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Search Results: 1 - 10 of 23252 matches for " Qianshan He "
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Study and Analysis of Meteorological Effect on Shanghai Sheshan National Tourist Resorts in Shanghai  [PDF]
Yuliang Rong, Xia Zhang, Qianshan He
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.57002
Abstract: In this paper, the main meteorological disasters in the Sheshan National Tourist and Vacation Areas are analyzed by using the climate data from 1955 to 2014, such as average temperature, relative humidity, wind speed, insolation duration. The influences of meteorological parameters on this area are studied with the climate comfort evaluation and meteorological disaster climate trend. It is found that the major meteorological disasters in this area including fog, typhoon, storm, wind, thunderstorms and high temperature, were occurred in different periods with higher frequency from May to October. Nineteen comfortable ten-day periods in a year are suitable for tourist activities, during March and May, late September and the end of December. And seventeen ten-day periods in a year are not suitable for tourist activities, from January to February and from June to the middle of September. Some suggestions for tourism weather service on the basis of these results are listed in the conclusion.
Short-Term Precipitation Forecasting Rolling Update Correction Technology Based on Optimal Fusion Correction  [PDF]
Meijin Huang, Qing Lin, Ning Pan, Nengzhu Fan, Tao Jiang, Qianshan He, Lingguang Huang
Journal of Geoscience and Environment Protection (GEP) , 2019, DOI: 10.4236/gep.2019.73008
Abstract: In order to improve the availability of regional model precipitation forecast, this project intends to use the measured heavy rainfall data of dense automatic stations to carry out historical precipitation in the high resolution: the Severe Weather Automatic Nowcast System (SWAN) quantitative precipitation forecast and the High-Resolution Rapid Refresh (HRRR) regional numerical model precipitation forecast in short-term nowcasting aging. Based on the error analysis, the grid fusion technology is used to establish the measured rainfall, HRRR regional model precipitation forecast, and optical flow radar quantitative precipitation forecast (QPF) three-source fusion correction scheme, comprehensively integrate the revised forecasting effect, adjust the fusion correction parameters, establish an optimal correction plan, generate a frozen rolling update revised product based on measured dense data and short-term forecast, and put it into business operation, and perform real-time effect rolling test evaluation on the forecast product.
Analysis of a haze event by micro-pulse light laser detection and ranging measurements in Shanghai

PAN Hu,GENG Fuhai,CHEN Yonghang,HE Qianshan,ZHANG Hu,KANG Yanming,MAO Xiaoqin,WANG Hongqiang,

环境科学学报 , 2010,
Abstract: 通过分析2008年6月至2009年5月期间浦东新区灰霾天气出现的特征,并以2008年12月19日至2008年12月21日一次典型的灰霾天气过程为例,利用激光雷达(Light laser detection and ranging,简称Lidar)数据资料反演得到气溶胶消光系数及其强度图和廓线图,结合地面气象数据和气溶胶观测资料,分析了此次灰霾天气形成的原因.一年的观测资料表明,上海地区冬季和春季易产生灰霾天气,冬季出现重度霾最多,秋季和夏季灰霾天气较少.较弱的太阳辐射以及静风、小风是导致灰霾天气发生的重要原因,且高湿度的霾天气对能见度影响更大.大气边界层(以下简称边界层)高度变化决定着灰霾天气发生的强度,当边界层高度在1km左右时,易发生轻微霾天气,当边界层高度降至600m左右时,易发生中度、重度霾天气,而太阳辐射强度变化决定着边界层高度的变化.轻微霾天气下,大气气溶胶垂直分布最强消光值约为015km-1,而重霾天气下可达0.30km-1以上.本次霾过程还受地面颗粒物排放的影响,主要是PM1和PM2.5,且在消光作用中散射性气溶胶的贡献大于吸收性气溶胶.轻微霾天气下PM2.5 浓度为50μg·m-3,黑碳浓度为5000ng·m-3,浊度为200Mm-1,而重度霾时则分别达到200μg·m-3、24000 ng·m-3和1400Mm-1.随着此次霾的出现,整层大气气溶胶光学厚度(AOD,550nm)不断增加,在重度霾时达到0.6左右,Angstrom指数在重度霾时显著降低,表明有大颗粒物导入,说明此次重度霾天气的发生还与气溶胶的输送有关.

