen Benefit für das Schlaganfallrisiko, sodass bei Patienten, die ein hohes Schlaganfallrisiko haben oder diesen besonders fürchten, m glicherweise eine etwas st rkere Blutdrucksenkung dennoch gerechtfertigt ist. Auf keinen Fall sollte man den systolischen Blutdruck 110 mmHg senken. Die renale Denervierung ist eine m gliche Option bei verzweifelten F llen, sollte aber nur in erfahrenen Zentren und im Rahmen von kontrollierten Studien durchgeführt werden. Wissenschaftlich relevant für künftige Studien ist die Frage der Beeinflussung zirkardianer Rhythmen und der erh hten Aldosteronspiegel bei gest rten zirkadianen Rhythmen. Telemonitoring kann die Blutdruckkontrolle deutlich verbessern und sollte eines der n chsten wichtigen Projekte in sterreich sein. Neben den Absolutwerten sollten wir in Zukunft bei unseren Patienten verst rkt auf die Blutdruckvariabilit t als wichtigen und unabh ngigen Risikofaktor achten. Diese kann elegant über die Standardabweichung bzw. den Smoothness-Index in der 24-h-RR-Messung erfasst werden.
Endotheliale Dysfunktion bei kardiovaskul ren Erkrankungen
Wenzel RR
Journal für Hypertonie , 2004,
Stability of the Sitnikov's circular restricted three body problem when the primaries are oblate spheroid
RR Thapa
BIBECHANA , 2014, DOI: 10.3126/bibechana.v11i0.10395
Abstract: The Sitnikov's problem is a special case of restricted three body problem if the primaries are of equal masses (m1 = m2 = 1/2) moving in circular orbits under Newtonian force of attraction and the third body of mass m3 moves along the line perpendicular to plane of motion of primaries. Here oblate spheroid primaries are taken. The solution of the Sitnikov's circular restricted three body problem has been checked when the primaries are oblate spheroid. We observed that solution is depended on oblate parameter A of the primaries and independent variable τ = ηt. For this the stability of non-trivial solutions with the characteristic equation is studied. The general equation of motion of the infinitesimal mass under mutual gravitational field of two oblate primaries are seen at equilibrium points. Then the stability of infinitesimal third body m3 has been calculated.
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