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Search Results: 1 - 10 of 282 matches for " Psoralea corylifolia Linn "
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SYNERGISTIC EFFET OF INDIGENOUS MEDICINAL PLANT EXTRACTS ON PSORIASIS
anusha swarna
International Journal of Phytopharmacy , 2013, DOI: 10.7439/ijpp.v3i1.39
Abstract: The present paper deals with evaluation of synergistic effect of two medicinal plants, Ponamia pinnata Linn and Psoralea corylifolia Linn. Extraction was carried out with soxhlet apparatus using the solvent ethanol. The anti-psoriatic activity was done by Induction of psoriasiform changes in guinea pig by propranolol method and Rat UV B rays Photo dermatitis model for psoriasis. Antimicrobial activity by plate hole diffusion method. Ethanolic extract exhibited significant effect of anti-psoriatic and antimicrobial activity. Both the extracts show synergistic effect on both psoriasis and antimicrobial studies when compared with the individual extracts.
Pesticidal Activity of a Novel Coumestan Derivative Isolated from Psoralea corylifolia Linn. Against Tribolium casteneum Herbst. Adults and Larvae (Coleptera:Tenebrionidae)
N.A. Khatune,M.E. Islam,M.A.A. Rahman,M.A. Baki
Journal of Agronomy , 2002,
Abstract: The pure compound, 6-(-3-methylbut-2-enyl)-6′-7-dihydroxycoumestan (1) isolated from the chloroform extract of the seeds of Psoralea corylifolia Linn. was evaluated for the pesticidal activity against both adults and different instars of Tribolium casteneum Hebrst. under laboratory conditions. The LD50 values for the compound were 910.34, 620.47, 388.45 and 1159.87, 714.88, 404.26 and 1395.70, 740.75, 493.97 and 1605.34, 835.61, 565.83 and 1652.84, 916.79, 729.50 and 1764.32, 994.16, 784.09 and 1678.52, 992.04, 795.67 and 2350.41, 1395.70, 985.12 ppm for the 1st, 2nd, 3rd, 4th, 5th, 6th, adult male and female, respectively at 24, 48 and 72 h post exposure. These results demonstrated that the earlier instars were more sensitive to the compound than those of late instars those follow to those of individual adults.
Chemical Composition and Insecticidal Activity of Essential oil obtained from DCM Extracts of Psoralea corylifolia against Agricultural pest
Monika Gupta,Aditi Gupta,Sudhakar Gupta
Current World Environment , 2013, DOI: http://dx.doi.org/10.12944/cwe.8.2.18
Abstract: The insecticidal activity of essential oils obtained from DCM extracts of Psoralea corylifolia (Fabaceae) against pupa of Epilachna insect was investigated in a series of laboratory experiments. Insecticidal activity was determined at 24 ± 4 C and 68 ± 5% R.H., in dark conditions. The DCM extracts of the dried seeds of the plants were subjected to Column chromatography and the oil obtained was then subjected to hydrodistillation using a Clevenger type apparatus. The major components in these essential oils are identified using GC-MS spectroscopy and their insecticidal activity was tested. The predominant components in the oil of Psoralea corylifolia are toluene, alpha-pinene, L-beta-pinene, beta-pinene, 3-carene, limonene, Gamma terpinene, terpinolene, alpha santolina alcohol, 4-terpineol, Cyclohexene, 1-methyl-4-(1-methyl ethenyl), caryophyllene, alpha caryophyllene, thumbergene. The mortality rate of the agricultural pests was checked against 1%, 5% and 10% conc. of essential oil. The essential oil from Psoralea corylifolia shows strong toxic effect against pupa of Epilachna insect. Finding insecticidal activity is of great importance as using plant extracts as insecticides, are biodegrable and do not leave toxic residues results in better crop and better human health.
PRELIMINARY PHYTOCHEMICAL SCREENING OF SEEDS OF PSORALEA CORYLIFOLIA
Mohammed RafiqKhan,Ranjini R
International Research Journal of Pharmacy , 2013,
Abstract: Psoralea corylifolia known as “Babchi” is a medicinal plant for the treatment of skin diseases. In India, indigenous herbal remedies such as Ayurveda and other Indian traditional medicines have since ancient times used plants in treatment of various disorders. In our present investigation preliminary phytochemical analysis of Psoralea corylifolia has been evaluated for the presence of bioactive constituents using various polarity solvents including hexane, butanol, ethanol and water. The phytochemical screening of the plant extracts revealed the presence of maximum compounds including carbohydrates, terpenoids, alkaloids, phenols, tannins, amino acid and proteins, cardiac glycosides. The results suggest that the ethanolic extract of Psoralea corylifolia has promising therapeutic potential and can be used as a base for the development of novel potent drugs in phytomedicine.
