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Search Results: 1 - 10 of 11775 matches for " Qiliang Qin "
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The Effect of Sodium Nitrite on Induction of Apoptosis in Human Gastric Adenocarcinoma Epithelia (AGS) Cells  [PDF]
Yanchao Liu, Qiliang Qin, Agula Bo, Hairong Zhang, Qing Zhang, Wenli Hao, Yueling Hu, Juan Sun
Pharmacology & Pharmacy (PP) , 2015, DOI: 10.4236/pp.2015.611052
Abstract: To examine the cytocidal effect of sodium nitrite on the cancer cell, we subjected human gastric adenocarcinoma epithelia (AGS) cells to various experimentation following exposure to sodium nitrite, and measured the resulting changes in the levels of cell death, lactate dehydrogenase (LDH) release, and caspase-3, -6, -8, and -9 activities. Our data revealed that, in AGS cells, treatment with ≥6.25 mM sodium nitrite for 8 h resulted in an obvious increase in cell death. LDH release was also markedly increased following sodium nitrite treatment, but at a concentration of ≥6.25 mM for 24 h. This increasing trend showed a positive correlation (r = 0.9564, P < 0.05). In addition, we detected pronounced increases in caspase activities with various concentrations of sodium nitrite: caspase-3 at ≥25 mM for 1 h, ≥12.5 mM for 3 h and 6 h; caspase-9 at 50 mM for 1 h and 3 h, and ≥6.25 mM for 6 h; and caspase-6 at 50 mM for 1 h and 3 h. We did not however, detect any observable increase in the activity of caspase-8 following sodium nitrite treatment at any concentration or for any duration of treatment in this study. This data demonstrates that, in AGS cells, higher concentrations or longer durations of treatment with sodium nitrite could exhibit a cytocidal effect, and that sodium nitrite could induce apoptosis via activation of the caspase-9, caspase-3 cascade (intrinsic pathway) and caspase-6.
Technological Progress, Spatial Competition and Industrial Location: Estimation and Predictions of Cement Industry in Northwest China  [PDF]
Fei Wang, Qiliang Mao
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.79100
Abstract: This study estimates a theoretical multi-region industrial location model by adopting real statistics to investigate the intuition of shaping spatial pattern of economic activities in a case of cement industry in Northwest China. Based on the estimation of key parameters, we simulate the impact of technological progress on variation of location. We find that, given trade cost, with technological progress, operating cost decreases, it is profitable for firms to expand sale range. In long term, technological progress would induce server spatial competition and promote further spatial concentration of industry. Original areas with larger market and fine industrial base are still main agglomerations, while original peripheral areas are further to a downward trend, and parts of original areas located next to hot pot areas have become peripheries. Our study on influence of technological progress on industrial location confirms the importance of investigation on intuition of spatial pattern of economic activities. Technological progress is essentially achievement of sustainable development. However, neglecting substantial spatial competition induced by technology improvement turns against spatial allocation of resources. Hence, optimal location of industries is one of important factors to ensure sustainable development.
A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression
Qiliang Li
Genome Biology , 2006, DOI: 10.1186/gb-2006-7-10-238
Abstract: Approximately 0.1% of the human genome sequence is responsible for the variation among individuals, and the majority of these differences are single-nucleotide polymorphisms (SNPs). Although most SNPs are stable and have no deleterious effects, others are likely to contribute to individuality, disease susceptibility, and individual responses to therapeutic drugs. At present, such 'functional' SNPs have mostly been identified in diseases that are caused by defects in a single gene (monogenic diseases), although SNPs have also been linked to complex diseases such as hypertension, diabetes, heart disease, and cancer, as well as to responses to drugs. SNPs are important not only in medicine but also in basic molecular biology as they represent a natural library of variations that can be used to elucidate and validate mechanisms of gene expression in vivo.In this regard, a SNP in the gene for myostatin - a transcription factor inhibiting muscle development - has recently been shown to contribute to the muscular hypertrophy typical of the Texel breed of sheep [1]. A G→A transition in the 3' untranslated region of the gene for myostatin creates a target site for a microRNA, which results in translational inhibition of myostatin and consequent muscle growth. Another SNP has recently been shown by De Gobbi et al. [2] to be responsible for a severe form of α-thalassemia found in Melanesia. This SNP disrupts gene expression by another novel mechanism, creating an illegitimate promoter site between the globin enhancers and the adult α-globin gene cluster, which has the effect of downregulating expression of the cluster. The molecular mechanism underlying this downregulation is not yet established, but the new findings provide the basis for some interesting speculations.Diseases caused by defects in the structure and expression of the globin genes, and thus of hemoglobin, represent the most complete repertoires of monogenic defects known to date. In nearly all cases, the molecul
On a Multiple Hilbert's Inequality with Parameters
Qiliang Huang
Journal of Inequalities and Applications , 2010, DOI: 10.1155/2010/309319
Abstract:
On a Multiple Hilbert's Inequality with Parameters
Huang Qiliang
Journal of Inequalities and Applications , 2010,
Abstract: By introducing multiparameters and conjugate exponents and using Hadamard's inequality and the way of real analysis, we estimate the weight coefficients and give a multiple more accurate Hilbert's inequality, which is an extension of some published results. We also prove that the constant factor in the new inequality is the best possible and consider its equivalent form.