Jiang Chengshun,Yao Li,Li Qianshan,

计算数学 , 2006,
Abstract: For some diffusion systems with nontrivial coupling at the boundary, numerical simulations are performed. The problems about when and where the blow-up probably occurs and the blow-up rate are discussed. Based upon different initial data, the experiments are divided into four groups and carried on with twelve kinds of boundary parameters. For the two kinds of boundary parameters which probably lead blow-up, experiments are classified by monitor functions and performed using moving mesh methods. Then the validity of algorithms is expounded and the results of experiments are analyzed. Finally an experiment is presented for a special case.
Dendritic Cells Decreased the Concomitant Expanded Tregs and Tregs Related IL-35 in Cytokine-Induced Killer Cells and Increased Their Cytotoxicity against Leukemia Cells
Ying Pan, Qianshan Tao, Huiping Wang, Shudao Xiong, Rui Zhang, Tianping Chen, Lili Tao, Zhimin Zhai
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093591
Abstract: Regulatory T cells (Tregs) are potent immunosuppressive cells and essential for inducing immune tolerance. Recent studies have reported that Tregs and Tregs related cytokines can inhibit the antitumor activity of cytokine-induced killer (CIK) cells, but dendritic cells co-cultured CIK (DC-CIK) cells can be used for induction of a specific immune response by blocking of Tregs and TGF-β, IL-10. As a novel identified cytokine, IL-35 is specially produced by Tregs and plays an essential role in immune regulation. However, it remains unknown whether IL-35 roles in tumor immunotherapy mediated by CIK and DC-CIK cells. In this study, we cultured CIK and DC-CIK cells from the same healthy adult samples, and investigated their phenotype, proliferation, cytotoxic activity against leukemia cell lines K562 and NB4 by FCM and CCK-8, measured IL-35, TGF-β and IL-10 protein by ELISA, detected Foxp3, IL-35 and IL-35 receptor mRNA by Real-time PCR, respectively. We found Tregs and IL-35 concomitantly expanded by a time-dependent way during the generation of CIK cells, but DC significantly down-regulated the expression of them and simultaneously up-regulated the proliferation ability as well as cytotoxic activity of CIK cells against leukemia cell lines. Therefore, our data suggested that DC decreased concomitant expanded Tregs and Tregs related IL-35 in CIK cells and might contribute to improve their cytotoxicity against leukemia cells in vitro.
A Novel Cellular Senescence Gene, SENEX, Is Involved in Peripheral Regulatory T Cells Accumulation in Aged Urinary Bladder Cancer
Tianping Chen, Huiping Wang, Zhiqiang Zhang, Qing Li, Kaili Yan, Qianshan Tao, Qianling Ye, Shudao Xiong, Yiping Wang, Zhimin Zhai
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087774
Abstract: Regulatory T cells (Tregs) play an essential role in sustaining self-tolerance and immune homeostasis. Despite many studies on the correlation between Tregs accumulation and age, or malignancies, the related mechanism hasn’t been well explored. To find out the mechanism of Tregs accumulation in aged urinary bladder cancer, we examined the novel cellular senesence gene SENEX and relevant apoptosis gene mRNA expression in sorted CD4+CD25hi Tregs from aged UBC donors, evaluated serum cytokine profiles related to tumor immunopathology, and further explored the relationship between SENEX expression, apoptosis gene expression and cytokine secretion. After having silenced down SENEX gene expression with RNA interference, we also evaluated the cellular apoptosis of Tregs sorted from aged UBC patients in response to H2O2-mediated stress. Our data indicated that upregulated SENEX mRNA expression in Tregs of aged UBC patients was correlated with pro-apoptotic gene expression and cytokine concentration. Silencing SENEX gene expression increased cellular apoptosis and pro-apoptotic gene expression of Tregs, in response to H2O2-mediated stress. Upregulated SENEX mRNA expression together with decreased pro-apoptotic gene expression and disturbances in cytokines synthesis may contribute to the Tregs proliferation and promote tumorigenesis and metastasis. Overall, upregulation of cellular senescence gene SENEX, was associated to regulatory T cells accumulation in aged urinary bladder cancer. Our study provides a new insight into understanding of peripheral Tregs accumulation in aged malignancies.