STUDIES ON THE COMPOSITION AND STANDARDIZATION OF “BAKUCHI OIL”, AN AYURVEDIC MEDICINAL OIL PREPARED FROM PSORALEA CORYLIFOLIA L. USED IN THE TREATMENT OF VITILIGO
Abeysekera Ajita Mahendra,Gunaherath Kamal Bandara,Gunawardena Ajantha Rohinie,Jayaweera Champa Disala
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: “Bakuchi oil” is Ayurvedic medicinal oil prepared from the dried fruits of Psoralea corylifolia L. (Fabaceae) and Sesame oil is used widely in the treatment of vitiligo in Sri Lanka. The standardization of the oil is important for its safe and effective clinical use. A method was developed to quantitatively extract psoralen, the major photoactive compound in the oil and quantify it by TLC fluorodensitometry. The precision of the method was 4.3% CV (n = 6). A TLC fingerprint of the oil highlighting six fluorescent secondary metabolites of Psoralea corylifolia (psoralen, isopsoralen, corylin, psoralidin, dehydroisopsoralidin and isobavachalcone) was also developed. Of these dehydroisopsoralidin is being reported for the first time from a natural source. Analysis of the oil indicates that Bakuchiol, a major secondary metabolite of Psoralea corylifolia is not incorporated into the medicinal oil.
Induced High Frequency Shoot Regeneration and Enhanced Isoflavones Production in Psoralea corylifolia
Amit N. Shinde,Nutan Malpathak,Devanand P. Fulzele
Records of Natural Products , 2009,
Abstract: High frequency shoot regeneration and evaluation of product synthesis at various stages in Psoralea corylifolia were investigated. In vitro regenerated shoots were induced from germinated seedling on MS medium supplemented with 2, 4, 8, 20 and 40 μM of thidiazuron and N 6–benzylaminopurine. The results revealed that optimum concentrations of thidiazuron (8 μM) into the medium increased shoot regeneration frequency. Root differentiation was achieved from regenerated shoots on growth regulator free MS medium with frequency of 91.2% and mean number of 4.5 roots per shoot. High concentrations of Indole-3-aceticacid (IAA) into the rooting medium resulted in slow growth. Regenerated shoots and roots enhanced isoflavones production compared to field grown plants. A reverse phase high performance liquid chromatography analysis revealed that in vitro regenerated shoots accumulated 0.85% dry wt of daidzein and 0.06% dry wt of genistein. Maximum daidzein (1.23% dry wt) and genistein (0.38% dry wt) were accumulated by roots which obtained from regenerated shoots, which is 6.3-fold more daidzein and 77-fold more genistein respectively than field grown plants. The regeneration protocol developed successfully in this study showed the possibility for rapid propagation of P. corylifolia and enhanced isoflavones production.
Insecticidal Activity of Bioactive Compound: 2H-Furo [2, 3-H]-1-Benzopyran-2-One, Isolated Form Seeds of Psoralea Corylifolia L against Sitophilus Oryzae
Kiran B
Asian Journal of Biomedical and Pharmaceutical Sciences , 2013,
Abstract: Insecticidal activity of the bioactive compound 2H-Furo[2,3-H]-1-benzopyran-2-one isolated from the seeds of P. corylifolia against S. oryzaewas observed at 1000ppm and 1500ppm concentration .50% of the seeds gotinfected by insects at 250 and 500ppm concentration. The number of insectsgradually increased with increase in storage period from 0 to 120 days. Intreated seeds at 1000 and 1500ppm concentration complete inhibition ofinsects was observed without altering the nutritive value. At 250 and 500ppmconcentration, significant insecticidal activity was observed. Hence thepercent mortality was increased with increase in concentration withoutbiodeterioration
ANTIMICROBIAL AND ANTIOXIDANT SYNERGY OF PSORALEA CORYLIFOLIA LINN. AND PLUMBAGO ZEYLANICA LINN.