A Multiple Hilbert-Type Integral Inequality with a Non-Homogeneous Kernel
Qiliang Huang and Bicheng Yang
Journal of Inequalities and Applications , 2013, DOI: 10.1186/1029-242X-2013-73
Abstract: By using the way of weight functions and technic of real analysis, a multiple Hilbert-type integral inequality with a non-homogeneous kernel is given. The operator expression with the norm, the reverses and some examples with the particular kernels are also considered.
On a Multiple Hilbert-Type Integral Operator and Applications
Qiliang Huang,Bicheng Yang
Journal of Inequalities and Applications , 2009, DOI: 10.1155/2009/192197
Abstract: By using the way of weight functions and the technic of real analysis, a multiple Hilbert-type integral operator with the homogeneous kernel of λ-degree (λ∈R) and its norm are considered. As for applications, two equivalent inequalities with the best constant factors, the reverses, and some particular norms are obtained.
On a Multiple Hilbert-Type Integral Operator and Applications
Huang Qiliang,Yang Bicheng
Journal of Inequalities and Applications , 2009,
Abstract: By using the way of weight functions and the technic of real analysis, a multiple Hilbert-type integral operator with the homogeneous kernel of -degree ( ) and its norm are considered. As for applications, two equivalent inequalities with the best constant factors, the reverses, and some particular norms are obtained.
MoS2 Nanoribbons Thermoelectric Generators
Abbas Arab,Qiliang Li
Physics , 2015,
Abstract: In this work, we have designed and simulated new thermoelectric generator based on monolayer and few-layer MoS2 nanoribbons. The proposed thermoelectric generator is composed of thermocouples made of both n-type and p-type MoS2 nanoribbon legs. Density Functional Tight-Binding Non-Equilibrium Green's Function (DFTB-NEGF) method has been used to calculate the transmission spectrum of MoS2 armchair and zigzag nanoribbons. Phonon transmission spectrum are calculated based on parameterization of Stillinger-Weber potential. Thermoelectric figure of merit, ZT, is calculated using these electronic and phonon transmission spectrum. Monolayer and bilayer MoS2 armchair nanoribbons are found to have the highest ZT value for p-type and n-type legs, repectively. Moreover, we have compared the thermoelectric current of doped monolayer MoS2 armchair nanoribbons and SZi thin films. Results indicate that thermoelectric current of MoS2 monolayer nanoribbons is several orders of magnitude higher than that of Si thin films.
Diffusive stability of Turing patterns via normal forms
Arnd Scheel,Qiliang Wu
Mathematics , 2013, DOI: 10.1007/s10884-013-9335-0
Abstract: We investigate dynamics near Turing patterns in reaction-diffusion systems posed on the real line. Linear analysis predicts diffusive decay of small perturbations. We construct a "normal form" coordinate system near such Turing patterns which exhibits an approximate discrete conservation law. The key ingredients to the normal form is a conjugation of the reaction-diffusion system on the real line to a lattice dynamical system. At each lattice site, we decompose perturbations into neutral phase shifts and normal decaying components. As an application of our normal form construction, we prove nonlinear stability of Turing patterns with respect to perturbations that are small in $L^1\cap L^\infty$, with sharp rates.
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