The Revolution of Communication Media and Its Impact on Education  [PDF]
Lei He, Jian He
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.38014
Abstract: Medium means “middle” originally. When it is used as an academic term in communication theory, it would be a bridge of information exchange between two agents. The more advanced medium is, the richer amount of information it can carry. And then the communicating way changes. The way of thinking changes, too. This paper firstly analyzed the development of communication process and the corresponding changes in media, and then discussed the major impact on education re- form in different media. Each of the change will affect the media choice of teaching strategies and teaching effectiveness. Especially when the information media are used in education, much more information changing happens than ever before. People can learn with auditory, vision, tactus, olfaction, and so on. “Communication” became one of the most important keywords in the study sup- ported by information technology.
The Relevant Inferences of Electrodynamics under Non-Void Backgrounds  [PDF]
An He
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105713
The paper was based on the definition of time-rate, and founded the general transformation between reference systems that background had different standard of time, and the self-consistent theoretical system has been formed to promote the classical electrodynamics. According to the principle, more discussion about the relationship between structure of time-rate in space and physical properties in its own area (gravity, centrifugal force, acceleration system) was presented. In view of the above, the paper expounded the role of macro mechanism of gravity and inertia force, and unified them finally. The possibility of tremendous instantaneous acceleration has been put forward.
miR-29b and miR-29c Are Involved in Toll-Like Receptor Control of Glucocorticoid-Induced Apoptosis in Human Plasmacytoid Dendritic Cells
Yongfeng Hong, Jianxian Wu, Jingpu Zhao, Huiping Wang, Yi Liu, Tianping Chen, Xiuli Kan, Qianshan Tao, Xianshan Shen, Kaili Yan, Zhimin Zhai
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069926
Abstract: Glucocorticoids (GCs) are frequently used to treat many of the acute disease manifestations associated with inflammatory and autoimmune disorders. However, Toll-like receptor (TLR) pathway-activated plasmacytoid dendritic cells (pDCs) are resistant to GC-induced apoptosis, which leads to the inefficiency of GCs in the treatment of type I interferon-related autoimmune diseases, such as systemic lupus erythematosus (SLE). Therefore, compounds promoting pDC apoptosis may be helpful for improving the efficacy of GCs. In this study, we performed screening to identify microRNAs (miRNAs) involved in TLR-inhibited GC-induced pDC apoptosis and found an array of miRNAs that may regulate pDC apoptosis. Among those demonstrating altered expression, 6 miRNAs were inhibited in TLR-activated pDCs. Bioinformatics analysis and functional studies indicated that miR-29b and miR-29c were 2 key miRNAs involved in TLR-inhibited GC-induced pDC apoptosis. Furthermore, both of these miRNAs promoted pDC apoptosis by directly targeting Mcl-1 and Bcl-2 in human primary pDCs. Our findings provide new targets that could improve the efficacy of GCs for the treatment of SLE.
Activated ERM Protein Plays a Critical Role in Drug Resistance of MOLT4 Cells Induced by CCL25
Li Zhang, Ruijing Xiao, Jie Xiong, Jun Leng, Altaf Ehtisham, Yi Hu, Qianshan Ding, Hui Xu, Shengwu Liu, Jin Wang, Dean G. Tang, Qiuping Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0052384
Abstract: We have previously demonstrated that the CCR9/CCL25 signaling pathway plays an important role in drug resistance in human acute T-lymphocytic leukemia (T-ALL) by inducing activation of ERM protein with polarized distribution in T-ALL cell line MOLT4. However, the mechanism of action of the activated ERM protein in the drug resistance of MOLT4 cells induced by CCL25 remains uncharacterized. Here we investigated the mechanism of CCR9/CCL25-initiated drug resistance in CCR9-high-expressing T-ALL cells. Our results showed that 1) the function of P-gp was increased after treatment with CCL25; 2) P-gp colocalized and co-immunoprecipitated with p-ERM and F-actin in CCL25 treated cells; and 3) ERM-shRNA conferred drug sensitivity coincident with release of ERM interactions with P-gp and F-actin after treatment with CCL25. These data suggest it is pivotal that P-gp associate with the F-actin cytoskeleton through p-ERM in CCR9/CCL25 induced multidrug resistance of T-ALL cells. Strategies aimed at inhibiting P-gp-F-actin cytoskeleton association may be helpful in increasing the efficiency of therapies in T-ALL.
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