P. Suman , P.V. Smitha , K.Y. Ramkumar , A. Siva , Ch. Murali Mohan and S. Hara Sreeramulu*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: Objectives: Psoralea corylifolia L. (seeds) and Plumbago zeylanica L. (bark) were combined in the ratio of 8: 2 and named as “Swithranasini” and used for the treatment of skin diseases in ayurvedic medicine. Scientific studies validating the therapeutic properties for this indigenous medicine are lacking. This study focused on determining antimicrobial efficacy of methanol and butter milk extracts along with antioxidant efficacies of these plant parts independently and in combination. Materials and Methods: Antimicrobial activity was tested against seven pathogenic bacteria and six pathogenic fungi by measuring the zone of inhibition. In vitro antioxidant activities were assayed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and Ferric reducing antioxidant power (FRAP) method. Results: Individual extracts of the two plants showed better zone of inhibition (12- 40 mm) when applied alone but the activity was more when applied in combination (18-50 mm) against the tested pathogens. DPPH activity of methanol extracts showed higher radical scavenging activity when compared with the positive control, ascorbic acid. The IC50 values are 442.080, 457.825, 432.040 and 394.563 ug/ml for A, B, A+B and ascorbic acid respectively. The FRAP method also showed excellent antioxidant potential in combination (85.454 mg of Gallic acid equivalents/g) when compared with individual extracts A (78.571 mg GAE/g) and B (75.472 mg GAE/g).Conclusion: The results validate the potent use of “Swithranasini” against skin infections and results are an evidence for the existence of synergism among the compounds.
Insecticidal and genotoxic activity of Psoralea corylifolia Linn. (Fabaceae) against Culex quinquefasciatus Say, 1823
Dua Virendra K,Kumar Arvind,Pandey Akhilesh C,Kumar Sandeep
Parasites & Vectors , 2013, DOI: 10.1186/1756-3305-6-30
Abstract: Background Indiscriminate use of synthetic insecticides to eradicate mosquitoes has caused physiological resistance. Plants provide a reservoir of biochemical compounds; among these compounds some have inhibitory effect on mosquitoes. In the present study the larvicidal, adulticidal and genotoxic activity of essential oil of Psoralea corylifolia Linn. against Culex quinquefasciatus Say was explored. Methods Essential oil was isolated from the seeds of P. corylifolia Linn. Larvicidal and adulticidal bioassay of Cx. quinquefasciatus was carried out by WHO method. Genotoxic activity of samples was determined by comet assay. Identification of different compounds was carried out by gas chromatography- mass spectrometry analysis. Results LC50 and LC90 values of essential oil were 63.38±6.30 and 99.02±16.63 ppm, respectively against Cx. quinquefasciatus larvae. The LD50 and LD90 values were 0.057±0.007 and 0.109±0.014 mg/cm2 respectively against adult Cx. quinquefasciatus,. Genotoxicity of adults was determined at 0.034 and 0.069 mg/cm2. The mean comet tail length was 6.2548±0.754 μm and 8.47±0.931 μm and the respective DNA damage was significant i.e. 6.713% and 8.864% in comparison to controls. GCMS analysis of essential oil revealed 20 compounds. The major eight compounds were caryophyllene oxide (40.79%), phenol,4-(3,7-dimethyl-3-ethenylocta-1,6-dienyl) (20.78%), caryophyllene (17.84%), α-humulene (2.15%), (+)- aromadendrene (1.57%), naphthalene, 1,2,3,4-tetra hydro-1,6-dimethyle-4-(1-methyl)-, (1S-cis) (1.53%), trans- caryophyllene (0.75%), and methyl hexadecanoate (0.67%). Conclusion Essential oil obtained from the seeds of P. corylifolia showed potent toxicity against larvae and adult Cx. quinquefasciatus. The present work revealed that the essential oil of P. corylifolia could be used as environmentally sound larvicidal and adulticidal agent for mosquito control.
ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF HEXANE EXTRACT OF SEED OF PSORALEA CORYLIFOLIA LINN.
Bina Gidwani
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: The main objective of this study is to determine anti-inflammatory and antimicrobial activity of hexane extract of seeds of of Psoralea corylifolia Linn. Anti-inflammatory activity of Psoralea corylifolia Linn. was evaluated by carrageenan induced rat paw oedema assay. The seed of plant was extracted in soxhlet apparatus using hexane as solvent. Nine healthy swiss albino rats of either sex were divided into 3 groups, each consisting of 3 rats. The evaluation was done by Hind paw method and compared with standard and control groups. Further, the antimicrobial activity of Psoralea corylifolia Linn was studied by Disc diffusion method using different gram positive and gram negative bacterial and fungal strains, which showed that it has prominent activity compared with the standard used. The hexane extract of Psoralea Corylifolia showed significant anti- inflammatory activity (44%) when compared with the standard (55%). For antimicrobial activity, zone of inhibition were found to be in concentration of 5μg / ml for bacterial strains and 4μg / ml for fungal strains.
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