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Search Results: 1 - 4 of 4 matches for " Puangsoi Worakul "
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Genome-Wide Association Study in Thai Tsunami Survivors Identified Risk Alleles for Posttraumatic Stress Disorder  [PDF]
Nuntika Thavichachart, Taisei Mushiroda, Thongchai Thavichachart, Ongart Charoensook, Anchalee Prasansuklab, Prathan Rutchatajumroon, Sookjaroen Tangwongchai, Puangsoi Worakul, Buranee Kanchanatawan, Siriluck Suppapitiporn, Atapol Sughondhabirom, Chutima Roomruangwong, Wasun Chantratita, Atsushi Takahashi, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura
Open Journal of Genetics (OJGen) , 2015, DOI: 10.4236/ojgen.2015.52004
Abstract: Posttraumatic stress disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event. Multiple environmental and genetic factors can contribute to PTSD susceptibility. Since it is rare to find members of the same family afflicted by the same catastrophic event, it is not practical to determine PTSD susceptibility genes by a gene linkage analysis. A natural disaster, such as the 2004 Tsunami, provided us with a rare chance for a genetic analysis of PTSD. To identify SNPs associated with PTSD susceptibility, we conducted a genome-association study (GWAS) in Thai-Tsunami survivors. Initial phase of the study with 396 chronic PTSD patients and 457 controls, we identified top ninety SNPs (P < 1 × 10-4), which were further assessed in the second phase with 395 chronic PTSD patients and 798 controls. Two SNPs (rs267950 and rs954406), were identified in the second phase, and subjected to fine mapping using a data set from both phases. SNP rs267943 showed the strongest association with PTSD susceptibility and was in complete linkage disequilibrium with SNP rs267950 with P = 6.15 × 10-8, OR = 1.46 and 95% CI = 1.19 - 1.79, reaching genome-wide significance. SNP rs267943 is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and, when linked to a synthetic promoter, could regulate transcription. To our knowledge, this is the first GWAS for PTSD susceptibility in an Asian population which could provide an important insight into the genetic contribution of PTSD and may lead to new treatment strategies for PTSD.
Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach  [PDF]
Nuntika Thavichachart, Prathan Rutchatajumroon, Taisei Mushiroda, Anchalee Prasansuklab, Sookjaroen Tangwongchai, Puangsoi Worakul, Buranee Kanchanatawan, Siriluck Suppapitiporn, Atapol Sughondhabirom, Chutima Roomruangwong, Ongart Charoensook, Wasun Chantratita, Atsushi Takahashi, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura
Open Journal of Genetics (OJGen) , 2019, DOI: 10.4236/ojgen.2019.93005
Abstract: Background: Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster. “Tsunami” occurred in Andaman coast of Thailand on December 26, 2004, in which 33.6% of survivors were diagnosed as PTSD. This study aimed to explore the single nucleotide polymorphism (SNP). rs267943 genotype is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and psychosocial factors for PTSD. Methods: Participants (N = 1970) were recruited from volunteers who have complete data both of DAP1 gene and psychosocial factor. Results: Using a binary logistic regression model, significant gene-environment interactions were found for the single nucleotide polymorphism (SNP) rs267943 and psychosocial factors including depression (adj. OR = 6.0, 95% CI = 4.29 - 8.39), neurotic personality (adj. OR = 2.73, 95% CI = 2.18 - 3.42), planning (adj. OR = 1.52, 95% CI = 1.20 - 1.93), use of emotional support (adj. OR = 1.32, 95% CI = 1.21 - 1.94) with statistical significant p < 0.001 and self-distraction (adj. OR = 1.52, 95% CI = 1.15 - 1.85) with statistical significant p < 0.05. Conclusion: This study demonstrated that GxE studies can be utilized to shed light on the origins of PTSD.
PREPARATION OF ISONIAZID AS DRY POWDER FORMULATIONS FOR INHALATION BY PHYSICAL MIXING AND SPRAY DRYING
SOMCHAI SAWATDEE,NIMIT WORAKUL,TEERAPOL SRICHANA
Malaysian Journal of Pharmaceutical Sciences , 2006,
Abstract: The main purpose of this study is to develop isoniazid as dry powder aerosol for delivery to the lower airways and to study the susceptibility of M. bovis and M. tuberculosis to the formulationsstudied. Isoniazid was formulated with trehalose, mannose and lactose by physical mixing and spray drying techniques. All formulations were evaluated for delivery efficiency and stability.Susceptibility tests of Mycobacterium species to the drug formulations were carried out. Isoniazid mixed with fine trehalose, micronised mannose or fine lactose produced the formulations whichgave fine particle fraction (< 5 μm) of over 60%. The different size of carrier particles strongly affects the deposition of isoniazid to the lower airways in vitro. The content of all isoniazid drypowder formulations was almost 100% of the theoretical content and found to be stable over 3 months storage. These formulations showed that their mass median aerodynamic diameter varied from 3.14 ± 0.38 to 4.40 ± 0.65 μm. Drug susceptibility testing of M. tuberculosis by broth microdilution showed that the MIC of isoniazid dry powder formulations were 1.7 to 3.4 times lower than standard isoniazid. Flow cytometry analysis of viable M. bovis revealed that MIC ofisoniazid dry powder formulations and standard isoniazid had no significant difference (p > 0.05).
Posttraumatic mental health establishment of the Tsunami survivors in Thailand
Thavichachart Nuntika,Tangwongchai Sookjaroen,Worakul Puangsoy,Kanchanatawan Buranee
Clinical Practice and Epidemiology in Mental Health , 2009, DOI: 10.1186/1745-0179-5-11
Abstract: The natural disaster known as "the Tsunami" occurred in Andaman coast of Thailand in December 2004, and there had been questions whether it could cause PTSD amongst the population who lives in the affected area and how to avoid PTSD condition to occur. The purpose of this study is to establish statistical results of psychosocial factors, and their correlation to PTSD and other mental disorders in order to generate the PTSD database. Cross sectional community surveys had been conducted in two phases from the same sampling group, the first phase is concerned with prevalence of PTSD, depression and related factors. Results were collected from 3,133 samples and shows that 33.6% suffered from PTSD, 14.27% with depression and 11.27% suffered from both. The second phase is focused on chronic PTSD and other mental disorders 2,573 samples were collected and only 21.6% were diagnosed with chronic PTSD. The statistical analysis has identified risks factors that could cause PTSD, and protective actions which could help to prevent PTSD.
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